Glaxon Serenity Stress Support: Less Stress, More Gains!

The Glaxon Goons are back on the blog, but this time were not talking about greens powders, high-stim pre workouts, fat burners, or magical fungi. Over the past few weeks, Joey Savage, Glaxon’s Mad Scientist, has been researching, testing, and formulating a product that nearly everyone can benefit from.

Glaxon Serenity Feels Good

Why take Serenity? Because it makes you feel good.

Serenity Stress Support has landed on planet Earth, and it’s here to make sure you stay calm, peaceful, and stress-free no matter how much chaos is happening around you.

Nobody likes to be stressed out, but stress is a normal part of life, and it’s important to find healthy ways of dealing with it. Stress is a very broad topic, taking on a multitude of forms, such as psychological, physical, social, and environmental. Everyone has a certain level of stress they can handle on a given day, and once that limit is exceeded, it can start to wreak havoc on their life.

If you’re chronically stressed out for weeks on end, then you may feel unmotivated, depressed, fatigued, anxious, or angry. Furthermore, if you remain in a high state of stress for long enough, not only does it impact your mental health, but your physical health will also decline. And we can’t talk about stress without mentioning cortisol…

Stress, Cortisol, And Health Oh My…

Cortisol is the body’s primary “stress hormone”. It’s classified as a glucocorticoid steroid, and gets secreted from the adrenal glands. Cortisol takes on several roles within the body, such as regulating stress response, blood pressure, inflammatory response, and blood sugar levels. Cortisol is a key component of the sympathetic nervous system, also referred to as your “flight or fight response”.

Glaxon Serenity Supplement Lab

Joey Savage dives deep on Serenity’s formula on the Supplement Lab’s YouTube channel!

Therefore, having acutely high levels of cortisol is a good thing if you quickly need to escape from danger. However, when it’s chronically elevated, things start to go downhill. Cortisol can make it extremely difficult to build muscle, lose fat, and alter your mood and judgement.

There are several activities you can do to reduce stress and cortisol levels, but when that’s not enough, supplements may come in very handy. It’s well-established that there are specific natural herbs and compounds that can significantly help you adapt to both physical and mental stressors. Fortunately, you don’t need to go digging through the research to find out what’s the optimal ingredients, dosages, and combination of herbs that result in the best effects. Glaxon did that for you and it goes by the name of Serenity.

Get ready, because we’re about to dive deep into the science behind Serenity’s stress reducing formula. But before all of that, make sure to sign up for Glaxon news and deal alerts, because they’re always up to something interesting in the Supplement Lab!

Glaxon Serenity - Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

Serenity Stress Support: A background

Serenity Stress Support is another capsule-based product from Glaxon, and they recommend taking three capsules as needed — and for optimal results, without food.

  • First, meet the DR Caps

    It’s important to note that Serenity uses a specific type of capsule called DR Caps, which help prevent ingredients from being broken down in the digestive system. Therefore, it enhances the potency of the ingredients, however it also prolongs the time it takes for you to start feeling the effects. So don’t be surprised if it takes at least an hour for it to fully kick-in, that’s just how the DR Caps work their magic.

  • Serenity Is Your Secret Weapon

    Serenity features a unique combination of four ingredients that synergistically work together to lower cortisol levels and as a result, decrease stress. It also was formulated to improve mood and overall sense of well-being.

    Glaxon Serenity Infographic

    The combination of four potent ingredients and DR Caps, makes for maximum benefits!

    You may be wondering what’s the best way to use this product? It’s really not designed to be taken every single day, but just during those times you’re feeling pretty overwhelmed. Glaxon suggests keeping Serenity around as your secret weapon!

    Since it can help reduce levels of both mental and physical stress, you can also use it during periods of intense training, such as competition prep. Or maybe, work has just picked up and your stress levels are on the rise, then Serenity is here to save the day.

    As we mentioned in the intro, the goal is not to completely eliminate cortisol, it’s necessary for overall health. But… you do want to manage it and make sure it doesn’t run rampant. Serenity is here to keep your stress levels in check and it always will be.

Serenity’s Mechanism of Action: An Overview

In order to fully understand how Serenity expresses its positive effects, we need to cover how cortisol is produced in the first place.

Whenever your brain senses stress, regardless of where it comes from (physical, emotional, or mental), it sends a signal to a specific region in the brain called the hypothalamus. Once the hypothalamus gets the message, it will start secreting corticotropin releasing hormone (CRH), which gets relayed to the anterior pituitary.

Glaxon Serenity

Serenity delivers less stress and more gains.

As a result, the anterior pituitary will produce a hormone called adrenocorticotropic hormone (ATCH) and that ends up traveling to the adrenal cortex. Finally, the adrenal cortex will start pumping out the cortisol.

Furthermore, in response to stress, the adrenal glands will also secrete a pregnane steroid hormone called cortisone, which is classified as an active metabolite of cortisol. Since cortisone is a precursor to cortisol, it can further increase levels of cortisol.

In response to the increased levels of cortisol, you may experience increased heart rate, blood pressure, rapid breathing, and sweating. Cortisol plays a huge role in your fight or flight response, meaning it’s preparing the body to defend itself from some sort of stressor or danger.

On a physiological level, cortisol increases blood sugar by breaking down glycogen, decreases amino acid uptake in the muscles, slows down digestion, suppresses the immune system, reduces serotonin production, increases lipolysis, and even prevents bone formation.

The Triple Threat To Reducing Cortisol…

Glaxon formulated Serenity based on cortisol’s physiological pathway and specifically selected four ingredients that would reduce cortisol production by inhibiting three separate mechanisms:

  • ACTH
  • 11-beta hydroxysteroid dehydrogenase, and
  • steroid 11β-hydroxylase.

You could say that Glaxon is attacking cortisol from every angle to give you less stress and more gains. So, without further ado, let’s see what each ingredient is capable of!

Glaxon Serenity Ingredients

  • Sunflower Phospholipids with 65% Phosphatidylserine – 616mg

    The first ingredient to kick off this distinct cortisol reducing formula is sunflower phospholipids, standardized to contain at least 65% of their bioactive compound, phosphatidylserine (PS).

    Glaxon Serenity Ingredients

    The main star of this formula has to be Shoden!

    PS is a naturally occurring phospholipid that’s considered to be an essential nutrient for optimal cell functioning.[1] It’s found in high concentrations within the brain, liver, heart, and skeletal muscle. Studies show that PS takes on several key roles in the body such as regulating calcium ion uptake and substrate binding, increasing the structural integrity of cells, and helps transmit signals between cells and neurons.[1] It can also activate specific enzymes including acetylcholinesterase and ATPase.[1]

    After discovering these unique properties, researches started to further examine the effects of PS supplementation, and they found that it led to improved mood, cognitive function, memory, and reduced serum cortisol levels.[1,2] One study in particular, found that PS supplementation led to a significant reduction in time to exhaustion in trained cyclists, suggesting that it may be an effective ergogenic aid.[1]

    Another study gave participants 600mg of PS for 10 days, and put them through a graded exercise test on an ergometer.[2] Their main outcome measures were plasma levels of cortisol, testosterone, growth hormone, and lactate. The results showed that just after 10 days, the PS group had increased testosterone and decreased cortisol levels compared to the placebo.[2] However, PS had no effect on lactate or growth hormone.[2]

    Although more research is needed to fully understand how PS works to lower stress levels and increase exercise performance, the current hypothesis is that it inhibits the secretion of ACTH.[1,2] As we outlined in the previous section, ACTH is one of the primary hormones involved in the cortisol synthesis pathway.

  • Ashwagandha (Withania somnifera) Extract [Std. for 35% Withanolides as Shoden®] Roots & Leaves – 120mg

    If you’re a regular reader on the PricePlow blog, then you know we’re a big fan of adaptogens, specifically, ashwagandha.

    This medicinal herb has been used for thousands of years in various parts of the world to treat multiple medical conditions. Although it’s benefits are widely known, ashwagandha has been growing tremendously in popularity throughout the sports supplement industry. More research is showing that it’s one of the most effective natural ingredients for helping manage both physical and mental stress.[3-6]

    Shoden LogoWe’ve covered various trademarked forms of ashwagandha on the blog. However, the Glaxon Goons hit us in our blind spot by including Shoden®, a specific type of ashwagandha that contains the highest standardized extract of withanolides on the market, clocking in at 35%.[3]

    PricePlow has never seen this trademarked ingredient included in any other supplement, and it may be one of the large contributors to why Serenity makes you feel so good. If you compare that to the most popular trademarked form of ashwagandha, KSM-66®, it only contains 5% (or sometimes 2.5%) of withanolides, so you can clearly see it doesn’t even come close for a targeted strike.

    By why are withanolides important in the first place…

    Ashwagandha contains over 50 different chemical compounds, including lactones and alkaloids, collectively known as withanolides.[3] These bioactive constituents are what help carry out ashwagandha’s positive effects. Depending on the extract and what part of the plant is used, the withanolide concentration can vary drastically, which is why it’s important to look for trademarked forms that list the standardized extract, such as Shoden®.

    Glaxon Serenity Graphic One

    Serenity will make you feel like your skipping through a field full of flowers… Seriously, just try it.

    Beyond helping you adapt to stress, ashwagandha also expresses antioxidant, anti-inflammatory, anti-cancer, anxiolytic, antidepressant, and immunomodulatory properties.[3-6] Several studies have concluded that oral supplementation of ashwagandha is effective at reducing anxiety, stress, cortisol levels, and improving mood.[3-6]

    A study was conducted in 2019 to determine the effects of ashwagandha (as Shoden®) supplementation on stress, anxiety, and hormone production in healthy adults.[3] The participants were randomly assigned to two groups, one received 240mg of Shoden per day and the other was given a placebo.

    After 60 days, the results showed that the Shoden® group had a significant decrease in levels of cortisol, DHEA-S (dehydroepiandrosterone sulfate), which led to better mood, along with reduced stress and anxiety.[3]

    Needless to say, ashwagandha is quite the powerful herb, so it’s not surprising that it’s starting to dominate the sports and health supplement industry. And we expect Shoden® to start showing up in more products in the future.

  • Magnolia (Magnolia officinalis) Extract [Std. to 90% Magnolol/Honokiol] Bark – 120mg

    While phosphatidylserine is lowering cortisol by inhibiting ATCH, and Shoden® is working its magic to help you adapt to stress, Glaxon also included magnolia and quercetin to synergistically block an enzyme known as 11-beta hydroxysteroid dehydrogenase (11β-HSD). This enzyme is responsible for converting cortisone into cortisol, thus by inhibiting it, there will be a decrease in serum cortisol levels.

    Glaxon Samples

    Glaxon now offers samples so you can see what all the hype is about!

    Although both ingredients have similar effects, we’re going to discuss each one separately and first up is magnolia!

    Magnolia bark extract, also known as magnolia officinalis, is derived from the thoupo magnolia tree, which is native to China, East and Southeast Asia.[7] It’s been widely used in Traditional Chinese Medicine to treat anxiety, depression, gastrointestinal distress, allergies, muscular pain, headaches, and fever.[7]

    Magnolia bark expressess anti-inflammatory, antioxidant, antibiotic, anticancer, antimicrobial, neuroprotective effects due to its high concentration of two neolignans: magnolol and honokiol.[7] And as you can see from the label, Glaxon included the exact standardization (90%), so you know that you’re getting a potent extract for maximum benefits!

    Research shows that magnolia bark extract is effective at reducing cortisol levels, stress, anxiety, depression, improving mood and overall sense of well-being.[7-10] Its main mechanism of action is through the inhibition of 11β-HSD,[7-10] which prevents the enzyme from being able to convert various substrates into cortisol. It’s great to see that Glaxon included ingredients that reduce cortisol in different ways, which seems to amplify the effects.

  • Quercetin – 50mg

    The last ingredient to round out this epic formula is 50mg of quercetin!

    Glaxon Serenity Graphic Three

    Serenity is a must-try.

    Quercetin is classified as a flavonol that’s naturally derived from various plants, such as onions, apples, tomatoes, cherries, and berries.[11] Research shows that it can boost immunity, decrease inflammation, and reduce allergy symptoms.[11] Furthermore, quercetin is a potent antioxidant, therefore it’s able to protect your cells from oxidative stress.[11]

    Similarly to magnolia, quercetin is also capable of blocking 11β-HSD, and as we discussed, leads to a decrease in cortisol production.[12] However, it can also further reduce cortisol levels through the inhibition of steroid 11β-hydroxylase, an enzyme that synthesizes cortisol by using 11-deoxycorticosterone as a substrate.[12] Preliminary research shows that oral supplementation of quercetin can result in decreased stress, anxiety, depression, and improve memory.[12]

    In addition to decreasing cortisol, studies show that quercetin is capable of blocking histamine release, reducing pro-inflammatory cytokines, leukotrienes synthesis, and suppressing interleukin IL-4 production.[13] Due to these properties, quercetin may be effective for treating a variety of respiratory conditions, including allergic rhinitis, asthma, and allergic reactions.[13]

    Although it’s indirectly correlated, breathing easier can definitely help lower levels of stress.

Watch Joey Savage explain all the science behind Serenity’s formula!

Subscribe to PricePlow on YouTube!

Serenity now! This is no run-of-the-mill stress relief supplement, to say the least!

Glaxon is carving their own path in the supplement space

Glaxon burst onto the supplement scene at the tail end of 2019, and when we were first introduced to this newcomer, we didn’t know exactly what to expect. What do you get when you combine a creative graphic designer, clean-cut CEO, gym bro, and an uber-nerdy scientist who are all unafraid to leave no stones unturned?

Glaxon Astronaut Stairs

What other supplement company can pull off an astronaut outfit?

Well… you get a company that’s not afraid to take risks, carve their own path, stand out, create epic products, and of course, have some fun along the way. Glaxon is the breath of fresh air the supplement industry needed, because at times, it can seem stale, monotonous, and somewhat boring. Especially when brands are just in it for the money and copy other companies formulas, then slap their label on it.

We told you that Glaxon would be the brand to watch for 2020 and they’re fulfilling that with every new product launch. Although they have products in several traditional categories, such as amino acids, fat burners, pre workouts, and sleep aids, don’t expect them to be your typical sports supplement company. Glaxon’s goal is to branch out as much as possible to bring a new audience to the industry, and that’s exactly what they’re doing moving forward.

And we think Serenity is a great start because everyone deals with stress whether it’s physical, mental, environmental, or emotional. Therefore, a large number of people outside of the fitness industry can greatly benefit from this product. We can’t wait to see what the Goons have in store for the future, and if you’re ready for more innovative formulas, wacky cartoons, educational videos, and astronaut photo-bombs, then make sure to subscribe down below!

Glaxon Serenity - Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Heather Jacques

Heather Jacques

Heather Jacques, AT, ATC, has a Bachelors of Science in Exercise Science with an emphasis in Athletic Training. She is a researcher, athletic trainer, and fitness enthusiast who is PricePlow’s Digital Content Manager. Heather constantly stays up to date with the latest scientific literature in order to provide the best information for the readers.

Heather’s goal is to educate, empower, and give people the tools to reach their fitness and health related goals. There are far too many myths out there and Heather is here to provide the truth.

1 Comment | Posted in , | Tagged , , , , , , , , , , , , , , , , , .

References

  1. Kingsley, M. et al; “Effects of Phosphatidylserine on Exercise Capacity during Cycling in Active Males”; Medicine & Science in Sports & Exercise; 38(1); 2006; https://journals.lww.com/acsm-msse/Fulltext/2006/01000/Effects_of_Phosphatidylserine_on_Exercise_Capacity.11.aspx
  2. Starks, Michael A et al. “The effects of phosphatidylserine on endocrine response to moderate intensity exercise.”; Journal of the International Society of Sports Nutrition vol. 5 11. 28 Jul. 2008; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503954/
  3. Lopresti, Adrian L et al. “An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study.”; Medicine vol. 98,37 (2019): e17186; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750292/
  4. Chandrasekhar, K et al. “A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.” Indian journal of psychological medicine vol. 34,3 (2012): 255-62; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/
  5. Andrade C, Aswath A, Chaturvedi SK, et al. “A double-blind, placebo-controlled evaluation of the anxiolytic efficacy of an ethanolic extract of withania somnifera”; Indian J Psychiatry 2000;42:295–301; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958355/
  6. Auddy B, Hazra J, Mitra A, et al. A standardized Withania Somnifera extract significantly reduces stress-related parameters in chronically stressed humans: a double-blind, randomized, placebo-controlled study. J Am Nutraceut Assoc 2008;11:50–6; https://www.semanticscholar.org/paper/A-Standardized-Withania-Somnifera-Extract-Reduces-A-Auddy-Hazra/46bdaebfcf4f00730ad217fd6bb88228964e4c2e
  7. Saccrica, A. et al; “Safety and Toxicology of Magnolol and Honokiol.”; Planta Med. 2018 Nov;84(16):1151-1164; https://www.ncbi.nlm.nih.gov/pubmed/29925102
  8. Homma, M. et al; “A Novel 11β‐Hydroxysteroid Dehydrogenase Inhibitor Contained in Saiboku‐To, a Herbal Remedy for Steroid‐dependent Bronchial Asthma”; Journal of Pharmacy and Pharmacology; 46(4); 1994; https://onlinelibrary.wiley.com/doi/abs/10.1111/j.2042-7158.1994.tb03799.x
  9. Talbott, Shawn M et al. “Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects.”; Journal of the International Society of Sports Nutrition vol. 10,1 37. 7 Aug. 2013; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750820/
  10. Woodbury, Anna et al. “Neuro-modulating effects of honokiol: a review.”; Frontiers in neurology vol. 4 130. 11 Sep. 2013; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769637/
  11. Li, Yao et al. “Quercetin, Inflammation and Immunity.”; Nutrients vol. 8,3 167. 15 Mar. 2016; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/
  12. Cheng, L. et al; “Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis”; Toxicology and Applied Pharmacology, 258(3), 343–350; 2012; https://www.sciencedirect.com/science/article/pii/S0041008X11004534
  13. Mlcek J, et al; “Quercetin and Its Anti-Allergic Immune Response”; Molecules. 2016;21(5):623; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273625/

Comments and Discussion (Powered by the PricePlow Forum)