Core GUT: Prebiotic, Probiotic, and POSTbiotics from Core Nutritionals

On October 4, 2021, Core Nutritionals announced the Core Lifeline Series, a new lineup of health-minded supplements that attack individual issues and organ systems. The first product released was Core GUT, a comprehensive gut microbiome support supplement covered here today:

Core GUT: Support Your Gut with Pre-, Pro-, and Post-Biotics

This five-capsule beast brings us four incredible types of ingredients to get your GI tract back on track:

Core GUT PricePlow

In five incredible capsules, Core GUT brings prebiotics, probiotics, postbiotics, and digestive enzymes to help improve your gut health and digestion!

  • Probiotics – Custom formulated non-proprietary blend of live organisms to provide the gut with beneficial bacterial support

  • Tributryin – This “postbiotic” provides the critical short-chain fatty acid butyrate, helping with proper digestive tract function and inflammatory response

  • Prebiotics – Using a prebiotic fiber, Core GUT provides the gut with the “raw materials” it needs to build a strong and healthy environment

  • Digestive enzymes – Added to ensure you can digest all types of food, ranging from fats to carbs to protein to milk sugars.

With these combined, this supplement and its three-pronged approach supports healthy gut bacteria and a strong gut lining, and this may lead to numerous downstream benefits that go beyond digestion, but even help with mood and immunity.

The details are covered below, but first, check our PricePlow-powered coupons and sign up for our Core Nutritionals news alerts, since more Lifeline supplements are on the way:

Core Nutritionals GUT – Deals and Price Drop Alerts

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Core GUT Ingredients

In five capsules (taken once daily, preferably with a meal), you’ll get the following fully-disclosed formula:

Core Nutritionals GUT Ingredients

Prebiotics, Probiotics, Postbiotics, and Digestive Enzymes… and it’s all open formula in Core GUT!

  • Core Probiotic Blend – 30 Billion CFU

    In general, probiotics are living organisms that consist of healthy bacteria. There are various strains that have various metabolic functions, leading to numerous benefits when fed to your gut.[1]

    When you see the unit of measurement “CFU”, it stands for colony forming units, indicating the total number of viable cells inside.[2] In September of 2018, the FDA released a Guidance stating that these numbers should include the live cells, not inactive, nonviable, or dead ones.[3]

    In Core GUT, don’t be fooled by the word “blend” — this is not proprietary! We rarely see probiotics labeled so well:

    • Bifidobacterium – 8.5 billion CFU

      Alongside Lactobacillus (which is covered next), Bifidobacterium is the most common family of probiotics.[1] These live in the intestines and stomach and help to fight off harmful bacterium. They’re often found in foods such as yogurt, buttermilk, kefir, sauerkraut, and even cured meat.

      CORE Provides the following:

      • Bifidobacterium breve – 2 billion CFU
      • Bifidobacterium infantis – 2 billion CFU
      • Bifidobacterium bifidum – 2 billion CFU
      • Bifidobacterium longum – 2 billion CFU
      • Bifidobacterium lactis – 500 million CFU

      From this family, we’ve seen the following benefits:

      Gut Health

      Core to SO many of our issues is gut health. Eliminating processed food will help tremendously, but what else can we do to restore our gut microbiota?

      • Improvements to diarrhea, gas, allergies, and IBS[4,5]
      • Reduction of bloating and abdominal discomfort[6]
      • Helpful in fighting ulcerative colitis[7,8]
      • Useful in the treatment of lung infections and other inflammatory conditions[9,10]
      • Immune system support[11]
      • Improved digestion and mineral uptake[12,13]
      A diverse approach

      Each strain provides its own unique benefits, since each one has its own metabolic process that digests and “resolves” differing bacterial concerns.

      It’s great to see that CORE dosed them large, but also dosed them wide — we’d rather have 2 billion CFU of four different strains than 8 billion CFU of a single strain. Meanwhile, most other brands don’t even tell you what’s inside of their proprietary blends!

    • Lactobacillus – 16.5 billion CFU

      The other most popular family of probiotics, and likely the most common, various lactobacillus strains help the body break down, digest, and absorb nutrients from food.[1]

      With Core GUT, you get an incredible spectrum inside:

      Stomach Icon

      Feed your gut the weapons it needs to keep you healthy

      • Lactobacillus acidophilus – 4 billion CFU
      • Lactobacillus plantarum – 2 billion CFU
      • Lactobacillus bulgaricus – 2 billion CFU
      • Lactobacillus casei – 2 billion CFU
      • Lactobacillus rhamnosus – 2 billion CFU
      • Lactobacillus brevis – 2 billion CFU
      • Lactobacillus gasseri – 500 million CFU
      • Lactobacillus fermentum – 500 million CFU
      • Lactobacillus reuteri – 500 million CFU
      • Lactobacillus paracasei – 500 million CFU
      • Lactobacillus salivarius – 500 million CFU

      Together, these yield numerous potential benefits (the following list only scratches the surface):

      • Treating lung (and other inflammatory) conditions[10]
      • Fighting numerous digestive disorders (ulcerative colitis, Crohn’s disease, IBS, and more)[14-17]
      • Increased antioxidant activity[18]
      • Improved ATP generation for cellular energy[19]
      • Reduction of cholesterol[20]
      • Anti-inflammatory and immune system benefits[21,22]
      • Dental health and periodontal protection[23]
      • Improvement of skin conditions[24]

      The same statement applies – it’s important to see a broad and powerful spectrum of probiotics in Core GUT. While many of the effects overlap — such as fighting IBS, diarrhea, and common inflammatory disorders — each added strain brings a few more weapons to the gut microbiome. It’s tough to know which one you need, but if you’re willing to take five capsules, you’re going to get a serious armory for your gut.

    • Saccharomyces – 5 billion CFU

      Core Nutritionals Lifeline Series

      Gut is the first of many in the Core Lifeline Series

      Saccharomyces boulardii is actually a probiotic yeast. It’s commonly used for the prevention and therapy of various gastrointestinal disorders such as bacterial-caused diarrhea[25-27] and IBS.[26] There seem to be other benefits, but if you’re ever dealing with diarrhea, this seems to be one of the best anti-bacterial approaches. It doesn’t hurt that Core GUT has other ingredients above that work on the ailment in different ways as well.

  • Tributyrin (as CoreBiome 30%) – 1g, yielding 300mg

    Known as a “postbiotic”, tributyrin is one of the hottest new ingredients in the gut health scene, and there are still too few supplements using it.


    With prebiotics (discussed next), you get fiber that healthy bacteria feed on in your digestive tract.[28] Meanwhile, probiotics are live bacteria taken to improve the gut’s healthy bacteria levels,[1] with the countless benefits touched upon above.

    But with “postbiotics”, we get a bioactive compound that is normally produced from fiber fermentation that has several benefits to gut health as well.[29] It turns out that taking more is also beneficial, even if we’re already getting the fiber and probiotics to generate them in the first place.

    This leads us to butyric acid:

    Butyrate: What is Butyric Acid?

    Short Chain Fatty Acids

    “Schematic representation of microbial metabolic pathways and cross-feeding mechanisms, contributing to SCFA formation in the human gut. Shaded geometric shapes summarize routes of formation for each of the three main SCFA: acetate, propionate, and butyrate.”[30]

    Our healthy bacteria break down our foods and nutrients to provide nutrition for the body. When they break down fiber, however, something else happens: a fatty acid known as butyric acid gets generated.[31]

    Butyric acid is a short chain fatty acid (SCFA) that’s critical to gut health.[31] It’s been linked to numerous critical biological processes such as immune system regulation, body weight maintenance, energy balance, and even cognitive function.[31] Butyrate helps supply energy within the colon, and when we’re deficient, we may experience various illnesses, such as those discussed above that probiotics often help treat.

    Benefits of Tributyrin

    Scientists have found that rather than just hoping you have the right bacterial mix to ferment fibers, you can also supplement more – and tributyrin has been found to be a safe and bioavailable way to increase butyrate. Its supplementation has been connected to several benefits and biological processes:[29,31]

    • Immune system improvements
    • Anti-inflammatory actions, combating many GI issues
    • Improved gene expression in digestive, gut, and GI systems
    • Better cellular communication in beneficial microbes
    • Improved microflora ratios (good vs. harmful bacteria)
    • Antioxidant effects and oxidative stress reduction
    • Better regular bowel movements and reduction of constipation[29,31]

    Tributryin + 3H2 (and some enzymatic help) yields glycerol and butyric acid, ready to help the gut

    This demonstrates that tributyrin (and butyrate in general) can help with food metabolism as well as providing additional healthy defense against pathogens.

    There’s one negative to the ingredient, but it’s been fixed by Core Nutritionals: the smell. When you smell a banana candy scent in Core GUT, this is the reason why: since tributyrin is based upon butyrate, which smells quite bad (as beneficial as it is, butyrate is what makes bile smell so bad, for instance), it’s been masked in CoreBiome so that you get the benefits without the bad smells.

  • Sunfiber Guar Fiber – 1g

    Core GUT

    Now this is how you do a gut health supplement. Have you tried tributyrin yet? If not, and you have any gut issues, then get this on your list!

    SunFiber is a fermented dietary fiber that functions as a prebiotic, helping the body to increase bifidobacteria and lactobacillus levels in the gut. Several research studies have shown that it can normalize both constipation and diarrheal conditions,[32] leading to more regularity regardless of what issues you have.

    This will also provide fuel for your gut to make its own butyrate. Even though Core GUT provides tributyrin, the goal is still to get your body to generate its own short chain fatty acids in the appropriate amounts.

    In addition, this type of fiber has been shown to improve appetite[33] blood sugar control, which is something we’ll always take[34] — especially when we believe that the very dietary issues that cause high blood sugar are also the same ones that lead to poor gut health.

  • Digestive Enzyme Blend (protease, lactase, amylase, and lipase) – 150mg

    When it comes to using digestive enzymes in their products, no brand is as consistent as Core Nutritionals, who adds them to many of their protein powders.

    Core Nutritionals Core Pro Peanut Butter & Jelly

    Core PRO Peanut Butter & Jelly is here, and it’s strawberry jelly – the way it should be! Use it with your protease here in Core GUT

    This is a blend made of the following:

    • Protease – helps break down protein
    • Lactase – helps break down lactose (milk sugars, great for users of CORE’s proteins, although most of their proteins add them as well)
    • Amylase – helps break down carbohydrates / starches
    • Lipase – helps break down lipids / fats

    For the athletes out there, it’s also good to know that protease also helps show improved recovery benefits by reducing the damaging effects of exercise faster.[35,36]

    For this reason, GUT should be taken with a protein-containing meal… but all meals should contain protein, so that’s a given.

Dosage and Instructions

Simply take five capsules per day with food. You could attempt to mix them up across two meals, but if that strategy over-complicates things, then just take all five capsules once a day with food.

Core GUT: The Lifeline Series is off to a great start

Gut health is all the rage right now, and as always, the sports nutrition sector of the supplement industry are the ones doing things best. Probiotics have become increasingly popular over the past decade, with the research growing leaps and bounds. However, in other parts of the industry, the formulas simply are not. They’re still proprietary, and they’re still not using enough beneficial strains.

Doug Miller Podcast

Doug Miller and his team at CORE Nutritionals always find a way to figure it out. Listen to him talk about recent events in Episode #050 of the PricePlow Podcast

Meanwhile, very few brands are using tributyrin, which we believe is the next big thing with gut health. Even fewer brands outside of sports nutrition are using it.

Leave it to Doug Miller and Core Nutritionals to solve both of those problems.

If this is your first look at the Core Lifeline Series, then get ready – we think some of the other formulas may be even better… but that all depends on what you and your body need.

If you’re dealing with gut health issues, this one’s a must-try. But as we always must say, the most important part is to remove the foods that are causing your gut problems — and that’s most often the refined sugars and toxic omega-6 seed oils (known as “vegetable oils”). Eliminate the bad, and add the good in Core GUT, and you’re on your way to a better digestive system.

Core Nutritionals GUT – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

Core Nutritionals GUT Label

The Full Core Nutritionals GUT Label

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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  4. Guglielmetti, S., et al. “Randomised Clinical Trial: Bifidobacterium Bifidum MIMBb75 Significantly Alleviates Irritable Bowel Syndrome and Improves Quality of Life — a Double-Blind, Placebo-Controlled Study.” Alimentary Pharmacology & Therapeutics, vol. 33, no. 10, 21 Mar. 2011, pp. 1123–1132, 10.1111/j.1365-2036.2011.04633.x;
  5. Brenner, Darren M., and William D. Chey. “Bifidobacterium Infantis 35624: A Novel Probiotic for the Treatment of Irritable Bowel Syndrome.” Reviews in Gastroenterological Disorders, vol. 9, no. 1, 2009, pp. 7–15;
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  7. Cui, Hai-hong, et al. “[the Effects of Bifidobacterium on the Intestinal Mucosa of the Patients with Ulcerative Colitis].” Zhonghua Nei Ke Za Zhi, vol. 42, no. 8, 1 Aug. 2003, pp. 554–55;
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  9. Natividad, Jane M. M., et al. “Differential Induction of Antimicrobial REGIII by the Intestinal Microbiota and Bifidobacterium Breve NCC2950.” Applied and Environmental Microbiology, vol. 79, no. 24, 4 Oct. 2013, pp. 7745–7754, 10.1128/aem.02470-13;
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  11. Arunachalam, K, et al. “Enhancement of Natural Immune Function by Dietary Consumption of Bifidobacterium Lactis (HN019).” European Journal of Clinical Nutrition, vol. 54, no. 3, Mar. 2000, pp. 263–267, 10.1038/sj.ejcn.1600938;
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  14. María Remes Troche, José, et al. “Lactobacillus Acidophilus LB: A Useful Pharmabiotic for the Treatment of Digestive Disorders.” Therapeutic Advances in Gastroenterology, vol. 13, 24 Nov. 2020, 10.1177/1756284820971201;
  15. Rönkä, Elina, et al. “Probiotic and Milk Technological Properties of Lactobacillus Brevis.” International Journal of Food Microbiology, vol. 83, no. 1, May 2003, pp. 63–74, 10.1016/s0168-1605(02)00315-x;
  16. Oberhelman, Richard A., et al. “A Phase One Safety Study of Lactobacillus Reuteri Conducted in the Peruvian Amazon: Observations from the Field.” The American Journal of Tropical Medicine and Hygiene, vol. 90, no. 4, 2 Apr. 2014, pp. 777–780, 10.4269/ajtmh.13-0639;
  17. Oliveira, Manuel, et al. “Lactobacillus Paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis.” Clinical and Developmental Immunology, vol. 2011, 2011, pp. 1–13, 10.1155/2011/807483;
  18. Wang, Jing, et al. “Lactobacillus Plantarum Exhibits Antioxidant and Cytoprotective Activities in Porcine Intestinal Epithelial Cells Exposed to Hydrogen Peroxide.” Oxidative Medicine and Cellular Longevity, vol. 2021, 2021, 10.1155/2021/8936907;
  19. Pessione, Enrica. “Lactic Acid Bacteria Contribution to Gut Microbiota Complexity: Lights and Shadows.” Frontiers in Cellular and Infection Microbiology, vol. 2, 2012, 10.3389/fcimb.2012.00086;
  20. Mishra, V, and D Prasad. “Application of in Vitro Methods for Selection of Strains as Potential Probiotics.” International Journal of Food Microbiology, vol. 103, no. 1, 15 Aug. 2005, pp. 109–115, 10.1016/j.ijfoodmicro.2004.10.047;
  21. Goto, Hiroaki, et al. “Anti-Influenza Virus Effects of Both Live and Non-Live Lactobacillus Acidophilus L-92 Accompanied by the Activation of Innate Immunity.” The British Journal of Nutrition, vol. 110, no. 10, 1 Nov. 2013, pp. 1810–1818, 10.1017/S0007114513001104;
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  24. Holowacz, S., et al. “Lactobacillus SalivariusLA307 AndLactobacillus RhamnosusLA305 Attenuate Skin Inflammation in Mice.” Beneficial Microbes, vol. 9, no. 2, 27 Feb. 2018, pp. 299–309, 10.3920/bm2017.0084;
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  26. Czerucka, D., et al. “Review Article: Yeast as Probiotics -Saccharomyces Boulardii.” Alimentary Pharmacology & Therapeutics, vol. 26, no. 6, 19 July 2007, pp. 767–778, 10.1111/j.1365-2036.2007.03442.x;
  27. Dinleyici, Ener Cagri, et al. “Effectiveness and Safety OfSaccharomyces Boulardiifor Acute Infectious Diarrhea.” Expert Opinion on Biological Therapy, vol. 12, no. 4, 16 Feb. 2012, pp. 395–410, 10.1517/14712598.2012.664129;
  28. Carlson JL, et al; “Health Effects and Sources of Prebiotic Dietary Fiber;” Curr Dev Nutr.; 2018 Jan 29;2(3);
  29. Wegh CAM, et al; “Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond”; Int J Mol Sci. 2019;20(19):4673;
  30. Ríos-Covián, David et al. “Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health.” Frontiers in microbiology vol. 7 185. 17 Feb. 2016, doi:10.3389/fmicb.2016.00185.
  31. Stilling, RM et al; “The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?”; Neurochemistry International, 99, 110–132;
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  33. Rao, Theertham Pradyumna. “Role of Guar Fiber in Appetite Control.” Physiology & Behavior, vol. 164, no. Pt A, 1 Oct. 2016, pp. 277–283, 10.1016/j.physbeh.2016.06.014;
  34. Cohen, M., et al. “Role of Guar and Dietary Fibre in the Management of Diabetes Mellitus.” The Medical Journal of Australia, vol. 1, no. 2, 26 Jan. 1980, pp. 59–61, 10.5694/j.1326-5377.1980.tb134625.x;
  35. Buford, Thomas W, et al. “Protease Supplementation Improves Muscle Function after Eccentric Exercise.” Medicine and Science in Sports and Exercise, vol. 41, no. 10, 2009, pp. 1908–14; 10.1249/MSS.0b013e3181a518f0;
  36. Miller, Paul C, et al. “The Effects of Protease Supplementation on Skeletal Muscle Function and DOMS Following Downhill Running.” Journal of Sports Sciences, vol. 22, no. 4, Apr. 2004, pp. 365–372, 10.1080/02640410310001641584;

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