ProSupps VEXXUM – 2015 Fat Burner Now Out!

Pro Supps has unleashed their latest and greatest fat-incinerating supplement, VEXXUM, and true to ProSupps form, it packs one serious punch! The makers of one of the industry’s strongest pre workouts, Hyde, held nothing back in this formulation.

VEXXUM proclaims itself to be a “true one cap dose”, and we’ve got the ingredient breakdown to see what kind of mayhem lies in store for those brave enough to try it.

ProSupps Vexxum

Could Vexxum be this year’s true gamechanger? ProSupps does bring some serious juice with their weight loss products…

When ProSupps claimed this was the fat burner you’ve been waiting for, they weren’t lying. This stuff looks unreal, and is an instant contender for our Best Fat Burners list (in the high-energy pills section), as you’ll see in our ingredient analysis below.

But first, check the lowest prices and sign up for price drop alerts because you’re not going to want to miss sales on this one!

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What are the Vexxum ingredients?

ProSupps Vexxum Ingredients

WHOA. This is like every popular stimulant out right now…. get ready for some speed here, folks!

VEXXUM’s ingredient profile comprises a hefty 12 different ingredients to ignite your metabolism!

As you can see from the Supplement Facts label, Pro Supps opted to go the proprietary blend route (which we’re not really fans of). SO, we’ll dive into each of the ingredients and see what they bring to the party:

  • CAFFEINE

    VEXXUM’s blend starts off with a triple-headed monster of caffeine in the forms of Caffeine Anhydrous, Infinergy™ Dicaffeine Malate, and Caffeine Citrate!  You’ve seen this trifecta before in Hyde, and just as in Hyde, we have no idea how much caffeine is actually in this cocktail of stims either…which is kind of important…

    You’re asking yourself…”What’s the difference between the 3 forms and how do each help?”  Well…

    • Caffeine Anhydrous

      Caffeine Anhydrous is the same thing as what you get in your daily cup of coffee except that nearly all of the water has been removed, 0.5% remains to be exact.  You’re also probably the most familiar with this form as nearly all pre workouts utilize this variation of caffeine.

    • Infinergy™ Dicaffeine Malate

      Infinergy

      Feel for yourself if Infinergy has any added extra kick atop of regular caffeine

      Forged through marriage of natural caffeine to malic acid, dicaffeine malate was born.  These two compounds are ionically bonded yielding about 75% caffeine content by volume.

      Developed by Creative Compounds, Infinergy™ claims to be easier on the stomach due to the buffering properties associated with malic acid.[1]  A number of other claims have been made about the enhanced benefits Infinergy™ has over regular caffeine, but no such studies have surfaced validating these claims.

    • Caffeine Citrate

      Our final iteration of caffeine comes in the form of caffeine citrate, or Cafcit.  It is made by combining caffeine anhydrous with citric acid monohydrate and sodium citrate dihydrate.

      Cafcit operates by the same mechanisms that caffeine does, it just hits a whole lot quicker!

      Just like Infinergy, Cafcit contains a smaller percentage of caffeine that pure caffeine anhydrous (1:2 ratio of caffeine to citrate), meaning you’d need larger doses of Cafcit to elicit the same effects with a lesser amount of regular old caff.

    Having 3 different forms of caffeine ensure a LONG burst of energy that sure to rev up your metabolism and get you going first thing in the morning!

    • Cocoabuterol™ Cocoa Seed Extract

      If you’ve been paying attention to the new lately, you’ve undoubtedly seen chocolate, and more specifically cocoa powder, being spotlighted for its cholesterol and blood pressure lowering benefits.[2,3]

      Genbolix (makers of AgmaPure and AmentoPump) bring a fairly new ingredient in the fat-burner market to VEXXUM with Cocoabuterol™.

      Cocaobuterol™ is naturally derived from cocoa and contains 4 different compounds:

      • N-coumaroyldopamine
      • N-caffeoyldopamine
      • EGCG
      • Theobromine
      Cocoabuterol

      This is possibly our favorite patented ingredient thanks to the N-coumaroyldopamine and N-caffeoyldopamine.

      The base of Cocaobuterol™ is N-coumaroyldopamine and N-caffeoyldopamine, which target β2 adrenoceptors in the body inducing both fat loss and muscle growth…exactly what we’d want in a fat burner!

      The reason EGCG is included is that N-coumaroyldopamine and N-caffeoyldopamine are rapidly metabolized by the body before having a chance to target the β2 adrenoceptors.  EGCG inhibits this mechanism[16] and allows N-coumaroyldopamine and N-caffeoyldopamine to do their job.

    • Lotus Seed Extract

      Lotus seeds come from the Nelumbo nucifera tree and has a long history of use in Ancient Chinese medicine.  Not only is it a powerful anti-oxidant, but has many effects that would contribute to the effectiveness of a thermogenic including:

      • Induce Lipolysis[17]
      • Suppress Weight Gain[17]
      • Reduce Triglycerides and Cholesterol Levels[18]
      • Reduce Food Intake[19]

      3 ingredients in and we’re off to a solid start!

      Let’s see what else VEXXUM has in store for us!

    • Theacrine (as TeaCrine®)

      Compound Solutions brings a rather unique form of theacrine to the stim party in their patent-pending compound TeaCrine®, which is >98% pure theacrine.

      Theacrine is a naturally occurring alkaloid compound found in the Camellia assamica tealeaf, coffee and certain exotic fruits.  Strangely enough, it is synthesized from caffeine in plants and mimics similar stimulatory effects as its relative.

      TeaCrine® has displayed a number of benefits[6] including:

      • Increase energy production
      • Decrease pain from exercise
      • Reduce stress and improve overall mood
      • Heighten focus and awareness
      • Increase motivation
      Theacrine

      Effect Size of 200 mg dose of TC over course of 7-day repeated dose study relative to baseline on: Energy: 0.63, Motivation to Exercise: 0.58, Concentration: 0.6

      In addition to the aforementioned perks, TeaCrine® works synergistically with caffeine and has shown evidence in early clinical studies of [6] enhancing caffeine’s effects and providing a longer-lasting energy boost compared to caffeine.  This is exactly what we want in the thermogenic!

    • Hordenine HCl

      Vexxum

      Impressed enough yet? We are…

      Hordenine is a molecule found in plants along with tyramine and synephrine.  It exhibits adrenergic effects which means that it causes the brain to release adrenaline and noradrenaline into the body.

      When these two neurotransmitters are released, they kickstart a metabolic process that liberates fatty acids and allows them to be used for energy[7]…MORE FAT BURNING!!

    • Octopamine HCl

      Structurally similar to synephrine, Octopamine is a trace amine found in the human brain that exhibits stimulatory effects and is also thought to have fat-burning properties to boot.

      Octopamine aids fat-burning in 2 different ways:

      • First, it prevents glucose uptake by fat cells (adipocytes) by inhibiting the β3 adrenoceptor[8], and
      • Secondly, it activates the α1-adrenergic receptors thereby inducing lipolysis[9]

      A word of warning to our athletes, octopamine is on the WADA banned substances list, so if you’re engaged in college or professional sports, VEXXUM isn’t an option for you.

      • Yohimbe Bark Extract

        VEXXUM continues its lineup of proven fat-burning ingredients with the inclusion of yohimbe bark extract.  Derived from the Pausinystalia yohimbe tree and the Rauwolfia Serpentina plant, yohimbe is a naturally occurring alkaloid proven to:

        • Suppress Appetite[10]
        • Support Weight Loss[11]
        • Enhance Cognition & Focus[12]
      • Sulbutiamine

        First developed by Japanese scientists, Sulbutiamine is a synthetic derivative of thiamine (Vitamin B1) made by joining 2 thiamine molecules with a sulphur group.  You may be wondering why would you want a synthetic variant of a naturally occurring B vitamin in a fat burner?

        Well, it turns out thiamine doesn’t cross the blood-brain barrier all that easily.  Thanks to the increased fat-solubility of sulbutiamine, it more readily makes the transition and thereby increased circulating levels of thiamine in the body.

        Sulbutiamine shines for its abilities to fight chronic fatigue and improve memory and cognition.[13,14]

      • Rauwolfia vomitoria Root Extract (std. 90% alpha-yohimbine)

        ProSupps Vexxum Ingredients

        In case you forgot where we were

        You’re not seeing double…there are indeed TWO versions of everyone’s favorite fat-incinerating supplement known to us insiders as “Y”. Rauwolfia, a.k.a. alpha-yohimbine, a.k.a. rauwolscine, is a synthetic derivative of the bark of the Pausinystalia yohimbe tree and mimics some of the same benefits.

        It is yet another stimulant in this fat-burning cocktail and primarily acts as an antagonist of α2 receptors.[15] This means it aids fat-burning by instructing the body to loosen up it’s tight grip over your fat stores, thus helping you to get over the hump and banish those “stubborn trouble spots” once and for all!

        Another perk of alpha-Y is that is more potent AND has a longer half-life than regular Yohimbe meaning it will stay around in the body longer (thereby inducing more fat burning) AND you need less of it compared to regular yohimbe to exhibit the same benefit!

      As you can see, Pro Supps wasn’t messing around when they crafted this beauty of a fat-burner and this surely isn’t for the stim-sensitive or faint of heart.

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      Recommended VEXXUM Dosage

      Pro Supps recommends to dose 1 cap to assess initial tolerance. Also, they advise to NOT take this within 4-5 hours of another other caffeinated or stim-based products.

      Finally, they warn that you should NOT exceed 2 caps within any 24 hour period. Knowing how loaded this fat burner is, you’d be wise to heed these warning…

      Final Thoughts / Pre-Review

      As you can see, Pro Supps has created one hell of a stim-bomb with their latest thermogenic! They’ve basically loaded this guy up with every known stimulant and fat-burner that has been shown to support weight loss efforts, with the possible exception of AMP Citrate, which is currently on the outs in the market.

      One thing we’re not entirely crazy about is the non-disclosed proprietary label. Caffeine is a tricky beast when it comes to proper dosing, and people’s tolerance to it,and at the very least they should disclose the caffeine content/pill.

      Overall, VEXXUM shows great promise and stands to be one of the most powerful and intense fat-burners to hit the market in some time!

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      References

      1. http://www.creativecompounds.com/exclusive-ingredients.php#infinergy
      2. Persson IA, et al. Effects of cocoa extract and dark chocolate on angiotensin-converting enzyme and nitric oxide in human endothelial cells and healthy volunteers–a nutrigenomics perspective. J Cardiovasc Pharmacol. (2011)
      3. Hamed MS1, et al. Dark chocolate effect on platelet activity, C-reactive protein and lipid profile: a pilot study. South Med J. (2008)
      4. http://www.genabolix.com/news/Cocoabuterol%28TM%29-Botanical%20Resource%20Clenbuterol.html
      5. http://hightowerpharmacology.blogspot.com/2011/12/pharmacology-of-n-coumaroyldopamine.html
      6. http://teacrine.com/teacrine/benefits
      7. Mauriege, P; Human fat cell beta-adrenergic receptors: beta-agonist dependent lipolytic responses and characterization of beta-adrenergic binding sites on human fat cell membranes with highly selective beta-antagonists; Institute of Physiology, University of Paul Sabatier, 1988
      8. Visentin V1, et al. Dual action of octopamine on glucose transport into adipocytes: inhibition via beta3-adrenoceptor activation and stimulation via oxidation by amine oxidases. J Pharmacol Exp Ther. (2001)
      9. Flechtner-Mors M1, et al. In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects. J Pharmacol Exp Ther. (2002)
      10. Lafontan M, et al. Alpha-2 adrenoceptors in lipolysis: alpha 2 antagonists and lipid-mobilizing strategies. Am J Clin Nutr. (1992)
      11. Callahan MF, Beales M, Oltmans GA. Yohimbine and rauwolscine reduce food intake of genetically obese (obob) and lean mice. Pharmacol Biochem Behav. (1984)
      12. Mizuki Y, et al. Differential effects of noradrenergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety. Prog Neuropsychopharmacol Biol Psychiatry. (1996)
      13. Bizot JC, et al. Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. Prog Neuropsychopharmacol Biol Psychiatry. (2005)
      14. Tiev KP, Cabane J, Imbert JC. Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo. Rev Med Interne. (1999)
      15. Perry BD, U’Prichard DC. (3H)rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. Eur J Pharmacol. (1981)
      16. HONG LU, XIAOFENG MENG, et.al. ENZYMOLOGY OF METHYLATION OF TEA CATECHINS AND INHIBITION OF CATECHOLO- METHYLTRANSFERASE BY ( )-EPIGALLOCATECHIN GALLATE. Drug Metab Dispos. 2003 May;31(5):572-9
      17. Ohkoshi E, Miyazaki H, Shindo K, Watanabe H, Yoshida A, Yajima H. Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice.Planta Med . 2007;73(12):1255-1259.
      18. la Cour B, Mℴlgaard P, Yi Z. Traditional Chinese medicine in treatment of hyperlipidaemia. J Ethnopharmacol . 1995;46(2):125-129.
      19. Du H, et al. Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet. J Biomed Sci. (2010)

      New trend starting?

      Pro Supps DNPX II

      We’re not sure if DNPX / DNPX II will be replaced, but our guess is that it won’t.

      This is similar to the “one capsule per day” dose that the new BPI Roxy is leaning towards. Could it be the start of a new trend of once-daily weight loss products, kind of like how we treat multivitamins?

      The issue is that stimulants and appetite suppressants typically wear off sooner than we’d like, so if you take one before breakfast (say, at 6:30am), then you’re going to want another jolt of energy after lunch.

      We’ll see how this one fares in that regard, because it is incredibly strong and will last quite long.

      The other Pro Supps weight loss products

      Vexxum is definitely not ProSupps’ first rodeo. Here’s a brief history of ProSupps’ other weight loss products:

      • Vanish

        Vanish is the oldest stimulant-based fat burner that has a yohimbe-based version and a yohimbe-free version for those who are too sensitive to it.

        We’re fans of this because of the rhodiola rosea extract, which is our favorite herb and acts as an adoptogen to regulate levels. It’s also a cognitive enhancer, which goes well with this product’s big blend of other focus boosters (like Vinpocetine and Huperzine A), making it quite popular.

        The question are the dosages – it’s too proprietary to know if we’re really getting enough of these ingredients. We hope that Vexxum is far less proprietary.

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      • DNPX and DNPX II

        DNPX and DNPX II are the newer Pro Supps’ existing fat burners, and is unique because it contains thyroid metabolite, 3,5-Diiodo-L-Thyronine.

        It also focuses on tea and cocoa extracts, which we’re finding have a ton of beneficial properties from their flavonols known as catechins. We recently wrote about epicatechin, one such flavonol that’s gaining in popularity due to general cardiovascular health benefits and even potential anabolic benefits!

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        Note that it’s a bit confusing determining the differences between DNPX and DNPX II – the stores seem to have the same labels, and they have the same dosages, so we’re not sure what’s what.

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      • Crash (stimulant-free)

        Crash is the “Nighttime PM Shredder”, which is a combination of agents to help you relax and get sleep (such as GABA and Valerian) as well as some non-stimulant thermogenics, like evodiamine.

        It’s our guess that you should have no problem using Crash at night when using the new Vexxum before bed.

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      And of course, we nearly don’t even need to mention the insane pre workout stack, Mr. Hyde (which has a whopping 419mg caffeine from three different sources. This is the product that really started putting Pro Supps on the map, and their fan base usually likes the stimulants quite a bit, which makes us think that Vexxum will be similar (but perhaps a touch weaker).

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