AP Regimen Pre-Workout RTD: Level Up with More in Each Bottle

AP Regimen’s Pre-Workout RTD is a ready-to-drink pre-workout supplement with 8 grams of citrulline malate, 2 more than its closest competitor!

If you’ve seen the fridge at your local gym, then you can probably agree that the ready to drink (RTD) pre-workout supplement space has been due for a serious shakeup. A space mostly filled with carbonated cans — which don’t always work best for a workout — the remaining non-carbonated (“still”) beverages haven’t changed much lately.

Seeing the opportunity at hand, AP Regimen has delivered and then some.

AP Regimen Pre-Workout RTD

AP Regimen’s Pre-Workout RTD has a whopping 405 milligrams of caffeine, 8 grams of citrulline malate, and amplifies it with the novel CitraPeak NO booster!

AP Regimen Pre-Workout RTD: More Pumps and Higher-Energy

With the AP Regimen Pre-Workout RTD, the ready-to-drink shakeup is here. This powerful bottle contains a massive 405 milligrams of caffeine paired with 8 grams of 2:1 citrulline malate, both of which are greater than the closest competition. Additionally, we have CitraPeak, a novel nitric oxide boosting ingredient that has incredible solubility, making it perfect for RTD application.

AP’s mission here is simple: to amplify workouts and to snag a slot or two in your gym’s fridge. Instead of yet another flavor of the same old formula, AP Regimen argues that this is what you should be trying. And after looking at the science behind CitraPeak — and knowing what a larger dose of citrulline itself does — we agree.

It’s all covered below, but first, take a look at our prices and sign up for our AP Regimen news alerts – there’s far more coming from the Florida-based brand in the near future:

AP Regimen Pre-Workout RTD – Deals and Price Drop Alerts

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AP Regimen Pre-Workout RTD Ingredients

In a single 12.5 fl oz bottle of Pre-Workout RTD from Alpha Prime, you get the following ingredients, which include a total of 405 milligrams of caffeine:

  • L-Citrulline Malate (2:1) – 8,000 mg

    AP Regimen Pre-Workout RTD Ingredients

    More citrulline, more caffeine, and definitely more CitraPeak than the competition!

    The non-essential amino acid citrulline is a powerful precursor to nitric oxide (NO),[1] the molecule that triggers vasodilation in the human body. Although your body’s capable of making citrulline on its own, that amount is pretty limited, so there’s usually a benefit to supplementing with extra citrulline.

    In vasodilation, the diameter of your arteries expand, permitting more blood to flow through them. As a result of this improved circulation, oxygen and nutrients are delivered more efficiently to cells all over your body, which both improves athletic performance during a workout and speeds up recovery afterward. Lactic acid clearance, in particular, speeds, which is a big deal since the accumulation of lactic acid in muscle tissue is partly what produces physical fatigue.

    According to the latest research, citrulline supplements are able to:

    • Increase oxygen uptake, thus increasing athletic power[2]
    • Improve athletic endurance, as seen in one amazing study where subjects who took a citrulline supplement were able to do 53% more bench press reps compared to placebo.[3]
    • Decrease post-exercise soreness by nearly 50%[3]

    As great as the citrulline part of citrulline malate is, the malate part is pretty swell as well: malate, or malic acid, plays a crucial role in the Krebs cycle, the process by which your cells produce most of their energy.[4]

    Because of both the citrulline and the malate, some studies have found that the synergistic combination can increase your body’s aerobic respiration efficiency, which increases the amount of energy that your body has available during exercise.[5]

    Note that this is actually citrulline malate 2:1, meaning we have 2 parts L-citrulline to 1 part malic acid. This gives us 5.33 grams of actual citrulline.[6] This is way more than the typical studied dose of 2-3 grams per day, so you’ll get some pretty good results from this part of AP Regimen Pre-Workout RTD.

    Arginine was the go-to amino acid NO precursor for many years, but has recently been replaced by citrulline owing to its greater oral bioavailability.[7,8] That’s nothing new, but what is new is seeing a dose this large in a single bottle:

    A step ahead of the competition: 8 grams instead of 6

    Note that this bottle’s closest competition has just 6 grams of citrulline malate 2:1, but AP Regimen’s scientists found a way to pack in two extra grams, which should lead to a stronger nitric oxide push. This doesn’t even consider the additional capacity from Citrapeak, which will move the needle even further (Citrapeak is discussed below).

    Our recommendation to gym owners and shelf-stockers is to stop wasting precious refrigerator shelf space on new flavors of the competition when you can add AP Regimen and give your customers more energy and better pumps.

  • Beta Alanine – 3,200 mg

    Beta alanine is another awesome endurance-boosting ingredient. It’s been around since the very beginning of the supplement industry and because of its proven effectiveness, it will probably continue being used for a long time to come.

    Beta Alanine Benefits

    We’re interested in section (B) here, where beta alanine alone shows great results compared to placebo.[9]

    Beta alanine works by combining with the essential amino acid, L-histidine, to form carnosine, which is mostly stored in muscle tissue and functions as an acid buffer.[10] Since carnosine itself is not orally bioavailable, and beta alanine is the rate-limiting bottleneck for carnosine production,[11,12] supplementing beta alanine is a great way to achieve a better acid-buffering status.

    Sports nutrition researchers have found that beta alanine supplementation can increase general athletic performance by increasing time to exhaustion,[13,14] power output,[15] and, when taken over long periods of time, improving body composition.[16]

    According to two meta-analyses that have analyzed 40 athletic performance studies, beta alanine works best at reducing fatigue during exercise sets lasting between 30 seconds and 10 minutes.[9,13]

    With a full 3.2 gram dose – the daily dose most often used in clinical trials – there’s a good chance you’ll get a tingling feeling. This is known as paresthesia, but not to worry – another meta analysis covering beta alanine trials up to 2019 has found that it’s safe and non-toxic, with the researchers concluding that it “does not adversely affect those consuming it”.[17]

  • Betaine Anhydrous – 2,500 mg

    Betaine, which also goes by the name trimethylglycine (TMG), is somewhat similar to creatine, a supplement with which most readers are probably familiar. Creatine helps increase energy production by donating phosphate groups to other molecules involved in the Krebs cycle, and as it turns out, betaine is also a positive modulator of ATP generation.[18]

    However, betaine donates methyl groups instead of phosphates, which means that it’s capable of lowering homocysteine blood levels,[19] an effect that can go a long way toward improving cardiovascular health for some individuals.

    Trimethylglycine

    From the MEN’s study: arm growth! Betaine built bigger arms… in trained subjects![20,21]

    Betaine is also an osmolyte, meaning that it helps bring water and other nutrients into your cells, making them stronger[20,22] and more resilient in the face of heat-induced metabolic stress.[23]

    There are tons of research studies demonstrating betaine’s benefits,[21,24-30] but a seminal study from 2013 showed that a daily 2.5-gram dose of betaine – the same amount used in AP Sports’ Regimen Pre-Workout RTD – produced 5.3 pounds of muscle gain and 6.4 pounds of fat loss, an incredible 3% reduction in body fat over the 1.5 month study periods.[20,21]

    In 2018, the same research team led a follow-up placebo-controlled study, testing 2.5 grams of betaine (or placebo) in 23 college-aged women, enrolling them into a weight training program for eight weeks.[30] The results were significant: Women in the betaine group lost 3.3% body fat (4.4 pounds) compared to -1.7% (2.8 pounds) in the placebo group.[30]

    This leads us to summarize that this dose of betaine is effective for performance enhancement, muscle gain, and fat loss — and it’s been demonstrated to work in both men and women.

    Normally, we suggest that athletes drink plenty of water with their betaine-based supplements so that they can take advantage of the osmotic, hydrating effect. But in the case of an RTD, the water’s already provided for you! However, with that said, we still suggest maintaining hydration throughout your workout, even if you add more water to the RTD bottle itself.

  • CitraPeak Glucosyl-Hesperidin – 200 mg

    Hesperidin is a flavonoid that occurs naturally in citrus fruits, particularly oranges.

    CitraPeak

    The CitraPeak sales sheet, which shows some key information and cites studies

    It’s capable of increasing nitric oxide production,[31,32] thus improving circulation to the point of restoring proper facial color in women afflicted with conditions that cause skin discoloration[32] and measurably increasing temperature on the surface of the skin.[33] Both of these effects imply a powerful vasodilatory effect.

    It works through metabolism into hesperetin (note the slightly different spelling), which upregulates endothelium nitric oxide synthase (eNOS) expression,[31] leading to greater nitric oxide production.

    CitraPeak was designed specifically for triggering vasodilation via NO production,[34] so it’s a great inclusion in AP Sports Regimen RTD Pre-Workout. Reason being, it’s not just hesperidin – it’s glucosyl-hesperidin, which has been shown to have 3.7-times greater bioavailability than normal hesperidin in animal models.[35] Based upon that study, CitraPeak’s datasheet states that it “Activates in 30 Minutes”.[34]

    Another study, which showed glucosyl-hesperidin‘s significant triglyceride-lowering effect in humans with high triglyceride levels after 24 weeks of use, also states that “G-Hesperidin is very soluble in water, and its solubility is about 10,000 times greater than that of conventional hesperidin”.[36] This research claim is based on data from a 1994 study testing the compound alongside probiotics.[37]

    The point is, not only does glucosyl-hesperidin work better than standard hesperidin, but it’s far more soluble — all the better reason to include it in a pre-workout RTD!

    Hesperidin has a bunch of other benefits too, including protecting the skin from UV light-induced damage, decreasing inflammation, fighting diabetes, and more.[38] These effects are out of the scope of this article, but if you’re new to this ingredient, it’s worth researching. We occasionally see it in weight loss supplements as well.

  • Caffeine Anhydrous – 350 mg (of 405 mg total)

    Caffeine is famous for its ability to fight fatigue and increase wakefulness and vigilance, effects that are driven by caffeine’s inhibition of adenosine receptors in the brain.[39]

    AP Regimen Pre-Workout RTD

    Ready for some fireworks? This one’s got plenty of energy inside

    Ordinarily, more and more of the nucleotide, adenosine, accumulates in your brain the longer you’re awake. But when the receptor for it is blocked, adenosine can’t exert its usual effects on your brain cells. As a result, global neural activity in the brain goes up,[39] helping with focus and motivation. Caffeine’s upregulation of dopamine, the “focus and motivation” neurotransmitter,[40] adds to this effect.

    Caffeine also activates AMP-activated protein kinase (AMPK), one of the primary metabolism switches in the human body, which increases your body’s rate of fat burning, thus increasing energy levels overall.[41,42]

    Caffeine’s inhibition of phosphodiesterase, an enzyme that degrades cyclic adenosine monophosphate (cAMP),[41,42] has the same effects, keeping sugar and fat metabolism high and providing your cells with extra energy to burn during workouts.[43]

    The ability of caffeine to increase the speed of so many different processes in the body while reducing both mental and physical fatigue is why it’s called an “ergogenic aid” – it increases the body’s capacity to do work.

    Research studies show that caffeine significantly boosts athletic performance during both endurance-based and high-intensity activities.[44]

    405 milligrams of caffeine total!

    Typically, 350 milligrams of caffeine is a pretty big dose, and there’s even more in AP’s RTD Pre-Workout (405 milligrams total once you calculate the next ingredient). So if you’re unsure of your tolerance, start small and work your way up. It’s OK to only drink half a bottle and sip the rest slowly, or even save it for another day.

  • Dicaffeine malate – 75 mg (yielding ~50 mg of 405 mg total)

    Dicaffeine malate has the same effects as pure caffeine. The only real difference between this and the anhydrous form is that when caffeine is “buffered” when it’s bound to malic acid, it takes longer to metabolize. So this is a slow-acting form of caffeine, whereas anhydrous is fast-acting.

    The idea behind this is to smooth the curve of caffeine levels in your blood, helping prevent a debilitating crash that can occur after the stimulant initially goes into effect.

    All in all, this brings us to a total of 405 milligrams of caffeine, since dicaffeine malate has a caffeine yield of ~73%.

  • Methylliberine (as Dynamine) – 25 mg

    This trademarked version of methylliberine, Dynamine, is formulated to cause the same type of stimulant effects in the central nervous system as caffeine.

    AP Regimen Pre-Workout RTD Baja Freeze

    As an alkaloid that is found naturally in Camellia sinensis (tea) leaves,[45,46] methylliberine has stimulant properties but doesn’t cause the same cardiovascular effects that caffeine does (i.e., vasoconstriction).[45-48] It increases your levels of dopamine and noradrenaline while inhibiting adenosine.[45-48]

    For a reminder on why dopamine and adenosine are important, scroll back up to the section titled Caffeine Anhydrous.

    Anecdotally, Dynamine generally adds a bit more “pop” to energy supplements, putting AP Regimen RTD’s power on the next level.

Flavors available

    Conclusion: An RTD Pre-Workout with More

    AP Regimen certainly knows how to formulate a pre-workout, but we already knew that, given their incredible Legacy Series Pre-Workout and Pump supplements. Their Pre-Workout RTD takes non-carbonated, ready-to-drink bottles to a new level, but it does come at a cost: a huge dose of caffeine.

    AP Regimen Legacy Series

    Are you ready for your legacy? After a year of hard work, AP Regimen has released their Legacy Series Pre-Workout and Pump Supplements

    If you can handle the 405 milligrams of caffeine, you’ll be treated to some incredible pumps — especially compared to other RTDs. It’s not just from the huge dose of citrulline malate, either. CitraPeak is a novel ingredient inside that we’re very excited about, and we think we may be seeing this in thermogenics as well.

    But if it’s a bit too much caffeine for you, drinking ½ to ⅔ of a bottle, and then saving the rest for later may be your safest bet. You may still get a clinical dose of L-citrulline (which starts at 3 grams, and a full bottle here has 5.33 grams), but you’ll want to look for more betaine and beta alanine elsewhere in your day if you want to hit those clinical doses.

    Regardless, the RTD game has been changed, and it’s time to start seeing some AP Regimen inside of store and gym fridges. We know most places already have those incredible AP Prime Bites protein brownies on the counter… so it’s only a matter of time before these RTDs take over too.

    As for those Prime Bites and other AP products, you may want to stay tuned to our alerts below… we have a lot more coming.

    AP Regimen Pre-Workout RTD – Deals and Price Drop Alerts

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    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

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    About the Author: Mike Roberto

    Mike Roberto

    Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

    Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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    References

    1. Morita, Masahiko, et al; “Oral Supplementation with a Combination of L-Citrulline and L-Arginine Rapidly Increases Plasma L-Arginine Concentration and Enhances NO Bioavailability.”; Biochemical and Biophysical Research Communications; U.S. National Library of Medicine; 7 Nov. 2014; https://www.ncbi.nlm.nih.gov/pubmed/25445598
    2. Bailey, Stephen J, et al; “l-Citrulline Supplementation Improves O2 Uptake Kinetics and High-Intensity Exercise Performance in Humans.”; Journal of Applied Physiology (Bethesda, Md. : 1985); U.S. National Library of Medicine; 15 Aug. 2015; https://www.ncbi.nlm.nih.gov/pubmed/26023227
    3. Pérez-Guisado, Joaquín, and Philip M Jakeman; “Citrulline Malate Enhances Athletic Anaerobic Performance and Relieves Muscle Soreness.”; Journal of Strength and Conditioning Research; U.S. National Library of Medicine; May 2010; https://www.ncbi.nlm.nih.gov/pubmed/20386132
    4. “Malic Acid: Uses, Side Effects, Interactions, Dosage, and Warning.” WebMD; https://www.webmd.com/vitamins/ai/ingredientmono-1495/malic-acid
    5. Bendahan, D. “Citrulline/Malate Promotes Aerobic Energy Production in Human Exercising Muscle.” British Journal of Sports Medicine, vol. 36, no. 4, 1 Aug. 2002, pp. 282–289, 10.1136/bjsm.36.4.282; https://bjsm.bmj.com/content/36/4/282
    6. “L-Citrulline DL-malate (2:1)”; Pubchem; https://pubchem.ncbi.nlm.nih.gov/compound/145710262
    7. Ochiai, Masayuki, et al; “Short-Term Effects of L-Citrulline Supplementation on Arterial Stiffness in Middle-Aged Men.”; International Journal of Cardiology; U.S. National Library of Medicine; 8 Mar. 2012; https://www.ncbi.nlm.nih.gov/pubmed/21067832
    8. Agarwal, Umang et al; “Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice.”; The Journal of nutrition; vol. 147,4; 2017; 596-602; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368575/
    9. Saunders, Bryan, et al. “β-Alanine Supplementation to Improve Exercise Capacity and Performance: A Systematic Review and Meta-Analysis.” British Journal of Sports Medicine, vol. 51, no. 8, 18 Oct. 2016, pp. 658–669; https://bjsm.bmj.com/content/51/8/658.long
    10. Trexler, E.T., Smith-Ryan, A.E., Stout, J.R. et al.; “International society of sports nutrition position stand: Beta-Alanine.”; J Int Soc Sports Nutr 12, 30 (2015); https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0090-y
    11. Harris, R. C., et al. “The Absorption of Orally Supplied β-Alanine and Its Effect on Muscle Carnosine Synthesis in Human Vastus Lateralis.” Amino Acids, vol. 30, no. 3, 24 Mar. 2006, pp. 279–289, 10.1007/s00726-006-0299-9; https://pubmed.ncbi.nlm.nih.gov/16554972/
    12. Dunnett, M., and R. C. Harris. “Influence of Oral ß-Alanine and L-Histidine Supplementation on the Carnosine Content of Thegluteus Medius.” Equine Veterinary Journal, vol. 31, no. S30, July 1999, pp. 499–504, 10.1111/j.2042-3306.1999.tb05273.x; https://pubmed.ncbi.nlm.nih.gov/10659307/
    13. Hobson, R M, et al; “Effects of β-Alanine Supplementation on Exercise Performance: a Meta-Analysis.”; Amino Acids; Springer Vienna; July 2012; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374095/
    14. Sale, Craig, et al; “Effect of β-Alanine plus Sodium Bicarbonate on High-Intensity Cycling Capacity.”; Medicine and Science in Sports and Exercise; U.S. National Library of Medicine; Oct. 2011; https://www.ncbi.nlm.nih.gov/pubmed/21407127
    15. Van, R, et al; “Beta-Alanine Improves Sprint Performance in Endurance Cycling.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Apr. 2009; https://www.ncbi.nlm.nih.gov/pubmed/19276843
    16. Kern, Ben D, and Tracey L Robinson; “Effects of β-Alanine Supplementation on Performance and Body Composition in Collegiate Wrestlers and Football Players.”; Journal of Strength and Conditioning Research; U.S. National Library of Medicine; July 2011; https://www.ncbi.nlm.nih.gov/pubmed/21659893
    17. Dolan, Eimear, et al. “A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation.” Advances in Nutrition, vol. 10, no. 3, 13 Apr. 2019, pp. 452–463, 10.1093/advances/nmy115; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520041/
    18. Lee I. Betaine is a positive regulator of mitochondrial respiration. Biochem Biophys Res Commun. 2015 Jan 9;456(2):621-5. doi: 10.1016/j.bbrc.2014.12.005. Epub 2014 Dec 8. PMID: 25498545. https://pubmed.ncbi.nlm.nih.gov/25498545/
    19. Olthof, M. R., & Verhoef, P. (2005). Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Current drug metabolism, 6(1), 15-22; https://pubmed.ncbi.nlm.nih.gov/15720203
    20. Cholewa, Jason M et al. “Effects of betaine on body composition, performance, and homocysteine thiolactone.” Journal of the International Society of Sports Nutrition vol. 10,1 39. 22 Aug. 2013, doi:10.1186/1550-2783-10-39; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844502/
    21. Cholewa, Jason M., et al. “Effects of Betaine on Performance and Body Composition: A Review of Recent Findings and Potential Mechanisms.” Amino Acids, vol. 46, no. 8, 24 Apr. 2014, pp. 1785–1793, 10.1007/s00726-014-1748-5; https://pubmed.ncbi.nlm.nih.gov/24760587/
    22. Boel De Paepe; “Osmolytes as Mediators of the Muscle Tissue’s Responses to Inflammation: Emerging Regulators of Myositis with Therapeutic Potential”; EMJ Rheumatol. 2017;4[1]:83-89; https://www.emjreviews.com/rheumatology/article/osmolytes-as-mediators-of-the-muscle-tissues-responses-to-inflammation-emerging-regulators-of-myositis-with-therapeutic-potential/
    23. Caldas, Teresa, et al. “Thermoprotection by Glycine Betaine and Choline.” Microbiology, vol. 145, no. 9, 1 Sept. 1999, pp. 2543–2548, 10.1099/00221287-145-9-2543; https://pubmed.ncbi.nlm.nih.gov/10517607/
    24. Roti, M; “Homocysteine, Lipid and Glucose Responses to Betaine Supplementation During Running in the Heat”; Medicine & Science in Sports & Exercise: May 2003 – Volume 35 – Issue 5 – p S271; https://journals.lww.com/acsm-msse/Fulltext/2003/05001/HOMOCYSTEINE,_LIPID_AND_GLUCOSE_RESPONSES_TO.1501.aspx
    25. Armstrong, Lawrence E, et al. “Influence of Betaine Consumption on Strenuous Running and Sprinting in a Hot Environment.” Journal of Strength and Conditioning Research, vol. 22, no. 3, May 2008, pp. 851–860, 10.1519/jsc.0b013e31816a6efb; https://pubmed.ncbi.nlm.nih.gov/18438230
    26. Hoffman, Jay R, et al. “Effect of Betaine Supplementation on Power Performance and Fatigue.” Journal of the International Society of Sports Nutrition, vol. 6, no. 1, 27 Feb. 2009, 10.1186/1550-2783-6-7; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-6-7
    27. Lee, Elaine C, et al. “Ergogenic Effects of Betaine Supplementation on Strength and Power Performance.” Journal of the International Society of Sports Nutrition, vol. 7, no. 1, 2010, p. 27, 10.1186/1550-2783-7-27; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-27
    28. Trepanowski, John F, et al. “The Effects of Chronic Betaine Supplementation on Exercise Performance, Skeletal Muscle Oxygen Saturation and Associated Biochemical Parameters in Resistance Trained Men.” Journal of Strength and Conditioning Research, vol. 25, no. 12, Dec. 2011, pp. 3461–3471, 10.1519/jsc.0b013e318217d48d; https://pubmed.ncbi.nlm.nih.gov/22080324/
    29. Pryor, J Luke, et al. “Effect of Betaine Supplementation on Cycling Sprint Performance.” Journal of the International Society of Sports Nutrition, vol. 9, no. 1, 3 Apr. 2012, 10.1186/1550-2783-9-12; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-9-12
    30. Jason Michael Cholewa, et al; “The Effects of Chronic Betaine Supplementation on Body Composition and Performance in Collegiate Females: a Double-Blind, Randomized, Placebo Controlled Trial”; Journal of the International Society of Sports Nutrition; BioMed Central; 31 July 2018; https://jissn.biomedcentral.com/articles/10.1186/s12970-018-0243-x
    31. Liu L, Xu DM, Cheng YY. Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells. J Agric Food Chem. 2008 Feb 13;56(3):824-9. doi: 10.1021/jf0723007; https://pubmed.ncbi.nlm.nih.gov/18197618/
    32. Endo, S. & Mitsuzumi, H. & Uchida, S. & Maruta, Kazuhiko & Ariyasu, Toshio & Fukuda, Shigeharu & Shimizu, R. & Takeda, R. & Shikata, C.. (2015). Dietary glucosyl hesperidin improves skin color and skin conditions in women-placebo-controlled double-blind comparative study-. 43. 1687-1699; https://www.researchgate.net/publication/296884702_Dietary_glucosyl_hesperidin_improves_skin_color_and_skin_conditions_in_women-placebo-controlled_double-blind_comparative_study-/citation/download
    33. Yoshitani, K., et al. “Effect of Alpha-Glucosylhesperidin on Poor Circulation in Women.” Journal of Japanese Society of Nutrition and Food Science (Japan), 2008; https://agris.fao.org/agris-search/search.do?recordID=JP2008008173
    34. Prinova; “CitraPeak: Vasodilator from Citrus Peels”; https://blog.priceplow.com/wp-content/uploads/citrapeak-sales-sheet.pdf
    35. Yamada, Mika, et al. “Bioavailability of Glucosyl Hesperidin in Rats.” Bioscience, Biotechnology, and Biochemistry, vol. 70, no. 6, 1 June 2006, pp. 1386–1394, 10.1271/bbb.50657; https://pubmed.ncbi.nlm.nih.gov/16794318/
    36. Miwa, Yoshikatsu, et al. “Glucosyl Hesperidin Lowers Serum Triglyceride Level in Hypertriglyceridemic Subjects through the Improvement of Very Low-Density Lipoprotein Metabolic Abnormality.” Journal of Nutritional Science and Vitaminology, vol. 51, no. 6, 1 Dec. 2005, pp. 460–470, 10.3177/jnsv.51.460; https://pubmed.ncbi.nlm.nih.gov/16521708/
    37. Takashi Kometani, et al; “Transglycosylation to Hesperidin by Cyclodextrin Glucanotransferase from an Alkalophilic Bacillus Species in Alkaline pH and Properties of Hesperidin Glycosides”, Bioscience, Biotechnology, and Biochemistry, Volume 58, Issue 11, 1 January 1994, Pages 1990–1994; https://academic.oup.com/bbb/article-abstract/58/11/1990/5951125
    38. Man, Mao-Qiang et al. “Benefits of Hesperidin for Cutaneous Functions.” Evidence-based complementary and alternative medicine : eCAM vol. 2019 2676307. 2 Apr. 2019, doi:10.1155/2019/2676307; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466919/
    39. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance”; J Int Soc Sports Nutr 7, 5 (2010); https://link.springer.com/article/10.1186/1550-2783-7-5
    40. Cappelletti, Simone et al. “Caffeine: cognitive and physical performance enhancer or psychoactive drug?.” Current neuropharmacology vol. 13,1 (2015): 71-88. doi:10.2174/1570159X13666141210215655 https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4462044/
    41. Nehlig A, Daval JL, Debry G.; “Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects”; Brain Res Rev. 1992;17(2):139-170. https://pubmed.ncbi.nlm.nih.gov/1356551/
    42. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance.”; J Int Soc Sports Nutr 7, 5 (2010); https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-5
    43. Diepvens, K et al; “Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea;” American Journal of Physiology; 2007; https://journals.physiology.org/doi/full/10.1152/ajpregu.00832.2005
    44. Burke LM. Caffeine and sports performance. Appl Physiol Nutr Metab. 2008 Dec;33(6):1319-34. doi: 10.1139/H08-130. PMID: 19088794. https://pubmed.ncbi.nlm.nih.gov/19088794/
    45. Roberto, Mike; “Dynamine: A Neuroactivating “Stimulant” by Compound Solutions”; The PricePlow Blog; Feb. 5, 2018; https://blog.priceplow.com/supplement-ingredients/dynamine
    46. Roberto, Mike; “Dynamine Achieves GRAS Status With Several New Safety Studies!”; The PricePlow Blog; July 5, 2019; https://blog.priceplow.com/dynamine/gras
    47. Murbach, TS et al; “A Toxicological Evaluation of Methylliberine (Dynamine)”; Journal of Toxicology; 2019; https://www.hindawi.com/journals/jt/2019/4981420/
    48. VanDusseldorp, TA et al; “Effect of Dynamine With and Without TeaCrine Over Four Weeks of Continuous Use on Cardiovascular Function and Psychometric Parameters of Healthy Males and Females”; Nutrients; 2020; https://www.researchgate.net/publication/339655396_Safety_of_Short-Term_Supplementation_with_Methylliberine_DynamineR_Alone_and_in_Combination_with_TeaCrineR_in_Young_Adults

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