Revive MD Prostate: A Complete Prostate Health Formula

The strongest man in the world trusts Revive MD to keep him healthy.

Revive MD, a leader in health and wellness supplements, has been launching some incredible products lately! Just last month, they launched Lipid, a comprehensive triglyceride and cholesterol management supplement that’s loaded with six ingredients at a seven capsule serving size. It’s obvious that Matt Jansen and Dr. Domenic Iacovone, founders of Revive MD, bring their best when it comes to formulating high quality supplements – especially since their products are used by elite athletes from all over the world.

Revive MD does whatever it takes to make the best product possible and that’s just one of the reasons why they’re quickly rising to the top. You may have even seen their logo on ESPN a few weeks ago, as Hafthor Bjornsson, World’s Strongest Man and Revive MD Athlete, broke the world record for the deadlift by easily pulling 501kgs (1,102.2lbs)!

Revive MD works with athletes that are pushing their bodies to the absolute limit and they need to do everything possible to stay healthy. They have earned the trust from huge names in the industry by creating products geared specifically for health and wellness with unrivaled formulas!

Revive MD Prostate Optimizes Hormone Levels and Supports Prostate Health

Revive MD Prostate Graphic

The next supplement in Revive MD’s lineup addresses prostate health.

Despite their success and platform of formulas, Revive MD is never satisfied – they’re always looking for gaps to fill within the sports supplement industry. This time, the brand is focused on optimizing men’s health with the release of Revive MD Prostate!

As always, Revive MD Prostate is packed – it features ten ingredients designed to support proper prostate function, balance estrogen levels, and promote healthy urinary flow. It has a solid combination of saw palmetto, pumpkin seed oil, and stinging nettle to help reduce the annoying symptoms associated with prostate issues. Furthermore, Revive MD also includes three key minerals that are crucial for optimizing men’s health. This is just another example of how Revive MD goes above and beyond with each formula to deliver the best results!

To learn more about Revive MD Prostate keep reading, but first, sign up for Revive MD news and deal alerts so you never have to pay full price on supplements trusted by elite athletes.

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Before diving into the science and research behind each ingredient, we first want to educate you on who this product is designed for!

What is Benign Prostatic Hyperplasia?

In case you’re not too familiar with anatomy and physiology, the prostate gland is located just underneath the bladder and it plays a key role in men’s health.

Revive MD Prostate Health Education

If you’re experiencing signs or symptoms correlated with prostate issues, we would highly recommend seeking out help from a qualified health care professional.

For various reasons, the prostate gland can get enlarged, causing it to apply pressure onto the bladder, resulting in excessive need to urinate, especially at night, and can even block urinary flow. If gone untreated, it can lead to poor kidney function, urinary tract infection, and even bladder stones. The disrupted sleep cycles of frequent urination will also affect overall health, given sleep’s importance. Enlargement of the prostate is often diagnosed as benign prostatic hyperplasia (BPH) and is more common in older males.

If you’re experiencing the signs and symptoms of BPH, we would highly recommend seeing a qualified health care professional for guidance before taking any supplements. BPH may not seem like a major issue, but if you currently have it or have dealt with it in the past, you know it can drastically decrease your overall quality of life and disrupt sleep.

Benign prostatic hyperplasia can be treated with various medications, however, there are also some natural supplements that may improve the severity of symptoms associated with BPH. Therefore, Revive MD decided to dive into the research to see what ingredients are most effective for supporting overall prostate health. They ended up developing a product packed with ten ingredients that offer several health benefits!

Revive MD Prostate Ingredient Breakdown

Now that the background information is covered, let’s go over why each ingredient is included in this product! Here’s what one serving (4 capsules) (2.22g) of Revive MD Prostate delivers:

  • Copper Bisglycinate Chelate – 500mcg (55% DV)

    Right off the bat, Revive MD is hitting you with the most bioavailable form of copper with copper bisglycinate chelate!

    Revive MD Prostate Ingredients

    Another stacked supplement from Revive MD.

    In case you didn’t know the importance of optimal absorption and bioavailability, we’re going to let you in on a secret… it’s crucial to get the most out of your supplements! Let’s say you’re taking a multivitamin that you think is packed with crazy amounts of vitamins and minerals but instead of being absorbed in the small intestine, they just pass right through you?

    Improve copper’s absorption by binding it to a well-absorbed amino acid

    The body must be able to uptake them to be utilized and unfortunately, the vast majority of vitamins and minerals on the market have terrible bioavailability. However, by combining a mineral with another molecule (such as an amino acid) that is easily absorbed by the small intestine, then the bioavailability significantly enhances!

    In this case, copper is chelated (bound) to the amino acid glycine, which solved the absorption issues. You’ll see this come up again when we cover zinc later on in this article. This is just a reminder to look at not only the amount of an ingredient, but also the form being used before buying any supplement!

    How does copper help?

    Now that you know Revive MD is using the best form of copper, what can it do to support overall health? Copper is an essential mineral that plays a key role in the production of red blood cells, it’s also a cofactor for multiple enzymes within the body.[1]

    Copper is most notably involved in the immune system, angiogenesis, brain development, regulation of gene expression, and maintenance of neurohormones.[1] Furthermore, copper helps protect the cells from oxidative stress by contributing to the production of superoxide dismutase.[1]

    Avoid deficiency to help avoid serious problems

    Copper can be found in a wide variety of foods, including whole grains, shellfish, seeds, nuts, and organ meats. However, if you fail to reach the recommended intake of 900mcg per day (for adults), then some serious health concerns may arise, such as cardiovascular disease, alzheimer’s disease, decreased immune response, anemia, and osteoporosis.[1]

    Revive MD Matt Jansen Expo

    Not only is the Cofounder of Revive MD a coach, bodybuilder, and entrepreneur, he’s an educator.

    A study from 2016 reported that a deficiency of essential trace minerals, such as copper, zinc, iron, calcium, and selenium are strongly associated an increased risk of prostate cancer.[2] The key finding from this study is that it’s important to have an optimal balance between all the trace minerals assessed in hope of preventing either BPH or prostate cancer.

    Copper has also been utilized in combination with standard pharmacological treatment to help identify and kill off prostatic cancer cells.[3,4] Furthermore, preliminary research is looking into the use of copper’s therapeutic utility for prostate cancer treatment.[5] More research is warranted on this area, but it’s definitely worth noting.

    With over half of your daily copper requirement supplied by Revive MD Prostate, it should be easy to meet the remainder of the recommended daily allowance (RDA) through your diet.

  • Selenium Citrate – 50mcg (90% DV)

    The next mineral included in Revive MD Prostate is selenium in the form of selenium citrate.

    Selenium is also considered to be an essential nutrient because the body cannot produce it on its own, so it must be supplied by diet and/or supplementation. Selenium is classified as a trace element that’s primarily present in organ meats, nuts, and seafood.[6]

    Once selenium is ingested, it goes on to synthesize several selenoproteins that are crucial for DNA synthesis, thyroid hormone metabolism, reproduction, and serve as potent antioxidants.[6,7] The recommended dietary allowance for selenium is around 55mcg for adults and Revive MD Prostate is nearly supplying you with the entire amount!

    Selenium deficiency leads to unoptimized men

    Selenium deficiency has been linked to male infertility, increased risk of infection, and various other health conditions.[6-8]

    Revive MD Prostate

    Revive MD Prostate has three essential minerals to optimize prostate health.

    Research shows that selenium plays a crucial role in testosterone metabolism and serves as constituent in sperm production.[7,8] Therefore, selenium supplementation is often recommended to male patients with infertility.[7,8]

    A meta-analysis published in 2017 found that men with higher serum selenium levels had significantly lower risk of prostate cancer.[9] The researchers noted that selenium is a major component of three proteins: albumin, selenoprotein, and glutathione peroxidase (GPx).[9] Those proteins carry out crucial functions such as preventing cellular injury by serving as a potent antioxidant system.[9]

    Selenium prevents the expression of oncogene, which is a cell that can transform into a tumor, and stimulates apoptosis.[9] Selenium can also inhibit cell proliferation by reducing cyclin in prostatic cancer cells.[9] Another meta-analysis from 2018 concluded that there’s a high probability that selenium has a protective role against the development and progression of prostate cancer.[10] Furthermore, an adequate intake of selenium may help prevent cardiovascular disease, cancer, cognitive decline, and thyroid disease.[6]

  • Zinc Bisglycinate Chelate – 10mg (90% DV)

    The last mineral we’re going to cover is zinc, and as we mentioned earlier, zinc bisglycinate chelate is a highly bioavailable form! Since the body has really no way to store zinc, it’s crucial to consume an adequate amount of it on a daily basis.

    Zinc can primarily be found in poultry, red meat, seafood, seeds, nuts, whole grains, and dairy products. It’s important to note that phytates, a naturally occurring compound in various grains, seeds, nuts, and beans, can significantly inhibit the absorption of zinc, therefore animal products are the best bet for hitting zinc’s recommended daily allowance.

    Revive MD Matt

    If you want to perform and your best, then health must come first!

    Not only is zinc essential for immune function, but it’s also involved in DNA synthesis, protein synthesis, wound healing, and cell division.[11] Zinc deficiency can cause impaired immune system function, reduced appetite, hair loss, hypogonadism in males, delayed wound healing, increased risk of prostate cancer, and lethargy.[2,11]

    Studies report that even a mild zinc deficiency can drastically decrease cytokine production, and suppresses the function of several cells involved in the immune system, including macrophages, neutrophils, lymphocytes and natural killer cells.[12]

    Regarding men’s health, zinc is considered to be an essential element for male fertility, prostate health, and testosterone production.[13] Zinc acts as an antibacterial agent in a male’s urea system, meaning it helps fight off infections.[13] In addition, zinc plays a crucial role in maintaining the integrity of the epithelial lining that surrounds the reproductive organs.[13]

    A study from 2011 found that patients with prostate cancer excreted up to three times the amount of zinc through urination then healthy subjects.[14] This significantly increases your risk of developing a zinc deficiency, which can further exacerbate other health issues.

    Overall, Revive MD Prostate is providing you with three minerals that are essential for optimizing men’s health.

  • Pumpkin Seed Oil Powder – 1g

    Although we just talked about the importance of zinc, it turns out that we’re not done yet!

    Pumpkin seeds are known for being a rich source of zinc, which may be why they have been used for the prevention and treatment of benign prostatic hyperplasia.[15] A study published in 2011 found that patients with BPH excreted a greater amount of zinc through their urine, resulting in significantly lower levels of zinc in their prostate tissue compared to healthy subjects.[15]

    In addition, research from 2009 reported that a combination of pumpkin seed oil and saw palmetto oil resulted in a reduction in symptoms associated with BPH.[16] More research is warranted, but the current theory as to why this combination may improve symptoms is by anti-androgenic activity, decreased globulin availability, anti-inflammatory effects, and an alteration of cholesterol metabolism.[16]

    Revive MD Chris Bumstead Bergamot

    Revive MD Bergamot supports your cardiovascular system!

    In isolation, pumpkin seed oil seems to be able to reduce symptoms of BPH as noted by a 12-month long research study from 2014.[17] This study recruited over 1,400 males between the ages of 50 and 80 years old that were diagnosed with BPH.[17] The participants were randomly assigned to receive either 500mg of pumpkin seed oil taken twice per day (1g total) or a placebo.[17]

    The researchers assessed the patients’ symptoms using the International Prostate Symptom Score (IPSS). In the end, they concluded that the participants supplementing with pumpkin seed oil had significantly lower symptoms as measured by the IPSS.[17]

    In a landmark study from 2019, researchers recruited a total of 60 males with an IPSS score of 14.8 on average,[18] meaning they had a significant level of symptoms associated with BPH. The subjects were instructed to take pumpkin seed extract once per day prior to sleep.[18]

    The researchers measured the participants’ frequency of nocturia using a bladder diary and post residual urine was recorded using an ultrasound.[18] After 12 weeks, the results showed that pumpkin seed extract supplementation significantly reduced nocturia frequency, post void residual urinary volume, and improved overall quality of life![18]

    Preliminary research has also revealed that pumpkin seed oil expresses the potential to inhibit a specific type of prostate hyperplasia induced by a mixture of testosterone and prazosin.[19]

  • Saw Palmetto Extract (Serenoa repens) (berry) (Std. to contain 85-95% Fatty Acids & Sterols) – 400mg

    Saw palmetto is a specific type of palm tree native to southern areas of the United States, its berries are used to make various supplements, liquid extracts, and even teas. Serenoa repens, more commonly referred to as saw palmetto extract, is a popular herbal supplement directed towards men’s health.

    Saw palmetto contains up to 95% fatty acids and sterols, such as beta-sitosterol, caprylic acid, oleic acid, and palmitic acid. It also contains lipases, tannin, and carotenoids, that are all attributed to its positive effects.[20] As you can see from the label, Revive MD shows the consumer that they are using the most potent extract by noting the standardization of bioactive compounds (85-95%).

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    Make sure you’re stocked up on the best supplements in the industry!

    There’s multiple studies showing that saw palmetto extract supplementation supports prostate health, improves urinary tract issues, prevents or slows down the rate of hair loss, boosts testosterone levels, and even expresses anti-inflammatory properties.[20-22]

    A meta-analysis, comprised of 18 randomized controlled trials and nearly 3,000 males, found that serenoa repens supplementation significantly reduced urinary tract symptom scores, nocturia frequency, and improved peak urinary flow.[23] Furthermore, when serenoa repens was compared to a urinary retention medication known as finasteride, it produced similar improvements in urinary flow and urinary tract symptoms with less adverse effects reported.[23]

    Saw palmetto has been found to be a potent inhibitor of the enzyme that converts testosterone into dihydrotestosterone (DHT) called 5-alpha reductase (5α-R).[20] DHT is the primary hormone that causes hair loss, therefore decreasing levels of DHT, helps slow or prevent hair follicles from falling out.

    Although more research is needed to figure out the exact mechanism, a study from 2001 reported that saw palmetto supplementation significantly improved symptoms associated with lower urinary tract infections in males compared to a placebo.[21] However, it did not have any notable effects on urinary flow.[21]

    Furthermore, preliminary research suggests that saw palmetto may be able to reduce the growth of prostate cancer cells and lower the severity of symptoms associated with benign prostatic hyperplasia.[21,22] The current hypothesis is that saw palmetto is able to modulate levels of Cox-2 expression, which is linked to an increased risk of prostate cancer.[22]

  • Stinging Nettle Extract 20:1 (root) – 300mg

    Known in the scientific literature as Urtica dioica, stinging nettle has been historically utilized to treat a variety of inflammatory conditions, including osteoarthritis and rheumatoid arthritis.[24]

    Revive MD Greens

    Revive MD Daily Greens makes sure you’re getting enough micronutrients in each day.

    There are several parts of the plant that seem to possess their own unique benefits, but when it comes to treating benign prostatic hyperplasia, the root shows the most potential.[24] And yet again, you can see from the label that’s exactly what Revive MD is using!

    Stinging nettle is a flowering plant that’s native to Europe, Africa, and parts of Asia. It contains a rich source of vitamins, minerals, polyphenols, fatty acids, and color pigments, which all contribute to its purported health benefits.[24] Stinging nettle is known for its potent anti-inflammatory and antioxidant properties, but it’s also been researched as a potential alternative treatment for BPH.[24]

    One study from 2012, discovered that stinging nettle extract was able to inhibit the conversion of testosterone to DHT, thus decreasing the chance of prostate enlargement.[25] Another study from 2005 concluded that that stinging nettle supplementation had beneficial effects for the treatment of BPH symptoms over a 18 month time frame.[26]

  • BioResponse DIM (Diindolylmethane) – 300mg

    If there’s one thing that Revive MD is known for it’s creating supplements geared towards optimizing hormone levels and BioResponse DIM is a phenomenal ingredient to do just that!

    Diindolylmethane, or DIM for short, is a compound found in a variety of cruciferous vegetables, such as kale, cauliflower, and broccoli![27] DIM is known for its ability to prevent estrogen levels from getting out of hand,[28] and although Revive MD Prostate is formulated for males, females can also greatly benefit from this ingredient!

    Revive MD Kidney Male Athlete

    Revive MD Kidney supports proper kidney function.

    Research shows that DIM serves as a potent aromatase antagonist, resulting in a significantly decreased conversion rate of testosterone to estrogen, which also results in naturally higher levels of testosterone.[28] Other studies have theorized that because DIM activates aryl hydrogen receptors, it may inhibit excessive estrogen absorption as well![29]

    Despite the misconception that males should try to eliminate estrogen all together, that could lead to some serious health conditions!

    The goal is to balance and optimize hormone levels which is why DIM is becoming a very popular ingredient in the dietary supplement industry. In addition to preventing estrogen levels from becoming too high, DIM increases the amount of “good” estrogen within the body known as estradiol 2-hydroxylase (EH) opposed to 16-alpha-hydroxyestrone, which is labeled as “bad” estrogen.[30]

    In summary, DIM is a great ingredient for both men and females who are looking to balance their hormone levels!

  • Beta-Sitosterol – 150mg

    This next ingredient is a Revive MD favorite because it’s now included in two of their supplements: Lipid and Prostate!

    Beta-sitosterol is a plant sterol, also known as a phytosterol, with nearly an identical chemical structure as cholesterol. It’s included in Revive MD Lipid due to its powerful ability to decrease the intestinal absorption of dietary cholesterol.[31,32]

    Revive MD Lipid Graphic

    You can also find beta sitosterol in Revive MD Lipid.

    Studies show that a greater amount of phytosterol consumption is associated with lower levels of LDL and triglycerides.[31-33] Furthermore, beta-sitosterol expresses the ability to block HMG-CoA reductase gene expression, resulting in lower rates of cholesterol synthesis.[33] This is crucial for preventing several cardiovascular conditions and maintaining optimal arterial health.

    In regards to promoting prostate health, beta-sitosterol also offers various other benefits! Interestingly enough, beta-sitosterol is one of the primary sterols found in saw palmetto, which we discussed previously. Research has attributed saw palmetto’s positive effects in the treatment of benign prostatic hyperplasia partly to it’s beta-sitosterol concentration.[34]

    Although the consensus on how effective saw palmetto is at treating symptoms of BPH is still unclear, it seems that the potency of the extract can vary widely, significantly impacting the benefits of the ingredient.[34] Not only does Revive MD Prostate note that they use a saw palmetto extract that’s standardized to contain 85-95% sterol and fatty acid content, it also includes an extra dose of beta-sitosterol to ensure you see best results!

    Beta-sitosterol in isolation expresses the ability to inhibit and/or reduce BPH symptoms and prostate cancer cell growth by acting as a 5α-reductase antagonist.[34,35] Overall, beta-sitosterol is an incredible ingredient and you’re getting it in two forms with Revive MD Prostate!

  • Pine Bark Extract (Std. to contain 95% oligomeric proanthocyanidins) – 50mg

    Revive MD Matt Gym

    Performance and muscle building are directly correlated to optimal health.

    Pine Bark Extract (PBE) supplementation can provide numerous health benefits since its expresses potent anti-inflammatory, antioxidant, immunomodulatory, antihypertensive, antispasmodic properties.[36] PBE has also been shown to relieve pain, improve lung function, decrease the risk of blood clot formation, and vasodilate the blood vessels.[36]

    The majority of these benefits are attributed to its rich concentration of proanthocyanidins.[36,37] Not only do proanthocyanidins give a wide range of plants their vibrant color – they’re also important constituents within proper nutrition. Proanthocyanidins, also known as phytochemicals, are responsible for several positive pharmacological effects, such as anticancer, antidiabetic, neuroprotective, antioxidant, and antimicrobial.[37]

    It’s crystal clear that these compounds are crucial for general health, but what can they specifically do for prostate function?

    Pine bark extract for benign prostatic hyperplasia (BPH)

    In a landmark study from 2018, researchers recruited 75 males with signs and symptoms of benign prostatic hyperplasia and split them into three groups.[38] The first group only received standard management, thus serving as the control group.The second group got standard management along with pine bark extract supplementation. Finally, the third group were administered standard pharmacological treatment.

    Revive MD Collagen Graphic

    Revive MD even sells a high quality collagen powder to support connective tissue.

    Over the course of the study, the researchers assessed various symptoms associated with BPH, including urinary frequency, urgency, nocturia, intermittency, straining, and emptying.[38] The researchers concluded that pine bark extract supplementation significantly improved BPH symptoms.[38]

    Although pine bark extract’s mechanism of action still needs more research to be fully understood, one study from 2018 noted that it was able to reduce DHT levels in mice.[39] This resulted in the inhibition of BPH development induced by testosterone-propionate.[39]

    It would be great to see more research conducted using pine bark extract, but so far the future is looking bright!

  • Lycopene – 20mg

    We are down to the final ingredient and Revive MD is rounding out this comprehensive formula with lycopene!

    Lycopene is a chemical compound that falls under the classification of carotenoids. It’s responsible for giving various foods, such as red carrots, tomatoes, grapefruits, and watermelon, their reddish coloring.[40] Similar to proanthocyanidins, carotenoids are also powerful antioxidants, therefore proving a multitude of health benefits. But, unless you’re eating a ton of tomatoes each day, you could benefit from getting some extra through supplementation!

    Revive MD Matt Jansen Quote

    Owner of Revive MD, Matt Jansen, is on a mission to provide you with supplements that will take your training and health to the next level.

    Researchers have found that high tomato consumption has been linked to lower risk of cancer, most notably, prostate, lung, and stomach.[40] This phenomenon is primarily attributed to tomatoes’ rich concentration of lycopene. A review study from 2010 reported that at least 12 clinical trials concluded that there’s an inverse relationship between lycopene consumption and levels of prostate specific antigen (PSA), which is a measure used to assess a patient’s risk of developing prostate cancer.[40]

    In other words, the males who consumed the greatest amount of lycopene either through diet, supplementation, or both, had lower risk of developing prostate cancer. It’s important to note that the vast majority of the research conducted on lycopene is epidemiological and more research is needed to determine its effectiveness!

    Revive MD Prostate is another fully loaded formula and if you’ve suffered from prostate issues in the past or are dealing with it now, this is a great product to try out. But keep in mind, you should always consult with a qualified healthcare professional before taking any supplements!

Revive MD: Experience The Difference

Now this is how you formulate a specific supplement. We’ve seen prostate formulas out there on Amazon, and they simply don’t hold a candle to this type of formula. If you’re willing to take seven capsules per day — and you should be if you’re truly concerned about this issue — then there’s truly no single alternative supplement.

Revive MD Prostate Front Back

Take back your life with Revive MD Prostate!

Revive MD has grown tremendously in a relatively short period of time. They’ve earned the trust from some of the best athletes in the world, across a wide range of sports, from strongman competitors to professional bodybuilders. Regardless if you’re a competitor, a gym rat, or weekend warrior, health should always be the number one priority.

But unfortunately, the majority of sports supplement companies spend more time formulating the next “hot” pre workout, rather than crafting superior health and wellness products. Several elite athletes and competitors have reached out to join Revive MD because there’s very few, if any, brands that create better supplements solely geared towards health.

PricePlow has started to notice that other companies are beginning to realize Revive MD’s success and are attempting to copy them. It’s obvious that Revive MD is making a huge difference in the industry by showing other brands and consumers how health needs to come first or else performance will drastically decline. If you’re looking for some of the best health products available, then we would highly recommend Revive MD.

Although Revive MD has an incredibly diverse line of products, they’re going to continue to expand their offerings moving forward! Get ready for several more launches from Revive MD by subscribing down below.

Revive MD Prostate – Deals and Price Drop Alerts

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About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public. Mike is currently experimenting with a low Vitamin A diet.

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References

  1. National Institutes of Health; “Copper – Fact Sheet For Healthcare Professionals.”; Office of Dietary Supplements; 2020; https://ods.od.nih.gov/factsheets/Copper-HealthProfessional/
  2. Singh, Bhupendra Pal et al.; “Status and Interrelationship of Zinc, Copper, Iron, Calcium and Selenium in Prostate Cancer.”; Indian journal of clinical biochemistry : IJCB vol. 31,1 (2016): 50-6. doi:10.1007/s12291-015-0497-x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731369/
  3. Denoyer, Delphine et al.; “Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution.”; Oncotarget vol. 7,24 (2016): 37064-37080. doi:10.18632/oncotarget.9245; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095059/
  4. Cater MA, Pearson HB, Wolyniec K, et al.; “Increasing intracellular bioavailable copper selectively targets prostate cancer cells.”; ACS Chem Biol. 2013;8(7):1621‐1631. doi:10.1021/cb400198p; https://pubmed.ncbi.nlm.nih.gov/23656859/
  5. Denoyer, Delphine et al.; “Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution.”; Oncotarget vol. 7,24 (2016): 37064-37080. doi:10.18632/oncotarget.9245; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095059/
  6. National Institutes of Health; “Selenium – Fact Sheet For Healthcare Professionals.”; Office of Dietary Supplements; 2020; https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/
  7. Qazi, Izhar Hyder et al.; “Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences.”; Antioxidants (Basel, Switzerland) vol. 8,8 268. 2 Aug. 2019, doi:10.3390/antiox8080268; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719970/
  8. Moslemi, MK et al.; “Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate.”; International journal of general medicine vol. 4 99-104. 23 Jan. 2011, doi:10.2147/IJGM.S16275; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048346/
  9. Cui, Zhigang et al.; “Serum selenium levels and prostate cancer risk: A MOOSE-compliant meta-analysis.”; Medicine vol. 96,5 (2017): e5944. doi:10.1097/MD.0000000000005944; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293444/
  10. Sayehmiri, Kourosh et al.; “The association between Selenium and Prostate Cancer: a Systematic Review and Meta-Analysis.”; Asian Pacific journal of cancer prevention : APJCP vol. 19,6 1431-1437. 25 Jun. 2018, doi:10.22034/APJCP.2018.19.6.1431; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103565/
  11. National Institutes of Health; “Zinc – Fact Sheet For Healthcare Professionals.”; Office of Dietary Supplements; 2020; https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/
  12. Beck FW, et al.; “Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans.”; Am J Physiol. 1997;272(6 Pt 1):E1002‐E1007. doi:10.1152/ajpendo.1997.272.6.E1002; https://pubmed.ncbi.nlm.nih.gov/9227444/?dopt=Abstract
  13. Fallah, Ali et al.; “Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men’s Health, Germination, Sperm Quality, and Fertilization.”; Journal of reproduction & infertility vol. 19,2 (2018): 69-81; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010824/
  14. Christudoss, Pamela et al.; “Zinc status of patients with benign prostatic hyperplasia and prostate carcinoma.”; Indian journal of urology : IJU : journal of the Urological Society of India vol. 27,1 (2011): 14-8. doi:10.4103/0970-1591.78405; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114577/
  15. Christudoss, Pamela et al.; “Zinc status of patients with benign prostatic hyperplasia and prostate carcinoma.”; Indian journal of urology : IJU : journal of the Urological Society of India vol. 27,1 (2011): 14-8. doi:10.4103/0970-1591.78405; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114577/
  16. Hong, Heeok et al.; “Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia.”; Nutrition research and practice vol. 3,4 (2009): 323-7. doi:10.4162/nrp.2009.3.4.323; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809240/
  17. Vahlensieck W. et al; “Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study.”; Urol Int. 2015;94(3):286‐295. doi:10.1159/000362903; https://pubmed.ncbi.nlm.nih.gov/25196580/
  18. Leibbrand, Martin et al.; “Effects of an Oil-Free Hydroethanolic Pumpkin Seed Extract on Symptom Frequency and Severity in Men with Benign Prostatic Hyperplasia: A Pilot Study in Humans.”; Journal of medicinal food vol. 22,6 (2019): 551-559. doi:10.1089/jmf.2018.0106; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590724/
  19. Tsai YS. et al.; “Pumpkin Seed Oil and Phytosterol-F Can Block Testosterone/Prazosin-Induced Prostate Growth in Rats.”; Urol Int 2006;77:269–274; https://www.karger.com/Article/Abstract/94821
  20. Murugusundram S.; “Serenoa Repens: Does It have Any Role in the Management of Androgenetic Alopecia?”;J Cutan Aesthet Surg. 2009;2(1):31–32; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840915/
  21. Gerber GS, et al.; “Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptoms.”; Urology. 2001;58(6):960‐965. doi:10.1016/s0090-4295(01)01442-x; https://pubmed.ncbi.nlm.nih.gov/11744467/
  22. Goldmann WH, et al.; “Saw palmetto berry extract inhibits cell growth and Cox-2 expression in prostatic cancer cells.”; Cell Biol Int. 2001;25(11):1117‐1124. doi:10.1006/cbir.2001.0779; https://pubmed.ncbi.nlm.nih.gov/11913955/
  23. Wilt TJ, et al.; “Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review.”; [published correction appears in JAMA 1999 Feb 10;281(6):515]. JAMA. 1998;280(18):1604‐1609. doi:10.1001/jama.280.18.1604; https://pubmed.ncbi.nlm.nih.gov/9820264/
  24. Johnson, TA et al.;”Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders.”; Phytomedicine : international journal of phytotherapy and phytopharmacology vol. 20,2 (2013): 143-7. doi:10.1016/j.phymed.2012.09.016; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529973/
  25. Nahata A, Dixit VK.; “Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats.”; Andrologia. 2012;44 Suppl 1:396‐409. doi:10.1111/j.1439-0272.2011.01197.x; https://pubmed.ncbi.nlm.nih.gov/21806658/
  26. Safarinejad MR.; “Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study.”; J Herb Pharmacother. 2005;5(4):1‐11; https://pubmed.ncbi.nlm.nih.gov/16635963/
  27. Aggarwal, Bharat B, and Haruyo Ichikawa; “Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives.”; Cell Cycle (Georgetown, Tex.); U.S. National Library of Medicine; Sept. 2005; https://pubmed.ncbi.nlm.nih.gov/16082211
  28. Balunas, Marcy J et al; “Natural products as aromatase inhibitors.”; Anti-cancer agents in medicinal chemistry; vol. 8,6; 2008; 646-82; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074486/
  29. Sanderson, J T, et al; “2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Diindolylmethanes Differentially Induce Cytochrome P450 1A1, 1B1, and 19 in H295R Human Adrenocortical Carcinoma Cells.”; Toxicological Sciences : an Official Journal of the Society of Toxicology; U.S. National Library of Medicine, May 2001; https://pubmed.ncbi.nlm.nih.gov/11294972
  30. Jellinck, P H, et al; “Ah Receptor Binding Properties of Indole Carbinols and Induction of Hepatic Estradiol Hydroxylation.”; Biochemical Pharmacology; U.S. National Library of Medicine; 9 Mar. 1993; https://pubmed.ncbi.nlm.nih.gov/8384853
  31. Gylling, H. et al; “Plant sterols and plant stanols in the management of dyslipidemia and prevention of cardiovascular disease”; Atherosclerosis; 232 (2); 2014; https://www.atherosclerosis-journal.com/article/S0021-9150(13)00694-1/fulltext#secsectitle0040
  32. Plat J. and Mensink RP; “Effects of plant sterols and stanols on lipid metabolism and cardiovascular risk;” Nutr Metab Cardiovasc Dis. 2001 Feb;11(1):31-40; https://pubmed.ncbi.nlm.nih.gov/11383323
  33. Field FJ, Born E, Mathur SN; “Effect of micellar beta-sitosterol on cholesterol metabolism in CaCo-2 cells”; J Lipid Res. 1997 Feb;38(2):348-60; https://pubmed.ncbi.nlm.nih.gov/9162754
  34. Penugonda, K. et al;”Fatty acid and phytosterol content of commercial saw palmetto supplements.”; Nutrients vol. 5,9 3617-33. 13 Sep. 2013, doi:10.3390/nu5093617; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798925/
  35. Berges RR, et al.; “Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia.”; Beta-sitosterol Study Group. Lancet. 1995;345(8964):1529‐1532. doi:10.1016/s0140-6736(95)91085-9; https://pubmed.ncbi.nlm.nih.gov/7540705/
  36. Rohdewald P.; “A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology.”; Int J Clin Pharmacol Ther. 2002;40(4):158‐168. doi:10.5414/cpp40158; https://pubmed.ncbi.nlm.nih.gov/11996210/
  37. Rauf, A. et al; “Proanthocyanidins: A comprehensive review.”; Biomedicine & Pharmacotherapy; Volume 116, 2019; https://www.sciencedirect.com/science/article/pii/S0753332219305359
  38. Ledda A, Belcaro G, Feragalli B, et al.; “Benign prostatic hypertrophy: Pycnogenol supplementation improves prostate symptoms and residual bladder volume.”; Minerva Med. 2018;109(4):280‐284. doi:10.23736/S0026-4806.18.05572-6; https://pubmed.ncbi.nlm.nih.gov/29947491/
  39. Ko, Je-Won et al.; “Inhibitory effects of Pycnogenol, a pine bark extract, in a rat model of testosterone propionate-induced benign prostatic hyperplasia.”; Laboratory animal research vol. 34,3 (2018): 111-117. doi:10.5625/lar.2018.34.3.111; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170226/
  40. Story, Erica N et al.; “An update on the health effects of tomato lycopene.”; Annual review of food science and technology vol. 1 (2010): 189-210. doi:10.1146/annurev.food.102308.124120; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850026/

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