We’ve been on a big kick with brain boosting supplements. We’ve covered the gamut from workout enhancers to gaming supplements with all kinds of products in between.
Recently, we’ve become quite enamored by NooWave Supplements, who we first featured in our blog post about The Socialite, a unique mental productivity supplement that helps one attack socially anxious situations and fully blossom into a social butterfly.
After that initial expose’, we dug into NooWave’s extensive line of supplements and couldn’t believe the wide array of products they’re offering — under everyone’s radar nonetheless. They literally have every aspect of mental enhancement covered.
Are you a High Performer?
So let’s go all out and look at their flagship nootropic, titled High Performer. It’s a rather impressive cognitive enhancing stack designed to supply the user with everything needed to accelerate in the business world or classroom setting. Be forewarned, this is a mighty potent blend of nootropics and will unleash a level of discipline, focus and motivation that should only be saved for the most dire of circumstances.
The breakdown is just ahead, but before we get there, take a moment to check the best deal and sign up for alerts from PricePlow:
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High Performer Ingredients
As we’ve seen with NooWave’s supplements so far, High Performer is very well dosed, and touts a transparent label. If you really are looking to enhance all aspects of mental performance, it really won’t get much better than what you’re about to lay your eyes on…
N-Acetyl L-Tyrosine (1g)
Starting off this powerfully packed product is the very conventional N-Acetyl L-Tyrosine, shown on the label to the right as NALT. N-Acetyl L-Tyrosine is an “optimized” version of L-Tyrosine that offers greater bioavailability, which means you can get a greater effect from an equivalent amount of L-Tyrosine.
NALT is best known for its memory and focus boosting properties thanks to its ability to increase the production of two big time neurotransmitters, dopamine and norepinephrine. Additionally, NALT also helps you relax during times of high stress by reducing levels of stress and anxiety.[1,2,3]
Good start right here, but it’s about to get a lot better:
Alpha GPC (600mg)
Up next is one of the PP crew’s all-star nootropics, Alpha GPC, short for alpha glycerophosphocholine. Alpha GPC is a highly bioavailable choline-containing compound used to increase production of the “learning neurotransmitter”, acetylcholine.
We completely enamored with this ingredient for a whole slew of reasons, but most of all for its focus-enhancing properties. While that may be the main reason it’s included in High Performer, we also need to point out that Alpha GPC enhances the “mind muscle connection” during workouts, strength levels, and even Growth Hormone (GH) output following a grueling workout![5,6]
What a dosage!
In case you couldn’t tell, this stuff is pretty freakin’ awesome, and the dose is equally amazing. If you’ve used Alpha GPC before, but never noticed much from it, chances are you’ve never used the right dose. 600mg is PLENTY enough to get you in the zone and completely forget about the cute girls sitting across the library, well maybe not…
The argument often comes down to whether you like Alpha GPC or Citicoline (CDP Choline) better as a premium choline supplement. At this whopping dose, that argument basically becomes a moot point. But it’s worth noting that NooWave seems to like both of these ingredients as well, since Citicoline is in The Socialite supplement instead.
Sulbutiamine is a synthetic variant of thiamine, one of the B-vitamins responsible for the body’s energy production processes. It was originally created by a collection scientists from Japan who combined 2 thiamine molecules with a sulphur group.
Sulbutiamine is highly touted for its ability to offset fatigue and improve memory and cognition.[7,8] You may wonder why not just use the naturally occurring form of thiamine found in food and vitamins though, and give pause to using a synthetic compound.
However, the problem with regular old thiamine is that it doesn’t cross the blood-brain barrier all that easily, but thanks Sulbutiamine’s increased fat-solubility, it easily crosses the barrier, which leads to increased levels of thiamine in the body. Ultimately, this helps combat brain fog which can set in during endless hours of tedious, strenuous mental work.
You might start to catch a trend here — this is a large dose too, where other products we’ve covered have buried it in proprietary blends.
Taking a look around the various stim based products on the market (including pre workouts, fat burners, and mental enhancers), chances are pretty high you’ll come across the ultimate “chillax” ingredient, L-Theanine. It’s become insanely popular recently in part due to its ability to take the “edgy” feeling off of stimulants, particularly caffeine.
Aside from taking the “bite” out of caffeine, L-Theanine is also enhances the cognitive focus effects of caffeine, and helps normalize the body’s stress response, particularly in high stress work-related situations.[10,11]
Be aware though, that this a rather large, and expensive, dose of a potent mellowing ingredient. It might even be a “make-it-or-break-it” ingredient for some of you that don’t like to get too “chill” when working under the gun.
We call caffeine the “everyman’s stim” because virtually everyone can tolerate it, in some dose or other. But in reality, caffeine should really be called “the everyman’s nootropic”, as it’s great for much more than just energy.
In fact, caffeine heightens just about everything in life, including focus, alertness, and motivation. It’ll keep you up during those late night study sessions, and give you the extra motivation and focus to see your work through to the end.
If 200mg is too much for you out of the gate (remember we still have a few other stims to go as well) start of with just 1 capsule (½ dose) and see how you fare.
Hordenine HCl (50mg)
Hordenine is a powerful beta-2 agonist extracted from Citrus Aurantium (a.k.a. bitter orange). It’s very similar to synephrine (our next ingredient), which also happens to be found bitter orange.
Beta-2 agonists are held in high regard for two primary reasons. First, they increase energy expenditure, which helps fat loss efforts (not the main goal here but a nice “fringe” benefit). Second, and more importantly, beta agonists like Hordenine act as noradrenaline reuptake modulators[13,14], which means hordenine helps helps noradrenaline stay active longer in the body, leading to greater energy, alertness, and focus!
Synephrine HCl (35mg)
Also found in Bitter Orange along with Hordenine is Synephrine. It’s structurally similar to the now-banned ephedra; however, unlike ephedra, Synephrine has been over and over again to be safe and effective for most healthy individuals.[15,16]
Synephrine is a rather strong Beta-2 and Beta-3 adrenergic receptor agonist[17,18] that loosens the body’s grasp on stored triglycerides and frees them to be used as a fuel source, a process known as lipolysis. This fat-liberation allows the body to basically “burn fat for fuel” and enjoy some nice fat loss effects while working the night away.
As if we’re not already bursting with nootropics, now we get to the REAL heavy hitters with our next three ingredients. Up first is Noopept, or N-phenylacetyl-L-prolylglycine.
Noopept is a proline-containing dipeptide that is an amino acid analogue. Research has shown noopept helps sensitize acetylcholine receptors to amplify their function.
Moreover, Noopept also binds to the NMDA glutamatergic receptors, which assists with “long term potentiation” (LTP). In brief, LTP is a process where stable, long-lasting memories are formed within the human brain. FYI, LTP is one of the reasons some memories last longer than others.
For more information, as well as an in-depth explanation of the science behind this potent nootropic, read our mega post Noopept: Enhancing the Smart Within.
Vinpocetine 99% (10mg)
Vinpocetine hasn’t been in the limelight nearly as much as Alpha GPC and our next ingredient, but it’s still a rather powerful nootropic in its own right. In fact, we’ve actually seen a slight uptick in its usage as of late, now that we think about it.
Vinpocetine boosts brain function and cognition by increasing vasodilation and blood flow to the brain. This ultimately helps enhance short term memory and overall cognitive function.
Huperzine A 1% (200mcg)
Yes, you read that right 200mcg. Huperzine is incredibly potent and even though this looks like a tiny amount compared to the doses of the other ingredients, 200mcg is a tremendous serving of Huperzine A.
As opposed to Alpha GPC which directly increase acetylcholine levels in the body, Huperzine indirectly boosts levels of this neurotransmitter. What we mean is that Huperzine extends the life of the already-existing acetylcholine in the body by preventing its breakdown.
Huperzine accomplishes this feat by inhibiting acetylcholinesterase, the enzyme responsible for the degradation of acetylcholine. It’s also important to note that Huperzine supports overall brain health as it defends against the “neuron death molecule” glutamine, and helps potentially create new brain cells, making it “neurogenerative”.
Seriously — did they leave anything out? As you can tell, that’s a lot of incredible stuff, and the price is going to come up along with it.
It’s also going to take more than just a couple of capsules to get a full serving, which brings us to the dosage section:
For best results, take a full serving (4 capsules), on an empty stomach with a Fish Oil Supplement, or after a light meal. Per NooWave, “many of the ingredients included in The High Performer are fat-soluble, so they are best absorbed when combined with some kind of fat source.”
If you’re a tad stim sensitive, NooWave suggests starting with a ½ serving to assess your tolerance and only increase to a full serving after you are comfortable.
If you want a rock-star nootropic with nothing overly questionable inside, this is it.
As you can see, High Performer is indeed a mighty powerful blend of nootropics that will keep you on point during the most trying crunch times you’ll encounter, like FINALS WEEK! For this reason, we’d suggest only relying on this stack when you really need to dive into your work hardcore and shut out any and all outside distractions.
You’ll be welcomed with a renewed sense of drive and motivation that you wouldn’t have experienced before and High Performer will make you that much more productive. Take it for a ride yourself the next time times are tough and there seems to be no end in sight to the work.
It’ll cost you, but when you want to throw the kitchen sink at your focus problems, we can’t really think of any better solution.
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- Banderet LE, Lieberman HR. Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull. (1989)
- Deijen JB, Orlebeke JF. Effect of tyrosine on cognitive function and blood pressure under stress. Brain Res Bull. (1994)
- Dollins AB, et al. L-tyrosine ameliorates some effects of lower body negative pressure stress. Physiol Behav. (1995)
- Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise.
- Alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects.
- Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine.
- Bizot JC, et al. Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. Prog Neuropsychopharmacol Biol Psychiatry. (2005)
- Tiev KP, Cabane J, Imbert JC. Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo. Rev Med Interne. (1999)
- Giesbrecht, Timo, et al; “The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness”; Nutritional Neuroscience; 2010
- Kimura K, et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. (2007)
- Owen GN, et al. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci. (2008)
- Frank M, et al; Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse; Equine Vet J. (1990)
- Barwell C.; School of Pharmacy; “Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat;” 1989
- Nedergaard O.; British Journal of Pharmacology; “Action of various sympathomimetic amines on the isolated stripped vas deferens of the guinea-pig;” November 1968
- Preuss, HG, et. al; “Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview;” Journal of Medicine; 2002
- Ostrovskaya et al. (2007). The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model.Journal of psychopharmacology, 21(66): 611-619; Doi: 10.1177/0269881106071335; Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/17092975
- Martinez, J., & Derrick, B. (1996). Long term Potentiation and Learning. Annual Review of Psychology, 47(1): 173-203. Retrieved from http://www.annualreviews.org/doi/abs/10.1146/annurev.psych.47.1.173
- Doxiderol; “Vinpocetine;” Retrieved February 2014
- Zhao, Q; Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; 2002
- Ved, H; Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate.; Division of Biochemistry, Walter Reed Army Institute of Research; 1997
- Ma, T; Huperzine A promotes hippocampal neurogenesis in vitro and in vivo.; State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University; 2013