360 RAGE: The Strongest Banned-Substance Free Pre Workout

360RAGE is the high stim option in 360CUT Performance Supplements line up of pre workouts.

360RAGE is the high stim option in 360CUT Performance Supplements line up of pre workouts.

When we introduced 360CUT’s new stim free pump pre workout, 360PUMP, we hinted that some big things were in the works from the company. While we don’t have details on a completely new product today, we do have details on an interesting new flavor that will be added to one of the company’s most popular products.

360CUT offers several pre workout powders, and for the serious stim fiend out there, the aptly named 360 RAGE is where to look for lots of intense, explosive energy – especially if you’re an athlete who does not want to mess with banned substances but still wants a hard kick.

New flavor alert: Maui Orange

They gave us a heads up that they’ll be introducing a new and exciting flavor to the lineup: Maui Orange. It’s rumored to be a “tangerine-pina colada flavor”, and PricePlow is ready to alert followers when it’s in stores.

We’d be remiss if we didn’t give you the full breakdown of what 360RAGE is packing inside. Before we do that though, take a second to check the best deal and sign up for price drop alerts:

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Our 360 RAGE Review

CJ and the team took down the new Maui Orange flavor, and it’s about as strong as it’s going to get without any banned substances!!

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360 RAGE Ingredients

360RAGE contains two unique blends that will give you the energy, focus, and stamina to get in the gym and create seven kinds of destruction on those weights, beginning with:

  • 360 Pump Matrix (3650mg)

    • Beta Alanine

      360RAGE uses a potent mix of stimulants to give one heck of an energy kick sure to get your motor running in the weight room no matter how tired you may be!

      360 RAGE uses a potent mix of stimulants to give one heck of an energy kick sure to get your motor running in the weight room no matter how tired you may be!

      A stalwart amongst the vast majority of pre workouts, beta alanine has been around quite a while so most of you are well acquainted with this powerful amino acid. Beta Alanine is needed by the body to form carnosine, a powerful lactic acid buffer in skeletal muscles.[1]

      This buffering of lactic acid helps to offset the “burn” you are well aware of when doing higher volume workouts.  With this buffering comes an increase in endurance, power, strength, and less fatigue.[2,3,4]

      Since this is the first ingredient in the blend, we’d venture to guess there’s around 1.6g (half of your daily dose) in 360RAGE. So you may want to add some bulk BA to get the clinical dose of 3.2g.

    • Citrulline Malate

      A combination of l-citrulline and malic acid, citrulline malate is another proven endurance booster included in 360 Rage. Much like our previous ingredient, citrulline malate also helps to buffer lactic acid build up in the body through its work in the Krebs Cycle.

      As a buffer, Citrulline Malate helps to boost endurance and overall ATP production in the body, leading to more “staying power” during your workout.[5,6,7] That’s not all though.

      Citrulline Malate also helps to boost nitric oxide levels in the body which leads to much better pumps.[8] Now, to really see this pump effect you really need between 6-8g, which you won’t get here. However, you should see some modest improvement in overall endurance and maybe a touch better pump.

    • Agmatine

      Another awesome ingredient included in 360RAGE and 360PUMP is Agmatine. Rather than directly boost nitric oxide levels, Agmatine actually prevents the body from breaking it down too soon.[9] This yields a stronger, longer lasting pump during your workout.

      Agmatine also is a neurotransmitter and neuromodulator in the body heavily involved in memory formation and cognition.[10]

      500mg is the typical dose we see in most pre workouts, and that’s what we’d venture to say is included in here, but we’re not 100% certain. If you really want to see agmatine’s effects in action you may want to stack this with 360PUMP or add bulk agmatine to get in the 1000mg to 1500mg range.

    • Grape Seed Extract

      The 360 PUMP Matrix included in 360RAGE may go a long way to help you get that swole look you want during your workout.

      The 360 PUMP Matrix included in 360 RAGE may go a long way to help you get that swole look you want during your workout.

      Grape Seed extract comes from the Vitis Vinifera plant which are often standardized for polyphenols to increase their efficacy. Research on grape seed extracts demonstrate they are able to increase nitric oxide production[11] and reduce oxidative stress after exercise[12]. This is most likely due to the high levels of catechins and tannins contained in grapes seeds.

    • Maritime Pine Tree Bark Extract

      Typically, Pine bark extract is used to help treat diabetes and support overall health. While that’s all well and good, doesn’t really make sense for a pre workout. However, research shows that it can also increase plasma levels of nitric oxide in the body, which increases blood flow to muscles.[13] More blood flow to the muscles means greater amounts of nutrients and oxygen to the working muscles which culminates in their ability to produce force at a higher threshold for longer periods of time.

    • L-Norvaline

      L-Norvaline is a derivative of the BCAA L-Valine that supports blood flow and overall cardiovascular function. As you would expect, it’s functions as a decent pump-aid as well

      Similar to Agmatine, Norvaline delays the breakdown of Arginine by inhibiting Arginase, the enzyme responsible for arginines breakdown.[14] Inhibiting arginase indirectly boosts NO production which leads to more blood flow and better pumps!

  • 360 Intensity Matrix (1985mg)

    • L-Tyrosine

      L-Tyrosine is an amino acid frequently used to improve focus and cognition. Tyrosine boots the production of two highly important neurotransmitters, dopamine and noradrenaline. Elevated levels of these two neurotransmitters not only improve concentration but also reduce stress and anxiety.[15,16]

      Given that this is up in front of caffeine, and the entire blend is quite large (nearly 2g), we’re thinking that this is quite a large hit of L-Tyrosine, and it’ll carry most of the focus for you here. If you haven’t taken high-dose L-Tyrosine you’re going to want to try this and see what you think.

    • Caffeine Anhydrous

      The main stim hit in 360 RAGE comes from caffeine. While the amount isn’t disclosed, we’d venture a guess the dose is close to ~350mg, based on the fact it’s the second ingredient in the blend.

      We asked 360CUT’s VP of Sales, who said:

      Unfortunately I cannot disclose the amount of caffeine, but I can say that gram for gram we currently have the strongest banned substance-free pre-workout on the market when you consider our dosages of caffeine, synephrine, and hordenine combined.

      –360CUT

      Consider this: There is significantly more caffeine than in 360PRE, which has 250mg. So is it possibly even 400mg?!

      Sounds like this will be a perfect amount for the intended users of this product – those who want to rage, essentially. For those who aren’t as caffeine-tolerant as the majority of us, but still want to try 360RAGE, we’d recommend starting with ¾ scoop.

      Either way, all we know is that it has over 250mg caffeine for sure, and we’re thinking.

    • Synephrine HCl

      360RAGE's blend of stimulants will give you everything you need to get explosive, long-lasting energy for your long gym sessions.

      360RAGE’s blend of stimulants will give you everything you need to get explosive, long-lasting energy for your long gym sessions.

      Synephrine is one of the main alkaloids contained in the plant Citrus Aurantium (bitter orange). Synephrine is structurally similar to ephedra, which has been banned in supplement use, but, unlike epehdra, been proven to be a safe and effective.[17,18]

      Synephrine is a potent agonist of the Beta-2 and Beta-3 receptors in your body,[19,20] which stimulates the release of triglycerides into the bloodstream (a.k.a. lipolysis). When in this state, your body burns fat for fuel and spares your glycogen stores for really intense exercise.

      As we know up above, the dose is going to be a good one.

    • Hordenine

      Hordenine is another of the bioactive alkaloids contained in Citrus Aurantium. Just like Synephrine, hordenine also functions as a beta-2 adrenergic agonist[21], but it also works as a noradrenaline reuptake modulator[22,23]

      What this means is that noradrenaline stay active longer in your system which leads to greater energy, alertness, and focus.

      Again, if you’ve liked products with this ingredient before, it sounds like this will be a seriously-dosed one as well.

    • Huperzine A

      Pina Colada

      Mix this with some orange, and that’s what 360CUT’s going for with the new Maui Orange flavor! Image courtesy Wikimedia

      Our last focus intensifier is the potent nootropic, Huperzine A, a.k.a. Toothed Clubmoss. Huperzine is an acetylcholinesterase inhibitor[24], the enzyme responsible for degrading acetylecholine (the “learning neurotransmitter).

      In addition to improving focus, huperzine also supports overall brain health. It prevents premature neuron cell death by blocking gluatmine and possibly aids the creation of new brain cells, making it neurogenerative.[25,26]

Flavors Available

As we already mentioned above, 360 RAGE will soon be available in the Maui Orange flavor. Also, if you’re looking to explore other flavorings from the company, 360RAGE also comes in the Raspberry Lemonade and Tropical Punch options as well.

What’s Maui Orange like?

We also asked 360CUT to describe this flavor, and they stated:

The Maui Orange is kind of a tangerine-pina colada flavor. Super refreshing!

–360CUT

Takeaway

Some days it can seem like you need a HUGE pick me up just to have the motivation to even think about going to the gym. On days like that, you no doubt need a solid dose of energy to get you motivated to hit the weights. 360RAGE is what you’re looking for on those days when it’s awfully tempting to skip your workout all together.

We’ll do our best to get 360CUT to disclose the caffeine, but for now, consider it around 350mg and consider a lot of the other effects to come from the huge L-Tyrosine dose!

Make sure to sign up below and check the best deal to be one of the first to try the new Maui Orange flavor!

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References

  1. Hill, CA et al.; Amino Acids; “Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity ;” February 2007
  2. Baguet, A et al.; Journal of Applied Physiology; “Important role of muscle carnosine in rowing performance;” July 2010;” 2005
  3. Roger C. Harris; et al.; “The effect of a supplement containing β-alanine on muscle carnosine synthesis, ventilatory threshold and exercise capacity in Korean cyclists, during 12 weeks combined endurance and weight training
  4. Kendrick IP, et al. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids. (2008)
  5. Giannesini B., et. al.; European Journal of Pharmacology; “Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle;” September 2011
  6. Perez-Guisado J, Jakeman PM; Journal of Strength and Conditioning; “Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness;” May 2010
  7. Hickner RC. et. al.; Medicine and Science in Sports and Exercise; “L-citrulline reduces time to exhaustion and insulin response to a graded exercise test;
  8. Curis E., et. al; “Citrulline and the gut;”; Current Opinion in Clinical Nutrition and Metabolic Care; September 2007
  9. Demady, D; Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme.; Department of Pharmacology, The University of Michigan Medical School; 2001
  10. Lu Y, Christian K, Lu B; BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory . Neurobiol Learn Mem. (2008)
  11. Belviranlı M, et al; Effects of Grape Seed Polyphenols on Oxidative Damage in Liver Tissue of Acutely and Chronically Exercised Rats . Phytother Res. (2012)
  12. Belviranlı M, et al; Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats . Br J Nutr. (2012)
  13. Parveen K, et al; Modulatory effects of Pycnogenol® in a rat model of insulin-dependent diabetes mellitus: biochemical, histological, and immunohistochemical evidences . Protoplasma. (2012)
  14. http://www.ncbi.nlm.nih.gov/pubmed/22281732 (norvaline)
  15. Deijen JB, Orlebeke JF; Effect of tyrosine on cognitive function and blood pressure under stress . Brain Res Bull. (1994)
  16. Dollins AB, et al; L-tyrosine ameliorates some effects of lower body negative pressure stress . Physiol Behav. (1995)
  17. Preuss, HG, et. al; “Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview;” Journal of Medicine; 2002
  18. http://www.ncbi.nlm.nih.gov/pubmed/21480414
  19. http://www.ncbi.nlm.nih.gov/pubmed/21537493
  20. http://www.ncbi.nlm.nih.gov/pubmed/16436104
  21. Frank M, et al; Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse; Equine Vet J. (1990)
  22. Barwell C.; School of Pharmacy; “Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat;” 1989
  23. Nedergaard O.; British Journal of Pharmacology; “Action of various sympathomimetic amines on the isolated stripped vas deferens of the guinea-pig;” November 1968
  24. Zhao, Q; Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; 2002
  25. http://www.ncbi.nlm.nih.gov/pubmed/9141073
  26. http://www.ncbi.nlm.nih.gov/pubmed/23454433
Posted in by Mike | Tagged , , , , , , , , , , , , , , , , .
  • Truth Speaker

    According to information from FDA warning letters, this product would be adulterated. Read and learn. Check the FDA warning letter recently sent to TruVision Health. http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/2015/ucm464091.htm

    In it, FDA states: “To the best of FDA’s knowledge, there is no information demonstrating that Bitter Orange Extract (synephrine 30%) was lawfully marketed as a dietary ingredient in the United States before October 15, 1994, nor is there information demonstrating that this ingredient has been present in the food supply as an article used for human food in a form in which the food has not been chemically altered.”

    If Bitter Orange Extract (synephrine 30%) requires an ndi notification to be legally marketed as a dietary supplement, then synthetic Synephrine HCL is in the same boat.