Velositol Increases Exercise Performance: New University Study Previewed

Velositol, dubbed “protein’s perfect partner” by supplement developer, Nutrition21, was recently studied to determine its effectiveness. Researchers tested the ingredient alongside a suboptimal dose (15 grams) of whey protein to see to what extent it enhances muscular strength, lean body mass, exercise performance, and whole body protein balance. Volunteers consumed Velositol over the course of an eight week resistance training program.


Made by Nutrition 21, the experts in Chromium and Insulin management, Velositol can boost Muscle Protein Synthesis by using chromium and a ‘tickle’ of insulin-spike from amylopectin!

The findings were quite remarkable.

The study was led by researchers from the Center for Applied Health Sciences (CAHS), located in Canfield, Ohio. The lead researcher and the organization’s chief scientific officer, Dr. Tim Ziegenfuss, previously conducted a double-blind crossover study to evaluate the effects of an amylopectin and chromium complex (as Velositol) on the anabolic response to low dose whey protein (6 grams).[1]

The landmark study compared the effects of 2 grams of Velositol with 6 grams of whey protein to 6 grams of whey protein alone. The results indicate that Velositol and protein doubled the muscle protein synthesis (MPS) response (48% vs. 24%), as measured by the fractional rate of MPS[1] Because the subjects that supplemented with whey protein and Velositol had higher levels of insulin secretion, the researchers theorized that Velositol boosts MPS by enhancing insulin sensitivity.[1]

Velositol Doubles the Power of Protein, but What Else Can it Do?

Although the findings from the CAHS study were significant, it only assessed Velositol’s potential in an acute setting on a fairly small sample size of 10 participants taking an extremely small amount of protein. So for the next trial, Ziegenfuss evaluated Velositol’s chronic effects on exercise performance and whole body protein balance, this time in combination with a higher dose of protein.

Before we dive into the nitty-gritty details of this exciting new research, sign up for Nutrition21 news alerts so you can stay up to date with one of the leading ingredient developers in the supplement industry!

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Research Review: Velositol’s Effects on Exercise Performance

Materials and Methods

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For this study, Ziegenfuss and colleagues recruited 35 recreationally-active middle-aged men. They used a randomized, active-controlled, double-blind design and randomly assigned the subjects to three groups:

  • Active Group: 15g of whey protein and 2g of Velositol
  • Comparator Group: 15g of whey protein
  • High-Dose Comparator Group: 30g of whey protein[2]

The participants consumed their assigned supplement directly after training and at similar times during rest days.

At zero, four, and eight weeks, the researchers collected the following data: body composition (using four compartment model with the Bod Pod, DEXA, and Bioelectrical Impedance); whole-body protein balance (via N-alanine); and upper/lower body performance (using a 1-repetition max and repetitions to failure (RTF) on the squat, bench press, and vertical jump power/height).[2]

It’s important to note that this was just part one of the study. Part two, which will be released at a later date, examines biomarker safety and recovery data. We will update this article as more information is published.


Velositol Chart

How Velositol expresses its muscle-building effects!

Here are some key findings from the study:

  • All participants gained strength and increased lean body mass and muscle size while improving their RTF in the squat.
  • The active group saw a statistically significant increase in lower body muscular endurance, compared to the other groups, as measured by RFT for squats.
  • Vertical jump power and height increased more for the active group compared to the other groups.
  • Relative squat strength improved more for the active group compared to the other groups.
  • Net protein balance was significantly greater in the active group at four weeks compared to the other groups. At eight weeks it no longer statistically significant.[2]


Ziegenfuss and colleagues found that consuming 2 grams of Velositol with 15 grams of whey protein was the most optimal combination.

Velositol PricePlow

New research shows that Velositol in combination with 15g of whey protein boosts exercise performance!

During an eight week resistance training program, the volunteers in this group saw greater increases in vertical jump height, vertical jump power, squat RFT, and squat strength. The men who took either 15 grams or 30 grams of whey protein alone did not see improvements to the same degree.[2]

The researchers theorize that Velositol carries out its performance-boosting benefits by optimizing early adaptations to whole-body protein balance.[2] Whole body protein balance is the difference between muscle protein synthesis and muscle protein breakdown.

So what this means, in plain language, is that Velositol helps the body utilize the protein better at an early point in time. However, more research is needed to fully understand Velositol’s mechanism of action in regards to improving exercise performance.

Keep in mind that this is just a preview of the study, which was presented this month at the annual conference of the International Society of Sports Nutrition (ISSN). Once the study is officially published, we’ll update this blog post with more details. So make sure you subscribe below for more information on Velositol!

To learn more, see our main Velositol article.

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About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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  1. Ziegenfuss TN, et al. Feb. 2017. “Effects of An Amylopectin and Chromium Complex on the Anabolic Response to a Suboptimal Dose of Whey Protein.” Journal of the International Society of Sports Nutrition vol. 14:6.
  2. Ziegenfuss TN. et al. Sept.10-12, 2020. “Effects of Velositol on Muscular Strength, Lean Mass, Whole-Body Protein Balance, and Exercise Performance During Eight Weeks of Resistance Training: Part 1.” Proceedings of the Annual Conference of the International Society of Sports Nutrition, Sep. 10-12, 2020, Daytona Beach, Fl.

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