Advanced Bionutritionals Nitro Reds: A Unique Pre-Workout with SuperFoods from MitoReds

Beetroot, tart cherry, pomegranate, maqui, camu camu, acai, grape skin, blood orange, and more. MitoReds® packs 2395mg of red plant polyphenols into Advanced Bionutritionals Nitro Reds, a pre-workout built on plants rather than scoop size.

Last year, we wrote about Advanced Muscle Plus, a strong-yet-simple muscle building formula from Advanced Bionutritionals that combined 2g DL185 Dileucine with 1.5g myHMB.

Well ABN is back, and this time they've taken a very unique route with Advanced Bionutritionals Nitro Reds, their novel pre-workout supplement. Instead of following the familiar citrulline, beta-alanine, and caffeine-heavy pre-workout template, Nitro Reds combines a large red-plant polyphenol blend with a clinically studied nitric oxide ingredient, a nootropic choline source, paraxanthine, and ergothioneine.

The front label calls it a "Pre-Workout With Nootropics", and that's a good description, but it goes further than that. Nitro Reds isn't just trying to create a pump or deliver a stimulant hit. The formula spreads its attention across circulation, cognitive performance, energy, and cellular redox support, with five active ingredients packed into a convenient 7.17g scoop.

Three of those ingredients come from NNB Nutrition, the sponsor of today's article. MitoReds® supplies the 2395mg plant-polyphenol foundation, GeniusPure® supplies Alpha-GPC standardized to 70%, and MitoPrime® adds 5mg of L-ergothioneine. Nitrosigine handles the nitric oxide side of the formula, while 200mg of enfinity® paraxanthine gives Nitro Reds its stimulant/nootropic component without using standard caffeine or its downsides.

If you're looking for a different kind of pre-workout that still has clinical backing, this architecture makes Nitro Reds worth a closer look. We get into it below, but first, check PricePlow for availability and sign up for our ABN price alerts:

Advanced Bionutritionals Nitro Reds Ingredients

Each container provides 30 servings. One scoop is 7.17g and contains:

• MitoReds® Polyphenol Blend - 2395mg

  MitoReds® Polyphenol Blend is the largest active ingredient in Nitro Reds by weight. The proprietary blend pulls from a broad collection of plant foods and botanicals, including red beetroot, carrot, jujube, tomato, pomegranate, hawthorn, goji, maqui, multiple berries, tart cherry, elderberry, acai, grape skin and seed, citrus fruits, apple, pear, watermelon, camu camu, plum, and blood orange.

  So MitoReds is a multi-source plant matrix intended to provide a range of polyphenols, exercise-supporting antioxidants, and other naturally-occurring phytochemicals. That gives Nitro Reds a very different base than the standard amino-acid-heavy pre-workout.

  There's useful human evidence behind several classes and components found in the blend. For example, an eight-week intervention using mixed berries found changes in several vascular and cardiometabolic markers, including platelet function, systolic blood pressure, and HDL cholesterol.^[1]

  Beetroot is also relevant to the exercise side of the story. A systematic review and meta-analysis found that beetroot and nitrate supplementation can support several exercise-performance outcomes, including muscular strength and endurance.^[2] There is a limitation, though: MitoReds doesn't disclose how much beetroot is inside or provide a standardization, so we can't translate the beetroot literature into a known nitrate dose for this product.

  Tart cherry is another component worth calling out here. A 2026 systematic review and meta-analysis pooling nineteen trials found that tart cherry juice supplementation significantly improved recovery of muscular force output at every timepoint measured after exercise-induced muscle damage, with the effect continuing to grow out to 96 hours post-exercise.^[3] As with beetroot, MitoReds doesn't disclose a specific tart cherry amount, so we can't map this research onto an exact dose here. Still, it's a well-studied recovery botanical layered into an already broad polyphenol base.

  With that said, across the entire spectrum of constituents, MitoReds contains strong component- and polyphenol-class research. We therefore view MitoReds as a broad plant-polyphenol and redox-support layer inside Nitro Reds, while keeping the component evidence separate from claims about the complete branded blend.

  

  For a pre-workout, that's an interesting and unique start. It gives the formula a nutritional and cellular-support angle that most products in the category simply don't try to build.

• Nitrosigine® Inositol-Stabilized Arginine Silicate - 1500mg

  Nitrosigine® is inositol-stabilized arginine silicate, and Nitro Reds uses it at 1500mg, which is the clinical dose used repeatedly in published human research.

  For instance, in a randomized, double-blind crossover study of 24 healthy young adults, 1.5g Nitrosigine was tested for acute effects on flow-mediated dilation, a common measure of blood-vessel responsiveness. The study found an acute vasodilation effect after supplementation.^[4]

  Earlier pharmacokinetic and pharmacodynamic work also used 1500mg daily and found changes in plasma arginine and nitric-oxide-related markers during supplementation.^[5]

  That makes Nitrosigine the most straightforward circulation ingredient in Nitro Reds, and a solid counterpart to what's found inside of MitoReds. It also fits Advanced Bionutritionals' recommendation to take the product about 30 minutes before physical activity.

• GeniusPure® Alpha Glycerylphosphorylcholine (Alpha GPC) (Standardized to 70%) - 450mg

  GeniusPure® Alpha GPC is where the nootropic side of Nitro Reds gets especially interesting. The label provides 450mg of GeniusPure standardized to 70% Alpha-GPC. On paper, that yields 315mg of alpha-GPC per scoop.

  That number matters because NNB Nutrition's GeniusPure has been studied directly at the same 315mg alpha-GPC dose!^[6]

  Yields the "Double Your Focus" Dose!

  

  Data shows GeniusPure Alpha-GPC boosts cognitive and exercise performance after just one dose. With 90% yield and unmatched stability, NNB Nutrition is setting a standard for rapid, noticeable results.

  A randomized, double-blind, placebo-controlled crossover trial enrolled 20 resistance-trained men and compared placebo with 315mg and 630mg Alpha-GPC conditions. Both Alpha-GPC doses improved total Stroop score compared with placebo, while the 630mg dose also reduced Stroop completion time. The improvement at the 315mg dose was 108%,^[6] which is where we get NNB's "double your focus" claim. And this was an acute dose -- it worked right on the first time using it!

  The dose alignment is the important part for Nitro Reds: the formula's 450mg of 70% GeniusPure works out to the 315mg Alpha-GPC yield condition tested in that modern human trial.

  Now what's happening here? Alpha-GPC supplies choline that can be used to synthesize acetylcholine, a neurotransmitter involved in attention as well as neuromuscular signaling. That gives the ingredient a logical role in a product designed to sit between a pre-workout and a nootropic.

  There's also an older but frequently cited data point on the acute performance side. In a small crossover trial, seven resistance-trained men who took 600mg of alpha-GPC 90 minutes before a squat and bench-press-throw protocol saw peak growth hormone rise 44-fold from baseline, compared to a 2.6-fold rise on placebo, along with a 14% increase in peak bench press force.^[7] That's a higher acute dose than the 315mg delivered by Nitro Reds and a small sample size, so it's best read as supporting evidence for A-GPC's role in acute neuromuscular and hormonal responses to training, not as a direct prediction of what this specific serving will do.

  So what we have here is direct, dose-matched cognitive evidence at the exact active Alpha-GPC amount delivered by Nitro Reds, with a plausible neuromuscular role alongside it.

  You can read more about it in our articles, "GeniusPure Alpha-GPC: Stable Alpha-GPC 70% and 90% from NNB Nutrition" and the specific study, "NNB Nutrition's GeniusPure Alpha-GPC Acutely Boosts Cognitive Performance in New Clinical Study".

• enfinity® Paraxanthine - 200mg

  

  NNB Nutrition is proud to announce GeniusPure Alpha-GPC, which is patent-pending stabilized alpha-GPC at 70% or 90%!

  enfinity® Paraxanthine provides the stimulant/nootropic component at 200mg. Paraxanthine is a primary metabolite of caffeine and is itself a methylxanthine with stimulant activity, so Nitro Reds contains no standard caffeine but should not be mistaken for a stimulant-free product.

  The reason to include enfinity over standard caffeine is to side-step the two other metabolites from caffeine, theophylline and theobromine, which increase the stimulant's side effects and increase variability. Paraxanthine is the metabolite users want, especially when caffeine is too aggressive.

  Human dose-response research has tested 50mg, 100mg, and 200mg paraxanthine in a randomized, double-blind crossover design. The 100mg and 200mg conditions produced the most consistent cognitive effects across the study's repeated testing, placing Nitro Reds at the top of that tested range.^[8]

  That's enough to explain why enfinity is here: it supplies the acute energy and focus side of the formula while the other ingredients cover circulation, cholinergic support, and redox biology. And it doesn't have the drawbacks of caffeine, which is perfect for a pre-workout that's not trying to run through brick walls.

• MitoPrime® L-ergothioneine - 5mg

  MitoPrime® L-ergothioneine closes out the formula at 5mg, and it might be the most quietly remarkable ingredient on this label. Ergothioneine is a diet-derived, sulfur-containing amino acid that humans get from food rather than make on their own in meaningful amounts, yet the body still built a dedicated transporter for it. That transporter, known as OCTN1 or ETT, pulls ergothioneine into cells and concentrates it in tissues that deal with heavy oxidative stress. We've covered this compound before in our deep dive on Ergothioneine: The Immunity and Energy Protector and our full ingredient profile on MitoPrime from NNB Nutrition, so check those out for the origin story.

  

  Meet MitoPrime: The most 'slept-on' immune system supplement ingredient on the market, based on pure L-Ergothioneine - a master antioxidant molecule that's been shown to outperform glutathione!

  That dedicated transport system is part of why some researchers have floated ergothioneine as a candidate vitamin rather than just another antioxidant. One review put it plainly, noting that given how selectively the body imports and retains it, ergothioneine "may even have the status of a vitamin."^[9] Another research group went further, publishing a paper that directly asked whether ergothioneine should be considered a "longevity vitamin" that's under-supplied in the modern American diet.^[10] No regulatory body has made that reclassification official, but it says a lot about how seriously this "forgotten" compound is now being taken.

  Human pharmacokinetic research confirms that orally consumed ergothioneine is absorbed and changes circulating ergothioneine status, supporting its use as an orally delivered dietary ingredient.^[11] Preclinical research also supports a connection between ergothioneine and mitochondrial redox protection, including animal work examining oxidative processes inside liver mitochondria.^[12]

  There's also direct human trial data worth highlighting. A 12-week, randomized, double-blind, placebo-controlled trial gave 80 healthy women a mushroom extract supplying 25mg of ergothioneine per day and found measurably higher skin moisture along with better wrinkle and texture scores compared to placebo.^[13] That's a five-times-higher daily dose than the 5mg in Nitro Reds and a completely different endpoint than pre-workout performance, but it's real human RCT evidence that daily ergothioneine intake can move measurable biomarkers, not just cell-culture or rodent data.

  Put together, that's a candidate-vitamin compound with confirmed human absorption, mitochondrial-protection data in animals, and a positive human RCT at a higher but relevant dose. That's not the same as showing that 5mg MitoPrime acutely increases human exercise performance, but we won't pretend otherwise.

  So it isn't the ingredient that should be expected to provide the immediate pre-workout "boost". Instead, it adds a cellular redox-support component to a product Advanced Bionutritionals also positions for daily use.

  

  Advanced Muscle Plus from Advanced Bionutritionals features 2g of research-backed dileucine (DL185™) and 1.5g myHMB® to combat age-related muscle loss. Studies show dileucine outperforms standard leucine by 60% for muscle protein synthesis, with proven strength gains in trained individuals over 40.

  And that makes MitoPrime a good complement to the formula's architecture. Nitrosigine, GeniusPure, and enfinity handle the more immediate pre-workout functions, while MitoPrime gives Nitro Reds a longer-horizon cellular-support angle.

How to Use Nitro Reds - Pre-Workout!

Advanced Bionutritionals instructs users to mix one scoop with 8 to 12oz of water daily. When using Nitro Reds as an exercise aid, the label recommends taking it about 30 minutes before physical activity.

Remember, one serving contains 200mg paraxanthine, and the label specifically says not to combine Nitro Reds with other stimulant sources, including caffeine. Users who are sensitive to stimulants should account for paraxanthine even though "caffeine" does not appear in the active ingredient panel.

The cool news is that we've found that paraxanthine can be taken ever so slightly closer to bedtime -- we can generally take it about an hour after our standard "caffeine cutoff" without problems. This is due to enfinity's lower half-life and lack of theobromine/theophylline that really jack up the half-life of caffeine.

The label also directs adults who are under medical care, taking medication, pregnant, nursing, or managing a medical condition to consult a healthcare professional before use.

Who Is Nitro Reds For?

Nitro Reds makes the most sense for someone who wants a hybrid pre-workout/nootropic that leans on a more natural fruit blend rather than a traditional high-scoop sports formula.

There's no citrulline, beta-alanine, or standard caffeine on the Supplement Facts panel. No beta-alanine tingles or niacin flush. Instead, the formula puts 1.5g Nitrosigine behind circulation, a "double your focus" dose-matched GeniusPure Alpha-GPC amount behind cognition, 200mg paraxanthine behind stimulation, and then uses MitoReds plus MitoPrime to add plant-polyphenol and ergothioneine support.

While we don't have exact standardizations in MitoReds, the ingredient architecture is easy to understand: acute circulation and cognition on one side, broader redox and cellular support on the other.

Nitro Reds Takes a Different Route

Advanced Bionutritionals Nitro Reds is a compact formula, but it doesn't look like most compact pre-workouts. Its five actives cover very different jobs rather than stacking multiple versions of the same pump or stimulant pathway.

The strongest dose-to-research matches are easy to spot. Nitrosigine is present at the familiar 1500mg research dose, while 450mg of 70% GeniusPure supplies 315mg Alpha-GPC, matching the lower dose in its recent human cognitive trial. enfinity adds 200mg paraxanthine for the noticeable stimulant/nootropic side of the product.

NNB Nutrition's MitoReds and MitoPrime then give Nitro Reds its more unusual identity. MitoReds brings a large, diverse plant-polyphenol base, while MitoPrime supplies ergothioneine for a longer-horizon cellular redox angle that is vastly underrated. Neither needs to be turned into an exaggerated acute performance claim to make sense in the formula -- we have GeniusPure and enfinity for that.

If Advanced Bionutritionals' mix of pre-workout and nootropic support sounds like your kind of product, check PricePlow for Nitro Reds availability and pricing, and sign up for updates as more coverage comes in.