Unmatched Supps Immuno-IGG: Serum-Derived Immunoglobulins for Gut and Immune Health

Unmatched Supps Immuno-IGG delivers powerful gut support with 50% immunoglobulin G content — significantly higher than typical colostrum supplements. This dairy-free formula strengthens intestinal barrier function for better training recovery and overall performance.

Your gut affects everything — from nutrient absorption and immune function to hormone regulation and even mental clarity. When gut health suffers, your training, recovery, and overall performance inevitably follow. Unmatched Supps Immuno-IGG delivers a concentrated dose of serum-derived immunoglobulins designed to strengthen intestinal barrier function and support your body’s first line of defense.

Unlike traditional colostrum supplements, Immuno-IGG provides a dairy-free solution with significantly higher immunoglobulin content and consistent potency. Backed by founders Kris Gethin and Doug Miller’s commitment to quality, this formula reflects their philosophy of enhancing performance while protecting long-term health.

What is Immuno-IGG? Introducing Immunolin

Immuno-IGG contains Immunolin, a serum-derived bovine immunoglobulin/protein isolate (SBI) that delivers a potent dose of immunoglobulins to support intestinal health and immune function. Each serving provides 2 grams of Immunolin with over 1 gram of IgG, which is more than 50% immunoglobulin G content, significantly higher than what you’ll find in typical colostrum supplements.

This article explains why that is beneficial, and why Immuno-IGG makes a strong strategic addition to your gut health stack. It has many tremendous uses, and while some stores have put it in the immune section (it does work for that), it should truly be considered for the gut health / colostrum section.

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Immuno-IGG Ingredients

Each scoop (2g) delivers one thing and one thing only:

• Immunolin® (Serum Derived Immunoglobulin) – 2g

  

  Immunolin is a high-quality protein-based (>90%) dietary supplement that contains over 50% immunoglobulins. This ingredient works primarily through two mechanisms:

  1. Binding to dietary antigens – helping to neutralize potentially harmful substances in the gut
  2. Strengthening gut barrier function – supporting the intestinal wall’s integrity

  The breakdown of immunoglobulins in Immuno-IGG includes:

  • Immunoglobulin G (IgG) – 1010mg
  • Immunoglobulin M (IgM) – 100mg
  • Immunoglobulin A (IgA) – 20mg
  • Bovine Serum Albumin – 100mg

  Let’s dig deeper into why these components matter for your health:

  How Immunolin Supports Intestinal Barrier Function

  Research has demonstrated that immunoglobulins can help maintain and restore proper intestinal barrier function. In a study on rats, spray-dried animal plasma (containing immunoglobulins) prevented increases in intestinal permeability caused by inflammation.^[1]

  

  This serum-derived supplement delivers industry-leading potency with over 50% IgG content – significantly outperforming traditional colostrum products while providing exceptional protein purity for maximum effectiveness.

  This is important because maintaining proper intestinal barrier function helps prevent “leaky gut”, a condition where the intestinal lining becomes more permeable, potentially allowing harmful substances to enter the bloodstream.

  Introducing IgG

  A big thing we’ll focus on here is immunoglobulin G (IgG), which is the primary antibody in blood and extracellular fluid that helps control infections in body tissues. It’s the most abundant type of antibody, representing about 75-80% of all antibodies in the body, and plays a crucial role in immune defense by recognizing and binding to specific antigens (like bacteria, viruses, and other harmful substances) in the gut.^[2] When these immunoglobulins bind to potential threats in the intestinal tract, they prevent them from damaging the gut wall or entering the bloodstream.

  

  Immunolin works strategically to bind inflammatory antigens, enhance nutrient absorption, and strengthen gut barrier integrity — addressing digestive health from multiple complementary angles.

  With that explained, now we can see why Unmatched chose Immunolin

  Immunolin vs. Colostrum: Why It’s Superior

  While bovine colostrum has been a popular source of immunoglobulins for gut health supplements, Immunolin offers several advantages:

  

  Scientific analysis showing how IgG (orange) dominates the immunoglobulin profile across multiple species. This research supports why bovine-sourced immunoglobulins make an effective supplement for human gut health support.^[2]

  1. Higher immunoglobulin concentration – Lab testing shows Immunolin provides approximately 50-60% IgG content compared to most colostrum supplements that deliver between 17-38% IgG, despite some claiming higher percentages.
  2. Lower endotoxin levels – Due to its collection and processing methods, Immunolin contains significantly lower levels of endotoxins than colostrum. This is crucial because endotoxins can trigger inflammatory responses in the gut.^[3]
  3. Completely dairy-free – Unlike colostrum (which is milk-based), Immunolin is derived from serum, making it suitable for those with dairy sensitivities or lactose intolerance.
  4. More consistent composition – Immunolin is manufactured using rigorous isolation, purification, and filtration methods in a cGMP facility, ensuring consistent quality across batches. Colostrum quality can vary widely based on factors like the cow’s health, collection time, and storage conditions.

  

  Effects on Intestinal Inflammation

  Another great benefit of immunoglobulins is their ability to reduce intestinal inflammation. A 2011 study showed that spray-dried porcine plasma (containing immunoglobulins) reduced levels of proinflammatory cytokines, including TNFα and IFNγ, in the intestinal tissue of weaned pigs.^[4]

  The researchers observed that dietary inclusion of plasma proteins led to:

  • Reduced intestinal permeability
  • Lower levels of inflammatory markers
  • Improved clinical indices of gut health (better fecal scores)

  While these studies were conducted on animals, they provide strong mechanistic evidence for how immunoglobulins support gut health — suggesting similar benefits for humans.

  We look forward to more research coming from the Immunolin team, but leave it to Kris and Doug to jump on a novel ingredient rather early. This one has a lot of merits over colostrum, especially hearing that several colostrum supplements are not living up to the IGG claims in independent lab tests.

How to Use Unmatched Supps Immuno-IGG

For optimal results, mix one scoop (2g) of Immuno-IGG with 16 ounces of cold water or your beverage of choice. Take daily with or without food, or as directed by your healthcare provider.

For those dealing with heightened digestive stress or seeking to strengthen their immune system before travel or high-stress periods, you may want to consider the following strategies:

• Use consistently for at least 2-4 weeks to allow for cumulative benefits
• Consider taking on an empty stomach for maximum absorption of immunoglobulins
• Pair with a comprehensive gut health approach that includes adequate fiber, glutamine, probiotics, and stress management

It goes without saying to avoid any foods, beverages, vegetables, or food additives that cause bile reflux. A simple diet is often better in this toxic environment!

Conclusion: Unmatched Quality for Gut and Immune Support

The Unmatched 2SHRED System offers stimulant-free 24-hour weight management with separate AM/PM formulas. Founded by Kris Gethin and Doug Miller, this system works around the clock without artificial ingredients.

Unmatched Supps’ Immuno-IGG represents a new standard in gut and immune support supplements. By focusing on high-quality, serum-derived immunoglobulins instead of traditional colostrum, they’ve created a product that delivers superior immunoglobulin content without the drawbacks of dairy-based alternatives.

This approach aligns perfectly with the Unmatched Supps brand philosophy: bridging the gap between performance and longevity. Founded by industry veterans Kris Gethin and Doug Miller, Unmatched has committed to creating supplements with zero artificial sweeteners and transparent, science-backed formulations. We’ve seen this same commitment to quality in their other innovative products like the 2SHRED AM/PM System, which takes a comprehensive 24-hour approach to metabolism support.

For anyone looking to optimize gut health, support digestive function, or strengthen their immune system, Immuno-IGG provides a simple yet powerful tool backed by scientific research. The higher concentration of immunoglobulins compared to colostrum, along with lower endotoxin levels and dairy-free formulation, makes this a standout choice for health-conscious consumers.