Over the past several months, we’ve received countless requests about where to locate one of the most popular fat burners of all-time: The original SYNEDREX by Metabolic Nutrition, which included DMAA.
People have hunted high and low for the well-known and effective thermogenic, but kept coming up empty since it’s long been bought up.
Apparently we weren’t the only ones getting asked – because it’s about to be “re-released” as a product from your favorite brand who fights for your right to use legal ingredients:
Hi-Tech Pharmaceuticals has re-engineered the one-time best seller into something even more powerful and better than ever, and as you can see, has a bottle and name to match!
Synadrene embodies everything that made Synedrex great but has been slightly modified to take advantage of the latest and greatest in terms of fat burning ingredients. From what we’re hearing from insiders, Synedrex users are going to be thrilled because this is as real as the real deal itself.
We’ve got the breakdown below, but first, take a moment to check the best deal and sign up for alerts from PricePlow:
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Taking a look at the latest Synedrex label and the new Synadrene label, you can see that it’s a “best of both worlds” hybrid between the original Synedrex (with DMAA) and the second Synedrex (which used the illegal AMP Citrate):
So first, let’s compare labels:
The Synedrex vs. Synadrene ingredients comparison:
Hi-Tech stated that they had bottles of both Synedrex formulas tested, and realized that there were not an efficacious doses of BMPEA or the two bottom ingredients — so they omitted them (quite like Metabolic Nutrition did in their second version), but get to use DMAA like the original formula, which is why this is the best of both worlds.
This is the glory of having all the HPLC equipment and expertise right in house!
Note that the proprietary blend in this new formula is less because you need less DMAA than AMP Citrate, so don’t be worried that you’re getting less – it’s actually a far better and more legal supplement.
Don’t feel like reading? Listen to Mike’s story and ingredient summary
A full review is coming, but if you want to hear the backstory and ingredient analysis without reading, check out Mike’s video below:
Now let’s get to the nitty gritty and see what all these unique ingredients are all about:
Synadrene Proprietary Blend (815mg)
The hallmark ingredient of all stim-based products, methylxanthine, the most famous of these being of course caffeine. Methylxanthines are potent stimulators of the CNS that antagonize all types of adenosine receptors. It’s via this biological action that many of caffeine’s well known effects (increased energy, alertness, and performance) can be attributed to.
We’re not sure how much is in here, but being listed first in the prop blend, you can rest assured there’s a considerable amount packed in here. We’ll reach out to Hi-Tech and see what we can squeeze out of them in regards to amounts.
Green Tea Extract
The benefits of Green Tea extract can hardly be debated as it’s been pretty well established to be beneficial for the cardiovascular system. Green tea’s ergogenic and “healthy-ifying” traits are due in large part to its high polyphenol and catechin content, the most prominent catechin being EGCG.
There’s more to EGCG, short for Epigallocatechin gallate, than just cardiovascular system support though. It’s also been shown to induce lipolysis[2,3], and when combined with caffeine, these effects are even further amplified, as it is here.
Hi-Tech has now gone on the record and stated that they’ve used a standardized Green Tea with 45% EGCg / 75% total catechins / 95% polyphenols.
Those of you familiar with Hi-Tech’s vast array of fat burners have no doubt encountered DMAA in some form or another during your supplementation days. But, just as a quick refresher, DMAA is classified as a sympathomimetic amine that’s extracted from the Geranium plant.
As a powerful CNS stimulant, DMAA triggers the release of norepinephrine in the body.[5,6] This gives users an incredible feel-good sensation unlike anything they’ve used before, or since really.
Anecdotally, DMAA is also said to provide tremendous amounts of appetite suppression as well – although there’s no quantifiable research results to prove this conclusively.
Sulbutiamine is a synthetic derivative of Thiamine well-known for its ability to offset fatigue as well as improve cognition and memory.[7,8]. This novel form of thiamine was originally created by a group of Japanese scientists who bonded 2 thiamine molecules with a sulphur group.
The reason for using this synthetic variation of Thiamine, is that the organic version doesn’t cross the blood-brain barrier all that easily. However, Sulbutiamine has an increased fat-solubility compared to Thiamin, which allows it to easily cross the barrier. From here, it can then increase circulating levels of thiamine in the body.
The main reason it’s included in a fat burner, is that it helps combat brain fog, a “side effect” of being on low calories and dieting for prolonged periods of time. One of the several reasons why Synedrex stood out – and why Synadrene will continue to stand out!
Sandalwood is a type of tree indigenous to India that yields an incredibly fragrant timber and oil. It’s traditionally been used for a wide number of ailments included cold/flu remedies, anxiety, muscle cramping, and GI distress.
From a weight loss perspective, sandalwood has exhibited various anti-diabetic properties. Additionally, it also helps improve memory, compounding off the anti-brain fog benefits we mentioned above.
This is a rare area of focus for fat burners, but it’s nice to see Hi-Tech taking a step in this novel direction to keep one of the most underrated ingredients in Synedrex in this next gen thermogenic.
So far, we’ve encountered ingredients that either stimulate lipolysis or improve cognition. However, Yohimbine performs a different trick of sorts, it actually prevents the body from storing fat. See, “Y”, as it’s sometimes called, is a strong alpha receptor agonist that inhibits the body’s fat storing mechanisms.
There’s more though, yohimbine also significantly reduces feelings of hunger[11,12], even more so when taken on an empty stomach.
Much like DMAA and caffeine, we’re not sure how much yohimbine is in Synadrene, so if you’re sensitive to yohimbe / yohimbine, proceed with caution to see how you react.
Alpha Lipoic Acid
Alpha Lipoic Acid (ALA) is a fatty acid located in the mitochondria of every cell in the human body that functions as a cofactor in energy production. ALA also helps regulate glucose and lipid metabolism in the body and improve glycogen storage. This action ultimately reduces blood sugar via ALA’s interactions with GLUT-4 (an important glucose transporter in the body).[14,15]
Activation of GLUT-4 kicks insulin into action, encouraging glucose uptake by muscles as well as “burning fat for fuel” by muscles.
Just like with sandalwood, Hi-Tech is making use of a rather infrequently used ingredient that really should be included more often. The sandalwood and ALA combo, alongside DMAA of course, are really attributed to being the serious difference-makers compared to the rest of the 1,3 Dimethylamylamine supplements out there.
Poly-Thyronine is a unique combination of thyroid hormone metabolites triiodothyronine (T2). It’s naturally occurring and is involved in virtually all physiological functions.
As for its inclusion in a fat burner, supplementing with thyronine metabolites has been shown to elevate metabolic rate and reduce appetite without adversely affecting your heart rate, blood pressure, or any other effect stimulants would affect in the body![16,17,18]
It’s also worth mentioning that these same studies also showed decrease in overall body weight and no cardiac side effects observed whatsoever!
So if you were a fan of Synedrex, fear not – it’s coming back, just from a different (and highly-trusted) brand and with a different name. This is what you need to try next.
Take 1 capsule up to 3 times daily – but we’re finding that one capsule in the morning and one capsule after lunch does just fine. Do not exceed 4 capsules in any 24 hour period.
Typically that first capsule is best taken on an empty stomach 15-30 minutes before breakfast, so you can let the appetite suppressants kick in and keep your eating under control!
KraseyFitBeauty has used both formulas of Synedrex, so we hooked her up with some Synadrene to see how it compared. Here’s what she had to say:
Overall, combined with Mike’s review, this is easily turning into one of the Best Fat Burners out right now, and we’ll need to update our Top 10 list with this one included, without a doubt.
Man, we just love Hi-Tech Pharma, and products like Synadrene are exactly why. The market asks for it, and they quickly receive. The FDA sends “warning letters” over DMAA, and they fight for consumer rights. Every industry needs a responsive, consumer-driven company with guts, and we are happy to say that we have Jared Wheat and Hi-Tech Pharmaceuticals.
Fans of Synedrex no longer have to go on an endless hunt to find their favorite fat burner, courtesy of Hi-Tech Pharmaceuticals. Synadrene takes all the best traits of the two versions and improves them by going back to DMAA and adding Green Tea Extract.
What’s left is an incredibly potent weight loss suppressant that will trim fat, suppress appetite, and vastly improve your cognition in mood. There’s no need to keep scrounging around for Synedrex, when the next evolution of the mighty thermogenic has arrived.
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- Effects of the long term ingestion of tea catechins on Energy Expenditure and Dietary fat oxidation in healthy subjects
- Wang Y, Yang Z, Wei X; Sugar compositions, α-glucosidase inhibitory and amylase inhibitory activities of polysaccharides from leaves and flowers of Camellia sinensis obtained by different extraction methods . Int J Biol Macromol. (2010)
- Westerterp-Plantenga MS, Lejeune MPGM, Kovacs EMR. Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obes Res 2005;13(7):1195-1204.
- Bloomer RJ, McCarthy CG, Farney TM et al.; “Effect of caffeine and 1,3-dimethylamylamine on exercise performance and blood markers of lipolysis and oxidative stress in trained men and women.” J Caffeine Res (In Press); Retrieved from http://online.liebertpub.com/doi/abs/10.1089/jcr.2011.0019
- Schilling, Brian, et al.; “Physiological and pharmacokinetic effects of oral 1,3-dimethylamylamine administration in men”; BMC Pharmacology and Toxicology; 2013; Retrieved from http://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/2050-6511-14-52
- Bizot JC, et al. Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. Prog Neuropsychopharmacol Biol Psychiatry. (2005)
- Tiev KP, Cabane J, Imbert JC. Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo. Rev Med Interne. (1999)
- Zhang L, et al; Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway . Neurosci Lett. (2001)
- Gupte AA, et al; Lipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high-fat-fed rats . J Appl Physiol. (2009)
- Wang Y, et al; alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice . Metabolism. (2010)