RAW Nutrition Essential Fat Burner: Boost Your Metabolism!

RAW Nutrition Essential Fat Burner

RAW Nutrition, renowned for its unwavering intensity, reflects of the fervor that four-time Mr. Olympia champion Chris Bumstead brings to every competition.

Indeed, RAW is his brainchild, and it’s only natural that the supplement manifests his passion. In the last couple of years, RAW has undergone a remarkable transformation, bidding farewell to its rough-hewn paper bag packaging in favor of a sleek, modern approach. With this change, what’s on the outside of its products now matches the elegant, sophisticated formulas on the inside.

Now RAW is giving us Essential Burner, a deceptively simple formula that, as we’ll see, has a clever two-part strategy at its core:

  1. Convert white adipose tissue (WAT) to brown adipose tissue (BAT)
  2. Activate existing BAT

Now, this is a strategy that’s increasingly common in the fat burner category. What sets Essential Burner apart from most of its competitors is how focused RAW’s ingredient selection is. Every single ingredient in this formula (except BioPerine, the formula’s bioavailability enhancer) does at least one of these two things.

Let’s get into how it works, but first, take a look at the PricePlow deals:

RAW Nutrition CBUM Essential Burner – Deals and Price Drop Alerts

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Ingredients

In a single 2-capsule serving of Raw Nutrition’s Essential Burner, you get the following:

RAW Nutrition Essential Fat Burner Ingredients

  • Green Tea Leaf Extract – 250 mg

    Every new study that comes out on green tea is just one more confirmation that this plant, and the brewed beverage made from its leaves, is practically a silver bullet for improving human health. Using extracts of the tea plant is a good way to bring its benefits to supplement formulas.

    Taking green tea extract has been shown to:

    • Accelerate fat burning and fat loss[1]
    • Improve circulation[2]
    • Increase insulin sensitivity[3,4]
    • Decrease blood pressure[5]
    • Enhance sense of overall well-being[5]

    Tea also seems to be great for liver health – the catechin antioxidants that occur naturally in tea can significantly decrease the amount of inflammation and liver adipose tissue in human subjects.[6]

    Finally, green tea extract activates genes related to fat browning – the conversion of metabolically inactive white adipose tissue (WAT) to metabolically active brown adipose tissue (BAT).[7] Unlike WAT, BAT is packed with mitochondria, which burn calories as heat in a process called thermogenesis.

  • Guarana Seed Extract (22% Caffeine)(Delivering 50 mg caffeine) – 239 mg

    Guarana seed naturally contains a lot of caffeine – up to four times the amount as coffee beans, gram-for-gram.[8] However, thanks to the presence of other bioactive constituents like tannins, caffeine from guarana is absorbed more slowly than caffeine from other sources, so you can think of this ingredient as a kind of natural time-release caffeine. The idea behind combining time-released caffeine with caffeine anhydrous, which we’ll discuss in the next section, is to give you the best of both worlds from caffeine use – a rapid energy hit from the anhydrous, stabilized by the more slowly absorbed caffeine from guarana.

    However, the stimulant effects of guarana appear to go beyond its caffeine content, as demonstrated in one study where guarana extract improved subjects’ reaction time more than an equivalent dose of caffeine.[9] Nobody knows exactly why this is the case, but nevertheless, this unexplained stimulant action of guarana has made it a popular ingredient in energy drinks for over a decade.

    Guarana also activates brown adipose tissue (BAT), meaning it switches on thermogenesis.[10]

  • Caffeine Anhydrous – 150 mg

    RAW Nutrition Essential Fat Burner

    Caffeine is a stimulant methylxanthine alkaloid capable of crossing the blood-brain barrier.[11] This gives it the ability to influence cells in the central nervous system.

    As most of us have personally experienced, caffeine can significantly improve mood, enhance focus, support athletic performance, and make the user feel more energetic.[12] Part of caffeine’s energizing effect is its ability to antagonize the action of adenosine, a byproduct of ATP hydrolysis that accumulates while we’re awake and makes us feel fatigue as it builds up in the brain.[13,14]

    But caffeine also increases cellular metabolism, giving us energy in a more literal sense. It does this by inhibiting an enzyme called phosphodiesterase, which is responsible for degrading a messenger molecule called cyclic adenosine monophosphate (cAMP).[12-16] The role of cAMP is telling cells to produce energy by burning calories. So caffeine’s inhibition of phosphodiesterase, by raising cAMP levels, ultimately increases the rate at which your body burns calories.

    Fat burner

    Since fatty acids are one of the substrates your cells burn for energy, caffeine’s upregulation of cAMP makes it a great fat-burning ingredient.[17] One study found that caffeine can increase the body’s rate of fat burning by an impressive 50%,[18] and a 2020 meta-analysis of 19 studies concluded that caffeine has this effect at doses as low as 3 milligrams per kilogram of bodyweight.[19]

    Ergogenic aid

    Caffeine can also help you burn fat indirectly, by enhancing your athletic performance and enabling you to burn more calories in your workout sessions. It’s been shown to increase strength, speed, power, and endurance,[12,13,15,17,18] making it one of the most inexpensive, safest, and effective ergogenic aids in the nutritional supplement category.

    Cognitive benefits

    Caffeine can also improve attentiveness, alertness, reaction time, and working memory.[20-22]

  • Theobromine – 100 mg

    Theobromine Half Life

    Taken from a patent application, this is actually about its antitussive effect, but shows that theobromine certainly lasts a while.

    Theobromine is, like caffeine, a stimulant methylxanthine alkaloid. While it does occur naturally in coffee and tea, chocolate is the primary natural source of theobromine.[23]

    Just like caffeine, theobromine inhibits the action of phosphodiesterase, the enzyme that breaks down cAMP.[24] Thus, theobromine can also, like caffeine (refer to the previous section), speed up cellular metabolism.

    It also antagonizes adenosine,[25] helping you fight fatigue and stay awake and alert.

    Where theobromine differs from caffeine is in its greater thermogenic activity.[26] Theobromine significantly upregulates peroxisome proliferator-activated receptor-γ coactivator (PGC-1α),[27] which triggers fat browning, the proliferation of new mitochondria in white adipose tissue (WAT) which converts WAT to brown adipose tissue (BAT).

    The end result of WAT-to-BAT conversion is increased caloric expenditure via thermogenesis,[26] the process by which your body converts calories into heat.

  • Gamma-Butyrobetaine HCl – 50 mg

    Gamma-Butyrobetaine is a precursor to carnitine. By increasing your body’s supply of carnitine, GBB supplementation can speed up the rate at which it burns fat, by actually shuttling fatty acids into your cells where they can be taken up by mitochondria and burned for energy.[28,29]

    GBB does this by upregulating brown adipose tissue (BAT), the metabolically active fat tissue we discussed in the previous section. More BAT means more thermogenesis, and ultimately, more calories burned as heat. Carnitine has actually been shown to significantly increase the core temperature of lab animals who take it.[30]

  • CaloriBurn GP Grains of Paradise Seed Extract – 30 mg

    WAT to BAT: Using NNB Nutrition's MitoBurn and CaloriBurn to Boost Thermogenic Brown Adipose Tissue

    WAT to BAT: How to Boost Thermogenic Brown Adipose Tissue with Diet, Exercise, and Supplements like NNB Nutrition’s MitoBurn and CaloriBurn GP (and others)

    CaloriBurn GP, a product from NNB Nutrition, possesses a remarkable ability to increase the activity of brown adipose tissue (BAT).[31] This potent extract originates from Aframomum melegueta, also known as grains of paradise, and is meticulously standardized to contain a certain amount of a phenolic ketone known as 6-paradol.

    Animal studies have revealed that direct injections of pure 6-paradol effectively trigger thermogenesis within existing brown adipose tissue (BAT).[31] This heightened thermogenic activity in BAT translates into an accelerated metabolism and increased calorie expenditure, ultimately facilitating easier fat loss and potentially expediting weight reduction.[32-34]

    This increased activity of BAT also confers metabolic advantages beyond weight management. Brown adipocytes take up glucose and fatty acids from the bloodstream for energy utilization, so increasing the activity of brown adipocytes leads to improved glycemic control and reduced blood triglyceride levels.[35]

    Human studies on grains of paradise have yielded some impressive results:

    In a study involving women, grains of paradise proved effective for reducing visceral fat, a type of body fat notorious for its adverse effects on cardiometabolic health.[36] Notably, the dosage administered in this study was a mere 30 mg/day, equivalent to the dose used in Essential Burner.

    CaloriBurn

    Another study, conducted in healthy young men, gave a single 40-milligram dose of grains of paradise (GP) and observed a substantial increase in basal metabolic rate of roughly 400 additional calories burned per day within just 30 minutes of ingestion. This study is all the more remarkable for the fact that it was conducted in a population known for its generally robust metabolic function.[37]

    It is important to note that in reference to the second study, the claim is not that participants burned an additional 400 calories in that particular day – rather, the rate of calorie expenditure was elevated by 400 calories per day within the initial 30 minutes post-ingestion. An analysis of the area under the curve (AUC) revealed that they burned roughly 25 extra calories per hour during the two-hour study period.[37]

  • Capsimax Cayenne (Capsicum annuum) Fruit Extract – 25 mg

    Capsimax from OmniActive Health Technologies is an extremely concentrated red hot chili pepper extract.[38] It was developed to help give you the benefits of capsaicin, without the unwanted gastrointestinal upset that often accompanies capsaicin supplementation.

    Capsimax does this by giving you lots of capsaicinoids that increase your core temperature and speed up metabolism, but without causing the burning sensation in your mouth or stomach that capsaicin itself often can. Capsaicinoids can increase the amount of fat your body burns while you’re in a caloric deficit.[39]

  • BioPerine (Black Pepper Fruit Extract) – 5 mg

    Bioperine

    BioPerine is a black pepper extract standardized for piperine,[40-43] an alkaloid that can inhibit certain enzymes in your stomach. Since those enzymes ordinarily break down nutrients before they can reach your intestines, piperine’s inhibition of them means they can be absorbed into your bloodstream rather than being digested prematurely.[44]

    Raw CBum Essential Pre-Workout

    RAW Nutrition’s Essential Pre-Workout is a great partner for the new Essential Fat Burner.

    This means that thanks to BioPerine, every other ingredient in Essential Burner is more bioavailable and hence more effective than it normally would be. That gives you, the consumer, maximum value for your dollar. Piperine is also a powerful antioxidant[45] capable of making your cells more insulin sensitive and warding off fatty liver.[46,47]

Conclusion

Essential Burner is a thermogenesis-focused formula. Every ingredient in here either causes WAT to BAT conversion, or burns extra calories by activating thermogenesis in existing BAT. That’s a smart formulation strategy, as the two main effects of the formula complement each other.

RAW Nutrition CBUM Essential Burner – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: PricePlow Staff

PricePlow Staff

PricePlow is a team of supplement industry veterans that include medical students, competitive strength athletes, and scientific researchers who all became involved with dieting and supplements out of personal need.

The team's collective experiences and research target athletic performance and body composition goals, relying on low-toxicity meat-based diets.

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References

  1. Hursel, R., et al. “The Effects of Catechin Rich Teas and Caffeine on Energy Expenditure and Fat Oxidation: A Meta-Analysis.” Obesity Reviews, vol. 12, no. 7, 2 Mar. 2011, pp. e573–e581, 10.1111/j.1467-789x.2011.00862.x; https://onlinelibrary.wiley.com/doi/full/10.1111/j.1467-789X.2011.00862.x
  2. Ras, Rouyanne T., et al. “Tea Consumption Enhances Endothelial-Dependent Vasodilation; a Meta-Analysis.” PLoS ONE, vol. 6, no. 3, 4 Mar. 2011, p. e16974, 10.1371/journal.pone.0016974; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048861/
  3. Hsu, Chung-Hua, et al. “Does Supplementation with Green Tea Extract Improve Insulin Resistance in Obese Type 2 Diabetics? A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial.” Alternative Medicine Review: A Journal of Clinical Therapeutic, vol. 16, no. 2, 1 June 2011, pp. 157–163; https://pubmed.ncbi.nlm.nih.gov/21649457/ (full text PDF)
  4. Venables, Michelle C, et al. “Green Tea Extract Ingestion, Fat Oxidation, and Glucose Tolerance in Healthy Humans.” The American Journal of Clinical Nutrition, vol. 87, no. 3, 1 Mar. 2008, pp. 778–784, 10.1093/ajcn/87.3.778; https://academic.oup.com/ajcn/article/87/3/778/4633440
  5. Brown, A. Louise, et al. “Effects of Dietary Supplementation with the Green Tea Polyphenol Epigallocatechin-3-Gallate on Insulin Resistance and Associated Metabolic Risk Factors: Randomized Controlled Trial.” British Journal of Nutrition, vol. 101, no. 6, 19 Aug. 2008, pp. 886–894, 10.1017/s0007114508047727; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819662/
  6. Sakata R, Nakamura T, Torimura T, Ueno T, Sata M. Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: a double-blind placebo-controlled study. Int J Mol Med. 2013 Nov;32(5):989-94. doi: 10.3892/ijmm.2013.1503; https://pubmed.ncbi.nlm.nih.gov/24065295/
  7. Chen, Li-Han et al. “Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat.” Food & nutrition research vol. 61,1 1347480. 14 Jul. 2017, doi:10.1080/16546628.2017.1347480 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533130/
  8. Moustakas, Dimitrios et al. “Guarana provides additional stimulation over caffeine alone in the planarian model.” PloS one vol. 10,4 e0123310. 16 Apr. 2015, doi:10.1371/journal.pone.0123310 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399916/
  9. Gurney, Tom et al. “Cognitive effects of guarana supplementation with maximal intensity cycling.” The British journal of nutrition vol. 130,2 (2023): 253-260. doi:10.1017/S0007114522002859 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277666/#ref1
  10. Bortolin, Rafael Calixto et al. “Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation.” Phytotherapy research : PTR vol. 33,5 (2019): 1394-1403. doi:10.1002/ptr.6330 https://onlinelibrary.wiley.com/doi/10.1002/ptr.6330
  11. Ikeda-Murakami K, Tani N, Ikeda T, Aoki Y, Ishikawa T. Central Nervous System Stimulants Limit Caffeine Transport at the Blood-Cerebrospinal Fluid Barrier. Int J Mol Sci. 2022 Feb 7;23(3):1862. doi: 10.3390/ijms23031862. PMID: 35163784; PMCID: PMC8836437. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836437/
  12. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance”; J Int Soc Sports Nutr 7, 5 (2010); https://link.springer.com/article/10.1186/1550-2783-7-5
  13. Cappelletti, Simone et al. “Caffeine: cognitive and physical performance enhancer or psychoactive drug?.” Current neuropharmacology vol. 13,1 (2015): 71-88. doi:10.2174/1570159X13666141210215655; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462044/
  14. Nehlig A, Daval JL, Debry G.; “Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects”; Brain Res Rev. 1992;17(2):139-170; https://www.sciencedirect.com/science/article/abs/pii/016501739290012B
  15. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance.”; J Int Soc Sports Nutr 7, 5 (2010); https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777221/
  16. Diepvens, K et al; “Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea;” American Journal of Physiology; 2007; https://journals.physiology.org/doi/full/10.1152/ajpregu.00832.2005
  17. Burke LM. Caffeine and sports performance. Appl Physiol Nutr Metab. 2008 Dec;33(6):1319-34. doi: 10.1139/H08-130; https://cdnsciencepub.com/doi/10.1139/H08-130
  18. Norager, C B, et al; “Metabolic Effects of Caffeine Ingestion and Physical Work in 75-Year Old Citizens. A Randomized, Double-Blind, Placebo-Controlled, Cross-over Study.”; Clinical Endocrinology; U.S. National Library of Medicine; Aug. 2006; https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2006.02579.x
  19. Collado-Mateo D, Lavín-Pérez AM, Merellano-Navarro E, Coso JD. Effect of Acute Caffeine Intake on the Fat Oxidation Rate during Exercise: A Systematic Review and Meta-Analysis. Nutrients. 2020 Nov 24;12(12):3603. doi: 10.3390/nu12123603. PMID: 33255240; PMCID: PMC7760526. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760526/
  20. Kahathuduwa CN, Dassanayake TL, Amarakoon AMT, Weerasinghe VS. Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutr Neurosci. 2017 Jul;20(6):369-377. doi: 10.1080/1028415X.2016.1144845; https://www.tandfonline.com/doi/abs/10.1080/1028415X.2016.1144845
  21. McLellan TM, Caldwell JA, Lieberman HR. A review of caffeine’s effects on cognitive, physical and occupational performance. Neurosci Biobehav Rev. 2016 Dec;71:294-312. doi: 10.1016/j.neubiorev.2016.09.001; https://www.sciencedirect.com/science/article/pii/S0149763416300690
  22. Klaassen EB, de Groot RH, Evers EA, Snel J, Veerman EC, Ligtenberg AJ, Jolles J, Veltman DJ. The effect of caffeine on working memory load-related brain activation in middle-aged males. Neuropharmacology. 2013 Jan;64:160-7. doi: 10.1016/j.neuropharm.2012.06.026; https://www.sciencedirect.com/science/article/abs/pii/S0028390812002845
  23. “Theobromine – an Overview | ScienceDirect Topics.” ScienceDirect; https://www.sciencedirect.com/topics/neuroscience/theobromine
  24. ‌Sugimoto, Naotoshi, et al. “Chronic Administration of Theobromine Inhibits MTOR Signal in Rats.” Basic & Clinical Pharmacology & Toxicology, vol. 124, no. 5, 12 Dec. 2018, pp. 575–581, 10.1111/bcpt.13175 ; https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcpt.13175
  25. Martínez-Pinilla, Eva et al. “The relevance of theobromine for the beneficial effects of cocoa consumption.” Frontiers in pharmacology vol. 6 30. 20 Feb. 2015, doi:10.3389/fphar.2015.00030; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335269/
  26. ‌Jang, Myeong & Kang, Nam & Mukherjee, Sulagna & Yun, Jong Won. (2018). Theobromine, a Methylxanthine in Cocoa Bean, Stimulates Thermogenesis by Inducing White Fat Browning and Activating Brown Adipocytes. Biotechnology and Bioprocess Engineering. 23. 10.1007/s12257-018-0434-y; https://www.researchgate.net/publication/329990151_Theobromine_a_Methylxanthine_in_Cocoa_Bean_Stimulates_Thermogenesis_by_Inducing_White_Fat_Browning_and_Activating_Brown_Adipocytes
  27. Liang, Huiyun, and Walter F Ward. “PGC-1alpha: A Key Regulator of Energy Metabolism.” Advances in Physiology Education, vol. 30, no. 4, 2006, pp. 145–51; https://journals.physiology.org/doi/full/10.1152/advan.00052.2006
  28. Charles J. Rebouche, E. Peter Bosch, Catherine A. Chenard, Kay J. Schabold, Steven E. Nelson; “Utilization of Dietary Precursors for Carnitine Synthesis in Human Adults”; The Journal of Nutrition, Volume 119, Issue 12, 1 December 1989, Pages 1907–1913; https://academic.oup.com/jn/article-abstract/119/12/1907/4738183
  29. Ann Louise Olson, Charles J. Rebouche; “γ-Butyrobetaine Hydroxylase Activity is Not Rate Limiting for Carnitine Biosynthesis in the Human Infant”; The Journal of Nutrition, Volume 117, Issue 6, 1 June 1987, Pages 1024–1031; https://academic.oup.com/jn/article-abstract/117/6/1024/4768474
  30. Ozaki, Kiyokazu, et al. “Carnitine Is Necessary to Maintain the Phenotype and Function of Brown Adipose Tissue.” Laboratory Investigation, vol. 91, no. 5, 14 Feb. 2011, pp. 704–710, 10.1038/labinvest.2011.6; https://www.nature.com/articles/labinvest20116
  31. Iwami, Momoe et al. “Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats.” Autonomic neuroscience : basic & clinical vol. 161,1-2 (2011): 63-7. doi:10.1016/j.autneu.2010.11.012 https://www.autonomicneuroscience.com/article/S1566-0702(10)00277-8/fulltext
  32. Sugita, J., Yoneshiro, T., et al; “Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men”; British Journal of Nutrition; (2013) 110(4), pp. 733–738; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/grains-of-paradise-aframomum-melegueta-extract-activates-brown-adipose-tissue-and-increases-whole-body-energy-expenditure-in-men/517F8F0D73864C919E42D502537BA01D/core-reader
  33. Sugita J, Yoneshiro T, et al; “Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans”; Journal of Nutritional Science and Vitaminology; 2014, 60(1): 22-27; https://www.jstage.jst.go.jp/article/jnsv/60/1/60_22/_pdf
  34. Rosenwald M, Wolfrum C; “The origin and definition of brite versus white and classical brown adipocytes”; Adipocyte; 2014;3(1):4-9; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917931/
  35. Kim SH, Plutzky J; “Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders”; Diabetes & Metabolism Journal. 2016;40(1):12-21; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768046/
  36. Sugita J, Yoneshiro T, et al; “Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans”; Journal of Nutritional Science and Vitaminology; 2014, 60(1): 22-27; https://pubmed.ncbi.nlm.nih.gov/24759256/
  37. Sugita, J., Yoneshiro, T., et al; “Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men”; British Journal of Nutrition; (2013) 110(4), pp. 733–738; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/grains-of-paradise-aframomum-melegueta-extract-activates-brown-adipose-tissue-and-increases-whole-body-energy-expenditure-in-men/517F8F0D73864C919E42D502537BA01D/core-reader
  38. OmniActive Health Technologies; Capsimax® Overview; 2020; https://www.capsimax.com/
  39. Janssens, Pilou L H R et al; “Acute effects of capsaicin on energy expenditure and fat oxidation in negative energy balance.”; PloS one; vol. 8,7; e67786; 2 Jul. 2013; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699483/
  40. Majeed, M, et al; “Use of piperine to increase the bioavailability of nutritional compounds”; United States Patent US5536506A; 24-Feb 1995; https://patents.google.com/patent/US5536506A/en
  41. Majeed, M, et al; “Use of piperine as a bioavailability enhancer”; United States Patent US5744161A; 30-Oct 1995; https://patents.google.com/patent/US5744161A/en
  42. Majeed, M, et al; “Use of piperine as a bioavailability enhancer”; United States Patent US5972382A; 12-Jan 1998; https://patents.google.com/patent/US5972382A/en
  43. Majeed, M; “Process for making high purity piperine for nutritional use”; United States Patent US6054585A; 23-Dec 1998; https://patents.google.com/patent/US6054585A/en
  44. Bhardwaj, R. et al. Aug. 2002. “Piperine, A Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4.” The Journal of Pharmacology and Experimental Therapeutics vol. 302, 2. 645-50; https://pubmed.ncbi.nlm.nih.gov/12130727/
  45. Mittal R, Gupta RL. In vitro antioxidant activity of piperine. Methods Find Exp Clin Pharmacol. 2000 Jun;22(5):271-4. doi: 10.1358/mf.2000.22.5.796644; https://pubmed.ncbi.nlm.nih.gov/11031726/
  46. Maeda A, Shirao T, Shirasaya D, Yoshioka Y, Yamashita Y, Akagawa M, Ashida H. Piperine Promotes Glucose Uptake through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle. Mol Nutr Food Res. 2018 Jun;62(11):e1800086. doi: 10.1002/mnfr.201800086; https://pubmed.ncbi.nlm.nih.gov/29683271/
  47. Choi S, Choi Y, Choi Y, Kim S, Jang J, Park T. Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice. Food Chem. 2013 Dec 15;141(4):3627-35. doi: 10.1016/j.foodchem.2013.06.028; https://pubmed.ncbi.nlm.nih.gov/23993530/

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