VAULT Caffeine-Free Brain Energy Drink: Powered by Free-Acid goBHB!

If you’re reading this blog, you’ve probably seen it all – keto, atkins, paleo, carnivore, low-fat, the list goes on.

What pretty much all popular diets have in common is their emphasis on maintaining healthy blood glucose. It’s now accepted common sense that we should try to keep glucose in a reasonable range, without excessively high peaks or low troughs.

Vault Caffeine-Free Energy Drink

Vault Caffeine-Free Brain Energy Drink is powered by a whopping dose of two forms of BHB – Free-Acid D-BHB and Potassium D-BHB… a combination that feels downright phenomenal

And of all the systems in the body, there’s none more sensitive to fluctuations in blood glucose than your brain!

In fact, the ketogenic diet’s arguably greatest benefit is that it can supply a steady, uninterrupted, and clean-burning source of energy to your neurons. And that’s exactly what the VAULT Caffeine-Free Brain Energy Drink is formulated to do.

The flagship ingredient here is beta-hydroxybutyrate (BHB), an exogenous ketone. But it’s not just any BHB — the first ingredient is actually free-acid BHB, providing near instant energy without a huge mineral load.

Contrary to popular belief, you don’t need to follow a ketogenic diet in order to reap the benefits associated with BHB metabolism. Taking exogenous BHB can yield many of the same benefits. You can think of VAULT as ketones in a can – and your brain will thank you.

And while this is caffeine-free, we conclude with how BHB may synergize with your caffeine use as well — you just won’t get any of it in this can.

Let’s get into how VAULT works, but first, check the PricePlow news and deals:

Vault Caffeine-Free Brain Energy Drink – Deals and Price Drop Alerts

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Vault Caffeine-Free Energy Drink Ingredients

In a single 12 ounce (1 can) serving of VAULT Caffeine-Free Brain Drink, you get the following:

  • D-Beta-Hydroxybutyric Acid, D-Beta-Hydroxybutyrate Potassium, Acetyl-L-Carnitine HCl – 12.7 grams

    This is a blend of three ingredients, and below we do the math showing that we’re getting at least 10 grams of BHB inside:

    • D-Beta Hydroxybutyrate (BHB) is an exogenous ketone. As you probably know from reading about the ketogenic diet, ketones are molecules your cells can use for fuel, as an alternative to glucose. They are actually the fourth macronutrient (after protein, fat, and carbohydrates).
      Vault Caffeine-Free Energy Drink Ingredients (Black Cherry)

      The Vault Caffeine-Free Energy Drink Ingredients (Black Cherry flavor, with sodium added)

      Although BHB is usually produced endogenously by your body’s cells, science has made it possible for us to take exogenous (externally supplied) BHB supplements. That part of the story is best explained on the PricePlow Podcast in Episode #131 with Rob Rogers of Ketone Labs, where we learned how BHB supplements came to be, and how their production has improved greatly over time.

      As it turns out, exogenous BHB supplementation offers numerous benefits for human health and performance.

      Note the forms of BHB used – free acid and then potassium-bound

      Up front, it’s important to note that VAULT uses D-BHB, which is the isomer shown to increase blood BHB levels more than L-BHB or MCT.[1]

      Before getting into the science, realize that we have two forms of BHB inside — the first is free acid BHB, which works in liquid and doesn’t have any minerals bound to it. After that, we have Potassium D-BHB, which supplies us with a phenomenal 760 milligrams of potassium, a mineral that humans (especially in the west) often have in shortfall.

      Doing some basic chemistry / molar math, we calculate that we have 2.8 grams of potassium D-BHB, which means we have at least 7.1 grams of free acid BHB… meaning at least ~10 grams of total BHB in Vault!

      We cover the potassium benefits below, but let’s get to the important part — the BHB:

      • Promotes Healthy Cognition, Decreases Anxiety

        Vault Energy Drink Watermelon

        The benefits of BHB are especially pronounced in the brain, which is exquisitely sensitive to fluctuations in blood glucose. The bottom line up front is that providing your brain with a steady, clean source of energy in the form of exogenous BHB can help optimize your cognitive performance, as well as stabilize your emotional state.

        For example, animal research has demonstrated that BHB supplementation can help decrease anxious behavior.[2,3]

        Impact on brain health

        One pre-clinical experiment showed that exogenous BHB can actually prevent the development of neurodegenerative diseases in mice. The study looked at 3xTgAD mice, a strain of mice that are genetically predisposed to developing amyloid and tau proteins, which are associated with severe neurodegenerative disorders due to their aggregation into plaques that disrupt neural function.[2]

        One group of mice ate a carbohydrate-rich diet, while the other group fed on ketones that increase serum BHB levels. Compared to the carbohydrate group, the ketone group did significantly better on a battery of cognitive tests throughout the study period.[2]

        According to the scientists behind this study, the mechanism likely has something to do with BHB’s ability to improve mitochondrial health and function, while decreasing neurological inflammation.

        Can improve Traumatic Brain Injury (TBI) and concussion outcomes

        Life is chaotic, and sometimes accidents happen. When it comes to hitting your head, concussion or even traumatic brain injuries (TBI) can be a concern, and not just for athletes.

        Whether you hit your head playing football or just doing work around the house, physical trauma to the brain causes a neurometabolic cascade that can have devastating effects on neuronal health and function.[5]

        Central to this is the neuron’s loss of ability to burn glucose for energy, which is a huge potential problem since neurons need uninterrupted energy availability to survive and thrive. Once they can’t burn sugar, they are at serious risk of death[5] – and this is a major factor in the onset of brain damage typically seen following a blow to the head.

        D-BHB vs. MCT vs. L-BHB

        D-BHB vs. MCT vs. L-BHB. In the late 2010s, it became clear that D/R-BHB was far superior to L-BHB or mixed racemic D/L-BHB.[1]

        Exogenous BHB comes into play as a potential alternative fuel. If we can give our neurons ketones to burn instead of glucose, then we can help prevent them from dying, and hence, mitigate any potential damage to the brain as a whole.[6]

        Although human research hasn’t yet been done on this specific use case,[7] the animal studies conducted thus far have been very promising.[6] They show across the board that exogenous BHB administration can substantially limit the damage to neural tissue following a TBI.[8]

        Consider preventative use for contact sports
        Rob Rogers of Axcess Global and Ketone Labs: goBHB is Back!

        Rob Rogers of Ketone Labs joins PricePlow for Episode #131 to explain the story behind goBHB, and how they’re BACK on the market for supplement formulators!

        This was also discussed in Episode #131 with Rob Rogers, who suggests that VAULT can actually be an incredible tool to drink before football games as a preventative measure — and as we’ll discuss, the electrolytes and performance boost on top of the cognition support aren’t bad to have either.

        Mood disorders and anxiety

        New theories of depression are coming to the fore, with recent studies suggesting that neurological inflammation plays an important role in the onset of depressive syndromes. Fortunately for us, BHB has been shown to downregulate the inflammatory factors – including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) – that seem to be responsible for the pathophysiology of depression. As a result, BHB administration can measurably decrease the behaviors associated with depression.[9]

        One study found that rodents who’d been micro-injected with BHB did significantly “better” on tests of mental and physical resilience, like the forced swim test (FST) and open field test (OFT).[10]

      • Decreases Hunger

        The metabolic improvements associated with exogenous BHB come with other important benefits, too. For example, one 2017 study showed that ingesting exogenous BHB can cause substantial drops in appetite, insulin, and ghrelin,[11] which can be thought of as the hormone that makes you hungry. Put simply, the more ghrelin you have circulating, the more you’ll want to eat.[12]

        Interestingly, this study supports an assertion commonly made by keto dieters – that the diet helps them eat a lot less than usual.

        Fat loss

        Vault Energy Drink Benefits

        Despite the enormous volume of research on how ketogenic dieting can affect weight loss, the findings in humans remains inconclusive. However, animal studies have provided us with some really persuasive evidence that exogenous BHB can help shed the extra pounds – and keep them off.[13]

        In one of these studies, overweight mice that ate a high-fat diet for 10 weeks had a higher basal metabolic rate (number of calories burned at rest), and lost significant amounts of fat when given BHB supplements for an additional 12 weeks.[13]

        The really interesting thing about this study design is that because of the 10-week-long period of high-fat eating, the animals were almost certainly already fat adapted. So this study suggests that exogenous BHB have special benefits that go above and beyond what the body is capable of producing endogenously.

      • Supports Cardiovascular Health

        According to a 2017 study in humans, BHB ingestion can significantly lower blood sugar, free fatty acid, and triglyceride levels.[4] All three of these are markers for cardiovascular health, which means that exogenous BHB can potentially help keep your heart and arteries functioning well.

        In another study, 6 weeks of supplementation with exogenous BHB actually decreased blood pressure in subjects between the ages of 18 and 35.[14]

        Visceral fat

        In one 2017 study, supplemental BHB improved blood lipids and helped burn visceral fat in rats.[15] This is a particularly important finding, because visceral fat mass is strongly associated with insulin resistance and the metabolic syndrome, which can have terrible consequences for cardiovascular health.

        BHB Supplements and Lipids

        Look at the increase in HDL alongside a decrease in LDL in this animal study![15]

        This study found higher HDL cholesterol, lower LDL cholesterol, and lower triglycerides.[15] That’s a big deal because this specific three-part combination is increasingly considered to be the gold standard for improving cardiovascular health. There’s a ton of peer-reviewed research showing that the HDL to triglyceride ratio, in particular, is strongly associated with insulin resistance.[16-21]

      • Metabolic Flexibility On Demand

        One thing we really love about exogenous BHB is that it’s supportive no matter who you are. What wasn’t understood enough in the 2010s is that you don’t actually need to be in a state of nutritional ketosis for BHB to work![22]

        In other words, BHB can help no matter what your current dietary carbohydrate intake happens to be. Exogenous ketones can help even if your goal is to use glucose for certain metabolic tasks (e.g. combining with carbs for high-performance athletics).

        Vault Caffeine-Free Brain Energy Drink

        This has been borne out by studies going all the way back to the early 1990s, which found that exogenous BHB can spare glucose by acting as a substitute fuel source. So if you’re, say, an endurance athlete who’s carbo-loading for an event, supplementing with BHB can help preserve your precious glucose supply for the high-intensity efforts where it’s absolutely required, leading to increased metabolic flexibility, decreased lactic acid production, and improved performance during exercise.[23]

        However, we’re more interested in the co-administration of carbs and BHB for focused bouts of strength and sprinting, too. This is something we hope to see in research over the next few years — we call it “double rocket fuel”.

        Great for ketogenic dieting or intermittent fasting

        But still, if you’re attempting an intermittent fasting (IF) or ketogenic diet regime, but struggling due to drops in energy, then goBHB is the perfect solution – you can supply your body, and most importantly, your brain, with easily-usable, clean-burning energy that won’t severely disrupt your fast.

        Anecdotally, many claim that BHB helps support the transition to ketosis. Although this is anecdotal, research has shown that MCTs can reduce symptoms of keto-induction (sometimes known as the “keto flu”,[24] and MCTs are metabolized directly into BHB, so the anecdotes make sense beyond the electrolyte support that BHB salts can also provide.

      • BHB in Human Athletes

        goBHB Productivity

        goBHB is not just a “keto” supplement — one of the best benefits is in fact productivity from improved mental clarity and stimulant-free energy!

        Although there isn’t a ton of research on the subject yet, the few studies that have been done on BHB in human athletes have shown that it’s useful in certain cases. Ketones on their own haven’t done much for anaerobic efforts like sprints or heavy lifting,[25,26] but they do have a significant glucose sparing effect during aerobic exercise.[27]

        Lactic acid (AKA lactate), which causes muscular fatigue, is a byproduct of glucose oxidation, so by encouraging your body to burn fat instead of glucose at lower intensities, exogenous BHB can reduce the formation of lactate and thus delay the onset of fatigue.[28]

        Interestingly, in keeping with the cognitive health benefits we discussed earlier, supplemental BHB can also help prevent the temporary decline in cognitive faculties that typically follows intense exercise.[26]

        Muscle protein synthesis

        Research going all the way back to 1988[29] shows that BHB can actually help us build muscle. The ketone does this from both ends – it not only increases muscle protein synthesis (MPS), but also inhibits the breakdown of existing muscle and the oxidation of MPS-stimulating amino acids like leucine.[30,31]

        You may have heard that BHB is “protein-sparing” — this is what people mean when that phrase is mentioned. This makes BHB an awesome ally for anyone who’s looking to improve body composition.

      That’s not the end of the blend, though. We also have a conditionally-essential compound that has another whole slew of benefits:

    • Acetyl-L-Carnitine HCl benefits

      But besides BHB, we also have acetyl-L-carnitine HCl (ALCAR) in this blend – an ingredient that comes with serious benefits of its own.

      L-Carnitine Function

      What better ingredient to add to a BHB drink than the molecule that helps shuttle long-chain fatty acids inside the mitochondria, enabling greater ATP generation?![32]

      We love seeing ALCAR in a brain-health-focused drink because ALCAR has a long history of use in the supplement industry as a nootropic ingredient. It has pronounced neuroprotective, neurotrophic (i.e., it helps new neurons grow) and strong mood-supporting effects.[33-35]

      Any form of carnitine works, fundamentally, by helping transport energy substrates into your mitochondria, which ultimately supports the production of adenosine triphosphate (ATP).[36] This process benefits the metabolic function of pretty much any type of cell, but because ALCAR is exceptionally bioavailable in the central nervous system thanks to its ability to cross the brain blood barrier,[37] ALCAR is great for supporting neuronal metabolic function specifically.

      Research in animals has shown that supplementation with ALCAR can increase the synaptic plasticity of their brains, thus facilitating learning.[38]

      And one particularly interesting human study, carried out in men and women over the age of 65 who were suffering from mild cognitive impairment, found that ALCAR significantly improved scores on a series of cognitive tests, compared to placebo.[39]

      We’re not sure how much ALCAR is inside of VAULT, but we’ll update this area if we can find that out.

  • Other Ingredients

    VAULT also offers significant vitamin and mineral support, which takes the form of:

    • Vitamin D (as Cholecalciferol) – 100 mcg (500% DV)

      Cholecalciferol (vitamin D3) is your body’s active form of vitamin D, the form it produces endogenously in response to sunlight. Because it’s the active form, cholecalciferol is more effective at raising your vitamin D blood level than the cheaper but less effective vitamin D2 (known as ergocalciferol).[40,41]

      BHB Applications

      Beyond caffeine-free energy drinks, there are tons of applications to consider with BHB, and formulators can now license goBHB to make their own

      Vitamin D affects tons of stuff, but one of its biggest benefits is hormone optimization. For men, this means upregulated testosterone production[42,43] by inhibition of the enzyme aromatase,[44] which is responsible for converting testosterone into estrogen. Studies on vitamin D consistently find that one’s serum vitamin D level has a positive correlation with testosterone levels.[42]

      A double-blind, randomized, placebo controlled study from 2011 showed that 3,332 IU of vitamin D3 (equivalent to 83 micrograms, just under the 100 microgram dose used in VAULT) can cause a 25% increase in total T, and a 20% increase in free T.[43]

      Vitamin D deficiency is associated not only with low testosterone but also with overweight/obesity, depression, high blood pressure, osteoporosis, cognitive decline, chronic fatigue syndrome, cancer, heart disease, and stroke.[45,46]

      Adequate vitamin D levels also help protect against cardiovascular disease (CVD) by downregulating inflammation, helping stabilize blood sugar, and preventing vascular calcification.[45]

    • Niacin (as Niacinamide) – 250 mg (1563% DV)

      Niacin (vitamin B3) is an important precursor to nicotinamide adenine dinucleotide (NAD+),[47-49] a molecule that your body needs to carry out a dizzying array of metabolic processes. For example, NAD+ is needed for liver function and DNA repair.[50-53]

      NAD+ Pathways

      The NAD Pathways, listed in blue.[47] For this product, Nicotinamide (NAM) is what we’re supplementing, shown at the bottom-right.

      Supplementing with niacin can increase your body’s production of adiponectin,[54] a hormone that has tons of downstream effects on cellular metabolism. Among other things, adiponectin increases whole-body insulin sensitivity – studies consistently show that overweight and obese individuals have low levels of adiponectin, on average.[55] Adiponectin works mainly by increasing the expression of AMP-activated protein kinase (AMPK),[56] an enzyme that acts as one of your body’s metabolic master switches. We like to think of AMPK as the need energy now hormone – the more of it you have, the faster your cells will generate new energy.

      Niacin can downregulate your fat cells’ production of inflammatory cytokines,[54] which has a huge potential upside for health since cytokine-induced inflammation is associated with metabolic dysfunction.[57]

    • Sodium – 210 mg (9% DV) (Black Cherry Flavor only)

      You might be surprised to see sodium in a product like VAULT, since it’s normally used to replenish electrolytes lost in sweat, which is generally a concern for athletes. So what’s it doing in a product like VAULT, which is designed to help optimize cognitive performance?

      As it turns out, sodium intake can have a powerful effect on the endocrine system – and more specifically, stress hormones. Research shows that elevated serum sodium can blunt the stress response and decrease anxious behavior.[58]

      Vault Caffeine-Free Energy Drink Ingredients (Cucumber Mint & Watermelon)

      Vault’s ingredients for Cucumber Mint and Watermelon — note that these two do not have sodium!

      The reason this matters for cognition is that the stress response itself can interfere with cognitive performance.[59] So, blunting that stress response through extra sodium intake can help keep your brain functioning under pressure.

      Note: Sodium is only in the Black Cherry flavor, as of 2024.

    • Potassium – 760 mg (16% DV)

      The potassium source comes from the D-BHB Potassium ingredient, listed second on the label. It’s extremely useful, especially in the wake of our low-potassium, high-sodium diets. A mountain of research clearly shows that the interaction between these two minerals, rather than absolute sodium intake, is what leads to the onset of hypertension[60] – too much sodium relative to potassium is what’s actually bad for the cardiovascular system.[61-65]

      This should be great news for everybody, because the latest research shows that it’s essentially impossible to meet the current guidelines for limiting sodium intake. The implication, then, is that increasing potassium intake is really our only option.[66,67]

While this is a cool formula, the D-BHB Acid and D-BHB Potassium are clearly the stars of the show – VAULT is a feel-great, taste-great drink, and is a fantastic way to get energy without caffeine.

But on the topic of caffeine…

Brain Energy and Focus For the Caffeine-Sensitive

Our culture seemingly runs on caffeine, and coffee pots are a fixture in offices all over the world. No matter what field you’re in, it seems like everybody’s instinct is to reach for another mug as soon as the going gets tough.

However, if you’ve been around long enough, you also know that caffeine is not for everybody. If you’re a slow metabolizer of caffeine, or just unusually sensitive to its effects, exogenous BHB is a great alternative, especially when looking for those nootropic effects.

The best part is that once you’re done with your work, the BHB you took aren’t going to keep you up that night.

But… BHB may synergize with caffeine too

While there’s not a ton of research on this subject yet, we’ve noticed anecdotally that combining BHB with caffeine can result in some desirable synergistic interactions.

Vault BHB Drinks

While both of these compounds have documented nootropic effects, they each have very different mechanisms of action, which means they can complement each other – what we typically see is that when caffeine is consumed alongside BHB, you can the upsides of caffeine, like increased energy, motivation, focus, and athletic performance, with a far less debilitating crash.

Since BHB is the preferred substrate for GABA,[68] and has been shown to increase the ratio of GABA to glutamate in animals,[69] you can think of it as a GABAergic or inhibitory compound. This means that it can, like fellow GABAergic substance theanine, “take the edge off” caffeine by mitigating its worst effects – i.e., reducing jitters and anxiety.

Plus, both caffeine and BHB have a positive impact on cellular energy production: While caffeine can increase the utilization of both glucose and fatty acids, BHB has been shown to help your body burn fat specifically.[70] Together, these two compounds have the potential to really crank up cellular metabolism, and help power your body with clean, sustained energy.

Conclusion – Vault for Stimulant-Free Energy

Vault: No Sugar, No Caffeine, No Artificial Ingredients

VAULT is a “simple” formula (in terms of number of ingredients), but quite powerful – the benefits of exogenous BHB are simply too great to ignore, and the dietary supplement industry needs to come back to the ingredient.

We love how BHB-loaded this formula is. It’s no underdosed supplement, that’s for sure. With 760 milligrams of potassium, this means we have 2.8 grams of potassium D-BHB (potassium portion ≈ 27.29% of the molecule). That means we have a maximum of 2.8 grams of ALCAR — likely less — and a minimum of another 7.1 grams of free acid BHB… so you’re looking at at least 10 grams of BHB, but more than likely higher than that.

No wonder why this stuff feels so good!

Our advice is that, given the fairly large dose of vitamin D3 in here, you should consider adding supplemental vitamin K2 (a recommended counterpart for cholecalciferol), especially if you’re planning to drink it on a regular basis.

Vault Caffeine-Free Brain Energy Drink – Deals and Price Drop Alerts

Get Price Alerts

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Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: PricePlow Staff

PricePlow Staff

PricePlow is a team of supplement industry veterans that include medical students, competitive strength athletes, and scientific researchers who all became involved with dieting and supplements out of personal need.

The team's collective experiences and research target athletic performance and body composition goals, relying on low-toxicity meat-based diets.

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References

  1. Cuenoud, Bernard, et al. “Metabolism of Exogenous D-Beta-Hydroxybutyrate, an Energy Substrate Avidly Consumed by the Heart and Kidney.” Frontiers in Nutrition, vol. 7, 19 Feb. 2020, doi:10.3389/fnut.2020.00013. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042179/
  2. Kashiwaya, Yoshihiro, et al. “A Ketone Ester Diet Exhibits Anxiolytic and Cognition-Sparing Properties, and Lessens Amyloid and Tau Pathologies in a Mouse Model of Alzheimer’s Disease.” Neurobiology of Aging, vol. 34, no. 6, June 2013, pp. 1530–1539, 10.1016/j.neurobiolaging.2012.11.023; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619192/
  3. Ari, Csilla, et al. “Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats.” Frontiers in Molecular Neuroscience, vol. 9, 6 Dec. 2016, 10.3389/fnmol.2016.00137; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138218/
  4. Stubbs, Brianna J et al. “On the Metabolism of Exogenous Ketones in Humans.” Frontiers in physiology vol. 8 848. 30 Oct. 2017, doi:10.3389/fphys.2017.00848; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670148/
  5. Giza, Christopher C., and David A. Hovda. “The Neurometabolic Cascade of Concussion.” Journal of athletic training vol. 36,3 (2001): 228-235. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC155411/
  6. Daines, Savannah Anne. “The Therapeutic Potential and Limitations of Ketones in Traumatic Brain Injury.” Frontiers in neurology vol. 12 723148. 22 Oct. 2021, doi:10.3389/fneur.2021.723148. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579274/
  7. McDougall, Alexandre et al. “The ketogenic diet as a treatment for traumatic brain injury: a scoping review.” Brain injury vol. 32,4 (2018): 416-422. doi:10.1080/02699052.2018.1429025; https://www.tandfonline.com/doi/abs/10.1080/02699052.2018.1429025
  8. Davis, Laurie M et al. “Fasting is neuroprotective following traumatic brain injury.” Journal of neuroscience research vol. 86,8 (2008): 1812-22. doi:10.1002/jnr.21628. https://onlinelibrary.wiley.com/doi/10.1002/jnr.21628
  9. Yamanashi, Takehiko, et al. “Beta-Hydroxybutyrate, an Endogenic NLRP3 Inflammasome Inhibitor, Attenuates Stress-Induced Behavioral and Inflammatory Responses.” Scientific Reports, vol. 7, no. 1, 9 Aug. 2017, doi:10.1038/s41598-017-08055-1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550422/
  10. Naofumi Kajitani, et al. “Prefrontal Cortex Infusion of Beta‐Hydroxybutyrate, an Endogenous NLRP3 Inflammasome Inhibitor, Produces Antidepressant‐like Effects in a Rodent Model of Depression.” Neuropsychopharmacology Reports, vol. 40, no. 2, 3 Mar. 2020, pp. 157–165, doi:10.1002/npr2.12099. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722664/
  11. Stubbs, Brianna J., et al. “A Ketone Ester Drink Lowers Human Ghrelin and Appetite.” Obesity, vol. 26, no. 2, 6 Nov. 2017, pp. 269–273, 10.1002/oby.22051; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813183/
  12. Wu, James T, and John G Kral. “Ghrelin: integrative neuroendocrine peptide in health and disease.” Annals of surgery vol. 239,4 (2004): 464-74. doi:10.1097/01.sla.0000118561.54919.61. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356251/
  13. Davis, Rachel A H et al. “Dietary R, S-1,3-butanediol diacetoacetate reduces body weight and adiposity in obese mice fed a high-fat diet.” FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 33,2 (2019): 2409-2421. doi:10.1096/fj.201800821RR; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338649/
  14. Holland, Angelia M., et al. “Blood and Cardiovascular Health Parameters after Supplementing with Ketone Salts for Six Weeks.” Journal of Insulin Resistance, vol. 4, no. 1, 24 Apr. 2019, 10.4102/jir.v4i1.47; https://insulinresistance.org/index.php/jir/article/view/47/172
  15. Caminhotto, Rennan de Oliveira, et al. “Oral β-Hydroxybutyrate Increases Ketonemia, Decreases Visceral Adipocyte Volume and Improves Serum Lipid Profile in Wistar Rats.” Nutrition & Metabolism, vol. 14, no. 1, 24 Apr. 2017, 10.1186/s12986-017-0184-4; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404327/
  16. Bertsch, Ruth Ann, and Maqdooda A Merchant. “Study of the Use of Lipid Panels as a Marker of Insulin Resistance to Determine Cardiovascular Risk.” The Permanente journal vol. 19,4 (2015): 4-10. doi:10.7812/TPP/14-237; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625988/
  17. Bartlett, Jacquelaine, et al. “Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor?” Circulation: Cardiovascular Quality and Outcomes, vol. 9, no. 3, May 2016, pp. 206–212, 10.1161/circoutcomes.115.002436; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871717/
  18. Wang, T. D., et al. “Efficacy of Cholesterol Levels and Ratios in Predicting Future Coronary Heart Disease in a Chinese Population.” The American Journal of Cardiology, vol. 88, no. 7, 1 Oct. 2001, pp. 737–743, 10.1016/s0002-9149(01)01843-4; https://pubmed.ncbi.nlm.nih.gov/11589839
  19. Jeppesen, Jørgen, et al. “Low Triglycerides–High High-Density Lipoprotein Cholesterol and Risk of Ischemic Heart Disease.” Archives of Internal Medicine, vol. 161, no. 3, 12 Feb. 2001, p. 361, 10.1001/archinte.161.3.361; https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/647239
  20. Castelli, William P. “Epidemiology of Triglycerides: A View from Framingham.” American Journal of Cardiology, vol. 70, no. 19, 14 Dec. 1992, pp. H3–H9, 10.1016/0002-9149(92)91083-G; https://www.ajconline.org/article/0002-9149(92)91083-G/abstract
  21. McLaughlin, Tracey, et al. “Use of Metabolic Markers to Identify Overweight Individuals Who Are Insulin Resistant.” Annals of Internal Medicine, vol. 139, no. 10, 18 Nov. 2003, p. 802, 10.7326/0003-4819-139-10-200311180-00007; https://pubmed.ncbi.nlm.nih.gov/14623617/
  22. Harvey, Cliff J. d C., et al. “The Use of Nutritional Supplements to Induce Ketosis and Reduce Symptoms Associated with Keto-Induction: A Narrative Review.” PeerJ, vol. 6, 16 Mar. 2018, p. e4488, 10.7717/peerj.4488; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858534/
  23. Okuda, Y., et al. “Ketone Body Utilization and Its Metabolic Effect in Resting Muscles of Normal and Streptozotocin-Diabetic Rats.” Endocrinologia Japonica, vol. 38, no. 3, 1 June 1991, pp. 245–251, 10.1507/endocrj1954.38.245; https://pubmed.ncbi.nlm.nih.gov/1838977/
  24. d C. Harvey, Cliff J., et al. “The Effect of Medium Chain Triglycerides on Time to Nutritional Ketosis and Symptoms of Keto-Induction in Healthy Adults: A Randomised Controlled Clinical Trial.” Journal of Nutrition and Metabolism, vol. 2018, 22 May 2018, doi:10.1155/2018/2630565. https://www.hindawi.com/journals/jnme/2018/2630565/
  25. Dearlove, David J., et al. “Nutritional Ketoacidosis during Incremental Exercise in Healthy Athletes.” Frontiers in Physiology, vol. 10, 29 Mar. 2019, 10.3389/fphys.2019.00290; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450328/
  26. Evans, Mark, and Brendan Egan. “Intermittent Running and Cognitive Performance after Ketone Ester Ingestion.” Medicine & Science in Sports & Exercise, vol. 50, no. 11, Nov. 2018, pp. 2330–2338, 10.1249/mss.0000000000001700; https://pubmed.ncbi.nlm.nih.gov/29944604/
  27. Cox, Pete J., et al. “Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.” Cell Metabolism, vol. 24, no. 2, Aug. 2016, pp. 256–268, 10.1016/j.cmet.2016.07.010; https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30355-2
  28. Scott, Benjamin E., et al. “The Effect of 1,3-Butanediol and Carbohydrate Supplementation on Running Performance.” Journal of Science and Medicine in Sport, vol. 22, no. 6, 1 June 2019, pp. 702–706, 10.1016/j.jsams.2018.11.027; https://pubmed.ncbi.nlm.nih.gov/30553764/
  29. Nair, K S et al. “Effect of beta-hydroxybutyrate on whole-body leucine kinetics and fractional mixed skeletal muscle protein synthesis in humans.” The Journal of clinical investigation vol. 82,1 (1988): 198-205. doi:10.1172/JCI113570 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC303494/
  30. Thomsen, Henrik Holm et al. “Investigating effects of sodium beta-hydroxybutyrate on metabolism in placebo-controlled, bilaterally infused human leg with focus on skeletal muscle protein dynamics.” Physiological reports vol. 10,16 (2022): e15399. doi:10.14814/phy2.15399. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391664/
  31. Mose, M et al. “Anabolic effects of oral leucine-rich protein with and without β-hydroxybutyrate on muscle protein metabolism in a novel clinical model of systemic inflammation-a randomized crossover trial.” The American journal of clinical nutrition vol. 114,3 (2021): 1159-1172. doi:10.1093/ajcn/nqab148. https://www.sciencedirect.com/science/article/pii/S0002916522004397
  32. Fielding, Roger et al. “l-Carnitine Supplementation in Recovery after Exercise.” Nutrients vol. 10,3 349. 13 Mar. 2018, doi:10.3390/nu10030349; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872767/
  33. Traina, Giovanna. “The Neurobiology of Acetyl-L-Carnitine.” Frontiers in Bioscience (Landmark Edition), vol. 21, 1 June 2016, pp. 1314–1329, doi:10.2741/4459. https://www.ncbi.nlm.nih.gov/pubmed/27100509
  34. Liu, Ting, et al. “Carnitine and Depression.” Frontiers in Nutrition, vol. 9, 14 Mar. 2022, doi:10.3389/fnut.2022.853058. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964433/
  35. Veronese, Nicola, et al. “Acetyl-l-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis.” Psychosomatic Medicine, vol. 80, no. 2, Feb. 2018, pp. 154–159, doi:10.1097/psy.0000000000000537. https://pubmed.ncbi.nlm.nih.gov/29076953/
  36. Eder, K, et al; “Free and Total Carnitine Concentrations in Pig Plasma after Oral Ingestion of Various L-Carnitine Compounds.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Jan. 2005; https://www.ncbi.nlm.nih.gov/pubmed/15830915
  37. Parnetti, L, et al; “Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type”; Eur J Clin Pharmacol. 1992; 42(1):89-93; https://www.ncbi.nlm.nih.gov/pubmed/1541322
  38. Ando, S, et al; “Enhancement of Learning Capacity and Cholinergic Synaptic Function by Carnitine in Aging Rats.”; Journal of Neuroscience Research; U.S. National Library of Medicine; 15 Oct. 2001; https://www.ncbi.nlm.nih.gov/pubmed/11592123
  39. Passeri, M, et al; “Acetyl-L-Carnitine in the Treatment of Mildly Demented Elderly Patients.”; International Journal of Clinical Pharmacology Research; U.S. National Library of Medicine; 1990; https://www.ncbi.nlm.nih.gov/pubmed/2201659
  40. Amphansap, Tanawat et al. “Efficacy of plain cholecalciferol versus ergocalciferol in raising serum vitamin D level in Thai female healthcare workers.” Osteoporosis and sarcopenia vol. 8,4 (2022): 145-151. doi:10.1016/j.afos.2022.12.001. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805961/
  41. Tripkovic, Laura et al. “Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis.” The American journal of clinical nutrition vol. 95,6 (2012): 1357-64. doi:10.3945/ajcn.111.031070. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349454/
  42. Wehr, E., et al. “Association of Vitamin D Status with Serum Androgen Levels in Men.” Clinical Endocrinology, Dec. 2009, 10.1111/j.1365-2265.2009.03777.x. https://pubmed.ncbi.nlm.nih.gov/20050857/
  43. Pilz, S, et al. “Effect of Vitamin D Supplementation on Testosterone Levels in Men.” Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones et Metabolisme, vol. 43, no. 3, 2011, pp. 223–5, 10.1055/s-0030-1269854. https://pubmed.ncbi.nlm.nih.gov/21154195/
  44. Kinuta, Keiko, et al. “Vitamin D Is an Important Factor in Estrogen Biosynthesis of Both Female and Male Gonads*.” Endocrinology, vol. 141, no. 4, 1 Apr. 2000, pp. 1317–1324, 10.1210/endo.141.4.7403. https://www.ncbi.nlm.nih.gov/pubmed/10746634
  45. Danik, J. et al. Aug. 2012. “Vitamin D and Cardiovascular Disease.” Current Treatment Options in Cardiovascular Medicine vol. 14,4; 414-24. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449318/
  46. Naeem, Z. Jan. 2010. “Vitamin D Deficiency – An Ignored Epidemic.” International Journal of Health Sciences vol. 4,1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068797/
  47. Cantó, Carles, et al. “NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.” Cell Metabolism, vol. 22, no. 1, July 2015, pp. 31–53, 10.1016/j.cmet.2015.05.023; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487780/
  48. Chini, Claudia C.S., et al. “NAD and the Aging Process: Role in Life, Death and Everything in Between.” Molecular and Cellular Endocrinology, vol. 455, Nov. 2017, pp. 62–74, 10.1016/j.mce.2016.11.003; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419884/
  49. Yang, Yue, and Anthony A. Sauve. “NAD+ Metabolism: Bioenergetics, Signaling and Manipulation for Therapy.” Biochimica et Biophysica Acta, vol. 1864, no. 12, 1 Dec. 2016, pp. 1787–1800, 10.1016/j.bbapap.2016.06.014; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521000/
  50. Rajman, Luis, et al. “Therapeutic Potential of NAD-Boosting Molecules: The in Vivo Evidence.” Cell Metabolism, vol. 27, no. 3, Mar. 2018, pp. 529–547, 10.1016/j.cmet.2018.02.011; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342515/
  51. Katsyuba, Elena, et al. “NAD + Homeostasis in Health and Disease.” Nature Metabolism, vol. 2, no. 1, 1 Jan. 2020, pp. 9–31, 10.1038/s42255-019-0161-5; https://pubmed.ncbi.nlm.nih.gov/32694684/
  52. Chini, Claudia C.S., et al. “Evolving Concepts in NAD+ Metabolism.” Cell Metabolism, vol. 33, no. 6, June 2021, pp. 1076–1087, 10.1016/j.cmet.2021.04.003; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172449/
  53. Weiner, H., and X. Wang. “Aldehyde Dehydrogenase and Acetaldehyde Metabolism.” Alcohol and Alcoholism (Oxford, Oxfordshire). Supplement, vol. 2, 1994, pp. 141–145; https://pubmed.ncbi.nlm.nih.gov/8974328/
  54. Wanders, Desiree et al. “Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.” PloS one vol. 8,8 e71285. 13 Aug. 2013, doi:10.1371/journal.pone.0071285. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742781/
  55. Achari, Arunkumar E, and Sushil K Jain. “Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction.” International journal of molecular sciences vol. 18,6 1321. 21 Jun. 2017, doi:10.3390/ijms18061321. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486142/
  56. “Adiponectin – an Overview | ScienceDirect Topics.” https://www.sciencedirect.com/topics/medicine-and-dentistry/adiponectin
  57. Zatterale F, Longo M, Naderi J, Raciti GA, Desiderio A, Miele C and Beguinot F (2020) Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes. Front. Physiol. 10:1607. doi: 10.3389/fphys.2019.01607. https://www.frontiersin.org/articles/10.3389/fphys.2019.01607/full
  58. Krause, E. G., et al. “Hydration State Controls Stress Responsiveness and Social Behavior.” Journal of Neuroscience, vol. 31, no. 14, 6 Apr. 2011, pp. 5470–5476, https://doi.org/10.1523/jneurosci.6078-10.2011.
  59. Sandi, Carmen. “Stress and Cognition.” Wiley Interdisciplinary Reviews. Cognitive Science, vol. 4, no. 3, 2013, pp. 245–261, www.ncbi.nlm.nih.gov/pubmed/26304203, doi:10.1002/wcs.1222. https://wires.onlinelibrary.wiley.com/doi/10.1002/wcs.1222
  60. Adrogué, Horacio J., and Nicolaos E. Madias. “Sodium and Potassium in the Pathogenesis of Hypertension.” New England Journal of Medicine, vol. 356, no. 19, 10 May 2007, pp. 1966–1978, 10.1056/nejmra064486; https://pubmed.ncbi.nlm.nih.gov/17494929/
  61. Dyer, Alan R., et al. “Urinary Electrolyte Excretion in 24 Hours and Blood Pressure in the INTERSALT Study.” American Journal of Epidemiology, vol. 139, no. 9, 1 May 1994, pp. 940–951, 10.1093/oxfordjournals.aje.a117100; https://www.ncbi.nlm.nih.gov/pubmed/8166144
  62. Elliott, P., et al. “Intersalt Revisited: Further Analyses of 24 Hour Sodium Excretion and Blood Pressure within and across Populations.” BMJ, vol. 312, no. 7041, 18 May 1996, pp. 1249–1253, 10.1136/bmj.312.7041.1249; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2351086/
  63. Cook, N. R., et al. “Effect of Change in Sodium Excretion on Change in Blood Pressure Corrected for Measurement Error. The Trials of Hypertension Prevention, Phase I.” American Journal of Epidemiology, vol. 148, no. 5, 1 Sept. 1998, pp. 431–444, 10.1093/oxfordjournals.aje.a009668; https://www.ncbi.nlm.nih.gov/pubmed/9737555
  64. Khaw, K T, and E Barrett-Connor. “The Association between Blood Pressure, Age, and Dietary Sodium and Potassium: A Population Study.” Circulation, vol. 77, no. 1, Jan. 1988, pp. 53–61, 10.1161/01.cir.77.1.53; https://www.ncbi.nlm.nih.gov/pubmed/3257173
  65. Xie, J. X., et al. “The Relationship between Urinary Cations Obtained from the INTERSALT Study and Cerebrovascular Mortality.” Journal of Human Hypertension, vol. 6, no. 1, 1 Feb. 1992, pp. 17–21; https://www.ncbi.nlm.nih.gov/pubmed/1583625
  66. ‌Maillot, Matthieu, et al. “Food Pattern Modeling Shows That the 2010 Dietary Guidelines for Sodium and Potassium Cannot Be Met Simultaneously.” Nutrition Research (New York, N.y.), vol. 33, no. 3, 1 Mar. 2013, p. 188, 10.1016/j.nutres.2013.01.004; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878634/
  67. Drewnowski, Adam, et al. “Reducing the Sodium-Potassium Ratio in the US Diet: A Challenge for Public Health.” The American Journal of Clinical Nutrition, vol. 96, no. 2, 3 July 2012, pp. 439–444, 10.3945/ajcn.111.025353; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396449/
  68. Lund, Trine M et al. “β-Hydroxybutyrate is the preferred substrate for GABA and glutamate synthesis while glucose is indispensable during depolarization in cultured GABAergic neurons.” Neurochemistry international vol. 59,2 (2011): 309-18. doi:10.1016/j.neuint.2011.06.002. https://linkinghub.elsevier.com/retrieve/pii/S0197-0186(11)00198-7
  69. Qiao, Ya-Nan et al. “Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy.” Cell discovery vol. 10,1 17. 13 Feb. 2024, doi:10.1038/s41421-023-00636-x . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10861483/
  70. Katsuya, Shohei et al. “Daily Intake of D-β-Hydroxybutyric Acid (D-BHB) Reduces Body Fat in Japanese Adult Participants: A Randomized, Double-Blind, Placebo-Controlled Study.” Journal of nutritional science and vitaminology vol. 69,2 (2023): 121-128. doi:10.3177/jnsv.69.121. https://pubmed.ncbi.nlm.nih.gov/37121721/ (full-text PDF at https://www.jstage.jst.go.jp/article/jnsv/69/2/69_121/_pdf/-char/en)

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