RYSE Supps Goes Big on Cognizin® in Pre-Workout Reformulations

RYSE Supps, a popular name in the sports supplement industry, has teamed up with the data-driven ingredient perfectionists at Kyowa Hakko to introduce their latest pre-workout supplement reformulations. The highlight of the late 2023 upgrades is the integration of Cognizin® Citicoline, a cutting-edge nootropic ingredient known for its support in brain energy, focus, attention, and memory.

RYSE Supps Cognizin Citicoline

RYSE Supps has recently updated their pre-workouts, and for the far better! That’s because they’re going big on Cognizin® citicoline, with doses ranging from 250-500mg!

For the official announcement, you can refer to Kyowa Hakko’s press release,[1] but in this article, we provide additional background about Cognizin, explaining how it makes RYSE’s featured supplements even better.

Kyowa Hakko: A commitment to research that brands can trust

Kyowa Hakko has long been looked up to for their groundbreaking research and extensive testing. The sports nutrition industry has taken a strong liking to their menu of branded ingredients, since they place such a heavy emphasis on research data for everything they manufacture. Beyond Cognizin®, Kyowa Hakko has made a mark with well-researched ingredients such as Setria Glutathione, Immuse LC-Plasma, VELOX, and more (you can read about them in our Kyowa Quality article).

You can sign up for our Kyowa Hakko news on PricePlow below, and then let’s get into the Cognizin-driven pre-workout lineup:

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RYSE x Kyowa Hakko: An Elevated User Experience

RYSE’s reformulated supplements are strategically crafted to elevate the overall user experience of their entire range of premium pre-workouts. In today’s crowded supplement landscape, we love to see two powerhouses working together to level the industry up with efficacious ingredients.

Now, let’s take a look at what this means for the RYSE pre-workout arsenal.

Which RYSE pre-workouts are being reformulated with Cognizin® Citicoline?

Here’s a list of the RYSE pre-workouts that have received the upgrade and the dosage of Cognizin included per full serving:

  • RYSE Loaded Pre (250 milligrams): Ideal for those venturing into high-stim pre-workouts without going full “stim junkie”.

    This version features L-Citrulline (4.5 grams) and Beta Alanine (3.5 grams), two tried-and-true pre-workout ingredients dosed above clinically-tested levels. Additionally, 120 milligrams of ZumXR™, an extended-release caffeine, ensures a steady energy flow, eliminating the crash commonly associated with other pre-workout supplements.

    RYSE Supps Loaded Pre-Workout with Cognizin

    Combining these with the pronounced effects of Cognizin® yields a “Loaded Pre” that certainly lives up to its name, especially for those who seek the mind-muscle connection.

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  • RYSE Stim Daddy (500 milligrams): This powerhouse embodies high-stim energy, boasting an impressive 21+ grams of active ingredients tailored for intense energy, laser-focused concentration, and euphoric mood.

    The dynamic formula includes large doses of nearly everything, including beta-alanine (6,400 milligrams), L-citrulline (6,000 milligrams), and betaine anhydrous (4,000 milligrams) for increased exercise performance. It also incorporates Dynamine (methylliberine 40%) (125 milligrams), a fast-acting compound that amplifies energy, mood, motivation, and focus, synergizing with caffeine for extended benefits.

    RYSE Supps Stim Daddy Pre-Workout with Cognizin

    But here, it’s the 500 milligrams of Cognizin® citicoline that really pushes this product to status worthy of the name “Stim Daddy”, since this is the dose that has the most clinical backing, as discussed in the section below these pre-workouts.

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  • RYSE Godzilla Pre-Workout (500 milligrams): Maximizing its 40 gram serving size, this titan delivers an intense pre-workout experience with monstrous pumps.

    Featuring a robust blend of citrulline (11 grams), beta-alanine (3.2 grams), and a substantial 400 milligrams of caffeine, this formula caters to those seeking the most impactful workout sessions.

    RYSE Supps Godzilla Pre-Workout with Cognizin

    Once again, we see the higher-end of 500 milligrams of Cognizin®, supporting razor-sharp focus and euphoria, elevating your mental acuity throughout your entire training session. This is a must-have if you’re chasing true Godzilla fame.

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  • RYSE CEO Pre-Workout (500 milligrams): The latest high stim pre-offering from RYSE, which is available at the end of 2023 and beginning of 2024 for a limited time.

    This formula features 300 milligrams of total caffeine, a near-Godzilla dose of L-citrulline at 10,000 milligrams, and arginine nitrate at 2,000 milligrams. To maintain muscle fullness and hydration, betaine and taurine are included. The combination of high-dose tyrosine, Cognizin, Dynamine, and CognatiQ creates a phenomenal cognitive experience, keeping you mentally locked in throughout your workout.

    RYSE Supps CEO Pre-Workout with Cognizin

    With this comprehensive approach, CEO PRE keeps it compliant but potently aggressive. We’re especially thrilled with the 500 milligram dose of Cognizin®, which deserves its own callout.

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All-in on Cognizin®

If you couldn’t see the trend, it’s clear: RYSE has gone all-in with Cognizin®, made by Kyowa Hakko, the sponsor of this article. RYSE isn’t just playing lip-service, either — 3 of the 4 of these supplements go big with a full 500 milligram dose! A year ago, we could find energy drinks on the market that had 250 milligrams, but pre-workouts were a bit more challenging.

As we’ll see in the next section, 250 milligrams is great, but 500 milligrams of Cognizin® is the real deal, with the most scientific backing that supplement formulators and savvy consumers alike are looking for:

Here’s how Cognizin® Citicoline works and why it’s so effective in pre-workouts

The full story’s in our article titled Cognizin® Citicoline: The Brain Choline, but below is a brief synopsis.

Choline is a vital component for forming the phospholipid bilayer membranes, the protective layer around the body’s cells.[2] It serves as a precursor to acetylcholine, a neurotransmitter linked to cognitive processes like learning and memory.[3] Research indicates that increasing acetylcholine synthesis can significantly enhance cognitive performance in both intellectual and cognitive motor skills.[4,5]

How Cognizin Citicoline Works

How Cognizin Citicoline Works

What sets Cognizin® apart is its unique composition. It’s not just a generic choline source; it’s citicoline, a compound derived from choline and cytidine. Citicoline serves as a direct precursor to phosphatidylcholine (PC), a crucial phospholipid for brain health.[6]

Compared to other forms of supplemental choline, citicoline stands out by promoting acetylcholine and phosphatidylcholine, as well as phosphatidylethanolamine and phosphatidylserine — three essential brain cell membranes.[7]

In the context of pre-workout formulations, Cognizin® adds a layer beyond the caffeine boost, offering support for focus, attention, and energy utilization in the brain.

The difference between 250 milligrams vs 500 milligrams of Cognizin®

Cognizin Citicoline Structure Function Claims

Cognizin can do a lot more than what’s mentioned in this article. Image courtesy Kyowa Hakko (2023)

Studies indicate that doses of 250+ milligrams of Cognizin® can contribute to enhanced focus, reduced errors during tasks, and overall improvements in brain and cognitive health.[8-13] At 500+ milligrams, Cognizin® is also associated with supporting memory and enhancing energy utilization in the brain.[7,12,14-16]

Point being, if you want to get the most out of the research performed on Cognizin®, 500 milligram doses are the goal. Note that these are studies that used actual Cognizin®, not just some generic citicoline, which has been difficult to reliably source without Kyowa Hakko’s expertise.

With respect to the pre-workout supplements discussed today, RYSE Stim Daddy, RYSE Godzilla Pre-Workout, and the limited-edition RYSE CEO Pre-Workout may potentially provide a more pronounced cognitive benefit compared to RYSE Loaded Pre. This should come as no surprise, given the higher overall ingredient dosages in the aforementioned formulas.

We’ve been waiting for Cognizin to enter some major pre-workout formulations, and thanks to RYSE, it came with a bang in their entire stim-based pre-workout arsenal.

2024: A big year for Cognizin®

Cognizin Memory Study in Healthy Older Adults

The latest study performed on Cognizin® Citicoline was published in 2021, showing improved memory in healthy older adults.[14]

We anticipate Kyowa Hakko and RYSE Supps to continue crushing it in 2024, given their consistent commitment to innovation. Whether it’s through pre-workouts, energy drinks, or other innovative formulations, Cognizin continues to demonstrate its versatility and efficacy in enhancing cognitive function.

As previously covered, we’ve already seen energy drinks like Bum Energy and C4 Smart Energy recognize the benefits of Cognizin in supporting mental clarity, focus, and sustained energy. So there’s lots to anticipate from this team.

For those seeking a more in-depth analysis, our comprehensive article titled Cognizin Citicoline: The Brain Choline provides a detailed breakdown of its mechanisms and superiority over other forms of choline. There’s also an article specifically dedicated to a recent study on memory: Cognizin® Citicoline Improves Memory in Older Adults.

You can also sign up for our Kyowa Hakko news alerts below and get notified anytime we cover a product with their ingredients, a new study, or other industry news – we have a feeling there’s a lot more to come:

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About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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  1. Kyowa Hakko USA. “Kyowa Hakko’s Cognizin® Featured in 16 New Re-Formulations in RYSE Supplements!” PRWeb. 06 Dec 2023. https://www.prweb.com/releases/kyowa-hakkos-cognizin-featured-in-16-new-re-formulations-in-ryse-supplements-302007369.html
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