Nitramine 2015: Myokem’s Reformulation for MORE Focus

Myokem has unveiled the newest version of it's popular pre workout Nitramine which removes picamilon in favor of L-Theanine and Theacrine.

Myokem has unveiled the newest version of it’s popular pre workout Nitramine which removes picamilon in favor of L-Theanine and Theacrine.

One of the victims of the recent witch hunt against all things containing picamilon was the focus-centric pre workout, Nitramine. Myokem got the very short end of the stick there, having just reformulated Nitramine right before the FDA threw its picamilon-hammer down (in that version, they upped caffeine to 175mg and removed rauwolscine).

So fans of Myokem have been eagerly awaiting the release of yet another the new formulation.

With the release imminently approaching, the brand has finally revealed the updated product, in addition to completely opening up the label!

Key Notes

  • Open formula that’s huge on focus
  • 175mg caffeine with added Theacrine
  • 1g ALCAR replaces 1g LCLT
  • L-Theanine replaces Picamilon
  • 500mg agmatine the main pump ingredient
  • Will definitely remain all over the place in our best pre workout guide

We’ll cover the new label below, but make sure to sign up for price drop alerts and check the best deal, but note that some stores may have the older formulas until early 2016, so check the labels or ask them to be sure:

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Nitramine Ingredients

Previous users of Nitramine will be glad to see that the majority of ingredients have been carried over to the new formula. The only two that are missing are picamilon, replaced by l-theanine, and L-Carnitine L-Tartrate (LCLT), which is replaced by Acetyl L-Carnitine (ALCAR), the more focus-based form of carnitine.

Users also now know how much of each ingredient they are getting as well, since Myokem has shifted to a fully open label:

  • Betaine Anhydrous (2g)

    Myokem Nitramine 2015 Ingredients

    The new version of Nitramine carries over many of the same ingredients in addition to fully disclosing amounts of all the ingredients.

    A carry over from the OG version, betaine is a great ingredient to include in any pre workout, given it’s effectively dosed. This choline derivative is an osmoregulator of creatine in the body, and some research indicates betaine works with creatine to improve the body’s production of it, as well as reducing muscle soreness.[1,2]

    Much like creatine, betaine also helps to improve strength, power, endurance and lean mass gains.[3,4,5]

    The clinical dose of betaine is 2.5g, so this is definitely close enough to achieve gains. If you end up taking a bit more than one scoop, you’ll easily hit that number, but 2g is more than most pre workouts have and we’re good to go on this first ingredient.

  • Beta Alanine (1.6g)

    Beta alanine is the incredibly popular endurance booster that makes most people feel “alive” when they take a pre workout thanks to the tingles they get when first supplementing with it.

    BA binds to histidine in the body and increases concentrations of carnosine, a powerful intracellular buffer of lactic acid.[6] Removing lactic acid eliminates the burning sensation you feel in the muscle belly during intense exercise, and leads to a host of benefits including: better endurance, greater power output, and increased strength.[7,8,9]

    To really see the full clinical effects of BA supplementation, you’ll need 3.2g. This means using two scoops of Nitramine (which is quite a wild ride), or adding some bulk BA.

  • Acetyl L-Carnitine (1g)

    Acetyl L-Carnitine (ALCAR) replaces L-Carnitine L-Tartrate (LCLT) in the new version. ALCAR is a unique form of carnitine supplements than can cross the blood-brain barrier.[10]

    In addition to improving focus, ALCAR also can reduce mental fatigue,[11] improve mood,[12] and increase Nitric Oxide levels.[13] More interesting, is that ALCAR works in tandem with caffeine to increase “fatty acid dumping”, a condition where fatty acids are excreted by the body when cells are engaged in fat burning.[14]

    As a side note, ALCAR often work synergistically with choline supplements, which we’ll cover below, to increase the body’s synthesis of acetylcholine, an important neurotransmitter heavily involved in memory formation and cognition.

    Is this better than LCLT?

    Replacing LCLT with ALCAR is an interesting maneuver. LCLT is great for soreness and recovery, and even has some purposes in natural testosterone boosting products.

    However, for the sake of Nitramine, which is focus-driven, ALCAR makes a lot more sense here. These two ingredients are what we consider the best two forms of carnitine – we never buy straight L-carnitine, we buy what we’re targeting.

    For total muscle growth and recovery, LCLT is better. But for focus, which is what Nitramine caters to, you want ALCAR. Good move for most of us, we love this ingredient.

  • N-Acetyl L-Tyrosine (750mg)

    Myokem Nitramine Burpee

    The next time your workout calls for some Burpee burnout sessions, make sure to have a scoop of Nitramine handy to power you through!

    L-Tyrosine supplements are often used as memory and cognition boosters, but require much higher doses to be effective (1.5-2g). N-Acetyl L-Tyrosine (NALT) is the more bioavailable, and expensive, form of L-Tyrosine, that usually requires a smaller dose to be effective.

    NALT increases the production of two crucial neurotransmitters, dopamine and noradrenaline. Greater concentrations of these neurotransmitters increases your overall mood and focus, while also reducing signs of stress and anxiety.[15,16]

  • Agmatine Sulfate (500mg)

    Agmatine is a noteworthy pump aid that’s been widely used in pre workouts for over a year now. Agmatine doesn’t directly increase nitric oxide levels, but prevents its premature breakdown in the body.[17]

    Higher circulating levels of NO helps create a longer lasting and harder pump during your workout.

    Furthermore, agmatine is also a powerful neurotransmitter and neuromodulator that can enhance cognition and memory formation greatly improve memory formation and cognition.[18]

    Nitramine uses the “standard” dose of 500mg that we see in most other pre workouts, but if you really want to see this ingredient shine, you’ll want to add some bulk agmatine to get to the 1-1.5g threshold. This isn’t, however, marketed to be a “massive crazy super pump pre workout”. Agmatine here gets the job done, but if you want pumps, you can add a top stim-free product.

  • Caffeine Anhydrous (175mg)

    The surprising factor in Nitramine to many users was the relatively moderate amount of caffeine that was included in it. The amount of energy and focus that you feel with Nitramine makes you swear there was close to 300mg of it in the OG version.

    Not falling into the trap of “more is better,” Myokem has kept the caffeine in check at a reasonable 175mg per scoop. You’ll still feel all the same increases in energy, focus, and performance as you did with the original, but a little smoother thanks to the inclusion of L-Theanine and Theacrine.

    Many times you honestly don’t even need a full scoop of Nitramine. It’s intense stuff – don’t be fooled by this caffeine dose!

  • Cognizin® Citicoline (100mg)

    Here's the last stock of the OG Nitramine. It can still be found if you know where to look...

    Here’s the last stock of the OG Nitramine. It can still be found if you know where to look…

    Choline supplements are the top choice when aiming to increase focus during exercise or studying. Most pre workouts opt for the bitartrate variation which is less bioavailable, and cheaper.

    Myokem breaks the bank by opting for the more expensive and bioavailable citicoline. This form of choline is taken up by the body much better[19] and if you’ve never used choline before, you’ll definitely “feel” this one. Choline supplements help you feel more focused during your workouts and create a rather potent “mind-muscle” connection.[20]

    Citicoline is also known as Choline CDP. Without question, it’s our favorite form, and feels incredible whether you’re in the gym, at work, or studying.

  • Teacrine® (100mg)

    TeaCrine® is a trademarked extract that contains a dose of 98% concentrated theacrine. Theacrine is chemically similar to caffeine and possesses many of the same benefits. The difference, however, is that theacrine doesn’t have a tolerance build up as is the case with caffeine.[21]

    Basically, this means that higher and higher doses aren’t needed to keep seeing the same effects. Other benefits of theacrine include reducing oxidative stress in the body when used for at least seven consecutive days,[22] and increasing dopamine levels in the brain, similar to caffeine.[23]

  • L-Theanine (100mg)

    Most associate L-theanine with helping to smooth out the harsh kick from high doses of caffeine and other stimulants. However, theanine does much more in the body.

    Theanine also enhances the cognitive focus effects of caffeine,[24] and helps alleviate stress, anxiety and fatigue.[25,26]

    Mike’s a big fan of using L-Theanine with higher doses of stimulants – it eliminates that typical “on edge” feeling. This will certainly help given the vast amount of stims and nootropic agents in Nitramine!

    Normally, we like a 3:1 caffeine:theanine ratio or so, but this is a bit more. That’s okay since there’s so many other stimulants involved with Nitramine – it really could change the way this supplement works if you’ve only tried v1.

  • Hordenine HCl (50mg)

    Hordenine is one of the many bioactive alkaloids contained in Citrus Aurantium (a.k.a. bitter orange). Like the other constituents found in the plant, hordenine also functions as a beta-2 adrenergic agonist.[27]

    More importantly though, Hordenine also functions as a noradrenaline reuptake modulator.[28,29] Basically, noradrenaline stays active longer in your system and results in greater energy, focus, and alertness.[28,29]

  • Higenamine (50mg)

    Myokem Preworkout

    You wouldn’t go a day without brushing your teeth, and you shouldn’t have a workout without a stellar pre workout.

    Higenamine is another beta adrenergic like our previous ingredient.[30] Similar to hordenine, higenamine increases production of noradrenaline, which kick starts a chain reaction in the body that ignites the “fight or flight” response. This all leads to better focus, greater concentration, and the mobilization of stored fats for use as energy.

  • Theobromine (50mg)

    Theobromine comes from the cocoa plant and is responsible for the quintessential “feel-good” sensation you get when eating large amounts of dark chocolate.

    Theobromine is often referred to as caffeine’s younger brother, and, much like caffeine, theobromine acts as a mild stimulant in the body. However, the energy derived from theobromine is smoother and longer-lasting than it’s big brother.[31]

  • Huperzine A (10mg)

    Rounding out the list of cognitive boosters is the powerful nootropic Huperzine A, a.k.a. Toothed Clubmoss. Rather than directly increasing levels of acetylcholine, Huperzine indirectly increases the body’s levels of this all-too-important neurotransmitter.

    Huperzine inhibits the enzyme responsible for degrading acetylcholine in the body, acetylcholinesterase, which indirectly increases circulating levels of the potent focus aid.[32]

    Huperzine also supports overall brain health, by preventing premature cell death brought about by the neurotoxin glutamine and may potentially even help create new brain cells[33,34]

  • BioPerine® (5mg)

    Our last ingredient is small but rather important. With all the ingredients contained in Nitramine, you’ll need some insurance to make sure your body actually absorbs all of the goodies contained within it.

    Black pepper extracts like BioPerine® help the body absorb other ingredients in sports supplements by preventing their premature breakdown in the body.[35]

Flavors Available

Nikky Nitramine

@nikkyfitness sporting her Nitramine

No news has been revealed in regards to specific flavors for the new version of Nitramine. Hopefully though, the brand carries over the two original flavors of Dragon Fruit and Havana Sunrise. As for new flavors, we’ll have to wait and see what Myokem has in the works.

Wrap Up

Myokem’s reformulation of Nitramine looks like a sure-fire winner for fans of the OG version. There are far too many similarities between the two for fans to be disappointed, but the differences are basically all for the better in terms of smoother focus.

The addition of Theacrine should help provide an additional boost in energy that helps sustain the effects of caffeine, while ALCAR is the better focus agent than LCLT.

We can’t wait to see the response from the masses when it’s released, and hopefully we can get our hands on some to give you all a full breakdown of the new formula’s effects!

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References

  1. Lee EC, et al. Ergogenic effects of betaine supplementation on strength and power performance. J Int Soc Sports Nutr. (2010)
  2. Effect of betaine supplementation on power performance and fatigue
  3. del Favero S, et al Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance . Amino Acids. (2012)
  4. holewa, J; Effects of betaine on body composition, performance, and homocysteine thiolactone.; Department of Kinesiology, Recreation, and Sport Studies, Coastal Carolina University; 2013
  5. Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise.
  6. Baguet, A et al.; Journal of Applied Physiology; “Important role of muscle carnosine in rowing performance;” July 2010;” 2005
  7. Roger C. Harris; et al.; “The effect of a supplement containing β-alanine on muscle carnosine synthesis, ventilatory threshold and exercise capacity in Korean cyclists, during 12 weeks combined endurance and weight training
  8. Hill, CA et al.; Amino Acids; “Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity ;” February 2007
  9. Kendrick IP, et al. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids. (2008)
  10. Vermeulen RC, Scholte HR; Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome . Psychosom Med. (2004)
  11. Parnetti L, et al; Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type . Eur J Clin Pharmacol. (1992)
  12. Soczynska JK, et al; Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders . Expert Opin Investig Drugs. (2008)
  13. Bloomer RJ, Tschume LC, Smith WA; Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects . Int J Vitam Nutr Res. (2009)
  14. Sachan DS, Hongu N; Increases in VO2max and metabolic markers of fat oxidation by caffeine, carnitine, and choline supplementation in rats . J Nutr Biochem. (2000)
  15. Deijen JB, Orlebeke JF; Effect of tyrosine on cognitive function and blood pressure under stress . Brain Res Bull. (1994)
  16. Dollins AB, et al; L-tyrosine ameliorates some effects of lower body negative pressure stress . Physiol Behav. (1995)
  17. Lu Y, Christian K, Lu B; BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory . Neurobiol Learn Mem. (2008)
  18. Kalman, D; A clinical evaluation to determine the safety, pharmacokinetics and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males.; Nutrition & Endocrinology Miami Research Associates; 2014
  19. http://www.ncbi.nlm.nih.gov/pubmed/22951317
  20. http://www.scirp.org/journal/PaperInformation.aspx?paperID=19921
  21. Cauli, O;Subchronic caffeine exposure induces sensitization to caffeine and cross-sensitization to amphetamine ipsilateral turning behavior independent from dopamine release.; Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari; 2008
  22. Li WX, et al.; “Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice.“; J Agric Food Chem.; 2013
  23. Feduccia A, et al.; “Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors.”; Pharmacol Biochem Behav; 2012
  24. Giesbrecht, Timo, et al; “The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness”; Nutritional Neuroscience; 2010
  25. Kimura K, et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. (2007)
  26. Owen GN, et al. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci. (2008)
  27. Frank M, et al; Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse; Equine Vet J. (1990)
  28. Barwell C.; School of Pharmacy; “Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat;” 1989
  29. Nedergaard O.; British Journal of Pharmacology; “Action of various sympathomimetic amines on the isolated stripped vas deferens of the guinea-pig;” November 1968
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  35. http://www.ncbi.nlm.nih.gov/pubmed/21434835
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