Podium Nutrition PUMP: Stim-Free Pre-Workout Pumps for Hybrid Athletes

In the sports supplement world, we spend a lot of time talking about the pump. Usually, this is in a weightlifting context, where bodybuilders and powerlifters enjoy muscular swelling for aesthetic reasons – or just because it feels awesome.

But behind the visual manifestation of the pump are some key mechanisms of action – including nitric oxide mediated vasodilation – that can really help improve performance. And not just by increasing top-end power, or helping you squeeze out another rep or two at the squat rack, but by boosting endurance and improving recovery, too.

Podium Nutrition PUMP

Podium Nutrition PUMP is a non-stim pre-workout for hybrid athletes, powered primarily by a combination of Nitrosigine and L-citrulline

Podium Pump: Stim-Free Pre-Workout Support for Functional Athletes

That’s where products like Podium Pump come in. As its name suggests, this is for ambitious functional athletes – think CrossFit – who want to win contests of hybrid athleticism (meaning strength and endurance). You know it’s going to be good when Mat Fraser, “World’s Fittest Man”, is involved in the brand!

With 6 grams of L-Citrulline paired with another gram of Nutrition21’s Nitrosigine alongside an efficacious 2 grams of taurine and some added dextrose, Podium Pump can perfectly support the workout needs of Podium’s functional athletes.

We’re glad to be covering this today because we think it’s a frequently overlooked field of athletic performance and supplement science — and having spoken to Podium’s leadership team, we think they’re on to something big here.

So let’s get into how Podium Pump can help you crush the competition during your local gym’s next WOD, but first, check PricePlow’s coupon-powered deals and sign up for our Podium news and alerts:

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Podium Pump Ingredients

In a single 2-scoop (13.2 gram) serving of Podium Pump from Podium Nutrition, you get the following:

  • L-Citrulline – 6,000 mg

    The amino acid citrulline is the supplement industry’s favorite nitric oxide (NO) booster.[1]

    Podium Nutrition Pump Ingredients

    Citrulline is a conditionally essential amino acid. This means that while your body can make citrulline on its own, it can’t necessarily make enough to fully cover your metabolic requirements. This means we can almost always stand to benefit from some supplemental citrulline.

    Your body converts citrulline into NO by the following pathway:

    Citrulline → Arginine → Nitric Oxide

    You’ve probably noticed that arginine is actually the direct precursor to NO – so why not take arginine instead? The answer is that citrulline is more orally bioavailable than arginine.[2,3]

    Why do we want more NO?

    NO triggers a mechanism called vasodilation in which your blood vessels expand in diameter. Thus, you get the same volume of blood in a bigger arterial space, leading to decreases in blood pressure and heart rate that[4-6] help you perform better at the same level of cardiovascular exertion.

    Vasodilation can also benefit performance and recovery by increasing the efficiency of nutrient delivery to, and waste removal from, your body’s cells.

    Studies on citrulline show that it can:

    Citrulline Arginine Nitric Oxide Reaction

    The Arginine Citrulline Cycle with a breakout showing the arginine-to-nitric oxide reaction. Image courtesy Wikimedia with added biochemistry sources.[7,8]

    • Increase power by improving oxygen uptake[9]
    • Prolong athletic endurance by about 50%[10]
    • Reduce post-exercise muscle soreness[10]
    • Upregulate exercise-induced growth hormone (GH) secretion[11]
    • Inhibit protein catabolism[12]
    • Increase the anabolic response to exercise[13,14]

    Citrulline can also upregulate your body’s production of ornithine,[15] an amino acid that’s involved in clearing ammonia from your blood and tissues.[16] Since the accumulation of ammonia in your tissues can produce both mental and physical fatigue, upregulating ornithine can help increase athletic endurance and improve recovery.

    Ornithine has also been shown to improve the ratio of cortisol to DHEA, which can improve sleep.[16]

  • Taurine – 2,000 mg

    Taurine is an osmolyte, meaning it can help improve cellular hydration.[17]

    Taurine Endurance

    Taurine’s effect on endurance, with success in doses anywhere from 1 gram to 6 grams.[18]

    A 2018 meta-analysis found that even a single 1,000 milligram dose – only half the dose used in Podium Nutrition Podium Pump – is enough to acutely increase athletic endurance.[18]

    Taurine is also an important antioxidant[19] that helps facilitate calcium signaling between muscle cells,[20] thus supporting muscular contractions. Taurine’s calcium-regulating properties can also help it support mitochondrial homeostasis, protecting mitochondria from excitotoxic stress.[21]

    Like citrulline, taurine is a conditionally essential amino acid.[17,18,22] This means that if you’re training hard, you probably will benefit from some supplemental taurine.

    Finally, taurine is GABAergic and can help downregulate neuronal inflammation and support neuronal mitochondria while improving inter-synaptic signaling.[22]

    Taurine is great for mental and physical performance, which is why we love seeing it in pre-workout formulas like Podium Nutrition Podium Pump.

  • Dextrose – 1,500 mg

    Podium Nutrition PUMP Watermelon Mint: Available at GNC

    The recent popularity of low-carb diets notwithstanding, every endurance and hybrid athlete knows the importance of staying carbed-up for maximum muscle glycogen and, hence, optimum performance. So how should we get those carbs? It’s common to see people reaching for honey, or sugar-sweetened beverages. However, if your goal is to fuel athletic performance, these fructose-containing carbs are not the best way to go.

    Ample research shows that muscle glycogen synthesis is more efficient with glucose than it is with fructose.[23-26] Since dextrose is chemically identical to glucose (it’s D-glucose, hence the name “dextrose”),[27] it’s an obvious choice as an affordable pre-, intra-, or post-workout carb that also tastes great.

    That’s because fructose gets processed by your liver, which turns it into liver glycogen.[23-25] Fructose is also absorbed more slowly than glucose/dextrose,[28,29] and must be converted into glucose[29-31] before your body can use it, which is a slow process.[32]

    Since muscle glycogen, as opposed liver glycogen, is what we’re after, it makes sense to see dextrose appear in Podium Nutrition Podium Pump.

  • Nitrosigine (Inositol-Stabilized Arginine Silicate) – 1,000 mg

    Synergizing alongside the citrulline, Podium Pump also has a gram of Nitrosigine, the industry’s premier patented NO-boosting ingredient made by Nutrition21,[33] and a personal favorite of the PricePlow staff.

    Nutrition21 Nitrosigine Graphic

    Nitrosigine is primarily found in pre-workouts due to its ability to boost nitric oxide levels… but don’t forget about its cognitive-supporting capabilities when dosed at 1.5 grams per day!

    As we briefly mentioned in the citrulline section of this article, the whole reason citrulline came into favor is because the bioavailability of arginine is, to put it mildly, not great.[34-37] When scientists discovered citrulline is vastly more bioavailable,[38] using citrulline as a precursor to arginine, and then to NO, was an obvious solution.

    Nutrition21, however, attacks the problem from a different, more direct, angle. Nitrosigine is a better form of arginine, engineered to have long lasting bioavailability. It is a patented and trademarked complex of arginine, inositol, and potassium silicate[33] that has been clinically studied at 1.5 grams to promote nitric oxide production for improved blood flow, better cognitive function, and energy.

    Fast-acting, long-lasting, and effects that can build over time

    Nitrosigine is both fast-acting and long-lasting, with NO levels rising as soon as 30 minutes after ingestion[39] and staying elevated for up to 6 hours.[40]

    Citrulline Malate vs. Nitrosigine

    Beyond that, there’s also evidence that the effects of Nitrosigine build up over time, as repeated intakes trend towards higher plasma arginine levels.[39] Research indicates that muscle pump benefits are most pronounced after several days of use,[41] and the cognitive research performed at 1.5 grams per day suggests that the benefits may be sustained with repeated intake.[42,43]

    Nitrosigine and the brain

    As mentioned above, Nitrosigine has an amazing body of research showing cognitive benefits. However, this research has all been performed at 1.5 grams per day,[42-44] which is greater than the dose here in Podium Pump. Those studies demonstrate benefits such as preventing post-workout cognitive decline,[43] greater cognitive flexibility,[42] improved feelings of energy,[45] and improved short-term memory performance[44] — but again, they used a 50% greater dose than what we have in two scoops here.

    There’s even more to say about this awesome ingredient, especially at the 1.5 gram dose level, so if you’re interested, read our long-form post titled Nitrosigine: The Nitric Oxide Booster That Enhances Brain Function.

    Nitrosigine Working Memory Study

    A new study published in late 2021 showed that Nutrition21’s Nitrosigine improves working memory and cognitive function in healthy young adults when dosed at 1.5 grams per day.[44] Read more about it in our article titled Study: Improved Working Memory from Nitrosigine in Healthy Young Adults.

  • Betaine HCl – 1,000 mg

    Betaine, also known as trimethylglycine (TMG), is a potent ergogenic aid.[46] It is, like taurine, an osmolyte, meaning it can help increase the water content of your cells and improve hydration status.[47,48] Extra water brings more nutrients to cells and makes them more resilient to heat stress[49] and other environmental stressors.[50]

    Betaine is an important methyl donor,[51,52] meaning it carries methyl groups (formula -CH3) to the sites of various metabolic processes like DNA methylation, protein metabolism, and energy production. One of methylation’s most important functions is to regulate the amount of homocysteine in blood – if this process is compromised by methyl group deficiency, homocysteine levels can rise too high,[53] which can cause cardiovascular damage and disease.[48,54]

    Research shows that betaine supplementation can significantly improve strength, power, athletic endurance, and body composition, but again, much of it comes at higher doses, such as 2.5 grams per day (and sometimes even 5 grams).[47,55-62]

    Betaine HCl over anhydrous?

    What’s unique about this ingredient here is that normally we see betaine anhydrous, whereas here, we have the hydrochloride form. We asked Podium why they made this decision — they stated it was best for the Neutral flavor system:

    Podium Nutrition Logo

    Betaine HCl separates in solution, so Betaine HCl was used to offset the basicity of the formula for taste purposes, given the main formula is meant to be neutral in taste. Allowed us to keep the “Neutral” naturally flavored and naturally sweetened.

    — Podium Nutrition

    That’s pretty interesting and cool to know.

  • Pine (Pinus elliottii) [Bark] Extract – 200 mg

    Pine bark extract is another NO boosting ingredient – it’s full of phenolic antioxidants[63,64] that have been shown to upregulate endothelial nitric oxide synthase (eNOS),[63,64] the enzyme responsible for generating NO in your arteries.

    Nitrosigine 2022 Cognitive Study Infographic

    A nitric oxide booster that improves cognition?! Yes – Nutrition21 passed around this helpful infographic after the Nitrosigine cognition study on healthy young adults was published at 1.5 grams per day.[44]

    Thanks to its vasodilatory, antioxidant and anti-inflammatory properties, pine bark extract has been used as a traditional treatment for cardiovascular diseases, and support for cardiovascular health.[63,64]

    One study suggests that pine bark extract’s anti-inflammatory effects are strong enough to confer neuroprotective benefits.[64]

  • VasoDrive-AP (Casein Hydrolysate) – 100 mg

    VasoDrive-AP combinestwo specific tripeptide proteins derived from the casein fraction of milk: isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP).[65] They’re sometimes referred to as lacto-tripeptides (LTPs).

    VasoDrive triggers vasodilation by two complementary mechanisms. First, it does upregulate endothelial nitric oxide synthase (eNOS), thus directly increasing the amount of NO your body produces.[66]

    But it also inhibits vasoconstriction by downregulating an enzyme called angiotensin-converting enzyme (ACE).[65] As you probably know, ACE inhibitors are prescribed to treat high blood pressure, making this an interesting ingredient to see in a pre-workout.

    Massive effect sizes at low (10mg/day) doses!

    According to a 2016 meta-analysis, casein-derived LTPs can help reduce blood pressure by about the same amount as more proven NO-boosting ingredients. On average, IPP and VPP doses in the ballpark of 10 milligrams per day reduces systolic blood pressure by about 3 mmHg and diastolic blood pressure by about 1.5 mmHg. In some of the studies reviewed by this meta-analysis, effect sizes on the order of 10 systolic and 6 diastolic were observed.[65]

    By comparison, citrulline has been shown to reduce systolic blood pressure by about 4 mmHg at standard doses.[67]

    While we’re used to seeing larger doses of VasoDrive-AP, we’re realizing that a plethora of successful research has been conducted at far lower doses — such as the meta analysis cited above with just ~10 total milligrams per day.[65] This is in line with Podium’s strategy for functional/hybrid athletes, as discussed in the Nitrosigine section — we’re shooting for performance-based blood flow improvements, not muscle swelling to the point of reduced functionality.

  • Setria L-Glutathione – 100 mg

    Glutathione (GSH) is the body’s master antioxidant. Your body makes its own GSH – however, as is often the case, its capacity for GSH production doesn’t necessarily cover all requirements. Thus, for many people, supplemental exogenous GSH can help improve health and performance.[68]

    Setria Glutathione Logo

    Glutathione is one of the most powerful antioxidants in the body.

    Made by Kyowa Hakko, Setria has been shown to help improve immunity by enhancing detoxification and decreasing oxidative stress,[69] which has made it a popular choice for health and wellness supplements.

    Synergistic effects between Setria and Citrulline

    We’ve seen Setria show up in a few pre-workout formulas.[70,71] The combination of these two ingredients has been shown to cause synergistic and sustained rises in nitric oxide (NO) levels.[70] They also appear to synergistically improve lean muscle mass and muscular strength,[71] although more research is needed to confirm those findings.

  • AstraGin (Panax notoginseng [Root] Extract and Astragalus membranaceus [Root] Extract) – 50 mg

    AstraGin is a patented bioavailability enhancer from NuLiv Science.[72-76]

    Podium Pump Watermelon Mint

    It consists of specific bioactive constituents extracted from Astragalus membranaceus and Panax notoginseng, two plants with a long history in traditional Chinese medicine. These bioactive constituents upregulate adenosine triphosphate (ATP) in the intestines, which can then use the extra ATP to facilitate nutrient transport into the bloodstream.[77,78]

    Internal studies have demonstrated that AstraGin can increase the bioavailability of amino acids, vitamins, and other nutrients.[68] For instance, it’s been shown to “promote intestinal epithelial repair by enhancing L-arginine uptake” and “activate the mTOR pathway”,[79] and as you know, we have a bonded form of inositol-stabilized arginine silicate in here from Nitrosigine!

    Ultimately, this ingredient is maximizing the value you get for your dollar from Podium Nutrition Podium Pump – after all, supplements do you no good if your body can’t absorb them.

In summary, this is a very wisely formulated pump supplement for Podium’s hybrid athlete demographic — not grossly too much like some of our bodybuilding readers always want, but definitely not too little.

Flavors Available

Podium Nutrition Creatine Monohydrate

It’s not just flavored — you can also get an unflavored Neutral version that can be stacked into one of their flavored pre-workouts (like FUSE Pre-Workout or HWPO Athlete Pre-Workout) or even their flavored Podium Creatine Monohydate supplement!

Here’s the current list of Podium Pump flavors:

    Conclusion: Podium Pump Brings Nitric Oxide to Functional Training

    Podium Pump is a powerful and focused formula – every ingredient is here to either improve circulation by upregulating NO or help your muscles do more work.

    It’s been a while since we last saw a compelling entry in the hybrid athlete pre-workout category, but Podium Nutrition Podium Pump is definitely one that we’ll be giving a go, especially when the training calls for it.

    Having spoken to the Podium team, we are 100% confident that this brand is on to very big things — and not just because of the athletes they sponsor. Stay tuned to PricePlow’s Podium Nutrition news alerts below, there’s a lot more coming:

    Podium Nutrition PUMP Non-Stim Pre – Deals and Price Drop Alerts

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    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

    About the Author: Mike Roberto

    Mike Roberto

    Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

    Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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    1. Morita, Masahiko, et al. “Oral Supplementation with a Combination of L-Citrulline and L-Arginine Rapidly Increases Plasma L-Arginine Concentration and Enhances NO Bioavailability.” Biochemical and Biophysical Research Communications, vol. 454, no. 1, Nov. 2014, pp. 53–57, 10.1016/j.bbrc.2014.10.029; https://www.sciencedirect.com/science/article/pii/S0006291X14018178
    2. Ochiai, Masayuki, et al; “Short-Term Effects of L-Citrulline Supplementation on Arterial Stiffness in Middle-Aged Men.”; International Journal of Cardiology; U.S. National Library of Medicine; 8 Mar. 2012; https://www.ncbi.nlm.nih.gov/pubmed/21067832
    3. Agarwal, Umang et al; “Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice.”; The Journal of nutrition; vol. 147,4; 2017; 596-602; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368575/
    4. Orozco-Gutiérrez, Juan José, et al. “Effect of L-Arginine or L-Citrulline Oral Supplementation on Blood Pressure and Right Ventricular Function in Heart Failure Patients with Preserved Ejection Fraction.” Cardiology Journal, vol. 17, no. 6, 2010, pp. 612–618; https://pubmed.ncbi.nlm.nih.gov/21154265/
    5. Wong, Alexei, et al. “Combined Whole-Body Vibration Training and L-Citrulline Supplementation Improves Pressure Wave Reflection in Obese Postmenopausal Women.” Applied Physiology, Nutrition, and Metabolism, vol. 41, no. 3, Mar. 2016, pp. 292–297, doi:10.1139/apnm-2015-0465; https://cdnsciencepub.com/doi/10.1139/apnm-2015-0465
    6. Alsop P, Hauton D. Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure. Eur J Appl Physiol. 2016 Sep;116(9):1651-61. doi: 10.1007/s00421-016-3418-7; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983290/
    7. Bryan, Nathan S., and Jack R. Lancaster. “Nitric Oxide Signaling in Health and Disease.” Nitrite and Nitrate in Human Health and Disease, 2017, pp. 165–178, 10.1007/978-3-319-46189-2_13; https://link.springer.com/chapter/10.1007/978-3-319-46189-2_13
    8. Ghellam, Mohamed & Koca, Ilkay. “Nitrate in All Respects: Metabolic Pathways, Sources, and Human Health”; Derleme Review; Volume 3, Issue 2, 120 – 130, May 27, 2019; https://www.researchgate.net/publication/333405488_Nitrate_in_All_Respects_Metabolic_Pathways_Sources_and_Human_Health
    9. Bailey, Stephen J, et al; “l-Citrulline Supplementation Improves O2 Uptake Kinetics and High-Intensity Exercise Performance in Humans.”; Journal of Applied Physiology (Bethesda, Md. : 1985); U.S. National Library of Medicine; 15 Aug. 2015; https://www.ncbi.nlm.nih.gov/pubmed/26023227
    10. Pérez-Guisado, Joaquín, and Philip M Jakeman; “Citrulline Malate Enhances Athletic Anaerobic Performance and Relieves Muscle Soreness.”; Journal of Strength and Conditioning Research; U.S. National Library of Medicine; May 2010; https://www.ncbi.nlm.nih.gov/pubmed/20386132
    11. Sureda A, Córdova A, Ferrer MD, Pérez G, Tur JA, Pons A. L-citrulline-malate influence over branched chain amino acid utilization during exercise. Eur J Appl Physiol. 2010 Sep;110(2):341-51. doi: 10.1007/s00421-010-1509-4; https://link.springer.com/article/10.1007/s00421-010-1509-4
    12. Breuillard, C., et al. “Citrulline and Nitrogen Homeostasis: An Overview.” Amino Acids, vol. 47, no. 4, 13 Feb. 2015, pp. 685–691; doi:10.1007/s00726-015-1932-2; https://link.springer.com/article/10.1007/s00726-015-1932-2
    13. Jourdan M, Nair KS, Carter RE, Schimke J, Ford GC, Marc J, Aussel C, Cynober L. Citrulline stimulates muscle protein synthesis in the post-absorptive state in healthy people fed a low-protein diet – A pilot study. Clin Nutr. 2015 Jun;34(3):449-56. doi: 10.1016/j.clnu.2014.04.019; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309748/
    14. Bahri S, Zerrouk N, Aussel C, Moinard C, Crenn P, Curis E, Chaumeil JC, Cynober L, Sfar S. Citrulline: from metabolism to therapeutic use. Nutrition. 2013 Mar;29(3):479-84. doi: 10.1016/j.nut.2012.07.002; https://www.sciencedirect.com/science/article/abs/pii/S0899900712002584
    15. Agarwal, Umang, et al. “Supplemental Citrulline Is More Efficient than Arginine in Increasing Systemic Arginine Availability in Mice123.” The Journal of Nutrition, vol. 147, no. 4, 1 Apr. 2017, pp. 596–602; 10.3945/jn.116.240382; https://academic.oup.com/jn/article/147/4/596/4584706
    16. Miyake, Mika, et al. “Randomised Controlled Trial of the Effects of L-Ornithine on Stress Markers and Sleep Quality in Healthy Workers.” Nutrition Journal, vol. 13, no. 1, 3 June 2014, 10.1186/1475-2891-13-53; https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-53
    17. Ripps, H. et al. Nov. 2012. “Review: Taurine: A “Very Essential Amino Acid.” Molecular Vision vol. 18. 2673-86. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501277/
    18. Waldron, M., et al. May 2018. “The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis.” Sports Medicine vol. 48,5; 1247-53. https://pubmed.ncbi.nlm.nih.gov/29546641
    19. Surai, Peter F et al. “Taurine as a Natural Antioxidant: From Direct Antioxidant Effects to Protective Action in Various Toxicological Models.” Antioxidants (Basel, Switzerland) vol. 10,12 1876. 24 Nov. 2021, doi:10.3390/antiox10121876 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698923/
    20. Li, Fei et al. “Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats.” American journal of physiology. Endocrinology and metabolism vol. 288,1 (2005): E29-36. doi:10.1152/ajpendo.00168.2004 https://journals.physiology.org/doi/full/10.1152/ajpendo.00168.2004
    21. El Idrissi, Abdeslem, and Ekkhart Trenkner. “Taurine regulates mitochondrial calcium homeostasis.” Advances in experimental medicine and biology vol. 526 (2003): 527-36. doi:10.1007/978-1-4615-0077-3_63 https://link.springer.com/chapter/10.1007/978-1-4615-0077-3_63
    22. Chen, C. et al. Aug. 2019. “Roles of Taurine in Cognitive Function of Physiology, Pathologies, and Toxication.” Life Sciences vol. 15, 231; https://pubmed.ncbi.nlm.nih.gov/31220527/
    23. Blom, Per C. S., et al. “Effect of Different Post-Exercise Sugar Diets on the Rate of Muscle Glycogen Synthesis.” Medicine & Science in Sports & Exercise, vol. 19, no. 5, 1 Oct. 1987, pp. 491–496; https://journals.lww.com/acsm-msse/Abstract/1987/10000/Effect_of_different_post_exercise_sugar_diets_on.12.aspx
    24. Conlee, Robert K., et al. “Effects of Glucose or Fructose Feeding on Glycogen Repletion in Muscle and Liver after Exercise or Fasting.” Annals of Nutrition and Metabolism, vol. 31, no. 2, 1987, pp. 126–132, doi:10.1159/000177259; https://pubmed.ncbi.nlm.nih.gov/3592616/
    25. Van Den Bergh, Adrianus J., et al. “Muscle Glycogen Recovery after Exercise during Glucose and Fructose Intake Monitored By13C-NMR.” Journal of Applied Physiology, vol. 81, no. 4, 1 Oct. 1996, pp. 1495–1500, doi:10.1152/jappl.1996.81.4.1495; https://journals.physiology.org/doi/full/10.1152/jappl.1996.81.4.1495
    26. Nilsson, L. H:son, and E. Hultman. “Liver and Muscle Glycogen in Man after Glucose and Fructose Infusion.” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 33, no. 1, Jan. 1974, pp. 5–10, doi:10.3109/00365517409114190; https://www.tandfonline.com/doi/abs/10.3109/00365517409114190
    27. Nall, Rachel. “What Is Dextrose and How Is It Used Medically?” Healthline, 2015; https://www.healthline.com/health/dextrose
    28. Fujisawa, T, et al. “The Effect of Exercise on Fructose Absorption.” The American Journal of Clinical Nutrition, vol. 58, no. 1, 1 July 1993, pp. 75–79, doi:10.1093/ajcn/58.1.75; https://pubmed.ncbi.nlm.nih.gov/8317393/
    29. Henry, R R, et al. “Current Issues in Fructose Metabolism.” Annual Review of Nutrition, vol. 11, no. 1, July 1991, pp. 21–39, doi:10.1146/annurev.nu.11.070191.000321; https://pubmed.ncbi.nlm.nih.gov/1892698/
    30. Chen, Minshen, and Roy L. Whistler. “Metabolism of D-Fructose.” ScienceDirect, Academic Press, 1 Jan. 1977. doi:10.1016/S0065-2318(08)60327-3; https://www.sciencedirect.com/science/article/abs/pii/S0065231808603273
    31. Mayes, P A. “Intermediary Metabolism of Fructose.” The American Journal of Clinical Nutrition, vol. 58, no. 5, 1 Nov. 1993, pp. 754S765S, doi:10.1093/ajcn/58.5.754s; https://pubmed.ncbi.nlm.nih.gov/8213607/
    32. Mendeloff, A. I., and T. E. Weichselbaum. “Role of the Human Liver in the Assimilation of Intravenously Administered Fructose.” Metabolism: Clinical and Experimental, vol. 2, no. 5, 1 Sept. 1953, pp. 450–458; https://pubmed.ncbi.nlm.nih.gov/13110753/
    33. Vijaya Juturu V., Komorowski, JR. 2002. US7576132B2 – “Arginine Silicate Inositol Complex and use Thereof.” The United States Patent and Trademark Office. https://patents.google.com/patent/US7576132
    34. Castillo, L, et al. “Splanchnic Metabolism of Dietary Arginine in Relation to Nitric Oxide Synthesis in Normal Adult Man.” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 1, 1 Jan. 1993, pp. 193–197; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45626/
    35. Wu, Guoyao. “Intestinal Mucosal Amino Acid Catabolism.” The Journal of Nutrition, vol. 128, no. 8, 1 Aug. 1998, pp. 1249–1252, 10.1093/jn/128.8.1249; https://academic.oup.com/jn/article/128/8/1249/4722724
    36. O’sullivan, D., et al. “Hepatic Zonation of the Catabolism of Arginine and Ornithine in the Perfused Rat Liver.” Biochemical Journal, vol. 330, no. Pt 2, 1 Mar. 1998, p. 627, 10.1042/bj3300627; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC1219183/
    37. van de Poll, Marcel CG, et al. “Interorgan Amino Acid Exchange in Humans: Consequences for Arginine and Citrulline Metabolism.” The American Journal of Clinical Nutrition, vol. 85, no. 1, 1 Jan. 2007, pp. 167–172, 10.1093/ajcn/85.1.167; https://pubmed.ncbi.nlm.nih.gov/17209193/
    38. Schwedhelm, Edzard et al.; “Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.”; British journal of clinical pharmacology vol. 65,1 (2008): 51-9.; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291275/
    39. Kalman, Douglas, et al. “A Clinical Evaluation to Determine the Safety, Pharmacokinetics, and Pharmacodynamics of an Inositol-Stabilized Arginine Silicate Dietary Supplement in Healthy Adult Males.” Clinical Pharmacology: Advances and Applications, Oct. 2015, p. 103, doi:10.2147/cpaa.s84206; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603712/
    40. Komorowski, J., et al. Apr. 2016. “A Pharmacokinetic Evaluation of the Duration of Effect of Inositol- Stabilized Arginine Silicate and Arginine Hydrochloride in Healthy Adult Males.” The Journal of the Federation of American Societies for Experimental Biology vol. 30. https://www.fasebj.org/doi/abs/10.1096/fasebj.30.1_supplement.690.17
    41. Greenberg, D., K. Emerson, S. Ojalvo Perez, S. Sylla, and J. Komorowski. “Inositol-Stabilized Arginine Silicate Reduces Exercise Induced Muscle Damage and Increases Perceived Energy: Original Research”. 2023. Journal of Exercise and Nutrition, vol. 6, no. 1, July 2023, doi:10.53520/jen2023.103141; https://www.journalofexerciseandnutrition.com/index.php/JEN/article/view/141 (Full-Text PDF)
    42. Kalman, Douglas et al. “Randomized Prospective Double-Blind Studies to Evaluate the Cognitive Effects of Inositol-Stabilized Arginine Silicate in Healthy Physically Active Adults.” Nutrients vol. 8,11 736. 18 Nov. 2016, doi:10.3390/nu8110736; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133120/ (2018 ISSN Summary, 2018 ISSN Poster Presentation)
    43. Evans, M. et al. July 2020. “Inositol-Stabilized Arginine Silicate Improves Post Exercise Cognitive Function in Recreationally Active, Healthy Males: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.” Journal of Exercise and Nutrition vol. 3,3; https://www.journalofexerciseandnutrition.com/index.php/JEN/article/view/69 (full-text PDF, 2018 ISSN Poster Presentation, 2018 ISSN Conference Summary)
    44. Gills, Joshua L., et al. “Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults.” Nutrients, vol. 13, no. 12, 1 Dec. 2021, 10.3390/nu13124272; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8703995/
    45. Rood-Ojalvo, S. et al. Sep. 2015. “The Benefits of Inositol-Stabilized Arginine Silicate as a Workout Ingredient.” Journal of the International Society of Sports Nutrition vol. 12(S1). https://jissn.biomedcentral.com/articles/10.1186/1550-2783-12-S1-P14
    46. Thein, L A et al. “Ergogenic aids.” Physical therapy vol. 75,5 (1995): 426-39. doi:10.1093/ptj/75.5.426; https://academic.oup.com/ptj/article-abstract/75/5/426/2632902
    47. Cholewa, Jason M et al. “Effects of betaine on body composition, performance, and homocysteine thiolactone.” Journal of the International Society of Sports Nutrition vol. 10,1 39. 22 Aug. 2013, doi:10.1186/1550-2783-10-39; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844502/
    48. Boel De Paepe; “Osmolytes as Mediators of the Muscle Tissue’s Responses to Inflammation: Emerging Regulators of Myositis with Therapeutic Potential”; EMJ Rheumatol. 2017;4[1]:83-89; https://www.emjreviews.com/rheumatology/article/osmolytes-as-mediators-of-the-muscle-tissues-responses-to-inflammation-emerging-regulators-of-myositis-with-therapeutic-potential/
    49. Caldas, Teresa, et al. “Thermoprotection by Glycine Betaine and Choline.” Microbiology, vol. 145, no. 9, 1 Sept. 1999, pp. 2543–2548, 10.1099/00221287-145-9-2543; https://pubmed.ncbi.nlm.nih.gov/10517607/
    50. Lee I. Betaine is a positive regulator of mitochondrial respiration. Biochem Biophys Res Commun. 2015 Jan 9;456(2):621-5. doi: 10.1016/j.bbrc.2014.12.005; https://pubmed.ncbi.nlm.nih.gov/25498545/
    51. Zhao, Guangfu et al. “Betaine in Inflammation: Mechanistic Aspects and Applications.” Frontiers in immunology vol. 9 1070. 24 May. 2018, doi:10.3389/fimmu.2018.01070 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976740/
    52. Craig, Stuart AS. “Betaine in Human Nutrition.” The American Journal of Clinical Nutrition, vol. 80, no. 3, 1 Sept. 2004, pp. 539–549, 10.1093/ajcn/80.3.539; https://www.sciencedirect.com/science/article/pii/S0002916522035602
    53. Olthof, M. R., & Verhoef, P. (2005). Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Current drug metabolism, 6(1), 15-22; https://pubmed.ncbi.nlm.nih.gov/15720203
    54. Prasad K. Homocysteine, a Risk Factor for Cardiovascular Disease. Int J Angiol. 1999 Jan;8(1):76-86. doi: 10.1007/BF01616850; https://www.thieme-connect.de/products/ejournals/abstract/10.1007/BF01616850
    55. Cholewa, Jason M., et al. “Effects of Betaine on Performance and Body Composition: A Review of Recent Findings and Potential Mechanisms.” Amino Acids, vol. 46, no. 8, 24 Apr. 2014, pp. 1785–1793, 10.1007/s00726-014-1748-5; https://pubmed.ncbi.nlm.nih.gov/24760587/
    56. Jason Michael Cholewa, et al; “The Effects of Chronic Betaine Supplementation on Body Composition and Performance in Collegiate Females: a Double-Blind, Randomized, Placebo Controlled Trial”; Journal of the International Society of Sports Nutrition; BioMed Central; 31 July 2018; https://jissn.biomedcentral.com/articles/10.1186/s12970-018-0243-x
    57. Roti, M; “Homocysteine, Lipid and Glucose Responses to Betaine Supplementation During Running in the Heat”; Medicine & Science in Sports & Exercise: May 2003 – Volume 35 – Issue 5 – p S271; https://journals.lww.com/acsm-msse/Fulltext/2003/05001/HOMOCYSTEINE,_LIPID_AND_GLUCOSE_RESPONSES_TO.1501.aspx
    58. Armstrong, Lawrence E, et al. “Influence of Betaine Consumption on Strenuous Running and Sprinting in a Hot Environment.” Journal of Strength and Conditioning Research, vol. 22, no. 3, May 2008, pp. 851–860, 10.1519/jsc.0b013e31816a6efb; https://pubmed.ncbi.nlm.nih.gov/18438230
    59. Hoffman, Jay R, et al. “Effect of Betaine Supplementation on Power Performance and Fatigue.” Journal of the International Society of Sports Nutrition, vol. 6, no. 1, 27 Feb. 2009, 10.1186/1550-2783-6-7; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-6-7
    60. Lee, Elaine C, et al. “Ergogenic Effects of Betaine Supplementation on Strength and Power Performance.” Journal of the International Society of Sports Nutrition, vol. 7, no. 1, 2010, p. 27, 10.1186/1550-2783-7-27; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-27
    61. Trepanowski, John F, et al. “The Effects of Chronic Betaine Supplementation on Exercise Performance, Skeletal Muscle Oxygen Saturation and Associated Biochemical Parameters in Resistance Trained Men.” Journal of Strength and Conditioning Research, vol. 25, no. 12, Dec. 2011, pp. 3461–3471, 10.1519/jsc.0b013e318217d48d; https://pubmed.ncbi.nlm.nih.gov/22080324/
    62. Pryor, J Luke, et al. “Effect of Betaine Supplementation on Cycling Sprint Performance.” Journal of the International Society of Sports Nutrition, vol. 9, no. 1, 3 Apr. 2012, 10.1186/1550-2783-9-12; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-9-12
    63. Iravani, S. et al. June 2011. “Pharmaceutical and Nutraceutical Effects of Pinus Pinaster Bark Extract.” Research in Pharmaceutical Sciences vol. 6,1; 1-11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203267/
    64. Park, Joon Ha et al. “Neuroprotective and Anti-Inflammatory Effects of Pinus densiflora Bark Extract in Gerbil Hippocampus Following Transient Forebrain Ischemia.” Molecules (Basel, Switzerland) vol. 26,15 4592. 29 Jul. 2021, doi:10.3390/molecules26154592 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347023/
    65. Fekete ÁA, Givens DI, Lovegrove JA; “Casein-Derived Lactotripeptides Reduce Systolic and Diastolic Blood Pressure in a Meta-Analysis of Randomised Clinical Trials.”; Nutrients; 2015; 7(1):659-681; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303860/
    66. Mas-Capdevila, Anna et al. “Evidence that Nitric Oxide is Involved in the Blood Pressure Lowering Effect of the Peptide AVFQHNCQE in Spontaneously Hypertensive Rats.” Nutrients vol. 11,2 225. 22 Jan. 2019, doi:10.3390/nu11020225; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412221/
    67. Barkhidarian, Bahareh et al. “Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis.” Avicenna journal of phytomedicine vol. 9,1 (2019): 10-20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369322/
    68. NuLiv Science; “AstraGin Product Dossier”. https://docdro.id/rA01t9O
    69. Lee, Shih-Yu, et al. “Astragaloside II Promotes Intestinal Epithelial Repair by Enhancing L-Arginine Uptake and Activating the MTOR Pathway.” Scientific Reports, vol. 7, no. 1, 26 Sept. 2017, p. 12302, 10.1038/s41598-017-12435-y. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614914/
    70. McKinley-Barnard, Sarah et al.; “Combined L-citrulline and glutathione supplementation increases the concentration of markers indicative of nitric oxide synthesis.”; Journal of the International Society of Sports Nutrition vol. 12 27. 10 Jun. 2015, doi:10.1186/s12970-015-0086-7; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472409/
    71. Hwang, Paul et al.; “Eight weeks of resistance training in conjunction with glutathione and L-Citrulline supplementation increases lean mass and has no adverse effects on blood clinical safety markers in resistance-trained males.”; Journal of the International Society of Sports Nutrition vol. 15,1 30. 27 Jun. 2018, doi:10.1186/s12970-018-0235-x; https://pubmed.ncbi.nlm.nih.gov/29945625/
    72. Lin, Hang-Ching, et al. “Method for Regulating Nutrient Absorption with Ginsenosides”; United States Patent and Trademark Office; Patent US20090181904A1; July 16, 2009; https://patents.google.com/patent/US20090181904A1/
    73. Lin, Hang-Ching, et al. “Method for Enhancing Nutrient Absorption with Astragalosides”; United States Patent and Trademark Office; Patent US20120196816A1; August 2, 2012; https://patents.google.com/patent/US20120196816A1/
    74. Lin, Hang-Ching, et al. “Method for Enhancing Nutrient Absorption with Astragalosides”; United States Patent and Trademark Office; Patent US20120196817A1; August 2, 2012; https://patents.google.com/patent/US20120196817A1/
    75. Lin, Hang-Ching, et al. “Method for Enhancing Nutrient Absorption with Astragalosides”; United States Patent and Trademark Office; Patent US8197860B2; June 12, 2012; https://patents.google.com/patent/US8197860B2/en
    76. Lin, Hang-Ching, et al. “Compound for enhancing nutrients uptake”; Taiwan Intellectual Property Office; Patent TWI271195B; 28-Dec 2004; https://patents.google.com/patent/TWI271195B/en
    77. Kiela, Pawel R., and Fayez K. Ghishan. “Physiology of Intestinal Absorption and Secretion.” Best Practice & Research Clinical Gastroenterology, vol. 30, no. 2, Apr. 2016, pp. 145–159, 10.1016/j.bpg.2016.02.007. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956471
    78. Cooper, Geoffrey M. “Endocytosis.” Nih.gov, Sinauer Associates, 2014. https://www.ncbi.nlm.nih.gov/books/NBK9831/
    79. Lee, Shih-Yu, et al. “Astragaloside II Promotes Intestinal Epithelial Repair by Enhancing L-Arginine Uptake and Activating the MTOR Pathway.” Scientific Reports, vol. 7, no. 1, 26 Sept. 2017, p. 12302, pubmed.ncbi.nlm.nih.gov/28951595/, doi:10.1038/s41598-017-12435-y; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614914/

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