You may have caught our article about nucleotides — a family of “building block” compounds that play a critical role in energy production throughout the body. This article will focus on perhaps the best nucleotide supplement on the market, NucleoPrime by novel ingredient developer NNB Nutrition.
In one sentence, nucleotides are the building blocks of RNA and DNA, leading to a broad list of benefits when supplemented.
NucleoPrime is a patented blend of equal parts adenosine monophosphate (AMP), guanosine monophosphate (GMP), uridine monophosphate (UMP), and cytidine monophosphate (CMP). NNB guarantees each product to contain 24 to 26% of AMP, GMP, UMP, and CMP. NNB backs this guarantee via high-performance liquid chromatography (HPLC) lab tests. HPLC is a gold standard form of analytic chemistry that tells us exactly what’s in each serving of a product. Nucleotides also have the coveted GRAS certification from the FDA.
Long story short: you know what you’re getting with NucleoPrime, and that means you’re getting the building blocks to better cellular energy. Let’s get into those benefits and how we’d stack it into an energy supplement:
It’s important to note that muscles use nucleotides as an energy source. Muscle fibers use ATP — adenosine triphosphate — as they contract. A recent trial, which was supported by NNB Nutrition, tested the effects of nucleotide supplementation on exercise performance by measuring peak anaerobic power and fatigue markers. The trial had nine participants perform four high-intensity interval sets on an exercise bike, gave the subjects NucleoPrime, then had them repeat the high-intensity interval training seven days later. As participants reached the fourth set, their anaerobic peak power and relative peak power decreased due to fatigue.
Participants after NucleoPrime supplementation maintained their peak power longer into the second training session when compared to the pre-supplementation session. This suggests that NucleoPrime may help improve endurance by allowing athletes to output power for longer. While the researchers saw no statistically significant differences between the two sessions, the improvements in power output when comparing within-session performance before and after supplementation are interesting. It’s important to note that the repeated-bout effect may confound this, as a recently worked muscle may be more resistant to damage when subsequently exposed to the same exercise.
The trial also sought to investigate the impact of NucleoPrime on fatigue. The researchers used both subjective measures of fatigue and plasma levels of cortisol. Participants reported high levels of fatigue 48 hours after the pre-supplementation training session. There was less fatigue noted 48 hours after the post-supplementation session, suggesting that NucleoPrime may reduce fatigue. The study also noted that plasma cortisol levels were lower after the post-supplement session compared to the pre-supplement session. However, it’s important to note that these differences in fatigue measures did not reach statistical significance. A 2013 double-blind trial published in Nutrients shows that nucleotide supplementation may improve time to exhaustion, peak heart rate, and peak running speed. These improvements were statistically significant compared to the placebo group.
Immune Health Benefits
The immune system benefits of nucleotide supplementation are well studied. A 2002 study shows that dietary nucleotide consumption may improve immune-system function. The mechanism at play for this improvement is still under investigation, but there are theories:
Immune cells turn over – are you able to replace yours fast enough?
This improvement may arise from the high turnover rate of immune system cells. Immune cells, barring those designed to stick around for a long time, take the James Dean approach to life — they live fast and die young. To replace these dead cells, the body needs nucleotides. Supplementation may provide the body with the resources it needs to get the immune system back on track.
Exercise also induces a state of relative immunosuppression because of induction of physiologic stress. This acute form of stress drives the healthy reaction to exercise. However, chronic stress can wreak havoc on proper immune system functionality by inducing longer-term immunosuppression.
A 2018 trial in football referees shows immunoglobulin A (IgA) levels fall as cortisol levels rise. Nucleotide supplementation appears to increase IgA and natural killer cell activity. This suggests that nucleotide supplementation may help athletes mitigate the immunosuppression induced by intensive exercise. Nucleotides may also serve as a protective agent for living immune cells. A 2005 trial suggests that nucleotide supplementation may help mitigate DNA damage induced by high-fat diets.[10,11]
Gut health is likely the future of modern medicine, at least in the face of today’s processed food supply, which doesn’t seem to be going anywhere anytime soon. If you’re a health enthusiast and haven’t gone down that rabbit hole yet, we highly suggest spending time on gastric microbiota research. Nucleotide supplementation appears to improve the gut’s ability to repair itself from injury by improving repair cell migration to sites of gastric injury. Supplementation also may help prevent gastric damage from occurring.
Before we can conclusively state that nucleotide supplementation is gut-protective, we need to see human trials. Regardless, this finding has us excited for the future of gut health supplements, which are desperately needed given the state of our food industry.
Nucleotides also appear to improve symptoms of indigestion. A trial performed in patients with irritable bowel syndrome (IBS) suggests that oral nucleotide ingestion may reduce IBS symptoms like diarrhea, abdominal pain, and bloating in those predisposed to the condition.
We know some of our readers live for the nootropic products, and nucleotide supplementation has data suggesting nootropic benefit. Two trials performed in mice-models suggest that supplementation may help improve memory retention.[14,15] One of these trials also measured levels of lipofuscin — a marker used in aging research. In mice treated with exogenous nucleotides, lipofuscin levels were lower throughout the brain compared to the control group. These findings suggest that dietary nucleotide supplementation may support brain health.
Who should take NucleoPrime? And at what dosage?
NucleoPrime is a supplement we recommend for anyone looking to improve their general health, immunity, and stimulant-free energy. We can see NucleoPrime becoming a cornerstone of anti-aging stacks as well as cellular health supplements. It may even have a spot alongside creatine in some ATP-driven muscle building supplements as well as testosterone enhancement, as it provides some of the tools the body needs to grow and repair.
We think of nucleotide supplementation the same way that we see creatine, CoQ10, and PQQ — harmless additions to our day-to-day supplementation that can help health overtime.
The most common use case of NucleoPrime will likely be in the anti-aging and cellular health space, where it’d stack wonderfully with NNB Nutrition’s BioNMN, a highly bioavailable NMN (Nicotinamide Mononucleotide) supplement that boosts NAD+ levels.
NucleoPrime dosage: 250mg twice per day
To get the most out of NucleoPrime, NNB recommends 250 milligrams twice per day. NucleoPrime is safe to incorporate into food, beverages, powders, and even potent enough to fit into a capsule.
Outside of anti-aging applications, as nucleotide supplementation gains favor in the sports nutrition industry, we’re hoping to see NucleoPrime integrated into high-end multivitamins, creatine supplements, and even post-workout recovery supplements. Product formulators are constantly looking for something new, and sometimes it’s best to get back to the basics with the building blocks our bodies need. NucleoPrime achieves both of these issues.
For those seeking to replicate the NNB trial, we recommend taking NucleoPrime after an intense workout to reap the recovery benefits that nucleotides may offer. To maximize the immune health and neuroprotective elements of nucleotide supplementation, consider taking NucleoPrime before and during periods of high stress. Starting supplementation before stressful events is to ensure that the immune-bolstering benefits of supplementation have time to ramp up, as most trials use a 14-day supplementation window.
Lab tests provided
Conclusion: Nucleotides bring immunity, recovery, and cellular energy
NucleoPrime is likely the best form of a new industry innovation – but something not new to our bodies and diets. While the research is still developing in terms of ergogenic benefits, nucleotide supplementation appears to improve markers of general health, especially true in a world in an immunity crisis due to our collective processed food driven metabolic sickness.
For those looking to boost their anti-aging and immunity stack, NucleoPrime is worth trying. NNB Nutrition is one of few companies we trust to bring this level of innovation to market.
This product is also 100% natural, non-GMO, non-allergenic, and even vegan friendly. NNB pulled out all the stops with NucleoPrime so that everyone can partake in the boost. If you want to pioneer nucleotide supplementation, NucleoPrime is a great way to give your stack a little “something extra”.
If you want to learn more about the background and biochemistry behind NucleoPrime, read our full article titled What are Nucleotides and How do they Affect Performance and Immunity?.