Nutrex Warrior Pre-Workout Gets Stronger With Nitrosigine!

Nutrex Research Inc

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In our last Nutrex Research article, we unveiled The Warrior Series, the culmination of a year’s worth of hard work. It includes a fresh new look, along with a solid mix of existing and new products, such as Vitadapt Complete, Alpha Pump, Outlift Amped, and Lipo-6 Hardcore. But in terms of excitement, one supplement stood out in the new Warrior Series.

The chains are off! And we’re excited to see the flagship product of the Warrior Series is Warrior Powerful Pre-Workout.

“Warrior may be stronger than any pre-workout you have ever tried. Its effects are intense. Just one serving feels like you stepped on dynamite. Fuel your mind and body to the max and crush goals in the gym. Charge ahead with high stimulant energy and zoned-in focus for unstoppable power. Push beyond your limits. No weight is too heavy, no training too intense. No pump has ever felt like this. Unleash the Warrior within and get ready to pull out all the stops.”

— Nutrex Research

Nutrex’s Warrior Pre-Workout: Push Beyond Your Limits

Nutrex Warrior Nitrosigine

Nutrex swamped out GlycerSize for Nitrosigine and delivers a stronger pump.

Up until now Nutrex was known for their clinically-dosed comprehensive pre-workout, Outlift. It has everything users need to conquer grueling training sessions. Nutrex formulated the supplement to be the most advanced pre-workout formula they offer and with nearly 400 milligrams of caffeine, it’s not for the faint of heart.

For most consumers who haven’t tried Nutrex’s products, Outlift is a great place to start. However, if you can tolerate a hefty dose of stimulants — for the purpose of maximizing training sessions — Warrior may be a good one to go with. We always recommend starting with half a serving to assess your tolerance, especially when they come this strong. Warrior Pre can also be a great tool for those big training sessions where you’re going for a new personal record or in competition.

We have everything you need to know about Warrior below. But first, sign up for Nutrex Research news and deal alerts, because they’re always launching new products, flavors, and offering giveaways.

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Warrior Pre-Workout Ingredient Breakdown

Nutrex Research carefully selected 10 ingredients to create a formula that delivers high-powered energy, locked-in focus, enhanced strength, power, endurance, and amplified pumps. It contains 400 milligrams of caffeine from two different sources, which is supposed to result in a sustained increase in energy.

Nutrex Research uses an open formula label that allows consumers to see the company uses solid dosages of each ingredient.

Here’s what one serving (8.8g) of Warrior consists of:

    • Betaine Anhydrous – 2.5g

      Nutrex Warrior Updated Ingredients

      Nutrex Warrior is now loaded with 1 gram of Nitrosigine.

      Warrior starts with the clinically-studied dose of betaine anhydrous, an ingredient known for boosting power, strength, and lean muscle mass.[1-4]

      Trimethylglycine, commonly referred to as betaine, is classified as an organic osmolyte. It’s naturally found in several plants, most notably beets.[1] Research shows that betaine supplementation can increase physical performance through three primary mechanisms: acting as a methyl donor,[1-3] maintaining electrolyte and fluid balance in the cells,[2,3] and increasing nitric oxide production.[4]

      The ultimate methyl donor for enhanced performance

      Since betaine is composed of three methyl groups bound together with a glycine molecule, it can donate a methyl group to a non-proteinogenic amino acid called homocysteine.[1-3] This helps increase performance in two ways. It positively affects muscle protein synthesis by lowering levels of homocysteine. And it’s likely that betaine boosts endogenous creatine production because it’s able to convert homocysteine into methionine, an amino acid that serves as a precursor to creatine production.[5]

Osmolyte action: adds to hydration and pumps

By acting as an osmolyte, betaine helps keep cells hydrated, which is further enhanced by the next ingredient.[1-3] There’s some evidence to suggest betaine can boost nitric oxide levels, resulting in improved blood flow, nutrient delivery, and waste removal in working muscles.[4]

Betaine is a powerful ingredient and it’s a great way to kick off the formula for Warrior.

    • Inositol Stabilized Arginine Silicate (as Nitrosigine) – 1g

      Nutrition21 Nitrosigine Graphic

      Nitrosigine is primarily found in pre-workouts, thanks to its ability to boost nitric oxide levels.

      A few months after releasing Warrior, Nutrex ditched the 1.5 grams of GlycerSize for 1 gram of Nitrosigine, also known as inositol stabilized arginine silicate (ASI). Since glycerol is notorious for clumping and grittiness, a result of its hydrostatic properties, it was a smart move to replace it with Nitrosigine. Both ingredients promote muscular pumps and enhance performance. But they work through slightly different pathways.

      Glycerol maintains hydration by helping the body retain water, thus creating a “water-based” pump in the muscles. Whereas, Nitrosigine increases nitric oxide production, resulting in improved blood flow and nutrient/oxygen delivery via vasodilation (expansion) of the blood vessels. Since the literature shows that you need a massive dose (1 gram/kilogram of body weight) of glycerol to see any notable benefits, then 1 gram Nitrosigine, as opposed to 1.5 grams of glycerol, is likely to be more effective for increasing pumps and performance.

      Nitrosigine is a patented ingredient from Nutrition21 and it has benefited from a lot of attention this year. Nitrosigine is made up of arginine, silicate, and inositol. Pure L-arginine has been found to have poor bioavailability, meaning that a large portion of it is metabolized in the gastrointestinal system before its absorbed and used for nitric oxide production. It’s known as the first-pass effect).[6,7] Therefore, it’s not very effective on its own. However, L-arginine serves as a direct precursor to nitric oxide, so if there was a way to fix this issue, then that would be the most ideal scenario.

      Fortunately, the masterminds at Nutrition21 discovered that if you bind L-arginine to silicate and add in a small amount of inositol to act as a stabilizer, the poor bioavailability issue is fixed! In other words, the silicate and inositol allow for L-arginine to be fully absorbed by the body and used to create nitric oxide.

      Nutrition21 LogoIn the past, companies would opt to use L-citrulline as opposed to L-arginine since it’s been shown to raise plasma arginine levels better than L-arginine itself. Now that Nitrosigine is on the market, companies have the option to use a superior form of arginine on its own or in combination with citrulline to promote even greater pumps!

      In fact, a randomized clinical trial conducted by researchers at the University of Arkansas found that 1.5 grams of Nitrosgine were just as effective as 8 grams of citrulline malate at boosting nitric oxide and arginine levels in healthy young adults.[6] This suggests that Nitrosigine may be stronger than citrulline malate on a gram-to-gram comparison. So using 1.5 grams of Nitrosigine, as opposed to 8 grams of citrulline malate, leaves more room for other beneficial ingredients.

      Moreover, multiple studies have shown that Nitrosigine enhances energy levels, focus, cognitive flexibility, and recovery while reducing inflammation and excessive muscular damage.[6-10] It’s important to note that the clinically-studied dose is 1.5 grams, but you should still see some benefits with 1 gram. Personally, we think it’s a good move for Nutrex to make this switch and create an even stronger version of Warrior.

      If you want to learn more about Nitrosigine, check out the following blog posts: Nitrosigine: The Nitric Oxide Booster That Enhances Brain Function Nitrosigine Put to the Test Against Citrulline Malate: New University Study Nitrosigine Prevents Cognitive Decline After Strenuous Activity

    • Creatine HCl – 1g

      Nutrex Volu-Gro

      Looking for more creatine, then add Volu Gro to your post-workout shake.

      Besides caffeine, creatine is the most studied ingredient in the sports supplement industry. At this point, it’s well established that creatine is safe, effective, and can significantly boost both aerobic and anaerobic performance.[11-13] Interestingly, researchers are now starting to assess if creatine supplementation can positively affect the brain.

      Creatine supplementation is extremely popular in strength sports, such as bodybuilding, powerlifting, CrossFit, and strongman competitions because of the role it plays in regenerating adenosine triphosphate (ATP). ATP is referred to as the cell’s energy currency since it’s used to fuel nearly every physiological function in the body. When someone’s running low on ATP, he or she can expect to see a significant drop in performance, no matter the activity.

      There are three main energy systems that are solely designed to take energy substrates (carbs and fats) and convert them into ATP. But in regards to creatine, the only one we’ll discuss is the creatine phosphate energy system.

      The Creatine Phosphate Energy System

      Within the first 10 to 20 seconds of exercise, you’re primarily relying on stored ATP to get going. But that quickly runs out and it takes a little while for other energy systems to start cranking out ATP. In the meantime, the body uses its creatine stores. After the ATP is broken down, it turns into adenosine diphosphate (ADP). At that point, creatine can donate a phosphate group and quickly convert back into ATP.

      This may seem like a minor detail, but creatine has been shown to have profound effects on performance, especially anaerobic activities such as sprinting and weightlifting.[11-13] Creatine is naturally found in animal-based products. However, if you need to consume a large amount to top off your creatine stores, a supplement is a fantastic option.

Why Nutrex chose Creatine HCL

There are several forms of creatine — the most popular is creatine monohydrate. For Warrior, Nutrex went with Creatine HCL, which is a creatinine molecule bound to hydrochloric acid. It’s not necessarily better than other forms, but the addition of HCL may improve creatine absorption and bioavailability.

Warrior Pre, Volu-Gro Post

Some users report less gastric discomfort with creatine HCL than with creatine monohydrate. Since the recommended dosage is between 3 to 5 grams per day, one gram is on the low end. However, creatine is extremely affordable, so consider picking up some to fill in the gap.

Using the tasty Nutrex Volu-Gro post-workout is simple and effective creatine + dextrose source (note: it stacks well with Vanilla IsoFit). Done and done.

  • Choline Bitartrate – 1g

    Warrior aims to deliver locked-in focus. Choline Bitartrate along with L-Tyrosine is a good combination for that.

    There are several neurotransmitters in he body that relay messages between cells and neurons. It’s how the central nervous system is able to communicate with the rest of the body. They are extremely important for several physiological processes, but most notably coordinated movement, like exercise.

    Nutrex Research Alpha Pump Updated

    If you want more pump and focus, but less stims, try stacking Warrior with Alpha Pump.

    One of the key neurotransmitters involved in skeletal muscle contraction is acetylcholine, which is synthesized in the body when an acetyl group and a choline molecule combine. But choline can be obtained through diet by eating sufficient amounts of foods like eggs and fish.[14] However, if you regularly exercise and are serious about getting the most out of every session, then choline is a great nutrient to supplement with. It’s exactly why Nutrex included choline bitartrate in Warrior.

    Choline bitartrate consists of choline bound to tartaric acid, similarly to creatine HCL. The tartaric acid is supposed to increase the bioavailability and absorption of choline by acting as a stabilizer. Once inside the body, the two molecules separate and choline can be used as a precursor for acetylcholine synthesis.

    Greater levels of acetylcholine can improve mind-muscle connection, focus, and mental energy.[15-18] Exercise is known for depleting levels of acetylcholine in the brain and muscles. It’s one of the reasons people feel fatigued at the end of a hard set. Therefore, having extra choline to help regenerate acetylcholine can significantly improve performance.[15-18]

    Lastly, choline is considered an essential nutrient. So getting an adequate amount each day is crucial for health and performance.[14,15]

  • L-Tyrosine – 750mg

    The two most common forms of tyrosine in the sports supplement scene are L-tyrosine and N-acetyl L-tyrosine (NALT). Both may be popular ingredients in pre-workouts and nootropics, but based on the research, if you had to choose one, L-Tyrosine is the better option. It has superior bioavailability, absorption, and has been shown to increase tyrosine levels for up to seven hours with just a 100 milligram dose.[19]

    L-Tyrosine

    Long story short from our analysis — for the best outcome from tyrosine, choose regular L-tyrosine.

    In regards to boosting athletic performance, tyrosine’s main benefit is its ability to increase the synthesis of multiple neurotransmitters. As we discussed, neurotransmitters are crucial for cell-to-cell communication. And while choline bitartrate helps maintain sufficient levels of acetylcholine, L-tyrosine can enhance levels of dopamine, epinephrine, and norepinephrine.[20]

    These three neurotransmitters are classified as catecholamines because they function as hormones. Similarly to choline, intense bouts of exercise can lead to the depletion of these key neurotransmitters. So supplementing with L-tyrosine can help sustain levels for longer.[20] Studies have found that tyrosine can boost physical performance by improving mood, focus, and cognition.[20] Other research shows that tyrosine can aid in adapting to stressful events.[20]

    750 milligrams is a generous dose and when combined with choline bitartrate, expect razor-sharp focus.

  • Caffeine Anhydrous – 300mg (out of 400mg total)

    Warrior is one of Nutrex’s most advanced pre-workouts and with 400 milligrams of caffeine, it’s a bit heavy on the stim side. There are two sources of caffeine that provide quick and longer-lasting energy.

    The first form of caffeine is caffeine anhydrous, providing 300 milligrams out of 400 milligrams total. It’s known as a fast-acting agent, so don’t be surprised if you get a rush of energy after a few minutes of taking Warrior. Practically everyone knows that caffeine is effective at enhancing mental and physical energy, but how is that accomplished?

    Nutrex Research The Warrior Series

    Warrior Pre-Workout is one of nine products in the complete Warrior Series line-up.

    Caffeine is the common name for trimethylxanthine and you can find it everywhere, such as in energy drinks, coffee, pre-workouts, nootropics, fat burners, and even in some functional foods. There’s no denying the power of caffeine, and because it’s readily absorbed and crosses the blood-brain barrier, it affects the body on multiple levels.[21-23]

    We could write a book on the effects and benefits of caffeine, but we’ll save some time. Just know that caffeine mainly works by serving as an adenosine antagonist, meaning it prevents adenosine from binding to its target receptor.[21-23] Adenosine is known for causing decreased neural system activity, leading to drowsiness. Therefore it’s ideal to inhibit it when you’re looking for optimal athletic performance. Several studies have shown that caffeine can significantly increase anaerobic and aerobic performance.[21-23]

    300 milligrams alone is enough to get anyone buzzing, but wait, there’s more…

  • Kaff Citrate (Caffeine Citrate) – 200mg (yielding 100mg out of 400mg total)

    Nutrex research Warrior Zone IsoFit

    Prepare for battle with Warrior and recover with IsoFit.

    To further increase energy and performance, Warrior also includes another 100 milligrams of caffeine, derived from Kaff Citrate. It’s not very common to see this form of caffeine in the sports supplements, however, when Nutrex was designing Warrior, they believed it would provide extra power.

    Kaff Citrate, also known as caffeine citrate, has three main components: caffeine anhydrous, citric acid monohydrate, and sodium citrate dihydrate.[24] There’s not a ton of research available on caffeine citrate specifically, but it’s commonly used in healthcare to treat certain medical ailments, including apnea and migraines.[24]

    Faster caffeine?!

    Due to its composition, Kaff Citrate increases energy even faster than caffeine anhydrous, so be prepared for a mad rush in energy. After looking at this formula, Kaff Citrate is one unique ingredient that definitely stands out. Nutrex said this is an advanced pre-workout — they’re not messing around!

    • Theobromine – 200mg

      Just in case 400 milligrams of caffeine is enough for you stim junkies out there, 200 milligrams of theobromine will make ensure you have all the added energy you need.

      Nutrex Research Warrior Series Two

      The Warrior Series features a mix of old and new products designed to provide results.

      Theobromine is known as caffeine’s cousin because it has a similar chemical structure and results in a slight stimulatory effect.[25-27] Theobromine derives from cocoa beans and classified as a methylxanthine.[26] And just like caffeine, its main mechanism of action is blocking adenosine receptors.[26]

      However, it can also inhibit phosphodiesterase, an enzyme responsible for deactivating key secondary messenger systems, including cAMP (cyclic adenosine monophosphate) and cGMP (cyclic guanosine monophosphate).[26]

      Theobromine is also known for suppressing appetite and has anti-inflammatory, anti-tumoral, and cardiovascular protective properties.[25-27]

    • Rauwolfia (Rauwolfia vomitoria) extract (root) – 1.5mg

      Rauwolfia, more commonly called alpha-yohimbine, is an alkaloid that’s known for being a strong sympathetic nervous system activator. You’ll most likely find it in advanced pre-workout formulas and intense fat burners.

      Nutrex OutLift Graphic

      OutLift is Nutrex Research’s clinically-dosed powerhouse.

      Alpha-yohimbine has a similar molecular structure and benefits to yohimbine, but without the negative side effects. Studies report that alpha-yohimbine is effective at increasing energy, fat loss, improving mood, libido, and suppressing appetite.[28-31]

      Beyond stimulating the central nervous system, its primary mechanism of action is serving as an alpha-2 antagonist, meaning it blocks substrates from binding to these receptors.[28] Due to this effect, it can boost fat loss by enhancing lipolysis and preventing fat storage.[29] This means more circulating energy to use to crush your workout.

      Warrior may not be marketed as a fat burner, but when you’re going to the gym with the goal of improving your physique, then rauwolfia can help amplify results. The ingredient is considered an alternative to regular yohimbine since many, anecdotally, experience less anxiety, nervousness, irritability, and headaches than with yohimbe.

      It’s important to note that 1.5 milligrams is a strong dose. So we always recommend starting with half a serving to assess your tolerance.

    • Toothed Clubmoss (Huperzia Serrata) extract (aerial) – 200mcg

      Warrior includes the tried-and-true combination of toothed clubmoss, more commonly called huperzine A, and choline bitartrate to top off acetylcholine levels.

      While choline bitartrate is hard at work raising acetylcholine levels, huperzine A ensures they stay elevated by inhibiting the acetylcholinesterase enzyme.[32-34] This dynamic duo is known for improving focus, mental energy, and, most importantly, mind-to-muscle connection.

      This is a great way to round out the formula, for yet another exceptional pre-workout from the team at Nutrex Research.

    Check out this video to learn more about Warrior Pre-Workout!

    Subscribe to PricePlow on YouTube!

    Warrior’s Mouth-Watering Flavors

    Typically, when a product first launches, there are only one or two flavor options, but not with Warrior. Right from the start, Nutrex released six unique flavors, such as Raspberry Hard Seltzer, Barbarians, and Sour Drops.

    Nutrex Research Warrior Flavors

    Nutrex launched Warrior in six unique flavors.

    Here’s an updated list of all Warrior Pre-Workout flavors:

      Nutrex Research is known for being flavor experts. They succeeded in making plant protein taste like dessert (Nutrex Plant Protein), turn an isolate into a creamy milkshake (IsoFit), and also offer several flavors in their other pre-workouts and amino acid supplements.

      A year of hard work with a tease toward the end

      Before the big reveal, Nutrex was very quiet. But we at least knew about this pre-workout. The brand even sent us some samples so we could provide feedback. Ben tested it out and thought it was incredible. He also realized he has a strong stimulant tolerance and can handle a full scoop, unlike many viewers.

      Subscribe to PricePlow on YouTube!

      Warrior Pre-Workout: Unleash The Warrior Within

      Nutrex Research has been around since 2002, and with all of the knowledge, experience, and resources they’ve acquired over the years, they’re ready to take things to the next level. The Warrior Series was a massive project, but after seeing the line, it seems to be well worth the time, money, and effort.

      Nutrex Warrior

      We consider Warrior pre-workout the flagship product of this new series.

      Nutrex aims to create supplements for serious consumers, regardless of your goals – and keep them affordable. You could be an accountant that wants to drop 20 pounds and run a marathon, an amateur bodybuilder dreaming of getting a pro card, or a powerlifter that wants to break records. Once you build a strong foundation with diet and a training plan, supplements can help amplify your results.

      Warrior Pre-workout is absolutely loaded, and that’s just what anyone would expect from an industry leader. With 10 powerful ingredients at generous dosages, it was designed to help push past plateaus.

      Nutrex is definitely a brand you’ll want to keep an eye on. And we’ve got you covered with the latest supplement industry news, deals, and reviews. Just subscribe below.

      Nutrex Warrior Pre-Workout – Deals and Price Drop Alerts

      Get Price Alerts

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      Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

      Posts are sponsored in part by the retailers and/or brands listed on this page.

    About the Author: Mike Roberto

    Mike Roberto

    Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

    Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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    30. Arthur JM, Casañas SJ, Raymond JR. “Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors”; Biochem Pharmacol.; 1993; https://pubmed.ncbi.nlm.nih.gov/8517875
    31. Wainscott DB, et al; “[3HRauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor”; Naunyn-Schmiedeberg’s Archives of Pharmacology 357 (1): 17–24; 1998; https://pubmed.ncbi.nlm.nih.gov/9459568
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