Psycho Pharma Edge of Insanity: The Heavy Metal of Pre Workouts

Psycho Pharma Edge of Insanity

Edge of Insanity is a high stim, focus and energy boosting pre workout from Psycho Pharma looking to push your limits to the edge.

Over the past few months, we’ve been hearing incessant musing about a particular pre workout that brings an insane rush of energy and focus. One so potent it potentially rivals the top DMAA pre workouts on the market.

The pre workout we’re talking about is none other than Edge of Insanity by Psycho Pharma. Well, we recently talked to the brand to find out a little more about this hard-hitting pre workout, and learned there’s actual a revised version that’s about to be released that’s potentially even harder hitting than the OG version.

You can read all about the revamped version of Edge of Insanity below, but before we get there, take a moment to check the best deal and sign up for alerts from PricePlow:

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Note: Some stores may still have the older version, so check the store’s label. If you see “Panthergy” or “N-Methylpentyl-Iminoglutaric Acid”, that is the older version. If you see isopropylnorsynephrine, that is the newer version.

Edge of Insanity Ingredients

As we mentioned up top, Edge of Insanity has been reformulated. Gone from the new version are the stimulants N-methylpentyl-iminoglutaric acid (a.k.a. Panthergy) and Synephrine. In their place, you’ll find isopropylnorsynephrine, eria jarensis, and theophylline.

  • PSYCHO Vascularity Endurance & Pumps Blend (6,028mg)

    • Beta Alanine

      Psycho Pharma Edge of Insanity Ingredients Old

      Note the old label contains Panthergy, which has been removed in the new version.

      Psycho Pharma Edge of Insanity Ingredients

      The new Edge of Insanity formula is still packing a lot of heat at 350mg caffeine per scoop plus Eria Jarensis and a whole lot of other potent stimulants.

      Leading off this insane energy pre workout is the best known endurance booster on the market, beta alanine. Known for its trademark tingling side effects, beta alanine enhances stamina and delays the onset of fatigue by increasing carnosine concentrations in the body which boosts your muscles buffering ability.[1,2]

      Seeing as this is the first ingredient in the 6g prop blend, and there being only 2 other ingredients in this blend, we’re estimating you’re getting at least 3g worth of beta alanine here, and definitely close to the 3.2g daily clinical doses used in studies.

      Get ready for some serious tingles, folks!

    • Arginine Alpha Ketoglutarate

      Commonly displayed as AAKG, Arginine Alpha Ketoglutarate is an anionic salt of L-arginine an alpha-ketoglutarate (AKG). This “enhanced” form of arginine was believed to enhance the bioavailability and effectiveness of arginine in the body, helping it survive the stomach and enhance uptake in the intestines. Research is mixed at best, as some studies show it increases plasma arginine levels, but other studies show it has no effect or possibly decreases performance.[3,4,5]

      This ingredient is an OK “co-pump enhancer” but we’re not fans of it being the only pump booster in pre workouts claiming to give pumps, which is why the next ingredient is especially helpful.

    • Agmatine Sulfate

      Psycho Pharma Edge of Insanity Pre Workout

      Add the “edge” to your training with Edge of Insanity.

      Agmatine is a very potent, yet extremely underrated, NO-boosting compound. This derivative of arginine indirectly increases nitric oxide production by inhibiting the enzyme that restricts nitric oxide production, arginase.[7]

      Typically, we’d like to 1-1.5g of agmatine in a pre workout. Given this is the last ingredient in a prop blend, there’s a solid chance you’re getting at least 500-750mg worth here.

  • Razor’s Edge Focus (680mg)

    • Caffeine Anhydrous

      Here’s where the insanity begins folks.

      Right out of the gate Psycho Pharma is hitting you with a powerful 350mg per serving of pure caffeine anhydrous, a.k.a. Immediate, intense energy.

      For many, this will provide just enough “edge” to the initial energy surge without going over the edge. Once you start to hit 400mg and above, even the most hardcore stim heads may get uncomfortable.

    • Eria Jarensis

      Psycho Pharma Edge of Insanity New Look

      Edge of Insanity has a new look, and NOW a new formula to match!

      Up next is the ultimate “feel-good” exotic stim blend Eria Jarensis. This plant is chock full of mood-enhancing, PEA-like compounds, which Psycho Pharma has standardized its extract for the N-phenethyldimethylamine content.

      Suffice it to say that with DMAA and DMHA likely on the outs for good, this is the leading “next level” stim of future pre workouts. We’ve gone into much more detail about this potent stim in our write up: Eria Jarensis Extract / N-phenethyl dimethylamine: The Next Big Thing?

    • Theophylline

      Also known as 1,3-dimethylxanthine, theophylline is another methylxanthine, similar to caffeine that’s traditionally used to combat respiratory diseases such as asthma or chronic obstructive pulmonary disease (COPD).[8,9] Theophylline also acts similar to caffeine in that it is a phosphodiesterase inhibitor and adenosine receptor blocker.[10]

    • Halostachine

      Halostachine is a mild sympathomimetic agent that can act as a partial adrenergic binding agent.[11] Research notes halostachine is approximately 19% as effective as epinephrine in stimulating the beta-2 receptor.[12]

      Where halostachine really shines is in the role of an alpha receptor agonist, which elevates body temperature and provides some mild vasoconstriction.

    • Isopropylnorsynephrine

      Psycho Pharma Edge of Insanity Shipping

      The new version of Edge of Insanity is available NOW. Can you handle it?

      Next up is a none too frequently used stimulant, isopropylnorsynephrine. This stimulant is an isopropyl derivative of the well known fat loss agent, synephrine. Isopropylnorsynephrine is a potent fat loss agent documented to be “active at 1 μg/ml and reproducing more than 60% of isoprenaline maximal effect in human adipocytes”.[13]

      Interestingly, this is the ingredient that Hi-Tech Pharma has been using as their DMAA replacement, since they can no longer manufacture supplements with the ingredient. It indeed looks powerful, but we’re just not sure how powerful.

    • Octopamine

      Octopamine is yet another stimulant / fat loss agent found in citrus aurantium (bitter orange). Octopamine restricts glucose uptake by fat cells by inhibiting beta-3 receptors in the body.

      Note that if you’re a drug tested athlete, octopamine is on WADA’s banned substance list.

    • Theobromine

      Theobromine Effects

      High-Dose Theobromine can dial up the “feels”

      A dual stimulant and vasodilator, theobromine is another relative of caffeine, often termed caffeine’s “weaker, younger brother”. The reason is, is that theobromine provides a smoother, more sustained (and gentler) release of energy than caffeine.[14]

    • N-Methyl Tyramine

      N-Methyl Tyramine (NMT) is a stimulant shown in animal studies to increase production of several powerful catecholamines including dopamine, epinephrine (adrenaline), and norepinephrine (noradrenaline).[15,16] The resulting cascade of neurotransmitters elevates focus, motivation and alertness.

    • Rauwolfia Vomitoria Extract

      Last up is one of the hardest hitting stimulants of all in rauwolfia vomitoria, which is standardized to 90% alpha-yohimbine. This is a more intense, aggressive feeling form of yohimbine, but typically without the uncomfortable side effects that typically come with yohimbine use for some users.

      Psycho Pharma has been kind enough to disclose the dose of alpha-Y for those that are particularly sensitive to the aggressive stimulant. Each serving of Edge of Insanity provides 5mg of alpha-yohimbine per scoop. WHOA BABY! Get ready for serious rush of energy with this one folks.

On the Formula

”Edge of insanity has been formulated to rival the effects of DMAA and 2 aminoisoheptane. I’ve personally guinea pigged and compared these many many times to arrive at this formula. 5 mg alpha Yohimbine is the only secret I’m releasing.

I dare others to use something this expensive and effective in their formulas.”

— Psycho Pharma

Flavors Available

Edge of Insanity comes in three flavors including:

  • Cosmic Candy
  • Rainbow Sherbet
  • Spiked Punch

Our Edge of Insanity Review: On the edge of uncomfortableness

Well if you want it strong, and you’re a fan of yohimbine-like ingredients, this is for you! But wow… killer strong.

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Possible Inspiration? The Metal Band Edge of Sanity

There was a heavy metal band from 1989-2003 founded by metal legend Dan Swanö named Edge of Sanity.

If you start following Psycho Pharma (just look at some of the other Psycho Pharma supplements!), you’ll notice a few other wildly named products, including some that seem to be metal inspired! \m/

Takeaway

The original Edge of Insanity was one of the most intense energy/focus pre workouts on the market, even including the ones with DMAA. There’s been a few tweaks, but you can rest assured this is one pre workout that’s still going to deliver one hell of a boost in energy, motivation, and aggression in the gym.

Who’s ready to talk a walk on the Edge of Insanity?

Psycho Pharma Edge Of Insanity - Deals and Price Drop Alerts

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Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer on your own.

Posts are sponsored in part by the retailers and/or brands listed on this page.

Note: Some stores may still have the older version, so check the store’s label. If you see “Panthergy” or “N-Methylpentyl-Iminoglutaric Acid”, that is the older version. If you see isopropylnorsynephrine, that is the newer version.

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References

  1. Trexler ET, Smith-Ryan AE, Stout JR, et al. International society of sports nutrition position stand: Beta-Alanine. J Int Soc Sports Nutr. 2015;12(1):30. doi:10.1186/s12970-015-0090-y. https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0090-y
  2. Hobson RM, Saunders B, Ball G, Harris RC, Sale C. Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino Acids. 2012;43(1):25-37. doi:10.1007/s00726-011-1200-z. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374095/
  3. Willoughby DS, Boucher T, Reid J, Skelton G, Clark M. Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow,  plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise. Int J Sport Nutr Exerc Metab. 2011;21(4):291-299. https://www.ncbi.nlm.nih.gov/pubmed/21813912
  4. Wax B, Kavazis AN, Webb HE, Brown SP. Acute L-arginine alpha ketoglutarate supplementation fails to improve muscular performance in resistance trained and untrained men. Journal of the International Society of Sports Nutrition. 2012;9:17. doi:10.1186/1550-2783-9-17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428651/
  5. Greer, BK; BT Jones (Jul 2011). “Acute arginine supplementation fails to improve muscle endurance or affect blood pressure responses to resistance training”. Journal of Strength and Conditioning Research. 25 (7): 1789–94. PMID 21399536. doi:10.1519/JSC.0b013e3181e07569. https://www.ncbi.nlm.nih.gov/pubmed/21399536
  6. Agmatine is one of our favorite NO-boosting compounds. Rather than directly boost nitric oxide production in the body, agmatine indirectly boosts it by inhibiting the enzyme that prohibits nitric oxide production, arginase.[7]
  7. Demady, D; Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme.; Department of Pharmacology, The University of Michigan Medical School; 2001
  8. Lal D, Manocha S, Ray A, Vijayan VK, Kumar R. Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease. J Basic Clin Physiol Pharmacol. 2015;26(5):443-451. doi:10.1515/jbcpp-2015-0006. https://www.ncbi.nlm.nih.gov/pubmed/25894641
  9. https://www.ncbi.nlm.nih.gov/pubmed/11951074
  10. https://www.ncbi.nlm.nih.gov/pubmed/1865359
  11. http://med.stanford.edu/kobilkalab/pdf/YaoNCB06.pdf
  12. http://molpharm.aspetjournals.org/content/65/5/1181.long
  13. https://www.ncbi.nlm.nih.gov/pubmed/21336650
  14. http://hyper.ahajournals.org/content/56/5/839.full.pdf
  15. Tsutsumi E, Kanai S, Ohta M, Suwa Y, Miyasaka K. Stimulatory effect of N-methyltyramine, a congener of beer, on pancreatic secretion in conscious rats. Alcohol Clin Exp Res. 2010;34 Suppl 1:S14-7. doi:10.1111/j.1530-0277.2009.00893.x. https://www.ncbi.nlm.nih.gov/pubmed/19298333
  16. Stohs SJ, Hartman MJ. A review of the receptor binding and pharmacological effects of N-methyltyramine. Phytother Res. 2015;29(1):14-16. doi:10.1002/ptr.5231. https://www.ncbi.nlm.nih.gov/pubmed/25274429
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