On May 9, 2024, NNB Nutrition announced that they have become the sole distributor of the new cutting edge RAMPS™ dileucine peptide supplement ingredient.[1] This is a patent-pending leucine dipeptide molecule that can outperform its branched-chain amino acid precursor, leucine, in stimulating muscle protein synthesis (MPS).
NNB is proud to announce that the initial exclusivity period for dileucine is over, and open distribution of the ingredient has begun.
NNB Nutrition has announced open distribution of RAMPS Dileucine, after an exclusive period with MuscleTech in their Peptide 185 supplement.
What is Dileucine?
Most readers are familiar with leucine, the branched-chain amino acid (BCAA) that’s a key regulator of the mTOR pathway, which is critical for activating muscle protein synthesis in an effort to build skeletal muscle.[2-5]
Dileucine is a peptide bond of two leucine molecules,[6] and research shows that various peptide metabolites are responsible for a great deal of the anabolic effects of BCAAs.[6] More peptides in circulation generally means more efficient muscle production.
RAMPS promotes the following benefits, with research shown below in the next section:
- 60% greater muscle protein synthesis activation versus leucine
- 90% more leucine in the muscle within 30 minutes of consumption
- Increased muscle protein synthesis without exercise* *(we don’t recommend avoiding exercise, but note for injuries and rest days)
Leucine vs. Dileucine in research
In a double-blind, randomized, crossover study published in 2021, researchers tested healthy young men, giving them 2 grams of leucine or 2 grams of dileucine peptide (the morning after they had all received identical dinners and had been abstaining from exercise), then measured numerous markers.[7]
As expected, the researchers saw that dileucine supplementation raised dileucine blood levels more leucine. But what was more interesting was that they also saw a significantly greater fractional synthesis rate (FSR) in the dileucine group, whereas there was no significant difference in muscle breakdown.[7]
The big story with dileucine is how it can increase fractional synthesis rate (FSR) significantly more than an equivalent amount of standard leucine.[7]
This means that dileucine’s net anabolic effect was greater than leucine’s. Dileucine actually increased MPS by about 160% compared to baseline, and about 60% more than leucine![7]
ISSN 2023 Presentation: 2g Dileucine vs. Leucine in Resistance-Trained Males
Effects of 10-weeks of Dileucine supplementation on athletic performance[8]
Another study was presented at the 2023 ISSN (International Society of Sports Nutrition) conference, where 32 resistance-trained males (average age 28) were recruited and given either 2 grams of dileucine, 2 grams of leucine, or placebo (2 grams of resistant starch) for 10 weeks.[8,9]
They trained 4 times per week, hitting every major muscle group with 3-4 sets at 6-10 reps.[9,10] The researchers found that dileucine improved maximum lower body strength and number of reps until failure more than leucine or placebo.[8]
University of Toronto: 2g Dileucine + 1g Leucine vs. 6g 2:1:1 BCAA vs. Collagen
A third randomized, double-blind, crossover study, which has been presented in Toronto but not yet published, used isotope tracking to show that dileucine increased leucine retention far greater than BCAA or collagen.[10] It also significantly reduced muscle breakdown in response to a whole-body resistance training regimen, whereas BCAA did not.[10]
In this poster presentation, dileucine significantly reduced muscle breakdown in response to whole-body resistance training, while BCAA did not.[10]
PricePlow will be first to provide coverage when these poster presentations are published in peer-reviewed journals — these are just a hint of what’s to come.
The History of RAMPS Dileucine Peptide
We first heard about dileucine on Episode #078 with Ralf Jaeger on the PricePlow Podcast, who mentioned some upcoming excitement about the ingredient at the 34:50 mark in the episode. Dr. Jaeger is with Ingenious Ingredients (ING2), who developed and patented the ingredient.
The body is “lazy”… but not when it comes to making dileucine
What struck our attention in that podcast is when he mentioned that the body is generally “lazy” with its energy, and never goes out of its way to do something unless there’s a very good biological reason. Yet it does go out of its way to form dileucine from leucine, which leads us to strongly believe that there is something incredibly important to the molecule.
MuscleTech Peptide 185 on the PricePlow Podcast
Raza Bashir of MuscleTech and Shawn Wells of Ingenious Ingredients join the PricePlow Podcast for Episode #123 to discuss the new dileucine ingredient in Peptide 185!
MuscleTech was then given an exclusive first-to-market opportunity with the ingredient, producing their Peptide 185 supplement with incredible fan-fare and repeated sell-outs. Peptide 185 is labeled as DL-185™ dileucine (L-leucyl-L-leucine monohydrate), which is branding that they plan to maintain.
One of the best discussions on Peptide 185 and RAMPS dileucine is again on the PricePlow Podcast, this time in Episode #123 with MuscleTech’s Raza Bashir and NNB’s Shawn Wells, who give an incredible breakdown of the ingredient, its mechanisms, and the excitement surrounding it.
Iovate/MuscleTech confirmed that Peptide 185 will remain on the market, but with NNB’s announcement, Iovate’s exclusive period is over, and NNB now has open distribution.
You can read NNB Nutrition’s official press release for more information.[1] We have a few great formulation ideas for RAMPS, so contact us if you’d like to consult in forming some novel uses.
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