Revive MD Vitamin B-Complex: Maintain Your Metabolism

Revive MD has made a name for itself with high-quality formulas designed to address specific health issues. The company has always brought exceptional scientific rigor to its production formulation, at least in part because co-founder Domenic Iacovone is a licensed medical doctor. Revive products contain only the best forms of each ingredient, with clinically-studied doses.

Revive MD B-Complex

Given that Iacovone’s business partner and co-founder Matt Jansen is an elite fitness trainer, it makes perfect sense that Revive has successfully marketed its nutraceutical approach to high-end athletes. But hindsight is 20/20 – back when Revive first hit the market with rigorous health and wellness formulas, this was an innovative business model for an industry focused mostly on candy-flavored preworkouts. Since then, the company’s meteoric rise has proven that, despite the frat boy stereotypes, performance-focused athletes do, in fact, care about their health and not just their appearance.

In the intervening years, we’ve seen a lot of companies copy this approach. So, Iacovone and Jansen deserve a lot of credit for helping move the industry forward.

Introducing Revive B Complex

Now Revive is tackling the Vitamin B Complex, a mainstay supplement category that most readers have probably dabbled with at some point.

Generally speaking, B vitamins are crucial for cellular energy production and can improve mood, especially in people with certain genetic susceptibilities. It’s why so many people with non-specific complaints like fatigue or lack of focus and motivation have anecdotally reported benefiting from B vitamin supplementation.

But there are also some more obscure, niche benefits to B vitamin supplementation that you’ve probably never heard of.

We’ll get into those, but first, check the PricePlow news and deals:

Revive MD B-Complex – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

This area is reserved for Team PricePlow's upcoming videos.

Subscribe to our channel and sign up for notifications so you catch it when it goes live!

Subscribe to PricePlow on YouTube!

Revive MD B-Complex Ingredients

In a single 1-capsule serving of B complex from Revive MD, you get the following:

  • Vitamin B1 (as Thiamine HCl) – 100 mg (8,333% DV)

    Revive MD B-Complex Ingredients

    Thiamine (also spelled thiamin) is one of your body’s major cofactors for adenosine triphosphate (ATP) synthesis.[1] ATP is a huge deal as it’s the body’s primary energy currency for all cellular functions, driving essential processes like metabolism, muscle contraction, neural transmission, and cell structure maintenance.

    If thiamine deficiency gets bad enough, the resulting drop in ATP synthesis can lead to massive neuronal die-off from the decline in cellular energy availability.[2] This syndrome, known as Wernicke-Korsakoff encephalopathy, often results from alcoholism as alcohol abuse causes thiamine depletion.

    Thiamine is also needed for healthy glucose metabolism,[3] and type 2 diabetes is associated with below-average thiamine levels. Additionally, thiamine megadosing can improve symptoms of hyperglycemia in people with pre-diabetes.[4] These facts suggest that thiamine deficiency may play a part in the development of type 2 diabetes.

    According to a 2013 meta-analysis of over 20 published studies, thiamine supplementation can support cardiac function in people with heart failure.[5]

  • Vitamin B2 (as Riboflavin-5′-Phosphate) – 20 mg (1,538% DV)

    Riboflavin (vitamin B2) is naturally abundant in leafy green vegetables, poultry, fish, dairy, and eggs.[6]

    Your body needs riboflavin to make flavoprotein enzymes that are needed for important physiological processes, such as electron transport, cell signaling, protein folding, and to metabolize fatty acids and foreign substances, including pharmaceutical drugs.[6]

    Riboflavin’s participation in the electron transport chain makes it important for adenosine triphosphate (ATP) production.[6]

  • Vitamin B3 (as Niacinamide) – 100 mg NE (625% DV)

    Nicotinamide Riboside NAD+ Pathway

    In the bottom right, we have NAM, which is short for Nicotinamide, otherwise known as Niacinamide, what we have here in this supplement. In the future, we hope Revive can upgrade this ingredient to NMN once the FDA is defeated in their case against the B3 vitamin.

    Niacin (vitamin B) is a prerequisite for nicotinamide adenine dinucleotide (NAD+) synthesis.[7-9] Upregulating NAD+ can benefit health in a powerful and fundamental way, as NAD+ is needed for a huge array of metabolic processes involved in generating cellular energy, as well as liver function and DNA repair.[10-13]

    One special benefit of niacin is its ability to increase your body’s expression of adiponectin,[14] a hormone with profound effects on metabolic health. For example, adiponectin improves systemic insulin sensitivity, and research shows that overweight and obese people are often deficient in adiponectin.[15] Adiponectin’s primary mechanism of action is to upregulate AMP-activated protein kinase (AMPK),[16] one of your body’s most important metabolic switches.

    Niacin can also decrease the amount of inflammatory cytokines produced by body fat,[14] which is a huge boon for health since this kind of inflammation is closely linked to metabolic disease.[17]

    Niacinamide is the flush-free form of niacin – it’s also known as nicotinamide and is often spelled NAM in research studies and the chart above.

  • Vitamin B6 (as Pyridoxal-5′-Phosphate) – 50 mg (2,941% DV)

    VItamin B6 is important for the activity and production of certain coenzymes that are needed for a huge number of metabolic processes and, ultimately, cellular energy production.

    Vitamin B6

    Pyridoxal phosphate, the active form of vitamin B6, can be converted into pyridoxamine phosphate (PMP) and other forms of B6 as needed.

    Pyridoxal 5′ phosphate (PLP), the active form of B6, is actually itself a coenzyme, which can be converted into pyridoxamine 5′ phosphate (PMP) as your metabolism requires. These two enzymes cooperate to regulate several hundred different metabolic processes in your body.[18] Arguably the most important of these is protein metabolism, which can’t occur without an adequate supply of PLP and PMP.[18]

    Another important B6-dependent metabolic process is your body’s regulation of homocysteine.[18] Since high homocysteine can significantly increase one’s risk of cardiovascular disease, it’s definitely something worth watching and keeping under control – for that, you’ll need an adequate supply of B6.

    Vitamin B6 is also an important neurotransmitter precursor,[18] which can definitely be a big deal for mood, motivation, and perceived energy. Your body uses B6 to make hemoglobin, which matters a lot if you care about athletic performance. Finally, B6 can affect immune function, gluconeogenesis, and glycogenolysis (the breaking down of glycogen for usable energy).[18]

    Taking B6 supplements is statistically linked to decreased risk of cardiovascular disease, cancer, and neurological illness.[18]

  • Vitamin B9 (as L-5-Methyl-THF-Calcium) – 667 mcg DFE (167% DV)

    Calcium L-5-methyltetrahydrofolic acid (L-5-Methyl-THF-Calcium) is a special form of 5-methyltetrahydrofolate (5-MTHF). a methylated type of folate (vitamin B9). Compared to other forms of folate, 5-MTHF exhibits superior bioavailability.[19-21]

    Folate deficiency can seriously increase one’s risk of the following conditions:

    • High homocysteine[22,23]
    • Fetal birth defects during pregnancy[24]
    • Cancer[25]

    Homocysteine regulation is big – low folate is one of the two most common causes of high homocysteine, a form of metabolic derangement that can wreak havoc on your cardiovascular system (vitamin B6 deficiency being the other one).[26]

    Vitamin B9

    In this long and complex conversion pathway, your body regulates homocysteine through the conversion of dietary folate (usually in the form of folic acid). One important part of this process is an enzyme called methylenetetrahydrofolate reductase (MTHFR) whose activity is often limited in genetically susceptible individuals.[27]

    Your body actually makes 5-MTHF, one of the active forms of folate, from folic acid by way of an enzyme called methylenetetrahydrofolate reductase (MTHFR). A lot of people – about 40%, according to one study[28] – have one of several genetic polymorphisms that can slow MTHFR functioning, thus increasing the carrier’s risk of functional folate deficiency and elevated serum homocysteine.

    By supplementing directly with 5-MTHF, you can bypass the MTHFR enzyme, thus sidestepping this potential bottleneck.

    Research shows that 5-MTHF supplementation can:

    • Raise blood plasma levels[19,21]
    • Decrease serum homocysteine concentrations by 14.6%[29]
    • Increase the amount of folate in your red blood cells by 23%[29]
    • Mitigate depressive and anxious symptoms[30,31]
  • Vitamin B12 (as Methylcobalamin) – 300 mcg (12,500% DV)

    Methylcobalamin, a type of vitamin B12, is PricePlow’s preferred form of B12. As a methyl donor, it can help support metabolic processes that depend on methylation.[32]

    We need B12 for red blood cell formation, and B12 deficiency can lead to megaloblastic anemia,[33,34] a form of anemia in which red blood cells increase in size but decrease in number, leading to an overall decrease in aerobic capacity.

    Vitamin B12 also plays some important roles similar to folate. For example, low B12 is associated with high homocysteine and, in pregnant women, significantly higher risk of fetal birth defects.[35-37]

    Like folate, B12 plays an important role in keeping your blood homocysteine concentration under control. Because of this – and its importance as a precursor to S-adenosylmethionine (SAMe) – even mild B12 deficiencies can lead to irreversible brain atrophy.[38]

    Even slightly low levels of B12 – on the low side of the normal range, as a matter of fact – are associated with impaired memory performance,[38] thanks in part to the effect that B12 deficiency has on blood homocysteine levels.[39] But B12 is also an important precursor to S-adenosylmethionine (SAMe), which is crucial for methylation, myelination, and phospholipid production in the central nervous system.[39]

    Although it isn’t clear that B12 supplementation can increase energy levels in people who aren’t B12 deficient, fatigue is an early sign of B12 deficiency,[40] and something we obviously would like to avoid.

  • Vitamin B7 (as Biotin) – 400 mcg (1,333% DV)

    Biotin (vitamin B7) is probably a familiar ingredient if you’ve ever taken a hair, skin, and nails supplement. Biotin deficiency can wreak havoc on all three of these, causing issues like dermatitis[41] and hair loss.[42,43]

    Revive MD NAC

    Revive MD NAC is out — the much-discussed glutathione precursor has a wide-ranging array of benefits, from supporting liver function to psychological support.

    Biotin regulates insulin production,[44] so supplementing with biotin might be a useful strategy for preventing type 2 diabetes. In fact, one study in rats found that biotin can actually improve symptoms of T2D,[45] but the research on this subject is far from conclusive.

    Finally, as is the case with B12 and folate, biotin deficiency can increase the risk of birth defects.[46]

  • Vitamin B5 (as D-Calcium Pantothenic Acid) – 110 mg (2,200% DV)

    Pantothenic acid (vitamin B5) is another nutrient that’s crucial for skin health. It helps ensure proper epidermal barrier function, and can even soften your skin.[47] One double-blind, randomized, placebo-controlled study found that pantothenic acid can alleviate symptoms of adult acne.[47]

    Vitamin B5 deficiency can interfere with the production of collagen and new skin cells.[48]

    Supplementing B5 seems to have a cardioprotective effect, too. It helps preserve arterial function by lowering LDL cholesterol.[49,50] The doses used in these studies are several times larger than the 110 milligram serving in Revive B Complex, but our editorial opinion here at PricePlow is that it probably doesn’t matter because 110 milligrams is still way more than we need to avoid B5 deficiency.

    Vitamin B5 is also important for acetylcholine synthesis and myelin production.[51] We often refer to acetylcholine as the learning neurotransmitter because it’s unbelievably important for memory consolidation, your brain’s process of converting short-term memories into long-term memories. In light of B5’s neurological role, it’s not surprising that B5 deficiency can, much like B12 deficiency, lead to neurodegenerative damage.[52]

    Finally, while we’ve discussed a lot of benefits in this article in relation to vitamin supplements, probably the most surprising is that B5 seems to have an anti-parasitic effect. Studies have shown that B5 may have the ability to inhibit the growth of Plasmodium falciparum, the protozoa parasite responsible for causing malaria.[53] As interesting as this is, please note that we are not proposing vitamin B5 as a possible malaria treatment. We need to see a lot more research before establishing that connection.

Conclusion

Revive MD Magnesium+

Be sure to check out Revive’s other vitamin and mineral products, like their Magnesium+ which features 2 forms of magnesium to aid in relaxation, cardiovascular health, and indigestion relief.

We don’t often get to do a deep dive on B vitamins. There are some broad commonalities between the various compounds that fall into this class of vitamins – all important for cellular energy production, for example. But as you can see, there are more obscure, idiosyncratic benefits associated with some of them. We love seeing the methylated forms of B12 and B9 used, because methylation is hugely important for overall health. And given how many of us are affected by the MTHFR polymorphisms, consuming more methyl donors is probably not a bad idea.

Revive has a wide variety of vitamin and mineral supplements that can help support everybody’s health. Be sure to check out the PricePlow blog to learn more about the science-backed formulas Dom and his team have to offer.

Revive MD B-Complex – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: PricePlow Staff

PricePlow Staff

PricePlow is a team of supplement industry veterans that include medical students, competitive strength athletes, and scientific researchers who all became involved with dieting and supplements out of personal need.

The team's collective experiences and research target athletic performance and body composition goals, relying on low-toxicity meat-based diets.

No Comments | Posted in | Tagged , , , , , , , , , , , , , , , , , .

References

  1. ‌Hernandez-Vazquez AJ, Garcia-Sanchez JA, Moreno-Arriola E, Salvador-Adriano A, Ortega-Cuellar D, Velazquez-Arellano A. Thiamine Deprivation Produces a Liver ATP Deficit and Metabolic and Genomic Effects in Mice: Findings Are Parallel to Those of Biotin Deficiency and Have Implications for Energy Disorders. J Nutrigenet Nutrigenomics. 2016;9(5-6):287-299. doi: 10.1159/000456663. Epub 2017 Feb 18. PMID: 28214879. https://pubmed.ncbi.nlm.nih.gov/28214879/
  2. Zubaran, C et al. “Wernicke-Korsakoff syndrome.” Postgraduate medical journal vol. 73,855 (1997): 27-31. doi:10.1136/pgmj.73.855.27 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2431190/
  3. Lonsdale D. Thiamin(e): the spark of life. Subcell Biochem. 2012;56:199-227. doi: 10.1007/978-94-007-2199-9_11. PMID: 22116701. https://pubmed.ncbi.nlm.nih.gov/22116701/
  4. Alaei Shahmiri F, Soares MJ, Zhao Y, Sherriff J. High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial. Eur J Nutr. 2013 Oct;52(7):1821-4. doi: 10.1007/s00394-013-0534-6. Epub 2013 May 29. PMID: 23715873. https://pubmed.ncbi.nlm.nih.gov/23715873/
  5. DiNicolantonio JJ, Niazi AK, Lavie CJ, O’Keefe JH, Ventura HO. Thiamine supplementation for the treatment of heart failure: a review of the literature. Congest Heart Fail. 2013 Jul-Aug;19(4):214-22. doi: 10.1111/chf.12037. PMID: 23910704. https://pubmed.ncbi.nlm.nih.gov/23910704/
  6. Pinto, JT, and Zempleni, J. “Riboflavin.” Advances in nutrition (Bethesda, Md.) vol. 7,5 973-5.15 Sep. 2016. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015041/
  7. Cantó, Carles, et al. “NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.” Cell Metabolism, vol. 22, no. 1, July 2015, pp. 31–53, 10.1016/j.cmet.2015.05.023; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487780/
  8. Chini, Claudia C.S., et al. “NAD and the Aging Process: Role in Life, Death and Everything in Between.” Molecular and Cellular Endocrinology, vol. 455, Nov. 2017, pp. 62–74, 10.1016/j.mce.2016.11.003; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419884/
  9. Yang, Yue, and Anthony A. Sauve. “NAD+ Metabolism: Bioenergetics, Signaling and Manipulation for Therapy.” Biochimica et Biophysica Acta, vol. 1864, no. 12, 1 Dec. 2016, pp. 1787–1800, 10.1016/j.bbapap.2016.06.014; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521000/
  10. Rajman, Luis, et al. “Therapeutic Potential of NAD-Boosting Molecules: The in Vivo Evidence.” Cell Metabolism, vol. 27, no. 3, Mar. 2018, pp. 529–547, 10.1016/j.cmet.2018.02.011; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342515/
  11. Katsyuba, Elena, et al. “NAD + Homeostasis in Health and Disease.” Nature Metabolism, vol. 2, no. 1, 1 Jan. 2020, pp. 9–31, 10.1038/s42255-019-0161-5; https://pubmed.ncbi.nlm.nih.gov/32694684/
  12. Chini, Claudia C.S., et al. “Evolving Concepts in NAD+ Metabolism.” Cell Metabolism, vol. 33, no. 6, June 2021, pp. 1076–1087, 10.1016/j.cmet.2021.04.003; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172449/
  13. Weiner, H., and X. Wang. “Aldehyde Dehydrogenase and Acetaldehyde Metabolism.” Alcohol and Alcoholism (Oxford, Oxfordshire). Supplement, vol. 2, 1994, pp. 141–145; https://pubmed.ncbi.nlm.nih.gov/8974328/
  14. Wanders, Desiree et al. “Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.” PloS one vol. 8,8 e71285. 13 Aug. 2013, doi:10.1371/journal.pone.0071285 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742781/
  15. Achari, Arunkumar E, and Sushil K Jain. “Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction.” International journal of molecular sciences vol. 18,6 1321. 21 Jun. 2017, doi:10.3390/ijms18061321 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486142/
  16. “Adiponectin – an Overview | ScienceDirect Topics.” Www.sciencedirect.com, www.sciencedirect.com/topics/medicine-and-dentistry/adiponectin. Accessed 2 Nov. 2021.
  17. Zatterale F, Longo M, Naderi J, Raciti GA, Desiderio A, Miele C and Beguinot F (2020) Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes. Front. Physiol. 10:1607. doi: 10.3389/fphys.2019.01607 https://www.frontiersin.org/articles/10.3389/fphys.2019.01607/full
  18. National Institutes of Health. “Vitamin B6 – Fact Sheet For Health Professionals.” Office of Dietary Supplements; https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/
  19. Prinz-Langenohl, R et al; “[6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C–>T polymorphism of methylenetetrahydrofolate reductase.”; British journal of pharmacology; vol. 158,8; 2009; 2014-21; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807663/
  20. Pietrzik, Klaus, et al; “Folic Acid and L-5-Methyltetrahydrofolate: Comparison of Clinical Pharmacokinetics and Pharmacodynamics.”; Clinical Pharmacokinetics; U.S. National Library of Medicine; Aug. 2010; https://www.ncbi.nlm.nih.gov/pubmed/20608755
  21. Knowles, L et al. “Treatment with Mefolinate (5-Methyltetrahydrofolate), but Not Folic Acid or Folinic Acid, Leads to Measurable 5-Methyltetrahydrofolate in Cerebrospinal Fluid in Methylenetetrahydrofolate Reductase Deficiency.” JIMD reports vol. 29 (2016): 103-107. doi:10.1007/8904_2016_529 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059208/
  22. Wierzbicki, Anthony S; “Homocysteine and Cardiovascular Disease: a Review of the Evidence.”; Diabetes & Vascular Disease Research; U.S. National Library of Medicine; June 2007; https://www.ncbi.nlm.nih.gov/pubmed/17654449
  23. Casas, J P, et al; “Homocysteine and Stroke: Evidence on a Causal Link from Mendelian Randomisation.”; Lancet (London, England);, U.S. National Library of Medicine; https://www.ncbi.nlm.nih.gov/pubmed/15652605
  24. Czeizel, Andrew E et al; “Folate deficiency and folic acid supplementation: the prevention of neural-tube defects and congenital heart defects.”; Nutrients; vol. 5,11; 4760-75; 21 Nov. 2013; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847759/
  25. Choi, Sang-Woon, and Joel B Mason; “Folate Status: Effects on Pathways of Colorectal Carcinogenesis.”; The Journal of Nutrition; U.S. National Library of Medicine; Aug. 2002; https://www.ncbi.nlm.nih.gov/pubmed/12163703
  26. Gupta, A et al. “High homocysteine, low folate, and low vitamin B6 concentrations: prevalent risk factors for vascular disease in heart transplant recipients.” Transplantation vol. 65,4 (1998): 544-50. doi:10.1097/00007890-199802270-00016 https://journals.lww.com/transplantjournal/Fulltext/1998/02270/HIGH_HOMOCYSTEINE,_LOW_FOLATE,_AND_LOW_VITAMIN_B6.16.aspx
  27. Spellicy, Catherine J et al. “The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency.” Frontiers in psychiatry vol. 3 109. 14 Jan. 2013, doi:10.3389/fpsyt.2012.00109 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544007/
  28. Chita, Dana Simona et al. “MTHFR Gene Polymorphisms Prevalence and Cardiovascular Risk Factors Involved in Cardioembolic Stroke Type and Severity.” Brain sciences vol. 10,8 476. 24 Jul. 2020, doi:10.3390/brainsci10080476 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059208/
  29. Venn, Bernard J, et al; “Comparison of the Effect of Low-Dose Supplementation with L-5-Methyltetrahydrofolate or Folic Acid on Plasma Homocysteine: a Randomized Placebo-Controlled Study.”; The American Journal of Clinical Nutrition; U.S. National Library of Medicine; Mar. 2003; https://www.ncbi.nlm.nih.gov/pubmed/12600857
  30. Shelton, Richard C et al; “Assessing Effects of l-Methylfolate in Depression Management: Results of a Real-World Patient Experience Trial.”; The primary care companion for CNS disorders; vol. 15,4; 2013; PCC.13m01520; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869616/
  31. Anderson, Shanna et al; “Anxiety and Methylenetetrahydrofolate Reductase Mutation Treated With S-Adenosyl Methionine and Methylated B Vitamins.”; Integrative medicine (Encinitas, Calif.); vol. 15,2; 2016; 48-52; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898281/
  32. Shorter KR, Felder MR, Vrana PB. Consequences of dietary methyl donor supplements: Is more always better? Prog Biophys Mol Biol. 2015 Jul;118(1-2):14-20. doi: 10.1016/j.pbiomolbio.2015.03.007. Epub 2015 Apr 2. PMID: 25841986. https://linkinghub.elsevier.com/retrieve/pii/S0079-6107(15)00043-7
  33. da Silva, Weslay Rodrigues et al. “Recognition and management of vitamin B12 deficiency: Report of four cases with oral manifestations.” Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry vol. 42,4 (2022): 410-415. doi:10.1111/scd.12685 https://onlinelibrary.wiley.com/doi/10.1111/scd.12685
  34. Langan, Robert C, and Andrew J Goodbred. “Vitamin B12 Deficiency: Recognition and Management.” American family physician vol. 96,6 (2017): 384-389. https://www.aafp.org/pubs/afp/issues/2017/0915/p384.html
  35. Wahbeh, Farah, and Mange Manyama. “The role of Vitamin B12 and genetic risk factors in the etiology of neural tube defects: A systematic review.” International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol. 81,5 (2021): 386-406. doi:10.1002/jdn.10113 https://onlinelibrary.wiley.com/doi/10.1002/jdn.10113
  36. Rogne, Tormod et al. “Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data.” American journal of epidemiology vol. 185,3 (2017): 212-223. doi:10.1093/aje/kww212 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390862/
  37. ‌Bala, Renu et al. “Hyperhomocysteinemia and low vitamin B12 are associated with the risk of early pregnancy loss: A clinical study and meta-analyses.” Nutrition research (New York, N.Y.) vol. 91 (2021): 57-66. doi:10.1016/j.nutres.2021.05.002 https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(21)00023-3
  38. Köbe, Theresa et al. “Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment.” The American journal of clinical nutrition vol. 103,4 (2016): 1045-54. doi:10.3945/ajcn.115.116970 https://www.sciencedirect.com/science/article/pii/S0002916523119289
  39. Gröber, Uwe et al. “Neuroenhancement with vitamin B12-underestimated neurological significance.” Nutrients vol. 5,12 5031-45. 12 Dec. 2013, doi:10.3390/nu5125031 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875920/
  40. Ankar, Alex, and Anil Kumar. “Vitamin B12 Deficiency (Cobalamin).” Nih.gov, StatPearls Publishing, 2019, www.ncbi.nlm.nih.gov/books/NBK441923/
  41. Mock, D. M. “Skin Manifestations of Biotin Deficiency.” Seminars in Dermatology, vol. 10, no. 4, 1 Dec. 1991, pp. 296–302; https://pubmed.ncbi.nlm.nih.gov/1764357/
  42. Lanska, Douglas J. “The Discovery of Niacin, Biotin, and Pantothenic Acid.” Annals of Nutrition and Metabolism, vol. 61, no. 3, 2012, pp. 246–253, 10.1159/000343115; https://pubmed.ncbi.nlm.nih.gov/23183297/
  43. Zempleni, Janos, et al. “Biotin and Biotinidase Deficiency.” Expert Review of Endocrinology & Metabolism, vol. 3, no. 6, 1 Nov. 2008, pp. 715–724, 10.1586/17446651.3.6.715; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726758/
  44. Dakshinamurti, Krishnamurti. “Vitamins and their derivatives in the prevention and treatment of metabolic syndrome diseases (diabetes).” Canadian journal of physiology and pharmacology vol. 93,5 (2015): 355-62. doi:10.1139/cjpp-2014-0479 https://cdnsciencepub.com/doi/10.1139/cjpp-2014-0479
  45. Sahin, Kazim et al. “Anti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and streptozotocin.” The British journal of nutrition vol. 110,2 (2013): 197-205. doi:10.1017/S0007114512004850 https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/antidiabetic-activity-of-chromium-picolinate-and-biotin-in-rats-with-type-2-diabetes-induced-by-highfat-diet-and-streptozotocin/7AB5308EABE89D233EB46A63DDD9226D
  46. Mock, Donald M. “Marginal biotin deficiency is common in normal human pregnancy and is highly teratogenic in mice.” The Journal of nutrition vol. 139,1 (2009): 154-7. doi:10.3945/jn.108.095273 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646213/
  47. Yang M, Moclair B, Hatcher V, et al. A randomized, double-blind, placebo-controlled study of a novel pantothenic Acid-based dietary supplement in subjects with mild to moderate facial acne. Dermatol Ther (Heidelb). 2014;4(1):93-101. doi:10.1007/s13555-014-0052-3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065280/
  48. Kobayashi D, Kusama M, Onda M, Nakahata N. The effect of pantothenic acid deficiency on keratinocyte proliferation and the synthesis of keratinocyte growth factor and collagen in fibroblasts. J Pharmacol Sci. 2011;115(2):230-4. doi: 10.1254/jphs.10224sc. Epub 2011 Jan 18. PMID: 21258175. https://pubmed.ncbi.nlm.nih.gov/21258175/
  49. Evans, Malkanthi et al. “Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation.” Vascular health and risk management vol. 10 89-100. 27 Feb. 2014, doi:10.2147/VHRM.S57116 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942300/
  50. Rumberger, John A et al. “Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation.” Nutrition research (New York, N.Y.) vol. 31,8 (2011): 608-15. doi:10.1016/j.nutres.2011.08.001 https://www.sciencedirect.com/science/article/abs/pii/S0271531711001461
  51. Ismail, Nashwah et al. “Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis.” Biochemical and biophysical research communications vol. 522,1 (2020): 220-225. doi:10.1016/j.bbrc.2019.11.052 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977085/
  52. Xu, Jingshu et al. “Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer’s disease.” Biochemical and biophysical research communications vol. 527,3 (2020): 676-681. doi:10.1016/j.bbrc.2020.05.015 https://www.sciencedirect.com/science/article/pii/S0006291X20309190
  53. Saliba, Kevin J et al. “Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.” Antimicrobial agents and chemotherapy vol. 49,2 (2005): 632-7. doi:10.1128/AAC.49.2.632-637.2005 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547364/

Comments and Discussion (Powered by the PricePlow Forum)