Nutristat PUMP SCRIPT: The Original Liquid Pump Enhancer That Started a Revolution

In the ever-evolving landscape of sports supplements, true innovation is rare. Yet that’s exactly what Nutristat delivered with PUMP SCRIPT over half a decade ago: the first-ever glycerol-based liquid muscle cell volumizer that fundamentally changed how athletes approach pump enhancement and hyperhydration.

The OG liquid glycerol muscle volumizer is still king. Nutristat’s PUMP SCRIPT delivers 23g of pharmaceutical-grade glycerol – 7x more than powdered products – for maximum pumps and performance.

While countless liquid glycerol products have flooded the market since its debut in 2019, PUMP SCRIPT remains the gold standard — the original formula that others have scrambled to imitate. This first-of-its-kind hyperemic solution wasn’t just a new product; it sparked an entirely new category in sports nutrition.

Nutristat PUMP SCRIPT: The OG Liquid Glycerol

Like they did with Bio ATP, which pioneered triacetyladenosine supplementation, Nutristat continues their tradition of scientific innovation with PUMP SCRIPT.

What makes PUMP SCRIPT revolutionary is its uncompromising approach to delivering glycerol. Not the smaller doses found in powdered products, but a massive 23 grams of 100% yield pharmaceutical-grade glycerol per serving. This breakthrough liquid delivery system solved the two fundamental problems that had plagued glycerol supplementation for years: inadequate dosing and clumping hygroscopic powder.

Before we dive deep into what makes PUMP SCRIPT the superior choice for those seeking extreme muscle pumps and performance enhancement, make sure to check our prices below and sign up for our Nutristat news alerts for the latest product updates and deals:

What is PUMP SCRIPT?

PUMP SCRIPT is Nutristat’s groundbreaking liquid muscle cell volumizer, scientifically formulated to deliver maximum hyperhydration and muscle fullness through a calibrated blend of key ingredients. Unlike conventional pump products that rely on powdered ingredients with variable bioavailability, PUMP SCRIPT uses a liquid delivery system to maximize absorption and effectiveness.

Each bottle provides 30 full servings of a hyper-saturation formula designed to:

• Enhance muscle cell hydration and volume
• Improve vascularity and pump intensity
• Support performance and endurance
• Maximize nutrient delivery to working muscles

The Liquid Revolution: Why PUMP SCRIPT Changed the Game

The supplement industry has long struggled with glycerol supplementation. Despite its proven benefits for hyperhydration, traditional powdered glycerol products faced two insurmountable challenges:

1. Dosing Limitations: Powdered glycerol products typically contain only 1-5g of glycerol per serving, with a maximum yield of about 65% (meaning only 3.25g of actual glycerol in a 5g dose). The smallest dose of glycerol currently shown to achieve muscle cell hyper-saturation in published research is 20g.
2. Clumping Problems: The highly hygroscopic nature of glycerol powder means it readily absorbs moisture from the air, creating frustrating clumps that ruin the user experience, which necessitates tons of silica and/or anti-caking agents to be added by either the ingredient suppliers or the brands working at contract manufacturers.

PUMP SCRIPT solved both problems with a simple yet revolutionary approach: a liquid formula delivering 23g of 100% yield pharmaceutical-grade glycerol per serving – over 7 times more actual glycerol than what you’d typically get from a powdered product.

PUMP SCRIPT Ingredients

• Pure Pharmaceutical Grade 100% Active Glycerol – 23,000mg

  At the heart of PUMP SCRIPT lies an impressive 23 grams of pharmaceutical-grade glycerol, delivering what research indicates is the optimal dosage for true hyperhydration and muscle-pumping effects. This isn’t just another pump ingredient, it’s the foundational compound that creates the dramatic cellular volumization that serious lifters chase.

  

  What is Glycerol?

  Glycerol (1,2,3-propanetriol) is a naturally occurring 3-carbon molecule that serves as the backbone of triglycerides in the human body. Beyond being a component of fat metabolism, glycerol possesses remarkable osmotic properties that have generated significant interest in sports performance research.^[1]

  When consumed in sufficient quantities, glycerol creates an osmotic gradient in the circulatory system that favors fluid retention, thereby enhancing hydration and protecting against dehydration. This unique mechanism of action separates glycerol from other pump ingredients that primarily work through nitric oxide pathways. We love those ingredients, but glycerol is simply different… especially at this dose.

  The Science Behind Glycerol Hyperhydration

  Research on glycerol hyperhydration has consistently shown that increases in total body water of 1 liter or more are achievable through proper glycerol supplementation.^[2]

  What’s often overlooked in the supplement industry is the dose-response relationship. Studies indicate that glycerol doses higher than 0.5 g/kg bodyweight are required to maximize fluid retention and create a meaningful osmotic gradient,^[3] and that makes for a pretty big dose.

  For instance, for a 200-pound (90.7kg) athlete, this translates to a minimum effective dose of approximately 45 grams – far beyond what typical powdered formulations provide. PUMP SCRIPT’s 23-gram dose represents an appropriate single-serving amount that creates substantial hyperhydration effects while staying within practical consumption guidelines.

  The Hyperhydration Mechanism

  When consumed, glycerol distributes rapidly throughout body fluids (except within the brain and eyes) and raises osmotic pressure and the body’s total water volume.^[1]

  

  Here’s what happens:

  1. Increased Osmotic Pressure: Glycerol raises the osmolality of body fluids
  2. Enhanced Water Movement: This osmotic gradient encourages increased movement of water throughout the body
  3. Superior Water Retention: The body holds onto more water, creating a state of hyperhydration
  4. Cellular Volumization: Working muscles receive enhanced hydration, delaying the onset of fatigue

  The “Water-Based Pump”

  While many pump ingredients focus exclusively on nitric oxide-mediated vasodilation, glycerol provides what researchers call a “water-based pump” or simply the “water pump”. Studies have shown that glycerol supplementation increases forearm blood flow during exercise too though — it’s not just water!^[4] This can create visibly enhanced vascularity through a completely different mechanism than NO boosters, and yes, you can stack them.

  This multi-pathway approach to pump enhancement makes glycerol an exceptional complement to traditional nitric oxide enhancers – rather than competing for the same biochemical pathway, it brings pumps through its own unique mechanism!

Performance Benefits Beyond Aesthetics

While the visual pump effect of glycerol is impressive, research demonstrates numerous performance advantages:

• Endurance Enhancement

  Multiple studies have shown that proper glycerol supplementation can significantly improve endurance capacity. Research has demonstrated improvements in exercise time to exhaustion of up to 24% following glycerol hyperhydration.^[5]

  One landmark study showed that cyclists given glycerol prior to exercise maintained average heart rates 2.8 beats/min lower than placebo while extending their time to exhaustion by 21%, pushing past the 90-minute mark while placebo subjects tapped out after 77 minutes.^[5]



• Superior Thermoregulation

  Glycerol’s hydration benefits extend to thermoregulation as well. Research has shown that glycerol supplementation:^[4]

  • Increases sweat rate by up to 33% over placebo during exercise
  • Lowers core body temperature by approximately 2 degrees compared to placebo
  • Provides greater heat dissipation capability during intensive training

  These benefits are especially valuable for high-volume training sessions or when training in challenging environmental conditions.

• Cardiovascular Efficiency

  Beyond muscle fullness, glycerol supplementation has been shown to improve cardiovascular function during aerobic activity. Research indicates that proper glycerol hyperhydration decreases heart rate while increasing cardiac stroke volume.^[6]

  One study observed significantly lower heart rates and higher cardiac stroke volume in subjects given glycerol compared to placebo.^[7] This translates to more efficient cardiovascular functioning, something that hints towards improvements in overall cardiac output and endurance.

Practical Application: Making the Most of PUMP SCRIPT

The research-backed 23-gram glycerol dose in PUMP SCRIPT can deliver:

• Dramatic cellular volumization (“the pump”)
• Enhanced nutrient delivery to working muscles
• Improved exercise endurance
• More efficient thermoregulation
• Enhanced cardiovascular efficiency

For maximum benefit, take PUMP SCRIPT approximately 45 minutes before training, allowing sufficient time for the glycerol to distribute throughout body compartments. This timeframe aligns with research protocols that demonstrated peak hyperhydration effects.

While glycerol alone creates significant hyperhydration, consuming PUMP SCRIPT with adequate fluid (12-16oz water) maximizes the cellular volumization effect. This combination creates the highest osmotic gradient for superior fluid retention in muscle tissue.



The Glycerol Advantage

What separates PUMP SCRIPT from the competition is the pharmaceutical-grade quality and 100% yield of its glycerol. Lower quality glycerol products offer reduced bioavailability and diminished osmotic potential, severely limiting their effectiveness. And who knows what’s in the competition’s byproducts when it’s not pharmaceutically pure.

With 23 grams of premium glycerol delivered in a clump-free liquid formula, PUMP SCRIPT represents the pinnacle of hyperhydration technology. This isn’t just another pump product, it’s a scientifically-validated approach to enhanced performance, superior muscle fullness, and extended training capacity.

• S7 Vascular Activity Blend – 50mg

  While glycerol drives PUMP SCRIPT’s cellular volumization benefits, Nutristat added a nitric oxide potentiator to create a unique, dual-pathway pump formula. S7 is a proprietary blend of seven plant-based ingredients scientifically shown to boost nitric oxide (NO) bioavailability by up to 230% over baseline values.^[8]

  What is S7?

  S7 is a science-backed combination of seven plant extracts: green coffee bean extract, green tea extract, turmeric extract, tart cherry, blueberry, broccoli, and kale.

  This polyphenol-rich blend works through a completely different mechanism than glycerol, making it the perfect complement to PUMP SCRIPT’s hydration-based pump technology.

  The Science Behind S7

  S7 stands apart from typical NO boosters that force nitrogen compounds into your system. Instead, it works by targeting endothelial function and triggering your body’s own natural nitric oxide production pathways.^[9]

  

  Nutristat introduces Bio ATP featuring triacetyladenosine (TAA), a novel adenosine form that enhances blood flow, promotes muscle fullness, and improves exercise performance. Not just another “ATP” supplement – this one works differently!

  Research has revealed several key benefits:

  1. Increased Bioavailable NO: A double-blind, placebo-controlled study found that S7 supplementation significantly increased circulating levels of bioavailable nitric oxide (measured as NOHb). The 50mg dose (exactly what’s in PUMP SCRIPT) increased NO levels by 53.43% over 90 days, compared to just 6.67% in the placebo group.^[8]
  2. Reduced Oxidative Stress: The same study demonstrated that S7 reduced mitochondrial ROS (reactive oxygen species) generation by 75% at the 50mg dose, helping to maintain optimal cellular function during intense training.^[8]
  3. Sustained Vascular Response: Most impressively, S7’s nitric oxide-boosting effects remain elevated for up to 3 hours after consumption—perfectly timed to support your entire training session.^[8]

  The Polyphenol Power Behind S7

  S7’s effectiveness comes from its precisely calibrated blend of plant-based compounds:

  • Catechins (36.8%): These powerful polyphenols support endothelial function and vascular health.^[9]
  • Chlorogenic Acids (26.2%): Found primarily in green coffee bean extract, these compounds help reduce oxidative stress and support nitric oxide bioavailability.^[9]
  • EGCG (18.4%): This specialized catechin from green tea has been shown to enhance antioxidant capacity and support healthy blood flow.^[9]

  

  The Perfect Partner for Glycerol

  What makes S7 valuable in PUMP SCRIPT is how well it complements glycerol’s mechanism. While glycerol creates the “water-based pump” through cellular hyperhydration, S7 activates the classic vasodilation pathway through nitric oxide, yet isn’t in most pre-workout supplements that you may be stacking it with. This dual-pathway approach creates a synergistic effect that neither ingredient could achieve alone.

  At the clinically-validated 50mg dose, S7 provides the vascular support that transforms PUMP SCRIPT from merely a hydration enhancer into a comprehensive performance and pump formula that attacks cellular volumization from multiple angles.

• Sea Salt – 110mg

  PUMP SCRIPT incorporates premium sea salt to maximize the cellular volumization benefits of glycerol through a well-established electrolyte synergy. This isn’t just any ordinary table salt – it’s Kosher, non-GMO sea salt that provides critical sodium ions that work alongside glycerol to enhance fluid retention and maximize the pump effect.

  The Sodium-Glycerol Synergy

  Research consistently demonstrates that sodium and glycerol operate synergistically to enhance intramuscular fluid retention.^[3] When sodium enters the bloodstream, it creates an osmotic gradient that pulls water into the vascular system, while glycerol enhances this effect by increasing total body water retention.

  The science is clear: sodium enhances the hyperhydration effects of glycerol supplementation in several key ways:

  1. Increased Plasma Volume: Sodium draws water into the bloodstream, increasing plasma volume and supporting better nutrient delivery to working muscles.^[10]
  2. Enhanced Cellular Uptake: Sodium facilitates greater water uptake into muscle cells through Na⁺/K⁺ pumps, maximizing the cellular volumization effect triggered by glycerol.^[1]
  3. Extended Hyperhydration: Sodium helps maintain the hyperhydration state created by glycerol for longer periods, extending your pump throughout your entire training session.^[2]
  

  Nutristat: Research. Purity. Performance.

  The Performance Connection

  During intense training, substantial amounts of sodium can be lost through sweat — up to 7g in some athletes during extended training sessions.^[11] This sodium loss can impair muscle function and performance when not properly replaced.

  The strategic inclusion of 110mg sea salt in PUMP SCRIPT helps offset these losses while simultaneously enhancing glycerol’s hyperhydration effects. The result is superior cellular volumization, improved performance, and those skin-splitting pumps that lifters chase.

  So this isn’t merely a flavor enhancer, it’s a scientifically-supported performance ingredient that creates a synergistic effect with glycerol that neither ingredient could achieve alone.

How to Use PUMP SCRIPT for Maximum Results

PUMP SCRIPT is designed for simple yet effective use:

• Take 1 full cap (30g) approximately 45 minutes prior to training
• This can be taken by itself or followed by a drink of 12-16oz of water
• Alternatively, mix it with a pre-workout solution



• For optimal ongoing benefit, hydrate with fluids afterward and throughout the day to ensure maximum cell storage and hydration

For maximum effectiveness, PUMP SCRIPT can be stacked with other Nutristat products:

• CREA SCRIPT (creatine monohydrate)
• BIO ATP (featuring triacetyladenosine)
• PRE SCRIPT (pre-workout formula)

Flavors Available

Here’s a current list of available PUMP SCRIPT flavors:

Conclusion: The Original Liquid Pump Enhancer Still Reigns Supreme

While imitation may be the sincerest form of flattery, PUMP SCRIPT remains the gold standard in liquid pump enhancement. This is the pioneer that created an entirely new category in sports nutrition. Where others have attempted to follow with half-sized bottles, Nutristat’s commitment to maximum efficacy and massive doses remains unmatched.

Nutristat PÜR NATIVE delivers Native Whey Protein extracted directly from milk, not cheese production. Lab-tested with 3.1g+ leucine per serving and enhanced with NativeZyme technology for superior absorption. Research shows faster recovery and better gains.

What sets PUMP SCRIPT apart isn’t just being first to market, it’s the scientific understanding behind it. By addressing the actual research-backed dose of glycerol required for muscle hyper-saturation (far more than what powdered products could ever deliver) and solving the frustrating clumping issues that plagued powdered glycerol products, Nutristat created something truly revolutionary.

For athletes serious about achieving skin-splitting pumps, enhanced vascularity, and improved training performance, PUMP SCRIPT delivers what powdered glycerol supplements simply cannot – a massive 23g dose of 100% yield glycerol in a convenient, effective liquid format.

From their premium protein innovation PUR Native to the game-changing PUMP SCRIPT, Nutristat consistently demonstrates their commitment to advancing supplement science with formulations that prioritize efficacy and real results.

Over six years after its groundbreaking introduction, PUMP SCRIPT remains unrivaled in its approach and effectiveness – the original liquid pump enhancer that continues to set the standard against which all others are measured.