BLO is Back! MyoBlox BLO 3D Brings Big Breakthrough Pumps & Hydration

Blo is back!

We always get excited about new products from MyoBlox, a hip and savvy lifestyle-and-performance brand from the San Francisco Bay Area that took the supplement scene by storm in 2017.

With flashy neon visuals that hearken back to hypebeast streetwear fashion — a popular style these days — MyoBlox has proven to be equally rigorous as they are elegant. But as time marches on, consumers demand bigger, stronger, better. And they’re about it get it thanks to a new… breakthrough ingredient:

MyoBlox BLO 3D

Myoblox BLO is Back with BLO 3D

Myoblox is bringing us their updated stim-free pre-workout, changing the name from BLO to BLO 3D. If you’ve been following sports supplements this year, you know what that means — the inclusion of the 3D Breakthrough pump ingredient!

Stim-free nitric oxide boosters are great for many reasons. Not everyone needs huge doses of caffeine, rauwolfia, yohimbine, and other stimulants in more “modern” pre-workout formulas. They just want the performance without the buzz or jitters. Evening gym goers are particularly affected – nobody wants to slam 300 milligrams of caffeine right before their 7 p.m. lifting session. (And if you do, we have an article on the new LOCO coming next.)

And sometimes, even with a stim pre-workout, you want to push even more nitric oxide induced blood flow into your muscles. No matter what the reason, BLO 3D has a sharp formula and launched with two cool flavors, so let’s cover it below:

MyoBlox BLO 3D – Deals and Price Drop Alerts

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Note: If you were a fan of the previous version of BLO, check out our original Myoblox Blo product page. Once it’s gone, it’s gone!

MyoBlox BLO 3D Ingredients

In a single 2-scoop (18 gram) serving of BLO Muscle Pump from MyoBlox, you get the following:

  • 3D Pump-Breakthrough – 6,000 mg

    3D Pump-Breakthrough is a trademarked blend of ingredients designed to give you massive pumps via several different mechanisms of action.

    In a word, the intended effect we’re going for with pumps is ergogenic (performance-boosting).

    3D Pump-Breakthrough Preliminary Study

    The patent filed for 3D Pump-Breakthrough cites a quality preliminary study that was conducted for the purpose of demonstrating how 3D Pump-Breakthrough works to increase performance during a workout.

    The study was conducted in resistance (weight) trained men whose average age was 28.

    Because the sample size in this study was small (as is the case with most preliminary studies), the researchers used a repeating design that enabled the subjects to serve as their own controls.[1]

    Each volunteer completed four identical workouts on separate days, taking one of four treatments before each workout:

    MyoBlox Blo 3D Ingredients

    1. Water
    2. 1.5 grams of glycerol
    3. 150 milligrams of amla fruit extract
    4. 1.5 grams of glycerol and 150 milligrams of amla fruit extract

    The workout consisted of leg extensions and weighted goblet squats, performed in three sets of 10-12 repetitions. The subjects rested for one minute after each set and two minutes between exercises.

    Upon the completion of each workout, their thigh circumference was scanned using a DEXA machine, which is a kind of low-dose X-ray that tracks physiological changes in athletes. The idea was that thigh circumference is affected by water content of the leg and, therefore, could be used as a proxy metric for hyperhydration.

    Every workout caused some expansion of thigh circumference and some increase in lean body mass – which is exactly what you’d expect – but the training sessions conducted after subjects took glycerol and amla in combination caused bigger increases than either treatment alone, or the placebo.

    The glycerol and amla mixture created a 2.21-centimeter increase in thigh circumference and an almost 700-gram increase in lean body mass. Compare that to the placebo-treated workout, after which the subjects had a 1.12-centimeter increase in thigh circumference and a ~30-gram increase in lean body mass.[1]

    So glycerol and amla taken together caused 2x the increase in thigh circumference, and 23x the increase in lean body mass. To be clear, “lean body mass” in this context includes anything that isn’t adipose (fat) tissue – meaning that water falls under that category.

    The last really interesting thing to note about this study is that amla, a relatively new consumer supplement ingredient that most of us aren’t familiar with, outperformed glycerol in the single-treatment workouts.

    That says a lot about amla’s efficacy, since glycerol is a proven osmolyte that’s won major acceptance among supplement manufacturers and consumers alike.

    Let’s break down the way that 3D Pump-Breakthrough works, ingredient-by-ingredient:

    • L-Citrulline (Vegan Fermented)

      The amino acid citrulline is what’s called a non-essential amino acid. This means your body can actually make citrulline on its own, out of other nutrients.

      MyoBlox Blo Benefits

      So if your body makes its own citrulline, why supplement? The answer is that the quantity the body is capable of producing in a day is extremely limited – adequate for covering your bare-minimum nutritional requirements, but definitely not anywhere close to what you’d need for optimal citrulline effects.

      Citrulline is important as an arginine precursor. Arginine is important because it’s a nitric oxide (NO) precursor, meaning that citrulline supplementation ultimately raises blood levels of NO[2] by raising your arginine levels.[3]

      Most good pre-workout formulas include a hefty dose of some NO-boosting ingredient like citrulline because NO triggers vasodilation, a process in which blood vessels (mainly arteries) expand. Wider blood vessels means a lower heart rate, reduced blood pressure, and improved athletic performance[4,5] owing to the increased efficiency of blood-borne nutrient and oxygen delivery. Better circulation also means faster recovery following exercise.[6]

      A 2020 meta-analysis of 13 peer-reviewed citrulline studies found that citrulline supplementation can in fact reduce rated perceived exertion (RPE) during exercise, and decrease soreness following exercise.[7]

      According to a 2020 meta-analysis published by the Journal of Sport and Health Science, the average dose used in these studies was 8 grams of citrulline malate,[7] which yields about 5.5 grams of pure citrulline.[8]

      A full dose of BLO actually has even more citrulline than this – 6.0 grams of citrulline per 1 scoop serving!

      The vegan-fermented sourcing of citrulline is good for vegans, obviously, but even for non-vegans, it can act as assurance of high quality.

    • Glycerol

      The polyol compound glycerol, strictly speaking a sugar alcohol, is a metabolic byproduct of burning both fat and carbohydrates for energy.[9,10]

      Glycerol Endurance

      When the going gets tough in the final loop of this heat-based event, the glycerol group pulled through far faster at the end.[11]

      It’s essential for the process of hepatic gluconeogenesis,[12] a process in which the liver converts non-sugar substrates like protein into glucose.

      When taken orally, and before it’s processed by the liver and kidneys, glycerol is rapidly distributed throughout the body. In fact, every part of your body gets some glycerol, except the brain and eyes, which seem to be unaffected by supplemental glycerol.[13]

      Once the glycerol you consumed has permeated most of your body’s fluids, it increases the osmotic pressure surrounding your tissues.[13]

      Hyperhydration and its Benefits

      The reason we like high osmotic pressure is that it helps create a state of cellular hyperhydration.[14]

      Myoblox Skywalk

      Tired of low-stim nootropic drinks? The new Myoblox Skywalk launched in early 2022 puts in plenty of caffeine, but keeps it smooth with a synergistic blend

      Remember that osmosis is the mechanism by which a difference in solute concentrations on either side of a cellular membrane causes water to move across that membrane. As a rule, water moves from the region of higher osmotic pressure (higher solute concentration) to the region of lower osmotic pressure (lower solute concentration).[15]

      In other words, when glycerol raises the osmotic pressure around your cells, water gets forced into your cells in volumes that are not easily achievable without the use of an osmolyte like glycerol.

      We refer to this higher-than-average state of cellular hydration as hyperhydration, and it comes with a few significant benefits. Among those is increased cellular endurance for muscle cells, which can delay the onset of fatigue.[13]This is key to the performance-boosting effect of glycerol, and of pumps in general.

      Glycerol is most effective when used with plenty of water, so be sure to drink a little extra after taking MyoBlox BLO.

    • Amla: What it is and how it works

      The fruit Phyllanthus emblica, colloquially known as amla, is a traditional therapy from Ayurvedic medicine.

      Amla Indian Gooseberry Phyllanthus Emblica

      Amla, also known as Indian Gooseberry, has many incredible cardioprotective properties

      For thousands of years,[16] amla has been prescribed by Ayurvedic practitioners to patients suffering from circulatory disorders of the cardiovascular system, and, as usual, the wisdom of the ancients has been largely corroborated by recent scientific research.

      Science is finding that specific antioxidants in amla seem to benefit endothelial function while inhibiting the formation of platelets,[17] thus minimizing the risk of cardiovascular events caused by inappropriate clotting.

      Amla’s tannins increase ATP production

      3D Pump-Breakthrough uses a special amla extract that’s standardized to contain a minimum of 68% low-molecular-weight tannins (LMWTs).

      The LMWTs identified so far include emblicanin-A, emblicanin-B, punigluconin, and pedunculagin.[18] These are metabolized upon ingestion into urolithins A, B, C, and D, respectively,[19] all of which have been shown to support mitochondrial health.[20]

      We harp on this all the time here at PricePlow, and it’s because mitochondrial health is the sine qua non of good overall health. The mitochondria are responsible for driving electron transport chain (ETC) activity and, ultimately, producing all of your body’s usable energy in the form of adenosine triphosphate (ATP).

      If your body were an engine, ATP would be the gasoline – it’s that fundamental to human health and activity. ATP production is positively correlated with athletic performance and overall health.[21,22]

      Besides increasing ATP production, urolithin B may also have anabolic effects.[23]

      Amla extracts have even been linked to cognitive benefits.[24]

    Update: After the initial publication of this article, a new 3DPump study is out. Dive into our comprehensive coverage titled “3DPump Breakthrough STUDY: 6g Takes on 8g L-Citrulline!.

    The glycerol in 3D PUMP is great, but we can continue to hydrate and methylate even more:

  • Betaine Anhydrous – 2,500 mg

    Betaine Muscle

    A landmark 2013 study showed that 2.5 grams of betaine every day can have profound effects on body mass and strength[25,26]

    Betaine, sometimes referred to by its technical name, trimethylglycine (TMG), is similar in its effects to creatine, although it acts by a very different mechanism. So if you’re trying to understand betaine for the first time, it can help to think of it as a “creatine-like” supplement.

    Betaine increases ATP production, just like creatine.[27] But whereas creatine is a phosphate donor, betaine is a methyl donor.

    The process of methylation that these methyl groups get used for is one of the body’s most fundamental metabolic activities. It ends up affecting tons of processes, from myelination to epigenetic expression, and also happens to be involved in controlling homocysteine blood levels.[28]

    Since high homocysteine is associated with atherosclerosis and cardiovascular events like heart attack and stroke,[29] keeping your methylation working properly goes a long way toward maintaining long-term exercise performance.

    In the short term, betaine can help boost athletic performance acutely because it’s an osmolyte, meaning that it helps promote cellular hydration by shuttling water into your cells. That water content comes with additional glucose and nutrients, making your cells stronger[25,30] and more resilient to heat stress,[31] which can definitely be a concern during intense exercise.

    Betaine is one of those supplement ingredients with a mountain of evidence supporting its use,[32-37] but we want to highlight one study in particular.

    Conducted in 2013, this study showed that subjects who took 2.5 grams of betaine daily – the same dose used in MyoBlox BLO – were able to gain 5.3 pounds of muscle and lose 6.4 pounds of fat over the 6 week study period. That translated to a 3% reduction in body fat.[25,26]

    This fat loss result was replicated by a 2018 placebo-controlled study that used the exact same method and dose in collegiate women. The women completed a resistance-based strength-training program alongside their 2.5 grams of daily betaine supplementation, and lost 4.4 pounds more body fat than the placebo group.[38]

  • L-Taurine – 2,000 mg

    Taurine is a sulfurous amino acid that falls into the “conditionally essential” category of amino acids, meaning that although your body can make some taurine on its own, it can’t make enough to fully cover your nutritional requirements.

    Naturally concentrated in muscle, heart, eye, and brain tissue,[39] supplemental taurine can increase athletic endurance and power output,[40,41] while also fighting oxidative stress and increasing insulin sensitivity.[42]

    Taurine Endurance

    Taurine’s effect on endurance, with success in doses anywhere from 1 gram to 6 grams.[41]

    Although its metabolic and athletic benefits are impressive, the most common use case for taurine is actually to improve mood and cognition, which is why the amino acid is often a main ingredient in popular energy drinks. In the brain, taurine acts like a neurotransmitter, where it exerts inhibitory effects on neurons – as opposed to excitatory – through GABAergic transmission.[43-47]

    Taurine actually binds to your brain’s GABA receptors, which can help push you into a state of relaxation[48] while speeding-up learning and enhancing memory.[49,50]

    Because of these effects, taurine is considered significantly anxiolytic and is often used to reduce anxiety symptoms.[51-53] This anxiolytic effect is part of the reason why taurine is often paired with caffeine: taurine helps “take the edge off” the high that caffeine gives you, preventing jitters and nervousness.

    A 2,000-milligram dose of taurine is great. The research literature has verified that doses of just 1,000 milligrams[41] are as capable of boosting endurance. So twice that amount may help you even more!

  • Aquamin – 1,200 mg

    Aquamin is a blend of minerals derived from seaweed. It’s mostly comprised of calcium and magnesium.[53] And here, we have a very large dose compared to competing hydration supplements!

    MyoBlox Blo 3D

    MyoBlox has long had incredible labels, and cool flavor names like Boom Pop

    The main reason you want to put minerals in a pre-workout is because during exercise, you lose minerals in sweat. In order to maintain the functioning of your metabolism, those minerals eventually need to be replaced, lest you develop a mineral deficiency.

    When it comes to performance, boron, one of the minerals in Aquamin, has been shown in some studies to help un-bind steroid hormones like testosterone from a protein called sex hormone binding globulin (SHBG).[54]

    The story behind SHBG is kind of complicated, but the gist is that your body uses it to move around and manage blood levels of different hormones. The problem is that when SHBG gets overactive, it can wind up binding too much of important hormones like testosterone. When that happens, the testosterone is converted from “free testosterone” to “bound testosterone.” That can be a problem since free testosterone is the form of the hormone that’s actually bioavailable. Binding it to SHBG is, in some ways, akin to just having lower testosterone levels.

    Since boron may be able to raise free testosterone,[55] taking it can give you a little androgenic boost to aid in performance, recovery, and overall energy levels.

    Boron, manganese, calcium, and a few other minerals in Aquamin, are great for joint and bone health,[56-58] which is important since intense exercise and heavy lifting can put undue stress on your joints and bones.

    Calcium For the Athlete

    Another nice bonus of supplementing with large amounts of calcium, like that found in Aquamin, is that taking calcium appears to amplify the testosterone-increasing effect of physical exercise.[59]

    In the same vein, calcium appears to mitigate some of the potential negative effects of intense training regimens. In one study, four weeks of calcium supplementation in athletes raised volunteers’ red and white blood cell counts,[60] an effect that did not appear in rested (sedentary/non-athletic) study participants.

    So calcium supplementation has some potential benefits for athletes specifically.

  • L-Ornithine – 1,000 mg

    Ornithine helps control ammonia levels in muscle tissue.

    BLO 3D

    Ammonia is a toxic metabolic byproduct, created at an accelerated rate by strong muscular contractions during physical exercise,[61] that progressively impairs muscular function as it builds up.[62]

    In other words, ammonia causes fatigue, much like lactic acid.

    By helping your body clear ammonia, ornithine can directly reduce fatigue,[63,64] both peripheral (muscles) and central (brain).[65]

    A citrulline precursor

    What’s interesting (and favorable) about ornithine is that it’s a precursor for L-citrulline.[66] In a study demonstrating reduced physical fatigue from larger doses of ornithine, the participants had slightly greater plasma L-citrulline levels than placebo throughout recovery, although it narrowly missed statistical significance.[64] This still could lead to some enhanced effects post-workout.

  • Pine Bark (Pinus Pilaster) (95% Proanthocyanidins) Extract (Organic) – 250 mg

    MyoBlox Blo 3D Label Side

    Pumps pumps pumps

    Much like citrulline, pine bark extract drives vasodilation by upregulating nitric oxide (NO) production. However, pine bark has the special distinction of being an antioxidant powerhouse, absolutely jam-packed with powerful phenolic compounds[67,68] that can stimulate endothelial nitric oxide synthase (eNOS),[67,68] the enzyme that’s responsible for synthesizing most of your arterial NO.

    Partly because of its vasodilatory effect on the cardiovascular system, and partly because of its insane antioxidant content, pine bark extract has been used for many years as a folk remedy for various cardiovascular diseases.[67,68]

    As usual, the wisdom of our ancestors has been vindicated, with modern research showing that pine bark extracts do in fact have broad cardioprotective effects.[67,68] Pine bark extract might help manage chronic inflammation effectively enough to reduce the risk of neurological complications.[68]

    But for a pre-workout, we really are after the massive pumps from increased NO production.

    If you need a refresher on NO, just hit up the citrulline section above.

  • Astragin (from Astragalus Membranaceus and Panax Notoginseng) Root Extract – 50 mg

    AstraGin increases ATP production, specifically in intestinal cells, which can then use that ATP to perform useful work. That means absorbing nutrients,[69,70] as nutrient absorption is the job of intestinal cells.

    AstraGin Citrulline

    One of AstraGin’s most popular use-cases is its ability to enhance citrulline absorption – especially right when we’d want it: during our workout![71]

    By raising the energetic state of your intestines, AstraGin can basically increase the bioavailability of whatever it’s paired with, which in this case is every other ingredient in the MyoBlox BLO formula.

    AstraGin is becoming increasingly more popular in premium supplements because of its added value for consumers. After all, the ingredients you actually absorb are the ones that benefit your health.

    For a long time, the black pepper alkaloid piperine performed this role in the supplement industry, but slowly, piperine is being replaced by AstraGin. With each year, as new research emerges, it’s becoming more and more clear that AstraGin is simply better at enhancing bioavailability.

    Over 20 different studies have demonstrated that AstraGin, or its specific bioactive constituents, can improve nutrient bioavailability.[71-76]

Flavors Available

MyoBlox BLO 3D Label

Another look at the label

    Want to try something fun? Many love the LOCO high-energy pre-workout, but don’t forget that you can also stack it with the highly-caffeinated MyoBlox Skywalk nootropic!

    Conclusion: BLO Up Your Arms

    True to MyoBlox form, we have some solid mainstay ingredients — given in huge doses—alongside some cutting edge, next-generation ones.

    We particularly enjoy seeing pine bark paired next to 3D PUMP Breakthrough, providing a very unique blend of both Amla fruit extract with pine bark — alongside citrulline and glycerol of course. Truth be told, there are many pine-tree derived supplements that deserve more attention and use – more or less the entire pine tree really seems to be a slept-on superfood.

    Drink water with this one!

    Remember to drink bigtime water!! Anytime you see four very well-dosed hydration ingredients together, it’s time to drive some water into those cells:

    1. Betaine
    2. Aquamin
    3. Taurine
    4. Glycerol

    So drink up, and get ready for some BLOwn-up training. Next up, we have the new LOCO… get ready and sign up for alerts below:

    MyoBlox BLO 3D – Deals and Price Drop Alerts

    Get Price Alerts

    No spam, no scams.

    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

    About the Author: Mike Roberto

    Mike Roberto

    Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

    Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public. Mike is currently experimenting with a low Vitamin A diet.

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    References

    1. Ziegenfuss, T, et al; “Compositions and methods for increase in muscle volume”; United States Patent and Trademark Office; Patent #US10993978B1; May 4, 2021; https://patents.google.com/patent/US10993978B1/en
    2. Sureda, Antoni, et al. “L-Citrulline-Malate Influence over Branched Chain Amino Acid Utilization during Exercise.” European Journal of Applied Physiology, vol. 110, no. 2, 25 May 2010, pp. 341–351, 10.1007/s00421-010-1509-4; https://pubmed.ncbi.nlm.nih.gov/20499249/
    3. Bailey, SJ et al.; “l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.”; Journal of Applied Physiology; 119(4) pp. 385-395; 2015; https://journals.physiology.org/doi/full/10.1152/japplphysiol.00192.2014
    4. Suzuki, I., Sakuraba, K., Horiike, T. et al. A combination of oral l-citrulline and l-arginine improved 10-min full-power cycling test performance in male collegiate soccer players: a randomized crossover trial. Eur J Appl Physiol 119, 1075–1084; 2019; https://link.springer.com/article/10.1007/s00421-019-04097-7
    5. ‌Takashi Suzuki, Masahiko Morita, Toshio Hayashi, Ayako Kamimura, The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males, Bioscience, Biotechnology, and Biochemistry, Volume 81, Issue 2, 1 February 2017, Pages 372–375; https://academic.oup.com/bbb/article/81/2/372/5955995
    6. Oral O. Nitric oxide and its role in exercise physiology. J Sports Med Phys Fitness. 2021 Sep;61(9):1208-1211. doi: 10.23736/S0022-4707.21.11640-8; https://pubmed.ncbi.nlm.nih.gov/21094266/
    7. Rhim, Hye Chang, et al. “Effect of Citrulline on Post-Exercise Rating of Perceived Exertion, Muscle Soreness, and Blood Lactate Levels: A Systematic Review and Meta-Analysis.” Journal of Sport and Health Science, Feb. 2020, 10.1016/j.jshs.2020.02.003. https://www.sciencedirect.com/science/article/pii/S2095254620300168
    8. “Citrulline Malate”; Pubchem; https://pubchem.ncbi.nlm.nih.gov/compound/Citrulline-malate
    9. Simon P Van Rosendal, Mark A Osborne, Robert G Fassett, Jeff S Coombes; “Physiological and performance effects of glycerol hyperhydration and rehydration”; Nutrition Reviews, Volume 67, Issue 12, 1 December 2009, Pages 690–705, https://doi.org/10.1111/j.1753-4887.2009.00254.x; https://academic.oup.com/nutritionreviews/article/67/12/690/1938382
    10. Baba, H et al; “Glycerol gluconeogenesis in fasting humans.”; Nutrition (Burbank, Los Angeles County, Calif.); vol. 11,2; 1995; 149-53; https://pubmed.ncbi.nlm.nih.gov/7647479/
    11. Wingo, Jonathan E. et al. “Influence of a Pre-Exercise Glycerol Hydration Beverage on Performance and Physiologic Function During Mountain-Bike Races in the Heat.” Journal of athletic training vol. 39,2 (2004): 169-175; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC419512/
    12. Ross, B D et al; “The rate of gluconeogenesis from various precursors in the perfused rat liver.”; The Biochemical journal; vol. 102,3; 1967; 942-51; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1270348/
    13. Patlar, Suleyman et al; “The effect of glycerol supplements on aerobic and anaerobic performance of athletes and sedentary subjects.”; Journal of human kinetics; vol. 34; 2012; 69-79; doi:10.2478/v10078-012-0065-x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590833/
    14. Robergs, R A, and S E Griffin; “Glycerol. Biochemistry, pharmacokinetics and clinical and practical applications.”; Sports medicine (Auckland, N.Z.); vol. 26,3; 1998; 145-67; doi:10.2165/00007256-199826030-00002; https://www.ncbi.nlm.nih.gov/pubmed/9802172/
    15. Rye, Connie, et al; “22.1. Osmoregulation and Osmotic Balance.”; Concepts of Biology 1st Canadian Edition; BCcampus; 1 May 2019; https://opentextbc.ca/biology/chapter/22-1-osmoregulation-and-osmotic-balance/
    16. Kalman, D., Hewlings, S., Sylla, S., Ojalvo, S., & Komorrowski, J; “An evaluation of the effects of inositol-stabilized arginine silicate (ASI; Nitrosigine) on cognitive flexibility”; Nutrients; 2016; https://blog.priceplow.com/wp-content/uploads/nitrosigine-cognitive-flexibility-issn-2018.pdf
    17. Evans, M., Zakaria, N., & Marzuk, M; “An Evaluation of the Effects of Inositol-Stabilized Arginine Silicate (ASI; Nitrosigine) in Preventing the Decline of Cognitive Function Caused by Strenuous Exercise”; International Society of Sports Nutrition 2018 Conference; 2018; https://blog.priceplow.com/wp-content/uploads/nitrosigine-preventing-cognitive-decline-caused-by-strenuous-exercise.pdf
    18. Suzuki, I., Sakuraba, K., Horiike, T. et al. A combination of oral l-citrulline and l-arginine improved 10-min full-power cycling test performance in male collegiate soccer players: a randomized crossover trial. Eur J Appl Physiol 119, 1075–1084; 2019; https://link.springer.com/article/10.1007/s00421-019-04097-7
    19. Mor A, Yılmaz AK, Acar K, Birinci MC, Ipekoglu G. Does Nitric Oxide Intake Affect Post-Exercise Recovery in Athletes? A Study on Cocoa, Caffeine and Nitric Oxide Supplement: Effect of Nitric Oxide Intake in Athletes. Progr Nutr [Internet]. 2020 Sep. 30 [cited 2022 May 4];22(3):e2020007; https://www.mattioli1885journals.com/index.php/progressinnutrition/article/view/8529
    20. Vanhatalo, Anni, et al. “Acute and Chronic Effects of Dietary Nitrate Supplementation on Blood Pressure and the Physiological Responses to Moderate-Intensity and Incremental Exercise.” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 299, no. 4, Oct. 2010, pp. R1121–R1131, 10.1152/ajpregu.00206.2010; https://journals.physiology.org/doi/full/10.1152/ajpregu.00206.2010
    21. Hasselmo ME; “The role of acetylcholine in learning and memory;”Curr Opin Neurobiol. 2006;16(6):710–715; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659740/
    22. Jones BE; “From waking to sleeping: neuronal and chemical substrates”. Trends Pharmacol. Sci.; 2005; 26 (11): 578–86; https://www.ncbi.nlm.nih.gov/pubmed/16183137
    23. Sanders LM, Zeisel SH; “Choline: Dietary Requirements and Role in Brain Development;” Nutrition today; 2007;42(4):181-186; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518394/
    24. Purves D, Augustine GJ, Fitzpatrick D, et al.; “Neuroscience;” 2nd edition. Sunderland (MA): Sinauer Associates; 2001. Acetylcholine. https://www.ncbi.nlm.nih.gov/books/NBK11143/
    25. Cholewa, Jason M et al. “Effects of betaine on body composition, performance, and homocysteine thiolactone.” Journal of the International Society of Sports Nutrition vol. 10,1 39. 22 Aug. 2013, doi:10.1186/1550-2783-10-39; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844502/
    26. Cholewa, Jason M., et al. “Effects of Betaine on Performance and Body Composition: A Review of Recent Findings and Potential Mechanisms.” Amino Acids, vol. 46, no. 8, 24 Apr. 2014, pp. 1785–1793, 10.1007/s00726-014-1748-5; https://pubmed.ncbi.nlm.nih.gov/24760587/
    27. Lee I. Betaine is a positive regulator of mitochondrial respiration. Biochem Biophys Res Commun. 2015 Jan 9;456(2):621-5. doi: 10.1016/j.bbrc.2014.12.005; https://pubmed.ncbi.nlm.nih.gov/25498545/
    28. Olthof, M. R., & Verhoef, P. (2005). Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Current drug metabolism, 6(1), 15-22; https://pubmed.ncbi.nlm.nih.gov/15720203
    29. Ganguly, Paul, and Sreyoshi Fatima Alam. “Role of homocysteine in the development of cardiovascular disease.” Nutrition journal vol. 14 6. 10 Jan. 2015, doi:10.1186/1475-2891-14-6; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326479/
    30. Boel De Paepe; “Osmolytes as Mediators of the Muscle Tissue’s Responses to Inflammation: Emerging Regulators of Myositis with Therapeutic Potential”; EMJ Rheumatol. 2017;4[2]:83-89; https://www.emjreviews.com/rheumatology/article/osmolytes-as-mediators-of-the-muscle-tissues-responses-to-inflammation-emerging-regulators-of-myositis-with-therapeutic-potential/
    31. Caldas, Teresa, et al. “Thermoprotection by Glycine Betaine and Choline.” Microbiology, vol. 145, no. 9, 1 Sept. 1999, pp. 2543–2548, 10.1099/00221287-145-9-2543; https://pubmed.ncbi.nlm.nih.gov/10517607/
    32. Roti, M; “Homocysteine, Lipid and Glucose Responses to Betaine Supplementation During Running in the Heat”; Medicine & Science in Sports & Exercise: May 2003 – Volume 35 – Issue 5 – p S271; https://journals.lww.com/acsm-msse/Fulltext/2003/05001/HOMOCYSTEINE,_LIPID_AND_GLUCOSE_RESPONSES_TO.1501.aspx
    33. Armstrong, Lawrence E, et al. “Influence of Betaine Consumption on Strenuous Running and Sprinting in a Hot Environment.” Journal of Strength and Conditioning Research, vol. 22, no. 3, May 2008, pp. 851–860, 10.1519/jsc.0b013e31816a6efb; https://pubmed.ncbi.nlm.nih.gov/18438230
    34. Hoffman, Jay R, et al. “Effect of Betaine Supplementation on Power Performance and Fatigue.” Journal of the International Society of Sports Nutrition, vol. 6, no. 1, 27 Feb. 2009, 10.1186/1550-2783-6-7; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-6-7
    35. Lee, Elaine C, et al. “Ergogenic Effects of Betaine Supplementation on Strength and Power Performance.” Journal of the International Society of Sports Nutrition, vol. 7, no. 1, 2010, p. 27, 10.1186/1550-2783-7-27; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-27
    36. Trepanowski, John F, et al. “The Effects of Chronic Betaine Supplementation on Exercise Performance, Skeletal Muscle Oxygen Saturation and Associated Biochemical Parameters in Resistance Trained Men.” Journal of Strength and Conditioning Research, vol. 25, no. 12, Dec. 2011, pp. 3461–3471, 10.1519/jsc.0b013e318217d48d; https://pubmed.ncbi.nlm.nih.gov/22080324/
    37. Pryor, J Luke, et al. “Effect of Betaine Supplementation on Cycling Sprint Performance.” Journal of the International Society of Sports Nutrition, vol. 9, no. 1, 3 Apr. 2012, 10.1186/1550-2783-9-12; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-9-12
    38. Jason Michael Cholewa, et al; “The Effects of Chronic Betaine Supplementation on Body Composition and Performance in Collegiate Females: a Double-Blind, Randomized, Placebo Controlled Trial”; Journal of the International Society of Sports Nutrition; BioMed Central; 31 July 2018; https://jissn.biomedcentral.com/articles/10.1186/s12970-018-0243-x
    39. Schuller-Levis, Georgia B, and Eunkyue Park. “Taurine: New Implications for an Old Amino Acid.” FEMS Microbiology Letters, vol. 226, no. 2, Sept. 2003, pp. 195–202, 10.1016/s0378-1097(03)00611-6; https://pubmed.ncbi.nlm.nih.gov/14553911/
    40. De Carvalho, Flávia G., et al. “Taurine: A Potential Ergogenic Aid for Preventing Muscle Damage and Protein Catabolism and Decreasing Oxidative Stress Produced by Endurance Exercise.” Frontiers in Physiology, vol. 8, 20 Sept. 2017, 10.3389/fphys.2017.00710; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611412/
    41. Waldron, Mark, et al. “The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis.” Sports Medicine, vol. 48, no. 5, 15 Mar. 2018, pp. 1247–1253, 10.1007/s40279-018-0896-2. https://pubmed.ncbi.nlm.nih.gov/29546641/
    42. Nandhini, A. T. Anitha, et al. “Taurine Modifies Insulin Signaling Enzymes in the Fructose-Fed Insulin Resistant Rats.” Diabetes & Metabolism, vol. 31, no. 4 Pt 1, 1 Sept. 2005, pp. 337–344; 10.1016/s1262-3636(07)70202-1. https://pubmed.ncbi.nlm.nih.gov/16369195/
    43. Ochoa-de la Paz, Lenin, et al. “Taurine and GABA Neurotransmitter Receptors, a Relationship with Therapeutic Potential?” Expert Review of Neurotherapeutics, vol. 19, no. 4, 20 Mar. 2019, pp. 289–291, 10.1080/14737175.2019.1593827. https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1593827
    44. Bureau, Michel H., and Richard W. Olsen. “Taurine Acts on a Subclass of GABAa Receptors in Mammalian Brain in Vitro.” European Journal of Pharmacology: Molecular Pharmacology, vol. 207, no. 1, May 1991, pp. 9–16, 10.1016/s0922-4106(05)80031-8. https://pubmed.ncbi.nlm.nih.gov/1655497/
    45. Kontro, P., and S. S. Oja. “Interactions of Taurine with GABAB Binding Sites in Mouse Brain.” Neuropharmacology, vol. 29, no. 3, 1990, pp. 243–247, 10.1016/0028-3908(90)90008-f; https://pubmed.ncbi.nlm.nih.gov/2158001/
    46. L’Amoreaux, William J, et al. “Pharmacological Characterization of GABAA Receptors in Taurine-Fed Mice.” Journal of Biomedical Science, vol. 17, no. Suppl 1, 24 Aug. 2010, p. S14, 10.1186/1423-0127-17-S1-S14; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994404/
    47. Molchanova, Svetlana M., et al. “Effect of Taurine on the Concentrations of Glutamate, GABA, Glutamine and Alanine in the Rat Striatum and Hippocampus.” Proceedings of the Western Pharmacology Society, vol. 50, 2007, pp. 95–97. https://pubmed.ncbi.nlm.nih.gov/18605241/
    48. Shell, W. et al. Apr. 2010. “A Randomized, Placebo-Controlled Trial of An Amino Acid Preparation on Timing and Quality of Sleep.” American Journal of Therapeutics vol. 17,2; 133-9; https://pubmed.ncbi.nlm.nih.gov/19417589/
    49. Yoto, A. et al. Sep. 2012. “Oral Intake of γ-Aminobutyric Acid Affects Mood and Activities of Central Nervous System During Stressed Condition Induced by Mental Tasks.” Amino Acids vol. 43,3; 1331-7; https://pubmed.ncbi.nlm.nih.gov/22203366/
    50. Goldberg, JS. 2010. “Selected Gamma-Aminobutyric Acid (GABA) Esters may Provide Analgesia for Some Central Pain Conditions.” Perspectives in Medicinal Chemistry vol. 4; 23-31; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918363/
    51. Zhang, Cheng Gao, and Sung-Jin Kim. “Taurine Induces Anti-Anxiety by Activating Strychnine-Sensitive Glycine Receptor in Vivo.” Annals of Nutrition & Metabolism, vol. 51, no. 4, 2007, pp. 379–386, 10.1159/000107687. https://pubmed.ncbi.nlm.nih.gov/17728537/
    52. Wu, Gao-Feng, et al. “Antidepressant Effect of Taurine in Chronic Unpredictable Mild Stress-Induced Depressive Rats.” Scientific Reports, vol. 7, no. 1, 10 July 2017, p. 4989, 10.1038/s41598-017-05051-3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504064/
    53. Sung, Min Jung, and Kyung Ja Chang. “Correlations between Dietary Taurine Intake and Life Stress in Korean College Students.” Advances in Experimental Medicine and Biology, vol. 643, 2009, pp. 423–428, 10.1007/978-0-387-75681-3_44. https://pubmed.ncbi.nlm.nih.gov/19239174/
    54. Bello M, Guadarrama-García C, Velasco-Silveyra LM, Farfán-García ED, Soriano-Ursúa MA. Several effects of boron are induced by uncoupling steroid hormones from their transporters in blood. Med Hypotheses. 2018 Sep;118:78-83. doi: 10.1016/j.mehy.2018.06.024; https://pubmed.ncbi.nlm.nih.gov/30037620/
    55. Naghii MR, Mofid M, Asgari AR, Hedayati M, Daneshpour MS. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. J Trace Elem Med Biol. 2011 Jan;25(1):54-8. doi: 10.1016/j.jtemb.2010.10.001; https://pubmed.ncbi.nlm.nih.gov/21129941/
    56. Frestedt JL, Kuskowski MA, Zenk JL; “A natural seaweed derived mineral supplement (Aquamin F) for knee osteoarthritis: a randomised, placebo controlled pilot study”; Nutr J. 2009; 8:7; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642861/
    57. Brennan O. et al; “Incorporation of the natural marine multi-mineral dietary supplement Aquamin enhances osteogenesis and improves the mechanical properties of a collagen-based bone graft substitute”; J Mech Behav Biomed Mater. 2015 Jul; 47:114-123; https://www.ncbi.nlm.nih.gov/pubmed/25884141
    58. Gaby, A. R. “Natural Treatments for Osteoarthritis.” Alternative Medicine Review: A Journal of Clinical Therapeutic, vol. 4, no. 5, 1 Oct. 1999, pp. 330–341; https://pubmed.ncbi.nlm.nih.gov/10559548/
    59. Cinar V, Baltaci AK, Mogulkoc R, Kilic M. Testosterone levels in athletes at rest and exhaustion: effects of calcium supplementation. Biol Trace Elem Res. 2009 Summer;129(1-3):65-9. doi: 10.1007/s12011-008-8294-5; https://link.springer.com/article/10.1007/s12011-008-8294-5
    60. Cinar V, Mogulkoc R, Baltaci AK. Calcium supplementation and 4-week exercise on blood parameters of athletes at rest and exhaustion. Biol Trace Elem Res. 2010 May;134(2):130-5. doi: 10.1007/s12011-009-8459-x; https://link.springer.com/article/10.1007/s12011-009-8459-x
    61. Wilkinson, D J, et al; “Ammonia Metabolism, the Brain and Fatigue; Revisiting the Link.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; July 2010; https://www.ncbi.nlm.nih.gov/pubmed/20138956
    62. McDaniel, John et al; “Hyperammonemia results in reduced muscle function independent of muscle mass”; American journal of physiology: Gastrointestinal and liver physiology; vol. 310,3; 2015; G163-70; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971815/
    63. Sugino, T, et al; “L-Ornithine Supplementation Attenuates Physical Fatigue in Healthy Volunteers by Modulating Lipid and Amino Acid Metabolism.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Nov. 2008; https://www.ncbi.nlm.nih.gov/pubmed/19083482
    64. Sugino, Tomohiro, et al. “L-Ornithine Supplementation Attenuates Physical Fatigue in Healthy Volunteers by Modulating Lipid and Amino Acid Metabolism.” Nutrition Research, vol. 28, no. 11, Nov. 2008, pp. 738–743, 10.1016/j.nutres.2008.08.008; https://pubmed.ncbi.nlm.nih.gov/19083482/
    65. Chen, Shu, et al. “Involvement of Ammonia Metabolism in the Improvement of Endurance Performance by Tea Catechins in Mice.” Scientific Reports, vol. 10, no. 1, 8 Apr. 2020, 10.1038/s41598-020-63139-9; https://www.nature.com/articles/s41598-020-63139-9
    66. Marini, Juan C. “Arginine and Ornithine Are the Main Precursors for Citrulline Synthesis in Mice.” The Journal of Nutrition, vol. 142, no. 3, 8 Feb. 2012, pp. 572–580, 10.3945/jn.111.153825; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278269/
    67. Iravani, S. et al. June 2011. “Pharmaceutical and Nutraceutical Effects of Pinus Pinaster Bark Extract.” Research in Pharmaceutical Sciences vol. 6,1; 1-11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203267/
    68. Li, Y. et al. Apr. 2015. “Pine Bark Extracts: Nutraceutical, Pharmacological, and Toxicological Evaluation.” The Journal of Pharmacology and Experimental Therapeutics vol. 353,1; 9–16. https://pubmed.ncbi.nlm.nih.gov/25597308/
    69. Kiela, Pawel R., and Fayez K. Ghishan. “Physiology of Intestinal Absorption and Secretion.” Best Practice & Research Clinical Gastroenterology, vol. 30, no. 2, Apr. 2016, pp. 145–159, 10.1016/j.bpg.2016.02.007; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956471
    70. Cooper, Geoffrey M. “Endocytosis.” Nih.gov, Sinauer Associates, 2014. https://www.ncbi.nlm.nih.gov/books/NBK9831/
    71. AstraGin® product dossier, sections 6.4 – 6.17; https://docdro.id/rA01t9O
    72. Lee, Shih-Yu, et al. “Astragaloside II Promotes Intestinal Epithelial Repair by Enhancing L-Arginine Uptake and Activating the MTOR Pathway.” Scientific Reports, vol. 7, no. 1, 26 Sept. 2017, p. 12302, 10.1038/s41598-017-12435-y. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614914/
    73. AstraGin® product dossier, section 6.9; https://docdro.id/rA01t9O
    74. AstraGin® product dossier, sections 6.10; https://docdro.id/rA01t9O
    75. AstraGin® product dossier, section 6.11 – 6.12; https://docdro.id/rA01t9O
    76. AstraGin® product dossier, sections 6.13; https://docdro.id/rA01t9O

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