Modere Magnesium Blend: Three Forms of Magnesium for Enhanced Recovery and Mood

Following Modere’s groundbreaking success with Curb in late 2024, the company continues to innovate in 2025 with the new Modere Magnesium Blend, a comprehensive mineral supplement that takes a sophisticated approach to magnesium supplementation.

Modere introduces new Magnesium Blend with three bioavailable forms of magnesium plus B6, vitamin C, and zinc in a refreshing citrus powder for enhanced absorption and muscle support.

Modere Magnesium: Three Bioavailable Forms of Magnesium and More

This isn’t your ordinary magnesium – it combines three highly-bioavailable forms of the essential mineral with synergistic vitamins and minerals designed to enhance absorption and effectiveness. It comes in a powder form, initially launching in a light and refreshing naturally-flavored, naturally-sweetened citrus flavor.

As we recently covered in our article titled “Meet Modere: How New Leadership is Revolutionizing Clean Health Innovation“, CEO Nate Frazier and his team are committed to developing science-backed supplements that support human biology for maximum performance. This new Magnesium Blend exemplifies this mission, delivering 300mg of total magnesium from three complementary sources – magnesium bisglycinate, magnesium malate, and magnesium lysine glycinate – alongside vitamin B6, vitamin C, and zinc for enhanced benefits.

Magnesium has a tremendous number of benefits, which are covered in this article, but Modere’s also reminding athletes that it’s great for muscle soreness and recovery.

Sign up for our Modere news alerts to learn about their upcoming innovations, and keep reading to learn why this may be one of the most complete magnesium supplements we’ve seen:

Modere Magnesium Blend: Key Points

Modere Magnesium Blend delivers several innovative features that help it stand out in the crowded magnesium market:

• Triple-Source Magnesium: 300mg total magnesium from three highly-bioavailable forms: magnesium bisglycinate, magnesium malate, and magnesium lysine glycinate, providing broad-spectrum coverage for different biological needs.
• Enhanced with Synergistic Nutrients: Contains an intelligent blend of vitamin B6 (1.7mg), vitamin C (90mg), and zinc (5.5mg) that work together to support magnesium’s effectiveness and provide additional benefits.
• Comprehensive Benefits: Formulated to support multiple aspects of health including:
  • Muscle recovery and relaxation
  • Mood and cognitive function
  • Cardiovascular health
  • Bone strength
  • Exercise performance
• User-Friendly Format: Comes as a sugar-free drink mix that’s:
  • Easy to mix and consume
  • Light and refreshing citrus flavor
  • Vegetarian/vegan friendly
  • Free from dairy and artificial sweeteners

Let’s examine magnesium’s main benefits in detail below:

The Benefits of Magnesium Supplementation

Magnesium is an essential mineral that plays a critical role in over 300 enzymatic reactions in the human body.^[1] Before exploring Modere’s innovative triple-magnesium formula, it’s important to understand why this mineral is so crucial for health and performance. Let’s examine the key benefits that make magnesium supplementation worth considering:

• Energy production and exercise performance benefits

  At its core, magnesium is fundamental to energy production in every cell of your body. It serves as a critical cofactor in forming and utilizing ATP (adenosine triphosphate),^[2] the primary energy currency of our cells. Without adequate magnesium, your body’s ability to produce and use energy becomes compromised.

  

  Research has shown that athletes and physically active individuals may have increased magnesium requirements, as the mineral is lost through sweat and utilized at a higher rate during exercise.^[3] Studies indicate that maintaining optimal magnesium levels can enhance various aspects of exercise performance:

  • Improved glucose availability in muscles during exercise^[1]
  • Enhanced oxygen utilization and energy efficiency^[3]
  • Reduced lactate accumulation during high-intensity activities^[4]
  • Better endurance performance and reduced fatigue^[1]

  Most notably, research has demonstrated that magnesium supplementation can support exercise performance in both strength and endurance activities. One study found that magnesium supplementation improved power output and muscle strength in athletes compared to a placebo group.^[3] Another investigation showed that maintaining adequate magnesium levels helped reduce exercise-induced oxidative stress and inflammation.^[4]

  For athletes and active individuals, ensuring optimal magnesium status isn’t just about preventing deficiency – it’s about supporting peak performance and recovery. The research suggests that requirements may be 10-20% higher in physically active individuals compared to sedentary people.^[1]

• Muscle function, recovery, and relaxation research

  Magnesium’s role in muscle function extends far beyond its contributions to energy production. The mineral is essential for proper muscle contraction and relaxation through its critical role in regulating calcium transport and intracellular signaling.^[2]

  

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  At the cellular level, magnesium acts as a natural calcium channel blocker, helping to modulate the calcium influx that controls muscle contractions. This regulation is crucial not only for normal muscle function but also for preventing excessive muscle tension and promoting proper recovery.^[3]

  Recent research has revealed several key mechanisms through which magnesium supports muscle health and recovery:

  The mineral plays a vital role in preventing excessive muscle damage during intense exercise. A 2019 study involving professional cyclists found that those supplementing with magnesium showed significantly improved muscle function and lower levels of muscle damage markers compared to a control group.^[3] This protective effect was particularly notable during prolonged, intense exercise periods.

  Moreover, adequate magnesium status appears to support faster muscle recovery after strenuous activity. Research indicates that magnesium supplementation can help reduce post-exercise muscle soreness and accelerate the recovery process.^[4] This benefit is especially relevant for athletes and active individuals who engage in regular training.

  Maintaining optimal magnesium levels can also help reduce muscle tension and support proper muscle relaxation. This may be especially beneficial for individuals experiencing exercise-related muscle tension or those looking to support overall muscle comfort.

  

  The average amount of calcium, magnesium, and iron in vegetables like spinach, lettuce, cabbage, and tomatoes has plummeted as much as 80–90% since 1914.^[5] Sadly we have to supplement it back in.

  Notably, the relationship between magnesium and muscle function appears to be dose-dependent, with research indicating that physically active individuals may require higher intake levels to maintain optimal muscle function and recovery.^[1] This understanding has important implications for supplement dosing strategies, particularly for those engaged in regular physical activity.

• Cardiovascular support

  Magnesium plays a vital role in maintaining cardiovascular health through multiple pathways. Most fundamentally, magnesium helps regulate blood pressure by acting as a natural calcium channel blocker and supporting proper blood vessel function.^[2,6]

  Research has consistently shown that adequate magnesium intake helps support healthy blood pressure levels. The mineral promotes vasodilation – the widening of blood vessels – which helps maintain healthy blood flow and circulation.^[7]

  

  Related to vasodilation, studies have also demonstrated magnesium’s role in supporting endothelial function – the health of the blood vessel lining. Proper endothelial function is essential for cardiovascular health, as it helps regulate blood flow and prevents unwanted clotting.^[7]

  Beyond blood pressure regulation, magnesium is crucial for maintaining normal heart rhythm. It works alongside other electrolytes like potassium and calcium to support proper electrical conduction in the heart.^[2] This is why magnesium status is important for maintaining normal cardiac function.

  Athletes and active individuals should pay particular attention to their magnesium status, as intense exercise can temporarily increase cardiovascular demands. Research has shown that maintaining optimal magnesium levels can help support normal cardiovascular function during and after exercise.^[3]

• Bone strength

  Magnesium’s role in bone health extends beyond its commonly known partnership with calcium. The mineral is essential for bone mineralization, density, and remodeling processes.^[2]

  Studies have found that adequate magnesium intake directly correlates with higher bone mineral density. This relationship is particularly important for athletes and active individuals, as intense training can increase demands on skeletal structure.

  Magnesium helps activate vitamin D, which is crucial for calcium absorption and bone mineralization. Without sufficient magnesium, vitamin D may remain inactive, potentially compromising bone strength regardless of calcium intake.^[2]

  

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  Research indicates that maintaining optimal magnesium levels helps prevent bone loss and supports healthy bone formation, particularly in physically active populations where skeletal stress is common.^[1]

• Mood, brain/cognitive function, and sleep

  Magnesium is increasingly recognized for its critical role in brain health and mood regulation. Recent research has uncovered that the mineral helps regulate neurotransmitter function and supports healthy brain activity.^[8]

  The mineral serves as a natural NMDA receptor antagonist, helping to modulate glutamate activity in the brain. This function is important for maintaining healthy cognitive function and supporting a balanced mood.^[2]

  Clinical studies have shown promising results regarding magnesium’s effects on mood. Research indicates that maintaining adequate magnesium levels can help support emotional well-being, particularly during periods of increased stress or physical demands.^[8]

  For athletes and active individuals, magnesium’s cognitive benefits are especially relevant. The mineral helps support mental clarity and focus during exercise, while also playing a role in stress management and recovery.^[1]

  Additionally, magnesium helps regulate sleep patterns,^[9,10] which is crucial for both cognitive function and mood stability. Research suggests that optimal magnesium status can support healthy sleep quality, contributing to better overall mental well-being.^[2]

These benefits only scratch the surface — since magnesium’s involved in over 300 biochemical reactions, it’s one of the most important minerals to get (if not the most important) — yet our diets don’t have enough due to depletion in our agriculture.^[5] This is why supplementation is so important.

Modere Magnesium Blend Ingredients

• Three Forms of Magnesium (300mg total)

  

  • Magnesium Bisglycinate

    Magnesium bisglycinate (also known as magnesium glycinate) represents one of the most bioavailable forms of magnesium supplementation. In this form, magnesium is bound to two molecules of glycine, an amino acid that helps facilitate absorption in the intestinal tract.^[11]

    Research has demonstrated that magnesium bisglycinate has superior absorption compared to other forms like magnesium oxide. This enhanced bioavailability is attributed to two key factors:^[11]

    1. The amino acid glycine helps protect the magnesium from binding to other substances in the digestive tract that could inhibit absorption
    2. The compound can be absorbed intact through amino acid transporters in the intestinal wall, providing an additional absorption pathway beyond typical mineral transport channels

    As an amino acid, glycine is easily absorbed — and that brings the magnesium along with it!

  • Magnesium Malate

    Magnesium malate combines magnesium with malic acid, a naturally occurring substance found in fruits like apples. The malate form offers unique benefits due to malic acid’s role in energy production within cells.^[12]

    

    While research on magnesium malate specifically has been more limited compared to other forms, the malic acid component may provide additional benefits. Malic acid is an important component of the citric acid cycle (Krebs cycle), which is essential for cellular energy production.^[12]

    The combination of these two magnesium forms in Modere’s blend provides complementary benefits – the high bioavailability of the bisglycinate form paired with the potential cellular energy support from the malate form. This strategic combination helps optimize both absorption and utilization of this essential mineral.

  • Magnesium Lysine Glycinate

    Magnesium lysine glycinate represents a novel form that combines magnesium with both glycine and lysine amino acids. This mixed amino acid chelate is designed to potentially enhance absorption and bioavailability, although research specifically on this form is currently limited.

    In theory, the addition of lysine to the chelation process may provide supplemental pathways for absorption, since amino acids can help facilitate mineral transport across the intestinal wall. However, while the benefits of glycine chelation are well-documented, more research is needed to definitively demonstrate any additional advantages of including lysine in the chelate structure.

  

  Magnesium glycinate (black) greatly outperforms magnesium oxide (white).^[11]

  This innovative form is included in Modere’s triple-magnesium blend alongside the well-researched bisglycinate and malate forms, representing a comprehensive approach to magnesium supplementation.

• Vitamin B6 – 1.7mg (100% DV) – Synergistic Support for Magnesium

  Vitamin B6 plays several important roles alongside magnesium in this formula, potentially enhancing its overall effectiveness. As a cofactor in over 100 enzymatic reactions, vitamin B6 is involved in numerous biological processes including neurotransmitter synthesis and amino acid metabolism.^[13]

  Research suggests that vitamin B6 may work synergistically with magnesium in a few key ways:

  • Enhanced Magnesium Status: Studies indicate that vitamin B6 supplementation may help increase both blood and intracellular magnesium concentrations.^[14]
  • Stress Response: When combined with magnesium, vitamin B6 appears to provide greater improvements in stress reduction compared to magnesium alone, particularly in severely stressed individuals.^[13]

  

  • Mood Support: The combination of magnesium with vitamin B6 shows promise for supporting emotional well-being and quality of life measures beyond what magnesium achieves independently.^[13]

  The 1.7mg dose of vitamin B6 in this formula appears modest compared to some research doses, however it’s provided in an optimal ratio with magnesium that has demonstrated benefits in clinical research. Studies suggest this specific combination may enhance the absorption and cellular uptake of magnesium while providing complementary neurological support.^[13,14]

• Vitamin C – 90mg (100% DV)

  Vitamin C is added to this formula not just as a complementary antioxidant, but as a key synergistic ingredient that works alongside magnesium to support recovery and overall health. The 90mg dose represents 100% of the recommended daily value.

  Vitamin C’s primary mechanisms in this formula include:

  • Antioxidant properties: During exercise, the body produces increased amounts of reactive oxygen species (ROS) and free radicals.^[15,16] Vitamin C acts as a powerful antioxidant that can help neutralize these exercise-induced free radicals, potentially reducing oxidative stress and supporting better recovery.^[17,18]
  • Exercise recovery benefits: Low levels of Vitamin C are associated with reduced performance.^[19] Research has shown that vitamin C supplementation may help reduce exercise-induced oxidative stress markers and support faster recovery times after intense training.^[17,18] This is particularly relevant for athletes and active individuals who place higher demands on their bodies.

  When combined with magnesium, vitamin C may provide additional synergistic benefits. Preclinical studies have shown magnesium and vitamin C working together to reduce oxidative stress markers, but more research is needed on the combination in humans.

• Zinc (as Zinc Citrate) – 5.5mg (50% DV)

  

  While this formula focuses primarily on magnesium, Modere has intelligently included a complementary dose of zinc – an essential mineral that works synergistically with magnesium to support several key biological processes.^[20]

  The 5.5mg dose is modest compared to standalone zinc supplements, but that’s by design – this amount is meant to complement the formula’s magnesium content rather than provide a full daily dose of zinc. This strategy makes sense given zinc and magnesium’s overlapping roles in:

  • Immune System Support

    Zinc plays a critical role in both innate and adaptive immunity by supporting the proper functioning of natural killer cells, neutrophils, and macrophages.^[21] This immune-supporting role complements magnesium’s anti-inflammatory properties, potentially providing enhanced protection against everyday immune challenges.

  • Hormone Optimization

    Research has shown that maintaining adequate zinc status helps support healthy testosterone levels and overall hormonal balance.^[22-25] When paired with magnesium, which also plays a role in hormone production and regulation, this combination may provide enhanced endocrine support.

  • Antioxidant Properties

    Both zinc and magnesium possess antioxidant properties that can help protect cells from oxidative stress.^[26,27] The combination of these minerals may provide enhanced protection against exercise-induced oxidative stress, supporting faster recovery and better overall health.

  

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  By including this strategic dose of zinc alongside the primary magnesium complex, Modere has created a more comprehensive mineral formula that may provide enhanced benefits compared to magnesium alone. This type of thoughtful formulation shows Modere’s commitment to evidence-based supplement design that considers both the primary ingredients and their supporting nutrients.

Dosage and Timing

Mix one scoop of Modere Magnesium Blend powder with ~10 ounces of cold water. The powder format allows for easier absorption compared to capsules or tablets, while the refreshing citrus flavor makes daily supplementation more enjoyable. Since magnesium can be depleted through sweat during exercise, athletes may consider splitting their daily serving into two half-doses.

When to Take It

Research suggests that magnesium supplementation timing can impact its effectiveness, particularly for athletic performance and recovery. For optimal results:

• General use: Take one serving in the evening, as magnesium may support relaxation and sleep quality.
• Exercise recovery: Consider taking a serving about 2 hours before training or post-workout to support muscle function and recovery.
• Multiple doses: If taking more than one serving daily, space them at least 4 hours apart to maximize absorption.

The 300mg dose is well-tolerated by most individuals while providing meaningful benefits. If you’re new to magnesium supplementation, start with half a serving to assess tolerance, then gradually increase to the full dose.

Conclusion: A Muscle-Friendly Magnesium Supplement

Modere Magnesium Blend represents another thoughtful innovation from the company that brought us Curb – and serves as further evidence of the forward-thinking direction discussed in our Meet Modere article about Nate Frazier, Jen Anderson, and the new leadership team at the company. This isn’t just another magnesium supplement – it’s a comprehensive mineral formula that takes direct aim at modern deficiency concerns while supporting athletic performance and recovery.

The triple-source magnesium approach (bisglycinate, malate, and lysine glycinate) demonstrates Modere’s commitment to bioavailability and effectiveness. By combining these highly-absorbable forms with synergistic nutrients like vitamin B6, vitamin C, and zinc, they’ve created a formula that addresses multiple aspects of health and performance.

And how can you not love a light, natural citrus flavor? No need to take 6+ capsules to get the equivalent amount of magnesium glycinate!

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To us, magnesium is one of the few no-matter-what type supplements. We simply don’t get enough in our food (or water) anymore. This formula is especially valuable for:

• Athletes seeking enhanced recovery and performance support
• Active individuals concerned about magnesium loss through sweat
• Anyone looking to support sleep quality and stress management
• Those wanting to maintain healthy magnesium levels in an increasingly depleted food supply

While the market is flooded with basic magnesium supplements, Modere has delivered a product that raises the bar through evidence-based formulation and quality ingredients. Whether you’re an athlete looking to optimize recovery or simply someone seeking to maintain healthy magnesium levels, Modere Magnesium Blend offers a premium solution backed by science.