MAXIMUS: Testosterone Enhancement with Dr. Cameron Sepah | PPP #062

Published on February 7, 2022 by Mike Roberto | 1 Comment

https://blog.priceplow.com/podcast/dr-cameron-sepah-maximus-062

On February 2, 2022, we hosted Dr. Cameron Sepah of Maximus on the PricePlow Podcast to talk about male hormones and self improvement. This was an incredible episode covering a wide variety of health-based topics, and everyone is sure to come away with some new knowledge.

Meet Dr. Cameron Sepah

Dr. Cameron Sepah Maximus PricePlow Podcast

Meet Dr. Cameron Sepah, founder of Maximus, whose here to help you boost testosterone in a clinically-meaningful way without TRT. Prepare to learn a ton about enclomiphene in this episode!

Cam, as we call him, competed as a track athlete. is a clinical psychologist, with a fellowship training in behavioral medicine, working at the intersection of psychology and medicine. He competed as a collegiate track athlete, racing in mid-distance to distance events. After his academic training (specializing in psychoneuroendocrinology amongst other fields) and publishing of several papers,[1] he created Omada Health, an online weight loss program. All in all, he’s a clinician-scientist who’s treated people for over a decade. In addition, he’s an assistant clinical professor of psychiatry at the UCSF School of Medicine.

Maximus: Mind, Body, and Masculinity

Cam recently founded Maximus, a consumer telemedicine company for men’s health and hormone optimization. Using at-home blood testing and online coaching, Maximus has put together the King Protocol, which is a clinically-validated process to safely increase testosterone and vitality in men – even healthy and young men.

This is not testosterone replacement therapy — it’s testosterone restoration.

Prepare to learn about enclomiphene citrate

Jumping right to hormone optimization, Maximus utilizes enclomiphene citrate — the isomer from clomid that’s safer and more useful in men — to meaningfully boost testosterone levels anywhere from 1.5x to 2.5x. Combined with group health coaching for nutrition, exercise, sleep, and focus, alongside some adjunct supplements, Maximus is changing men’s lives at an astonishing rate.

The full show notes with timestamps are covered below – and we have a separate article detailing enclomiphene citrate.

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Our Discussion with Dr. Cameron Sepah of Maximus

  • 0:45 – Dr. Cam’s Introduction

  • 2:50 – A couple of Dr. Cam’s legendary Twitter threads:

  • 3:50 – Dr. Cam’s Background in medicine and psychiatry

    Became interested in the hormone side of health. Psychiatry took a very “neurotransmitter approach” – for instance, SSRIs are based on an “almost stupidly simplistic theory” of the monamine hypothesis, even though the research hasn’t fully supported that, and it’s more complicated than serotonin – it’s really a “bio-psycho-social phenomenon”. Hormones also influence brain function!

  • 4:45 – The problem: Human testosterone and sperm levels are tanking

    Testosterone levels have declined 50% over 50 years[2] and so have sperm counts.[3-6] The question is why?! This is a dramatic phenomenon – it’s happened over a couple of generations, alongside the obesity epidemic.

    Male Function Reporting

    Due to an onslaught of endocrine-disruptions, men’s hormonal systems aren’t working like they used to. Maximus has a three-pronged solution called the KING Protocol. Image courtesy Maximus.

  • 5:45 – Body fat is one culprit… but not the only one

    Body fat — the extra belly fat in particular — has the aromatase enzyme in it, converting testosterone to estradiol. The more body fat you have, the less masculine and more feminine you become. But even adjusting for obesity and increased depression, testosterone and sperm are still going down! There’s something more than just obesity causing these issues.

  • 6:45 – Endocrine-disrupting chemicals

    Endocrine-disrupting chemicals are in everything – the water we drink (note from Mike: consider the famous atrazine frog study[8]), plastics on our foods that release microplastics, teflon non-stick pans and air fryers, plastic bottled water (they’ve gotten rid of BPA but not BPS), etc. These are xenoestrogens — they mimic estrogens in the body and disrupt the endocrine system.

  • 7:45 – It’s happening to dogs too!

    Sperm count is even going down in dogs[9] – they’re drinking the same water and eating the same processed food as us. That adds evidence that it’s environmental. Forbes: You’re not the man your father was.[10] He wasn’t eating 66%-84% of his food from processed food like we do.[11]

  • 9:20 – “We essentially have a hormonal handicap these days – and it’s the public health tragedy that no one’s talking about”

  • 9:45 – Mike: polyester clothing and synthetic fabrics are a vastly underrated endocrine disruptor

    Mike briefly also adds in the contributions from polyester clothing, something he’s been researching that looks extraordinarily devastating – especially if worn as underwear.[12-16] Digging into those studies, we’ll definitely need to cover this in greater detail later on.

  • 10:15 – ACTION Plan – Where do we begin?

    1. Maintaining a healthy level of body fat

      Linoleic Acid Consumption Bodyfat Obesity

      Increased Linoleic Acid Consumption… Increased Linoleic Acid bodyfat Composition[7]… increased obesity. We believe that this omega-6 fatty acid, coming mostly from industrialized processed seed oils, is the most major culprit in the obesity crisis.

      15% (slightly visible abs) is a good place to get to and achievable naturally. Don’t need to be single-digits. Remove as many ultra-processed foods as possible, don’t kill yourself over getting rid of 100% processed food though — read The Cure for Obesity and Diabetes Is Processed Food Parts 1, 2, and 3.[17-19]

      Ancestral processed food like yogurt and butter is fine – but a Cheeto is not. Be selective of processed foods, they should be the minority, not the majority.

    2. Reasonably avoid plastics

      Avoiding plastics doesn’t need to make you OCD. Drink filtered water, preferably from reverse osmosis filtration. Don’t keep stuff in plastics – try to use steel and glass to store your food. Cook in cast iron, not teflon pans.

    3. Fight fire with fire

      You can do things pharmacologically to combat the chemical onslaught we face to get your testosterone back to ancestral levels. This is where Maximus is heading, so hang in there…

  • 14:40 – The pareto principle – 20% of your efforts produce 80% of your results.

    This keeps us from being overly annoying. Reality is, eating out is terrible for you, so be picky.

  • 15:15 – DUMP THE PROCESSED SEED OILS / VEGETABLE OILS!

    Refined seed oils are huge contributors to inflammation and a lot of metabolic damage.[20-22] Request food be cooked in butter or olive oil if eating out (can mention allergies to soy and canola and such). Soybean oil, canola oil, and safflower oil are used everywhere — chemically refined, never used prior to 50 years ago.

    Trick: Go to McDonald’s and get the beef patties only, they’ll never be cooked in oil! But don’t forget to enjoy yourself on occasions – remember the pareto principle.

  • 18:00 – Note that age-related testosterone decline is not necessarily inevitable.

    Great athletes can keep their testosterone levels high through age, well into their 60s.

  • 20:00 – How do we “fight fire with fire”? Can supplements help? Not much…

    There are a million test boosters using evidence-based ingredients. Take ashwagandha, for instance — it can yield a 14.7% increase in testosterone.[23] “There’s a difference between statistical significance and clinically-meaningful results”. It’s a reliable effect, but it’s not a meaningful effect. Your amount of testosterone probably varies by that much on a daily basis. That’s basically the same as getting 8 hours of sleep instead of 7.

  • 22:00 – Going to need to go the pharmaceutical route

    “So supplements, while they have their purpose, for testosterone improvement, there’s no good evidence behind it. That’s why, if you want to boost testosterone, you have to go the prescription pharmaceutical route.”

    Maximus Testosterone Eligibility

    Unlike TRT, the Maximus KING Protocol can be used by a far greater subset of men, including healthy young ones.

  • 23:05 – Testosterone replacement therapy (TRT) and its major issues

    “The gold standard of treatment today has been testosterone replacement therapy, or TRT”. TRT does work – you inject more to top off levels. But the problem is the way that it works — exogenous testosterone tells your body that it doesn’t need to produce more of its own, and the testicles essentially shut down and shrink. It promotes infertility. Paper: “Testosterone Is a Contraceptive and Should Not Be Used in Men Who Desire Fertility”[24] Any guys under 50, or those who want to maintain fertility should not be on TRT.

  • 24:00 – Primary hypogonadism vs. secondary hypogonadism

    Primary hypogonadism is when the testicles do not work – due to injury, disease, or genetic issue. If that’s the case, then TRT is the first line of treatment. Reality: that’s only a small percentage of guys – akin to type-1 diabetics.

    Secondary hypogonadism is more akin to type-2 diabetes – it’s environmental. The signal between brain and testes has been dampened for the major factors discussed above. Don’t jump to injecting testosterone – that doesn’t seem clinically correct.

  • 26:20 – SERMs – Selective Estrogen Receptor Modulators

    Enclomiphene Mechanism of Action

    A superior SERM: The Enclomiphene Mechanism of Action

    SERMs started as anti-cancer drugs and are fertility drugs. SERMs selectively block the estrogen receptor – this causes the brain to want more, and to do that, it produces more testosterone by sending more LH (luteinizing hormone) and FSH (follicle stimulating hormone).

  • 28:50 – TRT vs SERMs

    On TRT, LH and FSH are completely shut down – can’t produce their own testosterone or sperm. On SERM, LH and FSH are twice as high. Testicles grow with it if dosed high enough.

    In addition, TRT is basically for life, and you have to run PCT to restart your own system if you want to get off of it. SERMs can be removed and testosterone just goes back down. SERMs have also been studied in healthy young men who don’t want to risk fertility loss. Minimal side effects when using the right SERMs – no worse than placebo.

    SERMs are far easier – just a pill. No creams or gels or injections with weird side effects (such as your gel rubbing off on a partner or kid).

  • 32:00 – What’s the gotcha? Why aren’t SERMs more popular?

    Zuclomiphene vs. Enclomiphene

    The problem with Clomid: The estrogenic zuclomiphene isomer lasts way too long. The solution? Remove it and use enclomiphene only!

    The problem is that the most popular SERM is clomid, or clomiphene citrate, which is actually two drugs that are stereoisomers of each other. Inside is zuclomiphene and enclomiphene. Clomid is 62% enclomiphene and 38% zuclomiphene.[25-28]

    Enclomiphene is most responsible for boosting testosterone, but zuclomiphene is an estrogen agonist – it mimics estrogen. While there’s less zuclomiphene in clomid, the zuclomiphene has a very long half-life – weeks[29-31] compared to about 10.5 hours for enclomiphene.[25,29,30]

    This leads to awful, estrogenic side effects over time in men.

  • 33:30 – The problem with Clomid: Enclomiphene vs. zuclomiphene

    So clomid causes a nice testosterone boost and feels great at first, but then zuclomiphene stays in the system for a long time, accumulating over time and wreaking havoc.

    So within months, you’re basically taking estrogen. Guys on clomid simply don’t feel good after a while – they’re more emotional, libido tanks, and they generally become more feminine.

  • 36:30 – The solution: Enclomiphene! Why not get rid of the isomer that’s causing all the side effects?!

    Enclomiphene Total Testosterone

    Enclomiphene and Total Testosterone

    A pharmaceutical company did just that, ran trials on enclomiphene, and didn’t see all of the clomid side effects.[25,26,32-38] It hasn’t been available until recently, and now Maximus uses it.

    Enclomiphene is the solution.

  • 37:50 – Dr. Cam’s personal experiences with both clomid and enclomiphene

    Cam took Clomid 10 years ago, testosterone went from say 500 to 750, up 1.5x but with too many side effects — not worth it. With enclomiphene, went from 450 to 900 – 2x gain, no side effects. This is consistent with the research.

  • 39:00 – SERM mechanism and SERMs vs aromatase inhibitors

    Be careful with aggressive aromatase inhibitors that block all estrogen, which is a bit too crude. Generally not taken standalone – estradiol gets cut in half and you don’t want it too low either. SERMs are more selective. They increase testosterone and estradiol, but the estradiol won’t bind because the estrogen receptors are blocked.

  • 40:45 – Enclomiphene side effects?

    Enclomiphene Free Testosterone

    Enclomiphene and Free Testosterone

    Gynecomastia? Actually it’s used to combat gyno.

    Hair loss? SERMs also don’t increase DHT levels proportional to testosterone — DHT is the “aggressive hormone” that’s blamed on hair loss. Dr. Cam notes that taking finasteride (a popular DHT blocker) is not good for sex drive, for some it’s permanent loss.

    DHT is important for competitiveness and virility – probably not a great idea to block systemically. Don’t want it too low, don’t want it too high either though. TRT causes high DHT levels in proportion[39-43] and enclomiphene keeps the proportion steady.[36]

    Because of the research and its stable ratios, enclomiphene is much more “hair-safe” because it’s not jacking up DHT levels disproportionately.

  • 45:00 – Maximus uses 3rd party, at-home blood tests

    Collects blood just before beginning medication – so that there’s a clean baseline. “We treat symptoms, not numbers” – this is different from TRT. They retest after 30 days.

  • 47:55 – Is this for getting huge and jacked?

    Enclomiphene Lean Mass Gains

    Enclomiphene Lean Mass Gains

    This is not better than testosterone for elite bodybuilders because it won’t take you to supraphysiological levels. Your testosterone isn’t going to 3000-5000 range like bodybuilders see.

    The improvement range is usually 1.5x to 2x improvement.

  • 49:00 – Will naturally high-T individuals get any benefits?

    To answer Ben’s question from 44:00 (“Can someone with already-high testosterone still double their levels?”), the answer is often the opposite of what many expect — higher-T users get greater effects than those with low-T or those trying to recover from TRT. They’ll go from ~200,300 to ~400,500.

    The healthier you are to start with, the better your mind-body connection is, the better your testicles produce more testosterone. But it matters how you feel more than actual numbers.

  • 50:00 – Testimonials

  • 50:40 – Total Testosterone vs. Free Testosterone, and Reference Ranges

    First, don’t compare to average men – compare to healthy men. They don’t look at age references as much as healthy references.

    Free testosterone is not bound to proteins like albumin or SHBG (sex hormone binding globulin). The human body is intelligent and balances itself properly. But for some individuals, there’s less free testosterone out there to bind to new sites. When SHBG is high, total testosterone goes high, but there’s still not much free testosterone.

    Enclomiphene Before and After

    One way to increase free testosterone is with boron,[44] but we’re not sure if that works in the long-term. Maximus advisor Dr. Eugene Shippen says that you shouldn’t mess with SHBG – it’s genetic, and you’re used to what you have. So try to focus on free testosterone.

  • 55:00 – Enclomiphene dosage for starters?

    Since Maximus ships enclomiphene with the original blood test, it means they’re providing the drug before knowing your scores — so what dose do they start with?

    The answer is 6.25 milligrams, which is the smallest dose generally tested in the research.[25,26,32-38] You don’t need much – and can always go up (and in a few cases, down to 3.125 milligrams). Later on, Cam mentions that they have 8 different dosages they can prescribe.

    While 12.5 milligrams was generally the best dose in research, that was in subjects with hypogonadism — not the generally healthy Maximus Tribe member! In addition, starting conservatively is the best way to approach medicine. Dr. Cam is on 6.25 himself.

  • 57:20 – Mike’s testosterone levels… high total testosterone, but low free testosterone!

    With a supplement, Mike got his total testosterone to go up from 681 to 791 (link to tests). However, free testosterone was only bumped from 63.5 to 66.1 – very low on the reference range! Didn’t test for SHBG, but it’s likely high.

  • 59:00 – Using better, more relevant reference ranges

    To help with Mike’s free testosterone levels, Cam references their preferred reference ranges with healthy 19-39 year old men, since the ones shown on blood tests are far too wide:

    Maximus Reference Ranges

    Maximus’ Reference Ranges

    Maximus' Testosterone Goals

    Maximus’ Testosterone Targets

    Although above average on total testosterone, Mike is indeed multiple standard deviations away from the bell curve in terms of free testosterone.

  • 1:00:00 – Muscle mass if improving free test?

    Using clomid as a proxy study, 12 weeks of clomid use led to 5 pounds of lean muscle mass gains.[45] So it’s possible Mike’s situation would lead to some worthy gains.

  • 1:01:00 – Ben’s blood work – lower SHBG, lower total test, higher free test, easier muscle gains

    This puts Ben at lower risk of diabetes, but he has more free testosterone and it’s easier for him to put on muscle than Mike.

  • 1:02:00 – Can TRT users transition to Maximus?

    Ben shares some experiences where he was on “huge!” doses of clomid and felt awful, but it was the effort to get “back on line”.

  • 1:05:00 – At-home blood tests and the future of telemedicine

    Dr. Cam explains the model and how it’s going to change everything. From the comfort and convenience of your own home, paired with at-home tests, you can have a virtual clinic nearly anywhere, run additional blood tests if necessary, and make changes on the fly. This is the future – no more generic prescribing.

  • 1:08:30 – Who do you talk to on the Maximus system?

    There’s always a board-certified licensed physician prescribing the medication.

  • 1:09:10 – Adding in supplements and discussing vitamin D

    Vitamins do have a purpose — covering for deficiencies. For example, boron, Vitamin D, zinc, etc. If these are low, then you’re in trouble no matter what.

    In a validation trial in Los Angeles, 66% of their users came in with sub-optimal Vitamin D! We generally like 10,000IU a day – this will get the overwhelming majority of people into the proper range. Multivitamins generally have a pittance of vitamin D.

    Maximus Tribe Wide

    Don’t forget your Hormone D

    Vitamin D and other fat soluble vitamins are actually hormones! Dr. Cam references a paper that calls it Hormone D![46]

    So make sure you don’t have deficiencies, especially in the fat-soluble vitamins that are involved in testosterone production. This includes A,D,E, and K — and Dr. Cam also adds in GG, for geranylgeraniol, which is part of a sidechain of Vitamin E that helps produce testosterone as well.

  • 1:16:52 – The KING Protocol – “Self-improvement should not be done alone”

    There are actually three parts to the Maximus program:

    1. The lab tests, enclomiphene prescription, and vitamins

      Maximus KING Protocol

      It’s not just about drugs – it’s about community and coaching too! See the Maximus KING Protocol

    2. Doctor consults and health coaching

      Eat, exercise, sleep, focus, and mindset coaching. Maximus preaches accountability.

    3. The community

      The company is called Maximus but the online community is called “Maximus Tribe”. “Self-improvement should not be done alone” – having other guys your age pushing you, you’re going to perform better. For instance, you can’t do high-intensity interval training correctly.

      So the users check in and track their streaks. They push each other in a positive way that guys enjoy. Ben mentions Tribe by Sebastian Junger.[47]

      The Maximus community on discord is at discord.maximustribe.com – provided as a public service for free.

      1:21:25 – We have a bigger mission out there – we’re trying to promote a positive, healthy masculinity and make guys do better. If I double everyone’s testosterone levels and they act like douchebags in the world, I haven’t done any good to the world.

      1:23:18 – Social is health. Loneliness is one of the best predictors of mortality.[48]

  • 1:25:00 – Live coaching on Maximus YouTube

    Radio show on Thursdays at 6:00pm PDT – Subscribe to the Maximus YouTube channel which is where it’s hosted.

  • 1:25:20 – Dr. Sepah teases his next supplement

    It’s magnesium acetyl taurate… stay tuned!

  • 1:26:46 – Dopamine Fasting and Focus

    Dr. Cameron Sepah

    Dr. Cameron Sepah pioneered Dopamine Fasting, a strategy both men and women should utilize!

    We don’t dig into it much this time, but the idea behind dopamine fasting is to take breaks from anything that gives dopamine hits (electronics, porn, shopping, emotional eating, gambling, etc) and focus on learning, relationships, creating, and health-promoting activities.[49] This is essentially a protocol to overcome the “addictiveness” of behavior addictions.

    College students quitting Facebook in 2017 yielded 13 more hours per day and much more creative productivity.[50] “A man distracted is a man defeated”

  • 1:28:25 – Future drugs coming – sexual enjoyment?!

    Dr. Cam explains that he has a sexual enjoyment drug on the way that’s more than just an ED drug — it actually improves enjoyability and sexual intimacy.

    Also there’s a hair and beard growth drug that’s not finasteride. This is a hormonal approach that can help with a thicker beard.

  • 1:30:20 – Getting off enclomiphene?

    The studies didn’t do discontinuation protocols, but the clinical experiences have been positive in this light. Some users get off of it for travel reasons and then get back on. This is like adding fuel to the fire, but then take the fuel away, the fire stays.

    Maximus offers a 90 day guarantee – if your levels don’t go up, they’ll refund you.

  • 1:34:25 – “Testosterone is like destiny”

    Exposure to intrauterine testosterone is very indicative of future status as testosterone. If your ring finger is longer than your pointer finger, then you’ve been exposed to a decent amount of testosterone.[51]

    “The amount of testosterone you’re exposed to in the womb, which shows up in how long your fingers are, basically predict your athletic performance… It actually made me sad — because no matter how hard you tried, how hard you train, it’s almost predestined. You won the genetic lottery in terms of your testosterone and if you didn’t, guess what – you get last place in the race and that’s the card that you’re dealt with.

    But literally for the first time in history, you have the ability to take control of your destiny. If you’re on the lower end of the testosterone spectrum, you don’t have to be anymore. You can literally go from being a low performer to a high performer.”

    — Dr. Cameron Sepah on the PricePlow Podcast

    • Watch the Maximus Introduction:

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About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public. Mike is currently experimenting with a low Vitamin A diet.

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References

  1. “S Cameron Sepah’s Research”; ResearchGate; https://www.researchgate.net/scientific-contributions/S-Cameron-Sepah-2046987906
  2. Travison, Thomas G., et al. “A Population-Level Decline in Serum Testosterone Levels in American Men.” The Journal of Clinical Endocrinology & Metabolism, vol. 92, no. 1, 1 Jan. 2007, pp. 196–202, 10.1210/jc.2006-1375; https://pubmed.ncbi.nlm.nih.gov/17062768/
  3. Carlsen, E., et al. “Evidence for Decreasing Quality of Semen during Past 50 Years.” BMJ : British Medical Journal, vol. 305, no. 6854, 12 Sept. 1992, pp. 609–613; https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1393072/
  4. Swan, S. H., et al. “The Question of Declining Sperm Density Revisited: An Analysis of 101 Studies Published 1934-1996.” Environmental Health Perspectives, vol. 108, no. 10, 1 Oct. 2000, p. 961, 10.1289/ehp.00108961; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240129/
  5. Skakkebaek, Niels E., et al. “Is Human Fecundity Declining?” International Journal of Andrology, vol. 29, no. 1, Feb. 2006, pp. 2–11, 10.1111/j.1365-2605.2005.00573.x; https://pubmed.ncbi.nlm.nih.gov/16466518/
  6. Rolland, M., et al. “Decline in Semen Concentration and Morphology in a Sample of 26 609 Men close to General Population between 1989 and 2005 in France.” Human Reproduction (Oxford, England), vol. 28, no. 2, 1 Feb. 2013, p. 462, 10.1093/humrep/des415; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042534/
  7. Guyenet, Stephan J, and Susan E Carlson. “Increase in adipose tissue linoleic acid of US adults in the last half century.” Advances in nutrition (Bethesda, Md.) vol. 6,6 660-4. 13 Nov. 2015, doi:10.3945/an.115.009944; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642429/
  8. Hayes, T. B., et al. “Atrazine Induces Complete Feminization and Chemical Castration in Male African Clawed Frogs (Xenopus Laevis).” Proceedings of the National Academy of Sciences, vol. 107, no. 10, 1 Mar. 2010, pp. 4612–4617, 10.1073/pnas.0909519107; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842049/
  9. Lea, Richard G., et al. “Environmental Chemicals Impact Dog Semen Quality in Vitro and May Be Associated with a Temporal Decline in Sperm Motility and Increased Cryptorchidism.” Scientific Reports, vol. 6, no. 1, 9 Aug. 2016, 10.1038/srep31281; https://www.nature.com/articles/srep31281
  10. Howe, Neil. “You’re Not the Man Your Father Was.” Forbes; October 2, 2017; https://www.forbes.com/sites/neilhowe/2017/10/02/youre-not-the-man-your-father-was/
  11. Eicher-Miller, Heather, et al. “Processed Food Contributions to Energy and Nutrient Intake Differ among US Children by Race/Ethnicity.” Nutrients, vol. 7, no. 12, 2 Dec. 2015, pp. 10076–10088, 10.3390/nu7125503; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690055/
  12. Shafik, A., et al. “Effect of Different Types of Textile Fabric on Spermatogenesis: Electrostatic Potentials Generated on the Surface of the Human Scrotum by Wearing Different Types of Fabric.” Archives of Andrology, vol. 29, no. 2, Jan. 1992, pp. 147–150, 10.3109/01485019208987718; https://www.tandfonline.com/doi/abs/10.3109/01485019208987718
  13. Shafik, A. “Effect of Different Types of Textiles on Male Sexual Activity.” Archives of Andrology, vol. 37, no. 2, Jan. 1996, pp. 111–115, 10.3109/01485019608988511; https://pubmed.ncbi.nlm.nih.gov/8886260/
  14. Shafik, Ahmed. “Effect of Different Types of Textiles on Sexual Activity.” European Urology, vol. 24, no. 3, 1993, pp. 375–380, 10.1159/000474332; http://europepmc.org/article/MED/8262106
  15. Shafik, Ahmed. “Contraceptive Efficacy of Polyester-Induced Azoospermia in Normal Men.” Contraception, vol. 45, no. 5, May 1992, pp. 439–451, 10.1016/0010-7824(92)90157-o; https://pubmed.ncbi.nlm.nih.gov/1623716/
  16. Shafik, A., et al. “Effect of Different Types of Textile Fabric on Spermatogenesis I. Electrostatic Potentials Generated on Surface of Human Scrotum by Wearing Different Types of Fabric.” Andrologia, vol. 24, no. 3, 24 Apr. 2009, pp. 145–147, 10.1111/j.1439-0272.1992.tb02628.x; https://pubmed.ncbi.nlm.nih.gov/1503251/
  17. Sepah, Cameron; “The Cure for Obesity and Diabetes Is Processed Food (Part 1): When the Poison Is the Antidote”; September 21, 2017; https://www.linkedin.com/pulse/cure-obesity-processed-food-when-poison-antidote-part-sepah/
  18. Sepah, Cameron; “The Cure for Obesity and Diabetes Is Processed Food (Part 2): Incentives, Influence, and Innovation”; November 10, 2017; https://www.linkedin.com/pulse/cure-obesity-processed-food-part-2-incentives-influence-sepah/
  19. Sepah, Cameron; “The Cure for Obesity and Diabetes Is Processed Food (Part 3): How Nutrifoods can Actualize Health”; December 5, 2017; https://www.linkedin.com/pulse/cure-obesity-diabetes-processed-food-part-3-how-nutrifoods-sepah/
  20. Hennig, Bernhard, et al. “High-Energy Diets, Fatty Acids and Endothelial Cell Function: Implications for Atherosclerosis.” Journal of the American College of Nutrition, vol. 20, no. 2, Apr. 2001, pp. 97–105, 10.1080/07315724.2001.10719021; https://pubmed.ncbi.nlm.nih.gov/11349944/
  21. DiNicolantonio, James J, and James H O’Keefe. “Importance of Maintaining a Low Omega–6/Omega–3 Ratio for Reducing Inflammation.” Open Heart, vol. 5, no. 2, Nov. 2018, p. e000946, 10.1136/openhrt-2018-000946; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269634/
  22. Patterson, E., et al. “Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids.” Journal of Nutrition and Metabolism, vol. 2012, 2012, pp. 1–16, 10.1155/2012/539426; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335257/
  23. Lopresti, Adrian L., et al. “A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania Somnifera) in Aging, Overweight Males.” American Journal of Men’s Health, vol. 13, no. 2, Mar. 2019, p. 155798831983598, 10.1177/1557988319835985. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438434/
  24. Patel, Amir Shahreza, et al. “Testosterone Is a Contraceptive and Should Not Be Used in Men Who Desire Fertility.” The World Journal of Men’s Health, vol. 37, no. 1, 1 Jan. 2019, pp. 45–54, 10.5534/wjmh.180036; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305868/
  25. Earl, Joshua A, and Edward D Kim. “Enclomiphene Citrate: A Treatment That Maintains Fertility in Men with Secondary Hypogonadism.” Expert Review of Endocrinology & Metabolism, vol. 14, no. 3, 4 May 2019, pp. 157–165, 10.1080/17446651.2019.1612239; https://pubmed.ncbi.nlm.nih.gov/31063005/
  26. Kim, Edward D., et al. “Oral Enclomiphene Citrate Raises Testosterone and Preserves Sperm Counts in Obese Hypogonadal Men, Unlike Topical Testosterone: Restoration instead of Replacement.” BJU International, vol. 117, no. 4, 1 Apr. 2016, pp. 677–685, 10.1111/bju.13337; https://pubmed.ncbi.nlm.nih.gov/26496621/
  27. Es, Huang, and Miller Wl. “Estrogenic and Antiestrogenic Effects of Enclomiphene and Zuclomiphene on Gonadotropin Secretion by Ovine Pituitary Cells in Culture.” Endocrinology, vol. 112, no. 2, 1 Feb. 1983, 10.1210/endo-112-2-442; https://pubmed.ncbi.nlm.nih.gov/6401242/
  28. Glasier, A.F., et al. “A Comparison of the Effects on Follicular Development between Clomiphene Citrate, Its Two Separate Isomers and Spontaneous Cycles.” Human Reproduction, vol. 4, no. 3, Apr. 1989, pp. 252–256, 10.1093/oxfordjournals.humrep.a136882; https://pubmed.ncbi.nlm.nih.gov/2497133/
  29. Fontenot, Gregory K., et al. “Differential Effects of Isomers of Clomiphene Citrate on Reproductive Tissues in Male Mice.” BJU International, vol. 117, no. 2, 1 Feb. 2016, pp. 344–350, 10.1111/bju.13244; https://pubmed.ncbi.nlm.nih.gov/26220499/
  30. Mikkelson, Thomas J., et al. “Single-Dose Pharmacokinetics of Clomiphene Citrate in Normal Volunteers**Supported by a Grant from Serono Laboratories, Inc., Randolph, Massachusetts.” Fertility and Sterility, vol. 46, no. 3, Sept. 1986, pp. 392–396, 10.1016/s0015-0282(16)49574-9; https://pubmed.ncbi.nlm.nih.gov/3091405/
  31. Mürdter, Thomas E., et al. “Genetic Polymorphism of Cytochrome P450 2D6 Determines Oestrogen Receptor Activity of the Major Infertility Drug Clomiphene via Its Active Metabolites.” Human Molecular Genetics, vol. 21, no. 5, 22 Nov. 2011, pp. 1145–1154, 10.1093/hmg/ddr543; https://pubmed.ncbi.nlm.nih.gov/22108178/
  32. Wiehle, Ronald D., et al. “Enclomiphene Citrate Stimulates Testosterone Production While Preventing Oligospermia: A Randomized Phase II Clinical Trial Comparing Topical Testosterone.” Fertility and Sterility, vol. 102, no. 3, Sept. 2014, pp. 720–727, 10.1016/j.fertnstert.2014.06.004; https://pubmed.ncbi.nlm.nih.gov/25044085/
  33. Wiehle, Ronald D., et al. “Enclomiphene Citrate Stimulates Testosterone Production While Preventing Oligospermia: A Randomized Phase II Clinical Trial Comparing Topical Testosterone.” Fertility and Sterility, vol. 102, no. 3, Sept. 2014, pp. 720–727, 10.1016/j.fertnstert.2014.06.004; https://pubmed.ncbi.nlm.nih.gov/23530575/
  34. Wiehle, Ronald D, et al. “AndroxalTM (Enclomiphene Citrate) Acts Centrally on the Hypothalamic-Pituitary-Gonadal Axis to Increase LH, FSH and Testosterone in Men with Adult Idiopathic Hypogonadotrophic Hyopogonadism.” Journal of Urology, vol. 179, no. 4S, Apr. 2008, pp. 426–426, 10.1016/s0022-5347(08)61251-3; https://www.auajournals.org/doi/10.1016/S0022-5347%2808%2961251-3
  35. Hill, Simon, et al. “Enclomiphene, an Estrogen Receptor Antagonist for the Treatment of Testosterone Deficiency in Men.” IDrugs: The Investigational Drugs Journal, vol. 12, no. 2, 1 Feb. 2009, pp. 109–119; https://pubmed.ncbi.nlm.nih.gov/19204885/
  36. Wiehle, Ronald D., et al. “Enclomiphene Citrate Stimulates Serum Testosterone in Men with Low Testosterone within 14 Days.” Journal of Men’s Health, vol. 11, no. 4, Dec. 2014, pp. 196–205, 10.1089/jomh.2014.0006; https://www.liebertpub.com/doi/10.1089/jomh.2014.0006
  37. Wiehle, Ronald, et al. “Testosterone Restoration Using Enclomiphene Citrate in Men with Secondary Hypogonadism: A Pharmacodynamic and Pharmacokinetic Study.” BJU International, vol. 112, no. 8, 4 Nov. 2013, pp. 1188–1200, 10.1111/bju.12363; https://bjui-journals.onlinelibrary.wiley.com/doi/10.1111/bju.12363
  38. Rodriguez, Katherine M., et al. “Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism.” Expert Opinion on Pharmacotherapy, vol. 17, no. 11, 1 Aug. 2016, p. 1561, 10.1080/14656566.2016.1204294; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009465/
  39. Giagulli, V A, et al. “Comparison of Plasma Androgen Glucuronide Levels after Percutaneous or Peroral Androgen Treatment in Men: Evidence for Important Splanchnic Contribution to Plasma 17 Beta-Hydroxyandrogen Glucuronides.” The Journal of Clinical Endocrinology & Metabolism, vol. 76, no. 2, Feb. 1993, pp. 429–431, 10.1210/jcem.76.2.8432786; https://pubmed.ncbi.nlm.nih.gov/8432786/
  40. Houwing, Natalie S., et al. “Pharmacokinetic Study in Women of Three Different Doses of a New Formulation of Oral Testosterone Undecanoate, Andriol Testocaps.” Pharmacotherapy, vol. 23, no. 10, 1 Oct. 2003, pp. 1257–1265, 10.1592/phco.23.12.1257.32707; https://pubmed.ncbi.nlm.nih.gov/14594344/
  41. Schnabel, Peter G., et al. “The Effect of Food Composition on Serum Testosterone Levels after Oral Administration of Andriol Testocaps.” Clinical Endocrinology, vol. 66, no. 4, 1 Apr. 2007, p. 579, 10.1111/j.1365-2265.2007.02781.x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1859980/
  42. Gooren, L. J. “A Ten-Year Safety Study of the Oral Androgen Testosterone Undecanoate.” Journal of Andrology, vol. 15, no. 3, 1 May 1994, pp. 212–215; https://pubmed.ncbi.nlm.nih.gov/7928661/
  43. Yin, Anthony Y., et al. “Reexamination of Pharmacokinetics of Oral Testosterone Undecanoate in Hypogonadal Men with a New Self-Emulsifying Formulation.” Journal of Andrology, vol. 33, no. 2, 1 Mar. 2012, p. 190, 10.2164/jandrol.111.013169; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168025/
  44. Naghii, Mohammad Reza, et al. “Comparative Effects of Daily and Weekly Boron Supplementation on Plasma Steroid Hormones and Proinflammatory Cytokines.” Journal of Trace Elements in Medicine and Biology: Organ of the Society for Minerals and Trace Elements (GMS), vol. 25, no. 1, 1 Jan. 2011, pp. 54–58, 10.1016/j.jtemb.2010.10.001; https://pubmed.ncbi.nlm.nih.gov/21129941/
  45. Soares, Andressa Heimbecher, et al. “Effects of Clomiphene Citrate on Male Obesity-Associated Hypogonadism: A Randomized, Double-Blind, Placebo-Controlled Study.” International Journal of Obesity (2005), vol. 42, no. 5, 1 June 2018, pp. 953–963, 10.1038/s41366-018-0105-2; https://pubmed.ncbi.nlm.nih.gov/29777228/
  46. Norman, Anthony W. “From Vitamin D to Hormone D: Fundamentals of the Vitamin D Endocrine System Essential for Good Health.” The American Journal of Clinical Nutrition, vol. 88, no. 2, 1 Aug. 2008, pp. 491S499S, 10.1093/ajcn/88.2.491s; https://pubmed.ncbi.nlm.nih.gov/18689389/
  47. Junger, Sebastian; “Tribe”; Twelve Books; 2016; https://www.amazon.com/dp/1455566381
  48. Rico-Uribe, Laura Alejandra, et al. “Association of Loneliness with All-Cause Mortality: A Meta-Analysis.” PloS One, vol. 13, no. 1, 2018, p. e0190033, 10.1371/journal.pone.0190033; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754055/
  49. Sepah, Cameron; “The Definitive Guide to Dopamine Fasting 2.0 – the Hot Silicon Valley Trend”; August 7, 2019; https://www.linkedin.com/pulse/dopamine-fasting-new-silicon-valley-trend-dr-cameron-sepah
  50. Mosquera, Roberto, et al. “The Economic Effects of Facebook.” Experimental Economics, 26 Sept. 2019, 10.1007/s10683-019-09625-y; https://link.springer.com/article/10.1007/s10683-019-09625-y
  51. Lutchmaya, S., et al. “2nd to 4th Digit Ratios, Fetal Testosterone and Estradiol.” Early Human Development, vol. 77, no. 1-2, Apr. 2004, pp. 23–28, 10.1016/j.earlhumdev.2003.12.002; https://pubmed.ncbi.nlm.nih.gov/15113628/

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