Stadice: Zeus Hygia's Mangiferin-Powered Cognitive Enhancement for the Digital Age

When we last spoke with Arun Kanth about Zeus Hygia's breakthrough Gremin ingredient, the conversation revealed more than just one innovative compound. Toward the end, Arun shared details about Stadice, a mangiferin-standardized extract from mango bark (Mangifera indica) designed to enhance cognitive performance.

"That would be very exciting to talk about mangiferin and Mangifera indica extract," Arun explained during the podcast, "because it's being studied for very interesting areas like improving focus, alertness, and memory during gaming and esports activities."

Stadice: Zeus Hygia's Cognitive Enhancement Ingredient from Mango Bark Extract

Stadice is Zeus Hygia's proprietary cognitive enhancement ingredient that targets the digital performance space where mental sharpness matters most. Unlike generic mango extracts, Stadice utilizes the company's patented Insolib technology to improve solubility and clinical efficacy, creating a standardized mangiferin extract backed by published human clinical research.

Clinical Cognitive Results and Placement in Onnit's Alpha Brain Pre-Workout

A 2024 clinical study with 60 healthy adults demonstrated that Stadice significantly improved mental speed by over 20% after just seven days, along with other notable enhancements in attention, memory, and learning discussed later in this article. Stadice has already gained commercial validation through its inclusion in Onnit's Alpha Brain Pre-Workout formula -- a testament to both its efficacy and safety profile.

The gaming and esports market increasingly recognizes that cognitive performance can be the difference between victory and defeat. Stadice addresses this need with clinically-demonstrated benefits that extend beyond gaming to anyone seeking enhanced mental performance, focus, and memory in our increasingly digital world.

Ready to explore the science behind this innovative cognitive enhancer? Let's dive into what makes Stadice a game-changing ingredient for mental performance.

What is Stadice?

Stadice is a proprietary Mangifera indica (mango bark) extract standardized to mangiferin, developed by Zeus Hygia Life Sciences to support cognitive wellness in healthy adults. Unlike generic mango extracts on the market, Stadice utilizes Zeus Hygia's patented Insolib Technology -- a proprietary encapsulation process that addresses the bioavailability challenges that have historically limited mangiferin's therapeutic potential.^[1]

The Insolib Technology Advantage

Traditional mango extracts face a significant hurdle: mangiferin, the primary bioactive compound, exhibits poor solubility in acidic environments like the human stomach. This limitation severely restricts bioavailability and therapeutic efficacy. Zeus Hygia's Insolib Technology addresses this issue through a pure aqueous-based encapsulation process that dramatically improves mangiferin's solubility across the entire pH range, from the acidic stomach (pH 1.0) to the more alkaline small intestine (pH 6.8).

The result is what Zeus Hygia calls the "world's first enriched mangiferin": a water-soluble, bioavailable form of mango bark extract that delivers consistent therapeutic benefits.^[1]

Target Applications: Digital Performance and Beyond

Stadice was specifically developed for the growing digital performance market, where mental sharpness can determine success or failure. The ingredient targets several key demographics:

• Gaming and Esports Athletes: Professional and competitive gamers who need sustained focus, rapid reaction times, and enhanced decision-making during extended gaming sessions.
• Cognitive Performance Seekers: Students, professionals, and anyone facing demanding mental tasks who want to optimize cognitive function naturally.
• Digital Wellness: With screen time increasing dramatically since 2019 (up to 52% in some reports), Stadice addresses cognitive fatigue and diminished mental performance associated with digital exhaustion.
• General Wellness: Adults seeking natural cognitive support for memory, focus, alertness, and stress management in their daily lives.

Comprehensive Cognitive Benefits

Stadice supports multiple aspects of cognitive performance through mangiferin's diverse mechanisms of action. The ingredient has been clinically validated for improvements in:^[1]

• Mental Speed: Enhanced information processing and reaction times
• Focused and Sustained Attention: Improved ability to concentrate on tasks for extended periods
• Working Memory: Better capacity to hold and manipulate information
• Learning and Memory: Enhanced encoding, consolidation, and recall of information
• Stress Management: Support for psychological resilience and mood stability

Stadice combines natural origin and safety with robust clinical validation. The ingredient falls under the Old Dietary Ingredient (ODI) category, providing regulatory clarity while delivering clinical benefits at a practical 300mg daily dose.^[1]

Manufactured in a DSIR-approved scientific laboratory and produced at a premium quality, USFDA-registered facility with GMP certification, Stadice meets the highest standards for quality, purity, and consistency, which are essential factors for any cognitive enhancement ingredient entering the competitive nootropics market.

Before getting into Stadice's own science, let's get into mangiferin itself:

The Science Behind Mangiferin: Nature's Cognitive Enhancer

Mangiferin is a naturally occurring xanthone glycoside from mango leaves. This unique class of polyphenolic compounds is known for potent biological activities, including cognitive enhancement properties.^[2]

A complex, natural compound, mangiferin has garnered significant scientific interest due to its unique ability to target multiple pathways simultaneously, making it ideal for cognitive support and neurological improvements. One study from 2017 even calls it a "natural miracle bioactive" in the title!^[3]

Crossing the Blood-Brain Barrier: A Critical Advantage

One of mangiferin's most important characteristics for cognitive enhancement is its ability to cross the blood-brain barrier -- a highly selective membrane that protects the brain from potentially harmful substances while allowing essential nutrients through.^[2] Many cognitive enhancers fail at this crucial step, rendering them ineffective for brain health applications.

Research has confirmed that mangiferin and its metabolites, such as norathyriol, successfully penetrate brain tissue in sufficient concentrations to alter brain electrical activity through changes in regional neurotransmitter signaling. This bioavailability in the brain is essential for mangiferin's cognitive benefits and sets it apart from many other natural compounds that only show promise in cell studies.^[2]

Comprehensive Neuroprotective Mechanisms

Mangiferin's cognitive benefits stem from its multi-target approach to brain health. Rather than acting on a single pathway, the versatile compound provides neuroprotection through several interconnected mechanisms:

• Neurotrophic Support: Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal growth, survival, and synaptic plasticity. Mangiferin helps maintain healthy BDNF levels, supporting the brain's capacity for adaptation and learning throughout life.^[4]
• Mitochondrial Preservation: As the powerhouses of brain cells, mitochondria are critical for cognitive function. Mangiferin helps preserve mitochondrial integrity and function, ensuring neurons have the energy needed for optimal performance. This contributes to sustained mental energy and reduced cognitive fatigue.^[2]
• Antioxidant Defense: Mangiferin demonstrates powerful free radical scavenging activity, reducing reactive oxygen species (ROS) and oxidative stress that can damage neurons and impair cognitive function. This antioxidant activity extends to preventing lipid peroxidation, which can compromise cellular membranes in brain tissue.^[3]
• Anti-inflammatory Protection: Chronic neuroinflammation contributes to cognitive decline and neurodegenerative conditions. Mangiferin effectively reduces inflammatory markers in the brain, including pro-inflammatory cytokines like IL-6, while supporting the body's natural anti-inflammatory pathways.^[5]

From Traditional Use to Modern Science

The therapeutic use of mango extract extends back centuries across multiple cultures. Traditional applications include their use as tea substitutes and medicinal preparations for treating fatigue, exhaustion, and various health conditions throughout Asia and Africa.^[2]

Modern scientific validation has confirmed many of these traditional applications while revealing the specific mechanisms behind mangiferin's broad therapeutic effects. This convergence of traditional wisdom and contemporary research provides strong confidence in mangiferin's safety profile and therapeutic potential, supporting its development into standardized, clinically validated ingredients like Stadice, which we'll get into next:

Clinical Research on Stadice: Validating Cognitive Enhancement in Gamers

While mangiferin's background provides a solid foundation (and further mechanisms are detailed below), the true test of any cognitive enhancer lies in quality human clinical trials. The 2024 study on Stadice stands as a landmark investigation, providing the first controlled clinical evidence for the cognitive benefits of this proprietary mangiferin extract in healthy adults.

Study Design: Gold Standard Clinical Research

The Stadice clinical trial employed the gold standard of clinical research: a randomized, double-blind, placebo-controlled design that eliminates bias and ensures reliable results.^[1]

Study Population: Gaming and Esports Focus

The researchers recruited 60 healthy adults aged 18-45 years with a specific focus on individuals regularly engaged in digital gaming: those who spend at least three hours per week playing virtual, mobile, computer, or laptop games online or offline.^[1] This population was chosen because gaming demands the exact cognitive skills that Stadice targets: rapid decision-making, sustained attention, working memory, and mental agility.

All participants were male with an average age of 35 years (35.06 ± 5.76 years in the Stadice group, 35.73 ± 5.71 years in placebo). The study achieved exceptional compliance with 90% adherence rates and zero dropouts.

Intervention Protocol: Seven Days to Cognitive Enhancement

Participants received either 300mg of Stadice or matching placebo capsules daily for seven consecutive days. This dosage and duration were carefully selected based on previous single-dose studies and safety data showing Stadice's LD50 greater than 5000mg/kg in preclinical studies.^[1]

Cognitive assessments were conducted at baseline (Day 1) and post-supplementation (Day 7) using validated instruments including the NIMHANS Neuropsychological Battery and Auditory Verbal Learning Tests, which are designed to precisely measure multiple aspects of cognitive performance.

Primary Results: Incredible Cognitive Improvements

The results exceeded expectations across multiple cognitive domains, with Stadice demonstrating statistically significant improvements compared to placebo:^[1]

• Mental Speed: +20.86% (vs. +1.2% placebo) - The most dramatic improvement occurred in mental processing speed as measured by the Digit Symbol Substitution Test, indicating enhanced information processing and psychomotor efficiency.
• Sustained Attention: +27.78% - The largest single improvement measured, demonstrating Stadice's ability to help users maintain focus during extended cognitive tasks.
• Focused Attention: +16.05% (vs. -3.3% placebo decline) - Not only did Stadice improve focused attention, but placebo participants actually showed decline, highlighting the active ingredient's protective and enhancing effects.
• Working Memory: +7.03% - Improvements in the brain's ability to temporarily hold and manipulate information, essential for complex problem-solving and decision-making.
• Auditory Verbal Learning: +7.69% - Enhanced ability to encode, retain, and recall auditory information, indicating improved memory consolidation processes.

Secondary Benefits: Stress and Mood Support

Beyond primary cognitive improvements, Stadice demonstrated valuable secondary benefits in psychological stress management. Participants reported improvements in handling nervousness, irritability, and mood swings, complementing the cognitive enhancements and overall mental performance under pressure.^[1]

Safety Profile: Excellent Tolerability

Zero adverse events were reported throughout the seven-day supplementation period.^[1] All laboratory safety parameters remained within normal physiological ranges, confirming Stadice's excellent safety profile at the therapeutic dose.

This safety data aligns with extensive preclinical studies showing mangiferin and mango extracts to be non-genotoxic and well-tolerated in acute and chronic toxicity studies, providing confidence for longer-term use.

Context with Previous Research

The Stadice study builds upon earlier research with mango extracts, including single-dose studies at 300mg and 500mg that showed improvements in cognitive task performance and brain electrical activity.^[1] However, the Stadice trial represents the first multi-day supplementation study on gamers with a standardized, bioavailable mangiferin extract, demonstrating that consistent daily dosing can produce sustained cognitive improvements.

This study provides insights into Stadice's applications for digital performance, which is a rapidly-growing market where cognitive enhancement can directly impact performance and career success, whether in competitive gaming or professional work.

The mechanisms underlying the ingredient are coming, but first, let's discuss where Stadice makes sense in the supplement industry:

Industry Applications and Market Position: Where Cognitive Performance Matters

Stadice addresses multiple high-growth markets where cognitive enhancement can deliver tangible benefits. It easily targets the broader cognitive health and nootropics market, serving professionals, students, and anyone seeking natural mental enhancement.

The gaming and esports sector stands as the primary target, however, with global esports revenue projected to surpass $2.5 billion by 2025 according to industry analytics. With 80% of gamers regularly consuming food or beverages while playing, the market actively seeks natural solutions for sustained attention, focus, memory, and visual processing.

Beyond focus and gaming applications, the ingredient also fits well within general wellness formulas, offering cognitive support for aging populations and individuals facing digital fatigue from increased screen time, a major concern this decade.

Commercial Validation: The Onnit Pre-Workout Use Case

The most significant validation of Stadice's commercial viability comes from its inclusion in Onnit's Alpha Brain Pre-Workout formula at 300mg per serving. As Arun Kanth explained in our podcast, "Stadice is already launched in the US. We're working with Onnit... one of their leading Alpha Brain supplements contains Stadice."

This partnership represents far more than simple ingredient adoption. Onnit's rigorous scientific and regulatory standards make their ingredient selection process highly selective. Their choice to include Stadice validates both the clinical efficacy data and the ingredient's commercial potential in the competitive pre-workout market. The 300mg dosing in Alpha Brain Pre-Workout aligns perfectly with the clinically validated dose, bringing the full cognitive benefits demonstrated in research.

Operational Excellence: US Market Presence

The company now maintains offices and warehousing facilities in the New York/New Jersey area, addressing previous supply chain challenges and enabling rapid sample availability for formulators and brands.

Future Research Pipeline

Arun mentioned during our discussion that "we will have a second clinical design also ready in couple of months time." This ongoing clinical development suggests potential expansion of Stadice's applications, possibly exploring longer-term supplementation, different dosing protocols, or new target populations.

The company's recent Series A funding provides the financial foundation for extended clinical programs, supporting both deeper research on existing ingredients and development of new compounds using their platform technology approach.

Formulation Considerations and Compatibility

Stadice's formulation advantages stem from the Insolib Technology's improvements to mangiferin's solubility and stability. The ingredient offers excellent compatibility with various delivery formats, from traditional capsules and tablets to ready-to-drink beverages, energy shots, gummies, and nutrition bars. The clean aqueous-based processing ensures label-friendly formulas without synthetic solvents or harsh chemicals.

Dosage Recommendations: Clinically Validated Protocols

The clinical research provides clear dosage guidance: 300mg daily represents the validated effective dose for cognitive enhancement.^[1] While other mangiferin-based research has explored single doses up to 500mg, the seven-day study at 300mg demonstrates sustained benefits with excellent safety margins.

The ingredient's safety profile, with LD50 greater than 5000mg/kg, provides substantial headroom for various formulation approaches.

Stadice's entry into the Onnit Alpha Brain Pre-Workout validates not only its efficacy but also its commercial potential in the competitive cognitive enhancement space. As the esports industry continues its explosive growth and cognitive performance becomes increasingly valuable across multiple sectors, Stadice is positioned to capitalize on these trends with solid clinical evidence, robust supply chain infrastructure, and proven commercial partnerships.

Next, for the advanced section for those who need to know the details:

Mechanisms of Action: How Mangiferin Enhances Cognitive Performance

Understanding how mangiferin works at the molecular level reveals why Stadice delivers such comprehensive cognitive benefits. Rather than targeting a single pathway, mangiferin operates through multiple interconnected mechanisms that work synergistically to optimize brain function and cognitive performance.

• Primary Cognitive Pathways

  

  Zeus Hygia's systematic approach to creating Stadice involved extensive literature review, clinical evidence analysis, and historical research. This scientific foundation led them to develop their proprietary mangiferin-standardized mango bark extract.

  • COMT Inhibition: Optimizing Dopamine Function

    One of mangiferin's most significant discoveries is its role as a catechol-O-methyltransferase (COMT) inhibitor -- it's the first natural compound demonstrated to have this specific activity.^[2] COMT is the primary enzyme responsible for breaking down dopamine in the prefrontal cortex, the brain region most crucial for executive function, working memory, and attention.

    By inhibiting COMT, mangiferin effectively increases dopamine availability in the prefrontal cortex and hippocampus.^[2] This enhanced dopaminergic signaling translates directly into improved cognitive performance: better working memory capacity, enhanced selective attention, and superior executive function... precisely the benefits observed in the Stadice clinical study!^[1]

  • Acetylcholinesterase Inhibition: Enhancing Memory Systems

    Mangiferin also functions as an acetylcholinesterase (AChE) inhibitor, preventing the breakdown of acetylcholine, which is the neurotransmitter essential for learning, memory consolidation, and focused attention. This mechanism explains mangiferin's ability to improve memory performance in scopolamine-induced learning deficits in animal studies.^[6]

    

    The combination of enhanced cholinergic activity with improved dopaminergic function creates an ideal neurochemical environment for cognitive performance, supporting both the acquisition of new information and its consolidation into long-term memory.

  • BDNF Preservation: Supporting Neuroplasticity

    Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal growth, survival, and synaptic plasticity (the brain's ability to form and strengthen connections between neurons). Mangiferin helps preserve and restore BDNF levels, which naturally decline with age and stress.^[1]

    By maintaining healthy BDNF levels, mangiferin supports the brain's capacity for adaptation and learning throughout life, contributing to both immediate cognitive improvements and long-term brain health.

• Secondary Neuroprotective Mechanisms

  • Wide-Ranging Antioxidant Defense

    Mangiferin provides great protection against oxidative stress through multiple antioxidant mechanisms. The compound effectively scavenges free radicals, reduces reactive oxygen species (ROS), and prevents lipid peroxidation that can damage cellular membranes in brain tissue.^[2] This antioxidant activity is essential for maintaining optimal cognitive function, as oxidative stress can impair memory formation and retrieval.

  • Anti-inflammatory Neuroprotection

    Chronic neuroinflammation contributes significantly to cognitive decline. Mangiferin addresses this through potent anti-inflammatory effects, including the reduction of pro-inflammatory cytokines like IL-6 in the hippocampus and upregulation of heme oxygenase-1, a key enzyme in anti-inflammatory pathways.^[5]

  • Mitochondrial Function Preservation

    Mangiferin helps preserve mitochondrial integrity and function, ensuring brain cells have the energy needed for optimal performance while reducing cognitive fatigue.^[2]

• Synaptic Plasticity and Long-Term Potentiation

  Perhaps most importantly for cognitive enhancement, mangiferin directly supports long-term potentiation (LTP) -- the persistent strengthening of synaptic connections that underlies learning and memory formation.^[2]

  

  This graph dramatically shows how Stadice outperforms regular mangiferin extract across different pH levels. While standard mangiferin barely dissolves, Stadice maintains excellent solubility from stomach acid to intestinal conditions, ensuring better absorption.

  Research shows that mangiferin increases the amplitude of pyramidal cell population spikes in the hippocampus, indicating enhanced excitability and improved signal transmission.^[2] This improvement in synaptic function provides the neurological foundation for the cognitive enhancements observed in clinical studies.

  Integration: A Synergistic Approach

  What makes mangiferin truly effective for cognitive enhancement is how these mechanisms work together synergistically. The COMT inhibition provides immediate improvements in working memory and attention through enhanced dopamine signaling, while acetylcholinesterase inhibition supports memory consolidation and learning. BDNF preservation ensures long-term neuroplasticity, while the antioxidant and anti-inflammatory effects provide the neuroprotective foundation necessary for sustained cognitive improvement.

  

  This condensed overview shows the key cognitive improvements from Stadice's seven-day study - sustained attention saw the biggest boost at 37%, while mental speed improved over 20%. The solubility chart demonstrates how much better Stadice dissolves compared to regular mangiferin extract.

  This multi-target approach explains why Stadice demonstrates such comprehensive benefits across different cognitive domains, from the rapid mental speed improvements seen within seven days to the sustained attention and memory enhancements that support long-term cognitive performance.

Conclusion: Cognitive Enhancement to the Future with Stadice

Stadice stands as a breakthrough achievement in cognitive enhancement, combining centuries-old traditional wisdom with cutting-edge biotechnology to deliver clinically proven mental performance benefits. Through Zeus Hygia's innovative Insolib Technology, this proprietary mangiferin extract overcomes the bioavailability challenges that have long limited natural cognitive enhancers, creating a truly enriched mangiferin with validated efficacy.

The clinical evidence speaks for itself: 20.86% improvement in mental speed, 27.78% enhancement in sustained attention, and meaningful gains across working memory, learning, and focused attention... all achieved within just seven days of supplementation. These results validate mangiferin's multi-target approach, from COMT inhibition enhancing dopamine function to acetylcholinesterase modulation supporting memory consolidation.

Zeus Hygia's track record of innovation extends beyond Stadice alone. The company's success with Gremin, their curcumin-green coffee extract combination for sports nutrition, demonstrates a consistent ability to identify promising natural compounds and transform them into commercially viable, scientifically validated ingredients. This pattern of innovation, backed by Series A funding and expanding research pipelines, positions Zeus Hygia as an upcoming leader in next-generation nutraceutical development.

The future holds significant promise for Stadice's continued development. With a second clinical study in progress and growing industry adoption (as evidenced by Onnit's inclusion of Stadice in their Alpha Brain Pre-Workout), this ingredient is poised to capture substantial market share in the rapidly expanding cognitive enhancement space. The global esports market's projected growth to $2.5 billion by 2025, combined with increasing awareness of digital fatigue and cognitive wellness, creates ideal conditions for Stadice's continued success.

For formulators and brands seeking science-backed cognitive enhancement solutions, Stadice offers the rare combination of clinical evidence, commercial validation, regulatory clarity, and proven manufacturing quality. As the demand for natural, effective cognitive enhancers continues to grow, Stadice stands ready to meet that demand with measurable results and exceptional safety.

The cognitive enhancement revolution has begun, and Stadice is leading the charge with science, innovation, and proven results.