GenoFlex by PEScience – New Joint Support Formula is Here!

PES GenoFlex

GenoFlex is the all new joint support formula from PES. More details to come!

It appears the next “big thing” in the supplement industry is taking a definitive focus on prevention and care. There’s been a rash of new products being released over the previous and coming months specifically geared towards joint support.

Although it’s not a new category, we’re finally starting to see a lot of newer ingredients that go beyond the glucosamine / chondroitin / MSM standard stacks, which still have great efficacy (especially glucosamine and MSM).

GenoFlex from PEScience is the newest product in development looking to compete with the likes of SNS’ Joint Support XT and the upcoming Scivation joint formula that’s due to be released in the coming months.

PES GenoFlex - Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

GenoFlex Ingredients

Just as we foreshadowed, PES has kept a slim profile that contains only three ingredients all transparently dosed. We even guessed one of the ingredients correctly (cissus quadrangularis). back when this was first announced in January 2016. Let’s see what else PES packaged together in Genoflex:

  • Cissus Quadrangularis (2,900mg)

    PES GenoFlex Ingredients

    True to form GenoFlex contains a new, unique ingredient in Passion Fruit that’s been shown to help improve joint flexibility. Will it work?

    Cissus quadrangularis is a perennial plant of the grape family that has a history of use in various Ayurvedic medicines. Cissus is predominantly used to help heal broken bones, injured ligaments, and damaged tendons. But how does it exactly help?

    Several compounds within Cissus Quadrangularis have been shown to improve the mobilization of the blast cells to the injured area.[1] These compounds increase the body’s retention of collagen, calcium, phosphorous and mucopolysaccharides, all of which provide the necessary building blocks to repair the damaged tissues.

    On top of that, Cissus is also a pretty potent anti-inflammatory agent. While some inflammation is beneficial following a workout (as part of the repair process), chronic inflammation leads to aches, pains, and swelling.

    Cissus reduces the release of two types of white blood cells (cytokines and neutrophils) that are released to damaged or injured areas of the body that also contribute to inflammation. and these contribute towards inflammation.[2]

    What ketone standardization?

    Unfortunately, PES won’t disclose what percentage of ketones they’ve standardized for. This leads us to wonder… has it been standardized for anything? Or is it just raw cissus (which still wouldn’t be a bad thing)?

    You can read more on our massive Cissus Quadrangularis post.

  • Passion Fruit Extract (150mg)

    One thing PES has become synonymous with over the years is the inclusion of new, unique ingredients that are emerging trends in the supplement industry. Passion Fruit is the shiny new toy in Genoflex.

    GenoFlex Jessica

    Speaking of flex.. this is PEScience Athlete @jessieschiefer

    This is where you may have to take a bit of a leap of faith, since there’s not much research on the ingredient, and definitely no human en-vivo research. Passion Fruit is rich in piceatannol which has been shown in one study to inhibits melanogenesis and promotes collagen synthesis.[3]

    Now, PES is using the seed extract, but we have to wonder why not use the peel when other research demonstrates peel extracts reduce pain and stiffness and improve physical function.[4] Perhaps it doesn’t matter, so long as we get that piceatannol.

    One issue is that it seems that piceatannol itself has low bioavailability in the body,[5] so this might be a good candidate for future liposomal enhancement (kind of like how we believe the best curcumin for joint pain is curcumin phytosome).

    This is the difference-maker

    Regardless, this ingredient is what separates GenoFlex from the vast majority of other joint products on the market and ultimately determines whether you put your trust in PES to deliver high-quality, and effective formulas.

    We look forward to trying it to see if we feel anything better — hopefully within one bottle’s use.

  • Boswellia Serrata Extract (100mg)

    PES GenoFelx Thank You

    Your joints take quite a beating from lifting day in and day out. Show them some TLC with GenoFlex!

    Boswellia Serrata, also known as Frankincense also has a long history of use in ancient medicines for its healing and medicinal qualities. It’s also found in another top joint formula, SNS Joint Support XT.

    PES has included the patent-pending AprèsFLEX® that specifically targets several markers of comfort including 5-lipoxygenase, 5-lox activating protein (FLAP) and TNF-α.

    AprèsFLEX® has been standardized for AKBA, Acetyl-11-keto- β -Boswellic Acid, which has been studied for its powerful anti-inflammatory actions. Not only is boswellia remarkably effective at improving joint function and stiffness[6,7], but it also inhibits MMP-3 activity, which protects against collagen degradation.[8]

    Finally, boswellia serrata is being studied for treating other diseases such as Crohn’s disease, Ulcerative colitis (UC) and stunting tumor growth.[9,10]


Take 4 capsules daily. For best results, take 2 capsules with each of your two largest meals each day.

Two new sheriffs in town

Prior to GenoFlex, our favorite joint supplement is SNS Joint Support XT. The one ingredient both share are the boswellia (which provides relief nearly immediately) – but things diverge from there.

PES has taken a very strong anti-glucosamine message with GenoFlex. They want something new, and don’t like the fact that glucosamine’s research is nearly all pointed towards osteoporosis, something most of us on this site don’t have.

However, nearly all joint support research is done on osteoporosis, so we don’t fully agree that the ingredient is completely useless for athletes, so long as it’s dosed properly and for long enough (months, not weeks).

Either way, PES has succeeded in bringing a new ingredient to the table, and for that we’re excited to try and compare to see if it acts faster.


Geno Smith Flexing

Geno.. Flex? (Note: Geno is not endorsing this product. This is a joke.)

Whether or not you’re a competitive lifter, weekend warrior, or average gym rat, your joints are going to take a pounding from the daily grind they experience day after day after day. After all, you’re not getting any younger and nobody’s gonna improve or make gains with a flaky shoulder!

With PES consistently introducing new ingredients to the table, we’re excited to see someone step outside the confines of convention and try something interesting. The ultimate question is does it work, and is it worth the money?

So to stay on top of it, make sure to sign up above or below for alerts on the latest developments with all of PES supplements!

PES GenoFlex - Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

No Comments | Posted in , , | Tagged , , , , , , , .


  1. Udupa, KN, and Guru Charan Prasad. “Further Studies On The Effect Of Cissus Quadrangularis In Accelerating Fracture Healing.” The Indian journal of medical research 52 (1964): 26-35.
  2. Jainu, Mallika, and Chennam Srinivasulu Shyamala Devi. “Attenuation of neutrophil infiltration and proinflammatory cytokines by Cissus quadrangularis: a possible prevention against gastric ulcerogenesis.” Journal of herbal pharmacotherapy 5.3 (2005): 33-42.
  6. Sengupta K, et al; Comparative efficacy and tolerability of 5-Loxin and AflapinAgainst osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci. (2010)
  7. Sengupta K, et al; A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Arthritis Res Ther. (2008)

Comments and Discussion (Powered by the PricePlow Forum)