Tecton Ketone Ester Hydration Drink: Finally, Great Taste in Ester Form

Published on October 6, 2023 by Mike Roberto and Drew Schibsted | No Comments

Keto diets have been all the rage in recent years. While the trend is somewhat on the wane, you no doubt are personally acquainted with several people who still swear by this powerfully therapeutic way of eating.

Ketones are Nature's Answer to an Energy Crisis -- Tecton Co-Founder Mike Chesne

Exogenous ketones and their current pitfalls

With keto’s explosion in popularity came all kinds of exogenous ketone supplements. The idea was that by directly supplying the body with the end product of ketogenic metabolism, you could reap most, if not all, of the benefits of the keto diet without imposing the severe carbohydrate restriction necessary to achieve ketosis.

However, exogenous ketone supplements have been traditionally plagued with issues – as we’ll discuss in detail in this article. For instance, the most common forms of exogenous ketones

come with hard upper limits on how much you can take, and can also cause GI upset, thanks to the molecules that the ketones come bound with.

Beyond those issues, they often taste salty (in the case of BHB salts) or wretchedly acidic (in the case of ketone esters).

Thankfully, there’s a better way now reaching the market:

Tecton Exogenous Ketone Ester Hydration Drink – A Better Exogenous Ketone

Today, we’re excited to tell you about Tecton, the latest and (in our opinion) greatest offering in the exogenous ketone supplement category.

This is a tasty beverage with just one active ingredient: Tecton’s special ketone glyceride ester, which is standardized to consist only of the biologically-active D/R BHB isomers we want for maximum metabolic impact.

Tecton Ketone Hydration

Introducing Tecton Ketone Hydration, a caffeine-free clean energy drink using Tecton’s proprietary beta-hydroxybutyrate glyceride ketone ester — finally, an ester that doesn’t taste like rubbing alcohol!

The really exciting thing about this drink is the dosing potential. Because of the glyceride ester’s unique properties, you can drink pretty much as many of these as you want in a day, every day, without suffering unwanted effects that plague other forms.

After years of watching this space, Tecton is the exogenous ketone supplement we always wanted – it represents the achievement of exogenous ketones’ full potential, and is really what they should have been from the very beginning.

Below, we get into the background of ketones, then dig into the benefits of Tecton’s proprietary ketone ester ingredient in their new clean energy drinks. But first, you can sign up for our Tecton news alerts and check on their Ketone Hydration Drink availability through PricePlow:

Tecton Ketone Ester Drink – Deals and Price Drop Alerts

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Ketones: A Primer

The average American consumes the “standard American diet”, a way of eating that’s relatively high in processed fats and dietary carbohydrates, the latter of which come mostly from refined grains. This leaves most of us dependent on glucose to fuel our cells – especially our brain cells, as the brain consumes 20% to 25% of bodily glucose despite accounting for just 2% of our body weight.[1,2]

However, although this is the state of affairs today, it’s not necessarily the historical norm. Before the agricultural revolution, many ancestral human cultures developed in environments where dietary carbohydrates were relatively scarce for at least half the year. This forced the people in those cultures to become fat-adapted – in the absence of easy access to carbs, their metabolisms habitually burned stored body fat for fuel.

Ketone bodies: generating energy from body fat

When the human body “burns” fat for fuel, in a process called beta-oxidation, it creates a ketone bodies as a chemical product.[3] These ketone molecules can be burned by every cell in the human body – including brain cells[4] – as an alternative to glucose.

The three types of ketone bodies are:

  1. Beta-hydroxybutyrate (← This is what we’re talking about today)
  2. Acetoacetate
  3. Acetone
Ketones: The Fourth Macronutrient

Ketones: The Fourth Macronutrient, and Nature’s Perfect Fuel

Ketones are synthesized mostly in the liver,[5] and used as cellular energy during times of food scarcity (or fasting), intensive exercise that uses up stored glycogen, and/or extremely low carbohydrate consumption.[6-8] In this state, called nutritional ketosis, the fat that gets converted into ketones by beta-oxidation can come from dietary fat or body (stored) fat. (See our beta-oxidation and ketogenesis flowchart image)

Ketones Are Why the Keto Diet Works

The ketogenic diet takes advantage of beta-oxidation by restricting dietary carbohydrate intake to the point where the body is forced to generate ketone bodies for fuel. Abbreviated to the keto diet for short, this way of eating enjoyed a meteoric rise in popularity during the 2010s, and has been used by millions upon millions of people all over the world to lose weight,[9-11] improve glycemic control and insulin signaling[12,13] improve metabolic and lipid blood markers,[14-16] reduce liver disease,[17] support cognition,[18,19] and far more.[20-23]

A landmark study from 2008 found that an incredible 95% of keto dieters with diagnosed type 2 diabetes were able to reduce or discontinue their medication within six months of starting a keto diet.[24] The renowned two-year-long Virta Health study reached similarly spectacular conclusions.[25-27]

Over time, ketogenic dieters exhibit higher total daily energy expenditure (TDEE) than sugar burners,[28,29] and lower levels of visceral fat,[30] a particularly harmful type of body fat that’s strongly associated with insulin resistance.[31]

Ketones and Brain Health

While all of this seemed exciting and novel back in the 2010s, the combination of fasting with ketogenic dieting has actually been practiced for thousands of years.[32] Ketogenic diets were used with great success in the 1920s to manage a variety of medical conditions, including epilepsy,[32] until institutional scientists took their managed consensus in a different direction during the 1970s.

How keto works: reducing glucose or producing ketones?

In understanding why the ketogenic diet works so fantastically well, we need to consider it from at least two angles: first, the reduction in blood glucose levels and insulin secretion; second, the production of ketones as an alternative fuel source.

So, does keto work because we’re avoiding the damaging effects of blood sugar swings and chronically elevated insulin, or do the ketones themselves have some therapeutic value?

The answer is both – and naturally, if the ketones themselves have some kind of intrinsic benefit, the next question should be, can we benefit human health and performance by supplying even more ketones?

Why Tecton’s BHB Ester Is Superior To BHB Salts

As the diet was taking the mainstream by storm throughout the 2010s, supplement manufacturers responded to the trend by bringing various exogenous ketones to market. The benefits of exogenous ketones, which we’ll discuss in depth, include:

Tecton: Created by Nature, Backed by Science

  • Greater energy levels
  • Easier transition into nutritional ketosis
  • Enhanced cognition
  • Easier weight loss
  • Decreased appetite
  • Increased athletic endurance
  • Better electrolyte balance
  • Higher ketone blood levels

The most popular kind of exogenous ketone by far, even from the very beginning, was beta-hydroxybutyrate (BHB), the exogenous ketone that is the molecular backbone of Tecton’s ketone ester.

Given the benefits of exogenous ketones we listed above, you’d think that the smart thing to do is take as much BHB as possible. You’d probably be right – but there’s a catch.

We Don’t Want Mineral Overload

Back in the early days of ketone supplementation, BHB was almost always sold as some kind of BHB salt, with the BHB molecule chemically bound to a mineral like sodium, calcium, magnesium, or potassium. Using minerals as a delivery system for BHB really hamstrung exogenous ketone supplements, because you can definitely overdo it on the minerals! All the minerals listed above have an officially-defined tolerable upper limit (TUL), a daily threshold of consumption over which adverse health effects may begin to appear.

Tecton Energy Comparison The mineral TULs serve as a natural limit on how much BHB salt an individual can consume. For example, if you’ve already exceeded the day’s TUL for sodium, then taking a sodium BHB salt probably isn’t going to make you feel so great – especially if potassium isn’t balanced. The same goes for calcium.

Ultimately, while savvy supplement users are fine with the challenge, it simply shouldn’t take constant calculations to ensure safety and tolerance with an ingredient. What’s the solution?

Tecton’s Ester Removes the Upper Limit on BHB Dosing

Fortunately, Tecton has a solution for this problem — and they made it taste far better than the competition while they were at it.

Tecton Ketone Hydration Benefits

What Tecton has done is create a BHB ketone ester in the form of beta-hydroxybutyrate glyceride. Recall that glyceride is a fatty acid ester of glycerol, a naturally-occurring alcohol that’s routinely taken in massive quantities as an aid for cellular hydration. We’ve covered glycerol dozens of times on this blog, as it’s commonly used in sports nutrition settings and is safely tolerated in large doses – up to 1g/kg in many studies.[33-35]

Since glycerol is extremely safe, and standard glycerol dosage ranges into the multiple tens of grams per serving, glycerol’s safety profile imposes no practical limit on the amount of BHB-glyceride an individual can consume. This is a key innovation – Tecton has invented a proprietary form of BHB[36-39] that can be used as much as necessary, making it easier to tailor a BHB dose to the individual needs of the consumer or patient.

Tecton’s Ester vs. Other Esters

While competing ketone esters do exist, we think Tecton’s new glyceride ester has some key advantages over the rest:

  1. Tecton’s ester tastes better

    Other ketone esters simply taste awful. They’re effective for those who can stomach them, but next to nobody wants something that tastes so terrible, let alone less efficacious dosing. This is why we’re pleased to report that Tecton’s drink has no alcoholic taste, unlike its competitors.

    This is no trivial advantage – having the ability to quaff multiple cans of ketone ester beverages enables some incredibly potent effects. The Tecton flavors are just better — plain and simple — and make it super easy to achieve therapeutic concentrations of ketones.

  2. Does not contain toxic substances

    Tecton Ketone Hydration

    All competing esters also contain 1,3-butanediol, a diol alcohol that can increase the body’s endogenous production of BHB. While this sounds nice in theory, one study that gave rats enough 1,3-Butanediol to therapeutically raise their serum BHB levels found that the alcohol also caused significant body mass loss, dehydration, metabolic acidosis, and sinusoidal dilation.[40]

    These are outcomes we definitely want to avoid. That’s why we love the fact that Tecton’s glyceride ester doesn’t contain any 1,3-butanediol.

    Moreover, Tecton’s BHB has been granted self-affirmed GRAS status, allowing it to be used in foods and dietary supplements.

Benefits of Exogenous Ketones

The best thing about exogenous ketones is that they’re therapeutic for everyone. Although ketogenic dieters can definitely benefit from extra ketone support, you don’t need to be in a state of nutritional ketosis for exogenous ketones to work.[41] In other words, exogenous ketones are beneficial for both high-carb and low-carb dieters!

Although in the beginning, ketones were marketed almost exclusively to low-carb dieters, a few years’ retrospect has shown how limiting this approach really was. As early as the 1990s, animal research was showing that exogenous ketones can spare glucose by taking its place as a fuel source for cellular-metabolic machinery. The upshot of this is greater metabolic flexibility during exercise, decreased lactic acid production, and enhanced performance.[42]

Tecton: Be Great

  • Exogenous Ketones In Human Athletes

    The limited number of studies conducted on human use of exogenous ketones during athletic performance shows that, while ketones don’t do much to support anaerobic efforts (i.e., sprints),[43,44] they do have great potential for use in endurance sports.[45] They can delay the onset of muscular fatigue by decreasing lactic acid production,[46] and also help protect the athlete’s cognitive abilities from being compromised by physical exhaustion.[44]

  • Can improve Traumatic Brain Injury (TBI) and concussion outcomes

    Of particular importance for athletes – especially athletes in contact sports like rugby, hockey, and football – is exogenous ketones’ ability to help improve outcomes in concussions and TBIs.

    Subjecting the brain to trauma initiates a neurometabolic cascade of neuronal dysfunction and adaptation. Part of this cascade is a dramatic impairment in the brain’s ability to take up glucose as a neuronal fuel source. Since the brain depends on an uninterrupted supply of cellular energy to survive, losing the ability to burn glucose can put your precious and irreplaceable neurons at serious risk of death.[47] Neuronal death from lack of cellular energy is a significant factor in damage to the brain following concussion.

    Although proper outcome-oriented studies haven’t yet been conducted in humans,[48] animal research shows that the administration of exogenous ketones can significantly increase the survivability of neural tissue following TBI.[49]

    Tecton: A Force for Good

    One of Tecton’s several battles in the force for good is working to combat TBI in sports and military applications. Tecton’s Ketone Ester can potentially be a game-changer in this field

    TBI is actually a primary driver of Tecton’s development, and is something we hope to cover in detail in a future episode of the PricePlow Podcast.

    Why use Tecton’s exogenous ketone ester for concussion?

    As one 2021 research review points out, achieving therapeutic blood ketone levels through nutritional ketosis, at least in a person who’s not already fat-adapted, takes 3-5 days.[50] That’s not nearly fast enough, considering that post-concussive metabolic derangement begins to affect the brain within 6 hours after injury.[50]

    Exogenous ketones, on the other hand, can achieve that concentration in a mere 30 minutes.[50] This makes them a much more reliable method for supporting cerebral metabolism.

    As the same review points out,

    “Oral administration of ketone salts can raise circulating levels of β-hydroxybutyrate to 1.0 mM, but limitations exist with gastrointestinal tolerability and the high mineral load.”[50]

    This just drives home the importance of using a ketone ester like Tecton’s for supporting the brain after concussion – again, esterifying BHB practically eliminates the limitations that need to be considered when administering a ketone salt!

  • Supports Healthy Cognition, Reduces Anxiety

    But exogenous ketones aren’t just for a brain in crisis. Research shows they can help support healthy cognition as well. More specifically, two animal studies have found that exogenous ketones can help reduce the incidence of anxious behavior in animals.[51,52]

    Exogenous ketones for neurodegenerative illness

    One of these studies, which was actually conducted using ketone esters, found that the ketones also reversed some of the cognitive deficits in the study’s model for Alzheimer’s disease. The study used 3xTgAD mice, which are genetically prone to the amyloid and tau pathologies that give rise to the brain plaque formations in Alzheimer’s. Compared to a group that ate carbohydrate-rich food, the 3xTgAD mice fed with BHB-elevating ketone esters did significantly better on learning and memory tests.[51]

    The authors propose that the ketones’ beneficial impact on mitochondrial function and inflammatory processes are probably behind these improvements in cognitive function.[51]

  • Suppresses Appetite

    A 2017 study found that consuming an exogenous ketone ester drink that’s designed to raise blood BHB levels significantly decreased appetite, insulin secretion, and ghrelin secretion.[53] That last point matters a lot because ghrelin is the body’s main hunger hormone. The higher your ghrelin, the more you want to eat.[54]

    Tecton Drink

    This study corroborates an anecdotal report we consistently see from keto dieters – that the keto diet leaves them a lot less hungry than normal.

    Weight loss?

    Although there are about a million studies on ketogenic dieting and weight loss, research on exogenous ketones’ anti-obesity effect in humans remains in a preclinical state. However, there’s some compelling evidence from animal models. For example, in one study, overweight mice that had been on a high-fat diet for 10 weeks (in other words, they were already fat-adapted) burned more calories and lost significant amounts of body fat when given exogenous ketones for another 3 months.[55]

  • Improves Markers of Cardiovascular Health

    A 2017 study found that exogenous ketone supplements decreased glucose blood levels, free fatty acids, and triglycerides.[56] All three changes can be a major boon for cardiovascular health. Another study found that taking ketone sales for 6 weeks can decrease blood pressure in subjects between 18 and 35 years old.[57]

    Another 2017 study found that BHB salts can improve blood lipids and decrease visceral fat in rats. Importantly, this study showed higher HDL and lower triglycerides, and lower LDL levels.[58] This combination is considered to be a trifecta of cardiovascular health – especially considering the importance of HDL/triglyceride ratio[59-63] and their connection to insulin resistance.[59,64]

Conclusion: Tecton is here to upend the BHB market

We see several really clear uses cases for Tecton:

Tecton Ketone Hydration: Zero Sugar, Zero Caffeine

  • Weight loss. We think the evidence that exogenous ketones can suppress appetite and promote healthy weight loss is compelling enough to give Tecton a shot in this role.
  • Clean energy support during intermittent fasting. The traditional advice regarding big IF proponents has been to use caffeine as a metabolic crutch whenever one is feeling down during a fast. We think this is a pretty bad idea for a number of reasons, and Tecton represents a vastly superior strategy.
  • Ease the transition to ketogenic diet or fasting-focused lifestyle. Getting into these is not easy, and many people struggle with the “keto flu” — a kind of withdrawal syndrome most experience after eliminating dietary carbohydrates as a primary energy source. With Tecton, you can give yourself an alternative energy source pretty much immediately, instead of waiting days or weeks for your body to become fully fat-adapted.
  • Cognitive energy. Tecton might be a great thing to help get you through the dreaded afternoon energy slump, particularly if you have any cognitive focus issues. We’ve seen the meteoric rise of nootropic supplements over the years, but few things can beat an actual energy substrate that feels clean like ketones. Tecton should give much more stable energy without setting you up for the compromised sleep quality, metabolic dysfunction, and weight gain that typically follow a reliance on caffeine and sugar to get through this challenging part of the day.
  • Tecton Ketone Hydration: MagmaFor athletes. As we discussed earlier, there’s great evidence that exogenous ketones can support athletic and mental performance. We think Tecton might be good for helping you get in “the zone” before a big game or important performance.
  • Metabolic health support. Metabolic flexibility — the ability to burn glucose and fatty acids for energy — is one of the keys to aging well. By directly supplying your body with ketones, you can help promote metabolic flexibility even if you’ve already begun to show signs of insulin resistance. Tecton is an especially attractive option for type 2 diabetics, as these patients should consume neither sugar nor caffeine — two ingredients that are excluded from Tecton.[65]

Ready to try?

Tecton is available in sugar and caffeine-free 12 ounce cans that are naturally flavored and sweetened, each with 10 grams of nature-identical ketones. But as major fans of the dietary supplement space, we’re also excited that Tecton is open to licensing their ingredient — and it can be put into dry applications — so we just may see it in other types of energy drinks, nootropics, and workout supplements formulated by experts around the industry.

Sign up for our Tecton alerts below so that you don’t miss out on future Tecton news, otherwise, check out a few cans using PricePlow:

Tecton Ketone Ester Drink – Deals and Price Drop Alerts

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About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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References

  1. Mergenthaler, Philipp, et al. “Sugar for the Brain: The Role of Glucose in Physiological and Pathological Brain Function.” Trends in Neurosciences, vol. 36, no. 10, Oct. 2013, pp. 587–597, 10.1016/j.tins.2013.07.001; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900881/
  2. Erbsloh, F., et al. “[the Glucose Consumption of the Brain & Its Dependence on the Liver].” Archiv Fur Psychiatrie Und Nervenkrankheiten, Vereinigt Mit Zeitschrift Fur Die Gesamte Neurologie Und Psychiatrie, vol. 196, no. 6, 1958, pp. 611–626, 10.1007/BF00344388; https://pubmed.ncbi.nlm.nih.gov/13534602/
  3. Paoli, Antonio. “Ketogenic Diet for Obesity: Friend or Foe?” International Journal of Environmental Research and Public Health, vol. 11, no. 2, 19 Feb. 2014, pp. 2092–2107, 10.3390/ijerph110202092; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945587/
  4. Hartman, Adam L., et al. “The Neuropharmacology of the Ketogenic Diet.” Pediatric Neurology, vol. 36, no. 5, May 2007, pp. 281–292, 10.1016/j.pediatrneurol.2007.02.008; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940242/
  5. Fukao, Toshiyuki, et al. “Pathways and Control of Ketone Body Metabolism: On the Fringe of Lipid Biochemistry.” Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 70, no. 3, Mar. 2004, pp. 243–251, 10.1016/j.plefa.2003.11.001; https://pubmed.ncbi.nlm.nih.gov/14769483/
  6. Felig, Philip, et al. “Amino Acid Metabolism during Prolonged Starvation.” Journal of Clinical Investigation, vol. 48, no. 3, 1 Mar. 1969, pp. 584–594; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC535724/
  7. Owen, Oliver E. “Ketone Bodies as a Fuel for the Brain during Starvation.” Biochemistry and Molecular Biology Education, vol. 33, no. 4, July 2005, pp. 246–251, 10.1002/bmb.2005.49403304246; https://iubmb.onlinelibrary.wiley.com/doi/10.1002/bmb.2005.49403304246
  8. Owen, Oliver E., et al. “Liver and Kidney Metabolism during Prolonged Starvation.” Journal of Clinical Investigation, vol. 48, no. 3, 1 Mar. 1969, pp. 574–583; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC535723/
  9. Castellana, Marco, et al. “Efficacy and Safety of Very Low Calorie Ketogenic Diet (VLCKD) in Patients with Overweight and Obesity: A Systematic Review and Meta-Analysis.” Reviews in Endocrine and Metabolic Disorders, 9 Nov. 2019, 10.1007/s11154-019-09514-y; https://pubmed.ncbi.nlm.nih.gov/31705259/
  10. Choi, Yeo Jin, et al. “Impact of a Ketogenic Diet on Metabolic Parameters in Patients with Obesity or Overweight and with or without Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials.” Nutrients, vol. 12, no. 7, 6 July 2020, p. 2005, 10.3390/nu12072005; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400909/
  11. Bueno, Nassib Bezerra, et al. “Very-Low-Carbohydrate Ketogenic Diet v. Low-Fat Diet for Long-Term Weight Loss: A Meta-Analysis of Randomised Controlled Trials.” British Journal of Nutrition, vol. 110, no. 07, 7 May 2013, pp. 1178–1187, 10.1017/s0007114513000548; https://pubmed.ncbi.nlm.nih.gov/23651522/
  12. Yancy, W.S., Foy, M., Chalecki, A.M. et al. “A low-carbohydrate, ketogenic diet to treat type 2 diabetes”. Nutr Metab (Lond) 2, 34 (2005); https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-2-34
  13. Noakes M, Foster PR, Keogh JB, James AP, Mamo JC, Clifton PM. “Comparison of isocaloric very low carbohydrate/high saturated fat and high carbohydrate/low saturated fat diets on body composition and cardiovascular risk.” Nutr Metab (Lond). 2006 Jan 11;3:7. doi: 10.1186/1743-7075-3-7; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1368980/
  14. Wood RJ, Volek JS, Liu Y, Shachter NS, Contois JH, Fernandez ML. Carbohydrate restriction alters lipoprotein metabolism by modifying VLDL, LDL, and HDL subfraction distribution and size in overweight men. J Nutr. 2006 Feb;136(2):384-9. doi: 10.1093/jn/136.2.384; https://pubmed.ncbi.nlm.nih.gov/16424116/
  15. Foster GD, Wyatt HR, Hill JO, McGuckin BG, Brill C, Mohammed BS, Szapary PO, Rader DJ, Edman JS, Klein S. A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med. 2003 May 22;348(21):2082-90. doi: 10.1056/NEJMoa022207; https://pubmed.ncbi.nlm.nih.gov/12761365/
  16. Brinkworth GD, Noakes M, Buckley JD, Keogh JB, Clifton PM. Long-term effects of a very-low-carbohydrate weight loss diet compared with an isocaloric low-fat diet after 12 mo. Am J Clin Nutr. 2009 Jul;90(1):23-32. doi: 10.3945/ajcn.2008.27326; https://pubmed.ncbi.nlm.nih.gov/19439458/
  17. Watanabe, Mikiko, et al. “Beneficial Effects of the Ketogenic Diet on Nonalcoholic Fatty Liver Disease: A Comprehensive Review of the Literature.” Obesity Reviews, 24 Mar. 2020, 10.1111/obr.13024; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379247/
  18. Chinna-Meyyappan, Arun, et al. “Effects of the Ketogenic Diet on Cognition: A Systematic Review.” Nutritional Neuroscience, 10 Nov. 2022, pp. 1–21, doi:10.1080/1028415x.2022.2143609; https://pubmed.ncbi.nlm.nih.gov/36354157/
  19. Altayyar, Mansour, et al. “The Implication of Physiological Ketosis on the Cognitive Brain: A Narrative Review.” Nutrients, vol. 14, no. 3, 25 Jan. 2022, p. 513, doi:10.3390/nu14030513; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840718/
  20. Li, Jian, et al. “Ketogenic Diet in Women with Polycystic Ovary Syndrome and Liver Dysfunction Who Are Obese: A Randomized, Open‐Label, Parallel‐Group, Controlled Pilot Trial.” Journal of Obstetrics and Gynaecology Research, vol. 47, no. 3, 18 Jan. 2021, pp. 1145–1152, 10.1111/jog.14650; https://pubmed.ncbi.nlm.nih.gov/33462940/
  21. Castaldo, Giuseppe, et al. “Effect of Very-Low-Calorie Ketogenic Diet on Psoriasis Patients: A Nuclear Magnetic Resonance-Based Metabolomic Study.” Journal of Proteome Research, vol. 20, no. 3, 9 Nov. 2020, pp. 1509–1521, 10.1021/acs.jproteome.0c00646; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016365/
  22. Włodarczyk, Adam, et al. “Ketogenic Diet: A Dietary Modification as an Anxiolytic Approach?” Nutrients, vol. 12, no. 12, 14 Dec. 2020, p. 3822, 10.3390/nu12123822; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765029/
  23. Seyfried, Thomas N., et al. “Press-Pulse: A Novel Therapeutic Strategy for the Metabolic Management of Cancer.” Nutrition & Metabolism, vol. 14, no. 1, 23 Feb. 2017, 10.1186/s12986-017-0178-2; https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-017-0178-2
  24. Westman, Eric C et al. “The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus.” Nutrition & metabolism vol. 5 36. 19 Dec. 2008, doi:10.1186/1743-7075-5-36; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2633336/
  25. McKenzie, Amy L, et al. “A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes.” JMIR Diabetes, vol. 2, no. 1, 7 Mar. 2017, p. e5, 10.2196/diabetes.6981; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238887/
  26. Hallberg, Sarah J., et al. “Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study.” Diabetes Therapy, vol. 9, no. 2, 7 Feb. 2018, pp. 583–612, 10.1007/s13300-018-0373-9; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104272/
  27. Athinarayanan, Shaminie J., et al. “Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-Randomized Clinical Trial.” Frontiers in Endocrinology, vol. 10, 5 June 2019, 10.3389/fendo.2019.00348; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561315/
  28. McClernon FJ, Yancy WS Jr, Eberstein JA, Atkins RC, Westman EC. The effects of a low-carbohydrate ketogenic diet and a low-fat diet on mood, hunger, and other self-reported symptoms. Obesity (Silver Spring). 2007 Jan;15(1):182-7. doi: 10.1038/oby.2007.516; https://pubmed.ncbi.nlm.nih.gov/17228046/
  29. Ludwig, David S, et al. “Do Lower-Carbohydrate Diets Increase Total Energy Expenditure? An Updated and Reanalyzed Meta-Analysis of 29 Controlled-Feeding Studies.” The Journal of Nutrition, 3 Dec. 2020, 10.1093/jn/nxaa350; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7948201
  30. Volek J, Sharman M, Gómez A, Judelson D, Rubin M, Watson G, Sokmen B, Silvestre R, French D, Kraemer W. “Comparison of energy-restricted very low-carbohydrate and low-fat diets on weight loss and body composition in overweight men and women”; Nutr Metab (Lond). 2004 Nov 8;1(1):13. doi: 10.1186/1743-7075-1-13; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538279/
  31. Usui, Chiyoko et al. “Visceral fat is a strong predictor of insulin resistance regardless of cardiorespiratory fitness in non-diabetic people.” Journal of nutritional science and vitaminology vol. 56,2 (2010): 109-16. doi:10.3177/jnsv.56.109 https://www.jstage.jst.go.jp/article/jnsv/56/2/56_2_109/_article
  32. Wheless, James W. “History of the Ketogenic Diet.” Epilepsia, vol. 49 Suppl 8, no. s8, 4 Nov. 2008, pp. 3–5, 10.1111/j.1528-1167.2008.01821.x; https://pubmed.ncbi.nlm.nih.gov/19049574/
  33. Hitchins, S et al. “Glycerol hyperhydration improves cycle time trial performance in hot humid conditions.” European journal of applied physiology and occupational physiology vol. 80,5 (1999): 494-501. doi:10.1007/s004210050623; https://link.springer.com/article/10.1007/s004210050623
  34. Robergs, R A, and S E Griffin. “Glycerol. Biochemistry, pharmacokinetics and clinical and practical applications.” Sports medicine (Auckland, N.Z.) vol. 26,3 (1998): 145-67. doi:10.2165/00007256-199826030-00002; https://link.springer.com/article/10.2165/00007256-199826030-00002
  35. Wagner, D R. “Hyperhydrating with glycerol: implications for athletic performance.” Journal of the American Dietetic Association vol. 99,2 (1999): 207-12. doi:10.1016/s0002-8223(99)00049-8; https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(99)00049-8
  36. Schmidt, Michael. “Composition comprising ketone body and nicotinamide adenine dinucleotide modulator and methyl donor”. United States Patent and Trademark Office. Patent US10376528B2. 13 Aug. 2019; https://patents.google.com/patent/US10376528B2/en
  37. Schmidt, Michael. “Composition comprising ketone body and nicotinamide adenine dinucleotide modulator and methyl donor”. United States Patent and Trademark Office. Patent US10456411B2. 29 Oct 2019; https://patents.google.com/patent/US10456411B2/en
  38. Schmidt, Michael. “Composition comprising ketone body and nicotinamide adenine dinucleotide modulator and methyl donor”. United States Patent and Trademark Office. Patent US10688115B2. 23 Jun. 2020; https://patents.google.com/patent/US10688115B2/en
  39. Schmidt, Michael. “Composition comprising ketone body and nicotinamide adenine dinucleotide modulator and methyl donor”. United States Patent and Trademark Office. Patent US11202790B2. 21 Dec. 2021; https://patents.google.com/patent/US11202790B2/en
  40. McCarthy, Cameron G et al. “Physiologic, Metabolic, and Toxicologic Profile of 1,3-Butanediol.” The Journal of pharmacology and experimental therapeutics vol. 379,3 (2021): 245-252. doi:10.1124/jpet.121.000796 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164310/
  41. Harvey, Cliff J. d C., et al. “The Use of Nutritional Supplements to Induce Ketosis and Reduce Symptoms Associated with Keto-Induction: A Narrative Review.” PeerJ, vol. 6, 16 Mar. 2018, p. e4488, 10.7717/peerj.4488; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858534/
  42. Okuda, Y., et al. “Ketone Body Utilization and Its Metabolic Effect in Resting Muscles of Normal and Streptozotocin-Diabetic Rats.” Endocrinologia Japonica, vol. 38, no. 3, 1 June 1991, pp. 245–251, 10.1507/endocrj1954.38.245; https://pubmed.ncbi.nlm.nih.gov/1838977/
  43. Dearlove, David J., et al. “Nutritional Ketoacidosis during Incremental Exercise in Healthy Athletes.” Frontiers in Physiology, vol. 10, 29 Mar. 2019, 10.3389/fphys.2019.00290; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450328/
  44. Evans, Mark, and Brendan Egan. “Intermittent Running and Cognitive Performance after Ketone Ester Ingestion.” Medicine & Science in Sports & Exercise, vol. 50, no. 11, Nov. 2018, pp. 2330–2338, 10.1249/mss.0000000000001700; https://pubmed.ncbi.nlm.nih.gov/29944604/
  45. Cox, Pete J., et al. “Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.” Cell Metabolism, vol. 24, no. 2, Aug. 2016, pp. 256–268, 10.1016/j.cmet.2016.07.010; https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30355-2
  46. Scott, Benjamin E., et al. “The Effect of 1,3-Butanediol and Carbohydrate Supplementation on Running Performance.” Journal of Science and Medicine in Sport, vol. 22, no. 6, 1 June 2019, pp. 702–706, 10.1016/j.jsams.2018.11.027; https://pubmed.ncbi.nlm.nih.gov/30553764/
  47. Giza, Christopher C., and David A. Hovda. “The Neurometabolic Cascade of Concussion.” Journal of athletic training vol. 36,3 (2001): 228-235. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC155411/
  48. McDougall, Alexandre et al. “The ketogenic diet as a treatment for traumatic brain injury: a scoping review.” Brain injury vol. 32,4 (2018): 416-422. doi:10.1080/02699052.2018.1429025; https://www.tandfonline.com/doi/abs/10.1080/02699052.2018.1429025
  49. Davis, Laurie M et al. “Fasting is neuroprotective following traumatic brain injury.” Journal of neuroscience research vol. 86,8 (2008): 1812-22. doi:10.1002/jnr.21628 https://onlinelibrary.wiley.com/doi/10.1002/jnr.21628
  50. Daines, Savannah Anne. “The Therapeutic Potential and Limitations of Ketones in Traumatic Brain Injury.” Frontiers in neurology vol. 12 723148. 22 Oct. 2021, doi:10.3389/fneur.2021.723148 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579274/
  51. Kashiwaya, Yoshihiro, et al. “A Ketone Ester Diet Exhibits Anxiolytic and Cognition-Sparing Properties, and Lessens Amyloid and Tau Pathologies in a Mouse Model of Alzheimer’s Disease.” Neurobiology of Aging, vol. 34, no. 6, June 2013, pp. 1530–1539, 10.1016/j.neurobiolaging.2012.11.023; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619192/
  52. Ari, Csilla, et al. “Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats.” Frontiers in Molecular Neuroscience, vol. 9, 6 Dec. 2016, 10.3389/fnmol.2016.00137; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138218/
  53. Stubbs, Brianna J., et al. “A Ketone Ester Drink Lowers Human Ghrelin and Appetite.” Obesity, vol. 26, no. 2, 6 Nov. 2017, pp. 269–273, 10.1002/oby.22051; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813183/
  54. Wu, James T, and John G Kral. “Ghrelin: integrative neuroendocrine peptide in health and disease.” Annals of surgery vol. 239,4 (2004): 464-74. doi:10.1097/01.sla.0000118561.54919.61 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356251/
  55. Davis, Rachel A H et al. “Dietary R, S-1,3-butanediol diacetoacetate reduces body weight and adiposity in obese mice fed a high-fat diet.” FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 33,2 (2019): 2409-2421. doi:10.1096/fj.201800821RR; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338649/
  56. Stubbs, Brianna J et al. “On the Metabolism of Exogenous Ketones in Humans.” Frontiers in physiology vol. 8 848. 30 Oct. 2017, doi:10.3389/fphys.2017.00848; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670148/
  57. Holland, Angelia M., et al. “Blood and Cardiovascular Health Parameters after Supplementing with Ketone Salts for Six Weeks.” Journal of Insulin Resistance, vol. 4, no. 1, 24 Apr. 2019, 10.4102/jir.v4i1.47; https://insulinresistance.org/index.php/jir/article/view/47/172
  58. Caminhotto, Rennan de Oliveira, et al. “Oral β-Hydroxybutyrate Increases Ketonemia, Decreases Visceral Adipocyte Volume and Improves Serum Lipid Profile in Wistar Rats.” Nutrition & Metabolism, vol. 14, no. 1, 24 Apr. 2017, 10.1186/s12986-017-0184-4; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404327/
  59. ‌Bertsch, Ruth Ann, and Maqdooda A Merchant. “Study of the Use of Lipid Panels as a Marker of Insulin Resistance to Determine Cardiovascular Risk.” The Permanente journal vol. 19,4 (2015): 4-10. doi:10.7812/TPP/14-237; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4625988/
  60. Bartlett, Jacquelaine, et al. “Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor?” Circulation: Cardiovascular Quality and Outcomes, vol. 9, no. 3, May 2016, pp. 206–212, 10.1161/circoutcomes.115.002436; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871717/
  61. Wang, T. D., et al. “Efficacy of Cholesterol Levels and Ratios in Predicting Future Coronary Heart Disease in a Chinese Population.” The American Journal of Cardiology, vol. 88, no. 7, 1 Oct. 2001, pp. 737–743, 10.1016/s0002-9149(01)01843-4; https://pubmed.ncbi.nlm.nih.gov/11589839
  62. Jeppesen, Jørgen, et al. “Low Triglycerides–High High-Density Lipoprotein Cholesterol and Risk of Ischemic Heart Disease.” Archives of Internal Medicine, vol. 161, no. 3, 12 Feb. 2001, p. 361, 10.1001/archinte.161.3.361; https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/647239
  63. Castelli, William P. “Epidemiology of Triglycerides: A View from Framingham.” American Journal of Cardiology, vol. 70, no. 19, 14 Dec. 1992, pp. H3–H9, 10.1016/0002-9149(92)91083-G; https://www.ajconline.org/article/0002-9149(92)91083-G/abstract
  64. McLaughlin, Tracey, et al. “Use of Metabolic Markers to Identify Overweight Individuals Who Are Insulin Resistant.” Annals of Internal Medicine, vol. 139, no. 10, 18 Nov. 2003, p. 802, 10.7326/0003-4819-139-10-200311180-00007; https://pubmed.ncbi.nlm.nih.gov/14623617/
  65. “Does Cutting out Caffeine Improve Blood Sugar Control?” Mayo Clinic, www.mayoclinic.org/diseases-conditions/type-2-diabetes/expert-answers/blood-sugar/faq-20057941#:~:text=Some%20studies%20suggest%20that%20drinking.

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