Nutrex Burn30 GLP1+: Harnessing GLP-1 Activation for Advanced Weight Management

Nutrex Research enters the GLP-1 supplement market with Burn30 GLP1+! Featuring 200mg GlucoVantage dihydroberberine alongside Gymnema sylvestre and GreenSelect Phytosome to support natural GLP-1 activation for weight management.

The Nutrex Research rebirth continues with another exciting launch under the stewardship of Chris Waldrum. It’s been much too long (two years now!) since we had Chris on Episode #093 of the PricePlow Podcast, but since he’s come on board, they’ve had one success after another. Following the successful releases of Outlift Burn and the updated Outlift Clinical, Nutrex has set its sights on the weight management market.

Activate GLP-1 and Combat Weight with Nutrex Burn30 GLP1+

Chris and his team are now taking on the ever-growing GLP-1 market with Burn30 GLP1+, a supplement designed to activate GLP-1 pathways for enhanced fat loss. It’s rare to see a new fat burner from Nutrex that doesn’t bear the legendary LIPO-6 name, so we’re very excited for this continued shift from the resurging brand.

Burn60 is centered upon a large 200 milligram dose of NNB Nutrition’s GlucoVantage dihydroberberine, dubbed as the super berberine and shown to boost GLP-1 levels in research. But there’s much more, including a liposomal green tea extract and some additional blood sugar supporting herbs and minerals.

We get into the science below, but before diving in, sign up for our Nutrex news alerts and check the latest prices with PricePlow:

What is GLP-1 and Why Is It Important?

Nutrex Research has been around since 2002, and they continue to put out innovative, effective products!

GLP-1 (Glucagon-Like Peptide-1) has become one of the most talked-about compounds in weight management. Originally identified for its role in blood sugar regulation, GLP-1 has gained tremendous attention for its effects on appetite control, with pharmaceutical GLP-1 receptor agonists showing remarkable weight loss results in clinical settings.

GLP-1 is naturally produced in your intestines after eating, and it performs several important functions:^[1]

• Slows gastric emptying, helping you feel fuller longer
• Signals the brain to reduce hunger and increase satiety
• Helps regulate blood sugar by stimulating insulin release
• Reduces glucagon secretion (which normally raises blood sugar)

The weight loss and pharmaceutical industries have been revolutionized by prescription GLP-1 agonist medications, but these come with significant drawbacks – they’re expensive, require injections, and worst of all, come with some brutal side effects, including muscle loss, GI distress, horribly long stomach emptying (gastroparesis), cancer risk, and even blindness.^[2-7] Burn30 GLP1+ represents Nutrex’s innovative approach to supporting natural GLP-1 pathways through dietary supplementation.

Nutrex Burn30 GLP1+ Ingredients

Each serving (2 capsules) of Burn30 GLP1+ contains two vitamins (B6 and B12), one mineral (chromium), and the GLP-1 Activator Blend, which we’ll start with first:

• Gymnema sylvestre (leaf) extract – 300mg

  Gymnema sylvestre is a woody climbing plant native to India, Africa, and Australia that has been used in Ayurvedic medicine for centuries. It serves as a cornerstone ingredient in Nutrex’s Burn30 GLP1+ at a substantial 300mg dose.

  The Sugar Destroyer: How Gymnema Works

  Gymnema contains bioactive compounds called gymnemic acids, which offer tremendous effects on sugar metabolism and cravings. These compounds have a unique molecular structure similar to glucose molecules, enabling them to:

  • Block sugar absorption in the intestines, helping reduce blood glucose spikes^[8]
  • Temporarily occupy sweet taste receptors on the tongue, reducing the perception of sweetness and sugar cravings^[9]
  • Support pancreatic function and potentially help regenerate beta cells^[10]

  Scientific Support for Weight Management

  Research suggests that Gymnema sylvestre can be valuable for weight management through multiple mechanisms:

  • Reduced sugar absorption means fewer “empty calories” entering the bloodstream^[11]
  • By blunting sweet taste perception, it helps break the psychological cycle of sugar cravings^[12]
  • Studies show it may help reduce body weight and BMI in those taking the extract regularly.^[13] Note that this study used additional ingredients, but one of them (chromium) is also in this formula.

  

  Gymnema and GLP-1 Connection

  While research specifically linking Gymnema to GLP-1 activation is still emerging, its mechanisms align well with GLP-1’s metabolic effects. Both support healthy blood sugar levels and can reduce food intake, especially sweet foods. Recent investigations suggest that Gymnema’s effects on insulin secretion may involve incretin pathways, potentially including GLP-1 ^[14].

  When combined with other ingredients in Burn30 GLP1+ like GlucoVantage (dihydroberberine) that have more established connections to GLP-1 signaling, Gymnema creates a more comprehensive approach to blood sugar control, appetite management, and sustainable weight loss. Its long history of safe use in traditional medicine makes it a valuable natural alternative to support healthy metabolism without the side effects associated with pharmaceutical GLP-1 agonists.

• GreenSelect Phytosome (Green Tea Leaf Extract) – 300mg

  GreenSelect Phytosome is a cutting-edge green tea extract formulation that addresses the poor bioavailability issues of traditional green tea supplements. This caffeine-free extract is complexed with phospholipids to dramatically enhance the bioavailability and absorption of green tea’s beneficial compounds found in literature.^[15]

  Metabolic and Weight Management Benefits

  Multiple research studies have highlighted green tea’s potential for supporting weight management through several key mechanisms:

  1. Energy Expenditure Boost: Green tea catechins have been shown to increase 24-hour energy expenditure by approximately 4-5%, primarily through thermogenic effects.^[15]
  2. Fat Oxidation Support: The catechin-caffeine combination can significantly enhance fat oxidation, potentially helping the body more efficiently use fat for energy.^[15]

  Potential GLP-1 Interactions

  According to research published by Liu and colleagues in 2014, green tea extract significantly increased glucagon-like peptide 1 (GLP-1) levels in patients with type 2 diabetes and lipid abnormalities, but only in the within-group comparison.^[16] The therapeutic arm taking 500 mg green tea extract three times daily for 16 weeks showed increased GLP-1 levels that were not observed in the placebo group.

  

  Additionally, a later study by Planes-Muñoz found that green tea extract stimulated GLP-1 secretion in enteroendocrine STC-1 cells, with the effect becoming stronger over time, especially after simulated gastrointestinal digestion.^[17]

  Powerful polyphenols to support metabolism

  Green tea extract is rich in powerful polyphenols, with epigallocatechin gallate (EGCG) being the most prominent. These compounds have been associated with multiple health benefits, including potential anti-obesity effects, improvements in metabolism, and supporting overall cardiovascular health. We often call green tea extract the “Swiss Army Knife” of metabolic boosters for this reason, but keep reading — GreenSelect has its own array of research.

  Additionally, the extract may support:

  • Improved insulin sensitivity^[18]
  • Enhanced metabolic function
  • Potential appetite regulation

  The GreenSelect Phytosome Advantage

  The issue is that traditional green tea extracts often struggle with poor absorption. GreenSelect’s phytosome delivery system addresses this limitation by:

  • Binding catechins to phospholipids
  • Improving cellular membrane penetration
  • Enhancing overall bioavailability of active compounds.

  Clinical research demonstrates GreenSelect Phytosome’s impressive weight loss effects. In a controlled study, subjects taking this extract along with a hypocaloric diet lost significantly more weight than the diet-only group (14 kg vs 5 kg over 90 days).^[19]

  

  A recent randomized, double-blind, placebo-controlled trial found that 60 days of GreenSelect supplementation had significant effects on fat metabolism in post-menopausal women. The supplemented group showed decreased respiratory quotient, increased fat oxidation percentage, reduced insulin levels, improved insulin sensitivity (HOMA index), reduced waist circumference, and increased resting energy expenditure compared to placebo.^[20]

  What’s also valuable is GreenSelect’s ability to help maintain weight loss after a diet — something even GLP-1 pharmaceuticals seem to fail to do! In a randomized placebo-controlled trial, women who had already lost weight through lifestyle changes continued losing weight when supplemented with GreenSelect Phytosome, while the placebo group began regaining weight.^[21]

  GreenSelect: Overall Metabolic Health Benefits

  Beyond weight management, GreenSelect Phytosome offers excellent all-around metabolic benefits. A controlled registry study found that after 24 weeks, 68% of subjects taking GreenSelect Phytosome no longer met metabolic syndrome criteria, compared to only 20% in the control group. The extract significantly improved waist circumference, blood lipids, blood pressure, and inflammatory markers.^[22]

  At 300mg per serving in Burn30, this clinical-grade extract provides a science-backed approach to supporting both weight management and overall metabolic health without the stimulant effects of caffeine-containing green tea extracts.

  GreenSelect Phytosome is included here at 300mg per serving, which falls within their range of doses used in clinical research for metabolic support.

• Dihydroberberine (as GlucoVantage) – 200mg

  At the heart of Nutrex’s innovative Burn30 GLP1+ formula lies one of the most exciting ingredients in the supplement world today: NNB Nutrition’s GlucoVantage® dihydroberberine. This advanced form of berberine is quickly establishing itself as a game-changer for natural metabolic support and weight management.

  What Makes GlucoVantage Stand Out?

  GlucoVantage isn’t just another berberine product… it’s the next evolution of this powerful plant compound. Traditional berberine has been used for centuries, but its effectiveness has always been limited by poor bioavailability, with less than 1% of standard berberine typically being absorbed by the body.^[23]

  

  GlucoVantage® dihydroberberine redefines metabolic health by boosting GLP-1 levels by 95% in new research. Its superior bioavailability and multi-faceted benefits—like better body composition, lipid profiles, and oxidative stress reduction—position it as a groundbreaking natural alternative to GLP-1 drugs.

  GlucoVantage overcomes this critical limitation, showing up to 5 times greater bioavailability than regular berberine in research studies,^[23] with recent human data backing up its impact on glycemia.^[24] This means smaller doses can deliver more powerful results with fewer side effects.

  The GLP-1 Connection: How Dihydroberberine Activates Natural Weight Management Pathways

  What makes GlucoVantage the rock star in Burn30 GLP1+ is its ability to naturally support GLP-1 signaling. Recent research has shown that berberine and its derivatives can enhance GLP-1 secretion from intestinal cells – the same hormone targeted by popular prescription weight loss medications.^[25]

  In a groundbreaking study, researchers found that berberine treatment restored GLP-1 secretion in diet-induced obese mice, not only reversing the decline in GLP-1 levels but actually increasing them above baseline compared to healthy controls.^[25] With GlucoVantage’s superior absorption, these effects may be achieved at a lower dose with fewer digestive side effects.

• Beyond GLP-1: Multi-Pathway Metabolic Support

  GlucoVantage’s benefits extend beyond just GLP-1 activation:

  • Improved Insulin Sensitivity: By activating AMPK (a critical metabolic regulator), dihydroberberine helps optimize insulin function, supporting healthy blood sugar levels and reducing fat storage.^[26]
  • Enhanced Body Composition: Research suggests dihydroberberine may help preserve lean mass while promoting fat loss, a critical advantage over pharmaceutical options that can lead to muscle wasting.^[27]
  • Reduced Fat Storage: By enhancing fat oxidation and inhibiting fat storage pathways, GlucoVantage helps direct calories toward energy production rather than fat storage.

  

  The Ideal Dose: Quality Over Quantity

  Nutrex has wisely included 200mg of GlucoVantage dihydroberberine in each serving of Burn30 GLP1+. This reflects the current science showing that a 200mg dose of dihydroberberine can achieve similar metabolic effects as much larger doses of standard berberine.^[24]

  This science-backed dosage strategy means you get maximum benefit with minimal digestive discomfort, which is a common side effect of high-dose berberine supplementation.

  The Natural Alternative

  GlucoVantage offers a natural approach to supporting your body’s own GLP-1 pathways, working with your biology rather than overriding it. When combined with the other strategic ingredients in Burn30 GLP1+, it provides comprehensive support for natural weight management without the harsh side effects of prescription options.

  By including this premium form of dihydroberberine, Chris Waldrum and his team at Nutrex Research shows their commitment to cutting-edge formulation and science-backed results in the Burn30 GLP1+ supplement.

• GBBGO (Gamma-Butyrobetaine HCl) – 30mg

  Next, Burn30 GLP1+ includes a strategic 30mg dose of Gamma-Butyrobetaine (GBB), which serves as a key precursor to L-carnitine in the body. While GBB doesn’t directly activate GLP-1 pathways, it plays a crucial complementary role in the formula’s fat-burning capability.

  GBB works by converting to L-carnitine through an enzymatic reaction catalyzed by γ-butyrobetaine hydroxylase.^[28] This conversion process is essential because carnitine plays a vital role in transporting long-chain fatty acids into mitochondria, where they can be broken down via β-oxidation to generate energy.

  GBB has the ability to:

  1. Increase Natural Carnitine Production: By providing the direct precursor to carnitine, GBB helps boost your body’s natural carnitine levels more efficiently than taking carnitine supplements directly.^[29]
  2. Enhance Thermogenesis: One of GBB’s most noticeable effects is its ability to increase sweating and body heat production, which many users report as a sign of elevated metabolic rate.^[29,30]
  3. Support Fat Oxidation: By increasing carnitine availability, GBB helps optimize the body’s ability to use stored fat for fuel, especially during exercise or caloric restriction.

  

  At the 30mg dose provided in Burn30 GLP1+, users can expect sufficient GBB to enhance thermogenesis and fat metabolism without overwhelming sweating that can occur at higher doses.

• Black Pepper fruit extract 10:1 – 5mg

  Black pepper extract is more than just a supporting player in the formula, it’s a strategic addition that amplifies the effectiveness of the entire supplement. This highly concentrated 10:1 extract contains piperine, the bioactive alkaloid that gives black pepper its characteristic pungency and intense therapeutic properties.

  Piperine’s first contribution to this formula is its ability to enhance the bioavailability of other ingredients. It accomplishes this primarily by inhibiting certain metabolic enzymes in the liver and intestinal wall that would otherwise break down beneficial compounds before they can be utilized by the body.^[31] Research has shown that piperine can increase the bioavailability of some compounds (curcumin) by up to 2000% in humans, making it a potential ingredient amplifier here.

  But relevant in a GLP-1 targeted supplement are the metabolic effects. In clinical studies, a combination containing piperine demonstrated its potential role in supporting the gut-hormone pathway that regulates appetite and glucose metabolism.^[32]

  Additionally, piperine itself offers thermogenic properties and has been shown to inhibit new fat cell formation through various mechanisms.^[33] The 5mg dose in Burn30 GLP1+ is calibrated to maximize absorption of the other active ingredients while providing its own modest thermogenic support.

  When combined with the other ingredients in the formula, especially GlucoVantage dihydroberberine, the black pepper extract creates a synergistic effect that enhances the overall efficacy of the supplement in supporting healthy weight management.

  Now on to the key mineral and some of the vitamins:

• Chromium (as Chromium Picolinate) – 250mcg (714% DV)

  

  Need a fiery workout experience? Check out Outlift Burn

  Nutrex Burn30 GLP1+ includes chromium picolinate at 250mcg (714% DV), complementing its GLP-1 activating ingredients with this essential trace mineral that supports proper insulin function.

  Chromium plays a key role in glucose metabolism by enhancing insulin’s action in the body. Research shows that chromium forms a complex with chromodulin, a protein that activates insulin receptors, potentially improving glucose uptake by cells.^[34] This increased insulin sensitivity may help maintain stable blood sugar levels throughout the day.

  Chromium also has potential effects on appetite regulation, which is important to those seeking “GLP-1-like effects”. Several notable studies have examined chromium picolinate supplementation at higher doses between 600-1000mcg daily, finding it may influence hunger and food cravings. In one 8-week trial, overweight women receiving 1000mcg of chromium picolinate showed reduced food intake, decreased hunger levels, and diminished cravings for high-fat foods compared to placebo.^[35]

  Another study found that 600mcg of chromium picolinate improved appetite regulation and specifically reduced carbohydrate cravings in participants with mood issues.^[36]

  While Burn30 GLP1+ contains a lower dose than these studies (250mcg vs. 600-1000mcg), chromium works synergistically with the formula’s other ingredients to support healthy glucose metabolism and may contribute to the overall appetite-regulating effects of the product.

  For optimal chromium benefits, consistent daily supplementation is recommended, ideally taken with meals to enhance absorption.

• Vitamin B6 (as Pyridoxine HCl) – 20mg (1176% DV)

  

  Vitamin B6 plays a critical role in protein metabolism and is involved in over 100 enzyme reactions in the body. For weight management, B6 is important for:

  • Supporting proper amino acid metabolism
  • Helping convert stored glycogen to glucose for energy
  • Facilitating neurotransmitter production that can influence appetite

• Vitamin B12 (as Methylcobalamin) – 100mcg (4167% DV)

  The highly bioavailable methylcobalamin form of vitamin B12 is included at a substantial dose to support:

  • Energy production and reduction of fatigue
  • Proper nervous system function
  • Metabolism of fats and proteins

  This is a great way to round out Burn30, covering gaps in both vitamins and supporting the methylation process.

How to Use Nutrex Burn30 GLP1+

As indicated on the label, take 2 capsules of Burn30 GLP1+ with morning or midday meals. For optimal results:

• Maintain consistent daily use
• Pair with a balanced nutrition plan
• Stay well-hydrated throughout the day
• Incorporate regular physical activity
• Do not exceed the recommended dosage

Though this supplement is designed to help control appetite, it’s not intended as a meal replacement. The best results will come from using Burn30 GLP1+ as part of a comprehensive approach to weight management that includes proper nutrition and exercise.

Conclusion: Nutrex Takes On The GLP-1 Supplement Market

Chris Waldrum returns to the PricePlow Podcast for Episode #091 to discuss leading the Nutrex Research Rebrand

With Burn30 GLP1+, Nutrex Research demonstrates their commitment to innovation and science-backed formulations. As Chris Waldrum told us in Episode #091 of the PricePlow Podcast exactly two years ago, his vision was to bring Nutrex back to the cutting edge of supplement formulation, and Burn30 GLP1+ delivers on that promise.

By targeting the GLP-1 pathway through natural ingredients rather than pharmaceuticals, Nutrex offers consumers an alternative approach to appetite control and weight management without the needles or potential side effects of prescription options. The formula combines clinically-tested ingredients like GreenSelect Phytosome and GlucoVantage with metabolism-supporting compounds to create a comprehensive weight management solution.

While no supplement can replace the fundamentals of proper diet and exercise, Burn30 GLP1+ provides a promising tool for those looking to optimize their weight loss journey through natural GLP-1 support. As the supplement industry continues to evolve alongside developments in weight management science, Nutrex has positioned itself at the forefront of this trend.

Stay tuned for more coverage of Nutrex’s innovative product line as the Nutrex rebirth continues under Waldrum’s direction!