Morphogen Nutrition: SHROOMS, PARTY, and BLISS!

Published on June 9, 2023 by PricePlow Staff and Drew Schibsted | No Comments

Morphogen Nutrition is one of the supplement industry’s heavy-hitters and rising stars. This is a company that runs a tight ship in both key aspects of supplement design and marketing – the Morphogen team has really turned product formulation into both a science and an art, and Morphogen’s product packaging and aesthetics are on point, too.

Morphogen Nutrition Party

Ben Hartman, Morphogen’s CEO and founder, has been on the PricePlow podcast not once, but twice – first in 2020, to discuss Morphogen’s approach to formula design, and again in 2022, to talk about Morphogen’s new emphasis on branding and packaging (having mastered the formulation game, of course).

We recently covered Morphogen PRIME, a whole-body organ health supplement, but Hartman and team aren’t done protecting your organs and mental state:

Three New Morphogen Products – BLISS, PARTY, and SHROOMS

We’re excited to announce that on 6/9/2023 and the week after, Morphogen is bringing their customary rigor to three new health and wellness products:

  • BLISS: support for mood, cognition, and stress resilience
  • PARTY: designed to help protect your body from, well… recreational stress
  • SHROOMS: packed with adaptogenic mushrooms that are each a kind of tonic for some dimension of human health

Longer articles will be coming later, but let’s briefly get into each one of these. First, the PricePlow news and deals:

Morphogen Nutrition – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

  • Morphogen SHROOMS

    Morphogen Nutrition Shrooms Ingredients

    Edible mushrooms – no, not that kind – are enjoying a huge surge of popularity with supplement formulators and consumers, as scientific evidence mounts that these adaptogenic fungi can have broad and far-reaching positive effects on many different aspects of human health.

    It’s hard to summarize these mushrooms, because each one seems to do a little bit of everything. But here are the major benefits identified for the medicinal mushrooms in Morphogen’s Shrooms:

    • Chaga Mushroom powder (Inonotus obliquus) (fruit body) — 200 mg: powerful anti-inflammatory[1] and pro-immunity[2] effects. It can also help keep blood sugar appropriately low,[3] which is a huge deal for overall health and longevity.
    • Cordyceps Mushroom extract (Cordyceps sinensis) (fruit body) — 200 mg: improves oxygen uptake,[4] mitochondrial resilience,[5] inflammation,[6-8] and glycemic control.[9]
    • Lion’s Mane Mushroom extract (Hericium erinaceus) (fruit body) – 200 mg: the beta glucans in lion’s mane can increase neurogenesis by upregulating a neurotrophic factor called nerve growth factor (NGF).[10-12] Lion’s mane is often described as a tonic for brain health.

      • Morphogen Nutrition Shrooms

    • Maitake Mushroom powder (Grifola frondosa) (fruit body) – 200 mg: a powerful immunity-enhancing mushroom.[13]
    • Reishi Mushroom extract (Ganoderma lucidum) (fruit body) — 200 mg: has been shown to inhibit 5-alpha reductase, the enzyme responsible for converting testosterone into DHT,[14] which is thought to be of benefit for long-term prostate health. Also good for lowering estrogen levels.[15]
    • Shiitake Mushroom powder (Lentinula edodes) (fruit body) — 200 mg: has synergistic immune-boosting effects with maitake mushrooms,[16] and pro-immunity effects in its own right.[17]
    • Turkey Tail Mushroom powder (Trametes versicolor) (fruit body) — 200 mg: can stimulate macrophage activity[18] and improve gut health through prebiotic effects.[19,20]

    Morphogen Nutrition SHROOMS – Deals and Price Drop Alerts

    Get Price Alerts

    No spam, no scams.

    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

  • Morphogen PARTY

    Let’s face it, everybody needs to blow off stress every once in a while – you work hard, and you should play hard too!

    Unfortunately, as most of us know, this can come with a high metabolic cost, usually felt the morning after. Party from Morphogen, which would probably be most effective when taken immediately before you start your partying, consists of ingredients that can help your body and mind against the unwanted effects of drinking in particular.

    This is a formula that has a heavy emphasis on upregulating glutathione, your body’s master antioxidant that plays an absolutely vital role in keeping inflammation and metabolic stress to the appropriate minimum.

    Here’s what’s in Party:

    Morphogen Nutrition Party Ingredients

    • Acetyl L-Carnitine (HPLC) – 500 mg: also known as ALCAR, this is a powerful neuroprotective antioxidant that crosses the blood-brain barrier,[21,22] protects DNA integrity, and reduces lipid peroxidation in brain tissue.[23]
    • Ginger Root extract (Zingiber officinale) (std. min. 20% gingerols) – 500 mg: full of gingerols and shogaols, bioactive constituents with impressive anti-inflammatory and antioxidant effects.[22,24]
    • ALA (Alpha Lipoic Acid) – 400 mg: upregulates glutathione (GSH), your body’s master endogenous antioxidant.[25,26]
    • Japanese Raisin Tree extract (Hovenia dulcis) (std. min. 98% Dihydromyricetin) – 400 mg: possesses antidiabetic, anticancer, antioxidant, anti-inflammatory and hepatoprotective effects, and is used in traditional Chinese medicine to prevent and treat hangovers.[27]
    • Katuika extract (Picrorhiza kurroa) (rhizome and root) – 400 mg: shown in animal studies to improve liver function and even reverse fatty liver.[28,29]
    • NAC (N-acetyl-L-cysteine) – 400 mg: upregulates GSH and protects the liver.[30,31]
    • Clovinol Clove extract (Lavangam) (flower bud) (std. min. 30% polyphenols) – 100 mg: another compound with potent liver-protective effects.[32]
    • Setria L-Glutathione Reduced – 50 mg: although most GSH preparations are not orally bioavailable,[33] oral Setria supplementation has been shown to effectively raise GSH blood levels.[34]

      • Morphogen Nutrition Party

    • Ubiquinol (Coenzyme Q10) — 50 mg: helps stabilize and optimize function of your body’s mitochondria, organelles responsible for producing all your cellular energy[35] which can be adversely affected by stress.
    • Saffron extract (Crocus sativus L.) (stigma) – 10 mg: in animal studies, saffron has been shown to protect the liver against fatty liver and alcohol ingestion.[36,37]
    • Vitamin B1 (as BenfoPure Benfotiamine) — 83 mg (69% DV): animal studies have shown that vitamin B1 can protect the liver against alcohol-induced injury – even when given 30 minutes after alcohol ingestion.[38]
    • Vitamin B3 (as Nicotinamide) — 8 mg (50% DV): stabilizes cellular metabolism by upregulating NAD+,[39] with antioxidant neuroprotective effects.[40]
    • Vitamin B12 (as Methylcobalamin) – 30 mcg (1250% DV): vitamin B12 plays a crucial role in the central nervous system,[41] and megadoses of B12 are often given as an energy booster. An added bonus of methylcobalamin is its ability to act as a methyl donor.
    • Vitamin C (as Ascorbic Acid) — 250 mg (278% DV): your adrenal cortex tissue consists largely of vitamin C,[42] and your adrenal glands lose vitamin C during stress.[43] It’s a good idea to replenish this any time you do something stressful.
    • Vitamin E (as Mixed Tocopherols) — 15 mg (100% DV): a powerful antioxidant that has synergistic effects with vitamin C on reducing stress and anxiety.[44]
    • Magnesium (as TRAACS Magnesium Bisglycinate Chelate) — 84 mg (20% DV): this crucial mineral is lost during stress[45] and should be replenished around any stressful event.

    Morphogen Nutrition PARTY – Deals and Price Drop Alerts

    Get Price Alerts

    No spam, no scams.

    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

  • Morphogen BLISS

    The modern world is fast-paced and stressful, and we can probably all benefit, at least occasionally, from taking something to support mood and metabolic function. Of course, some options are healthier than others – we don’t want to manage today’s crisis by borrowing against our future health. That’s where Bliss from Morphogen comes in – it’s full of ingredients that can help you perform, rest, and recuperate more effectively.

    Although there are a few ingredients in Bliss that can help promote restful sleep, we hesitate to call this product a sleep aid because of the vitamin D, which can mess with your circadian rhythm if taken before bed.

    In a single 3 capsule serving of Bliss from Morphogen, you get the following:

    Morphogen Nutrition Bliss Ingredients

    • Vitamin D3 (as Cholecalciferol from Lichen (Vegan)) – 100 mcg / 4,000 IU (500% DV): vitamin D3 is the active form of vitamin D in the human body, and has superior dosing and pharmacokinetic properties compared to vitamin D2.[46] Vitamin D plays a role in inflammation inhibition, regulation of blood sugar metabolism, blood pressure, and vascular calcification,[47,48] so it’s not much of a surprise that vitamin D deficiency can cause symptoms of anxiety or depression.[49]
    • Chamomile extract (Matricaria chamomilla) (flower) – 350 mg: chamomile is an excellent sleep aid. Thanks to its main bioactive constituent, apigenin, chamomile has depressant effects that can speed up sleep onset and improve sleep quality.[50-53] It can also have anti-depressive and anti-anxiety normalize hypothalamic-pituitary axis (HPA) function, and improve patient scores on the Hamilton Depression Rating Scale (HDRS).[54-60]
    • St. John’s Wort (Hypericum perforatum) (herb) (std. min. 0.3% hypericin) – 200 mg: thanks to its effect on intracellular sodium uptake, St. John’s Wort can also inhibit the uptake of key neurotransmitters like serotonin and dopamine, thus prolonging their action and helping normalize brain chemistry.[61-64] This ingredient is recognized as useful in mild-to-moderate cases of depression.[65]
    • Velvet Bean extract (Mucuna pruriens) (seed) (std. min. 98% L-DOPA) – 125 mg: thanks to its bioactive constituent L-dopa, velvet bean extract can upregulate the neurotransmitter dopamine.[66,67]
    • Oleoylethanolamide (OEA) (from oleic acid) – 100 mg: OEA is a chemical analog of the endocannabinoid anandamide (AEA).[68] Endocannabinoids have analgesic, anti-depressant, pro-sleep, anti-inflammatory, vasodilatory, and appetite suppressant effects. If you want to read more about endocannabinoids, check out our article Anandamide: The Body’s Blissful Endocannabinoid Molecule.

      • Morphogen Nutrition Bliss

    • SAM-e (as S-Adenosyl-L-Methionine Tosylate Disulfate) – 100 mg: SAM-e is a precursor to glutathione (GSH), your body’s master endogenous antioxidant.[69,70] Probably thanks to its ability to reduce oxidative stress on the brain through GSH upregulation,[71,72] SAM-e can improve dopaminergic signaling[73,74] and mood.[73,75-77]
    • Anandamide (AEA) (from arachidonic acid) – 50 mg: for a summary of AEA, refer to the OEA bullet point above. Again, read our article Anandamide: The Body’s Blissful Endocannabinoid Molecule if you want to learn more about AEA, OEA, and other endocannabinoids.
    • Kava Extract (Piper methysticum) (root) (std. min. 30% kavalactones) – 50 mg: kava can potentiate receptors for the neurotransmitter GABA.[78] A randomized, placebo-controlled crossover trial using kava extract found that it has significant anti-anxiety effects, even in cases where anxious symptoms are accompanied by depression.[79]
    • Kanna extract (Sceletium tortuosum) (aerial parts) (std. min. 0.5% alkaloids) – 50 mg: kanna is an herb native to South Africa that’s long been traditionally used to improve mood,[80] particularly when one expects to shortly enter a high stress situation.[81] Kanna’s mechanism of action is upregulation of cyclic adenosine monophosphate (cAMP), a secondary messenger molecule that regulates cellular metabolism and is downregulated in cases of depression and anxiety.[82]
    • 5-HTP (5-Hydroxytryptophan) (from Griffonia simplicifolia) (seed) – 50 mg: 5-HTP upregulates the neurotransmitter serotonin, and has been shown to improve sleep quality.[83,84] Although some small studies have found that 5-HTP can improve mood,[85] a recent meta-analysis concluded that larger, longer-term trials are needed to confirm this.[86]

    Morphogen Nutrition BLISS – Deals and Price Drop Alerts

    Get Price Alerts

    No spam, no scams.

    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

Conclusion: Ben Hartman’s at it again

This trio, especially thanks to PARTY, is definitely something different compared to the standard supplement offering you see from active nutrition brands. Perhaps we got a little glimpse of what Ben Hartman likes to enjoy when it’s finally time to shut the laptop!

A while back, we also covered CALM (renamed from “MorphoCALM”), and it’s also along these same lines. If you’re looking to slow things down a bit more, then that’s well worth researching as well.

Back to the three supplements discussed above: we haven’t done full product reviews on these yet, but it would seem Morphogen Nutrition has knocked it out of the park yet again – stay tuned for further updates on these promising supplements from the PricePlow media team.

Morphogen Nutrition SHROOMS – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: PricePlow Staff

PricePlow Staff

PricePlow is a team of supplement industry veterans that include medical students, competitive strength athletes, and scientific researchers who all became involved with dieting and supplements out of personal need.

The team's collective experiences and research target athletic performance and body composition goals, relying on low-toxicity meat-based diets.

No Comments | Posted in | Tagged , , , , , , .

References

  1. Alhallaf, Weaam, and Lewis B Perkins. “The Anti-Inflammatory Properties of Chaga Extracts Obtained by Different Extraction Methods against LPS-Induced RAW 264.7.” Molecules (Basel, Switzerland) vol. 27,13 4207. 30 Jun. 2022, doi:10.3390/molecules27134207 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268247/
  2. Kim, Yeon-Ran. “Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus.” Mycobiology vol. 33,3 (2005): 158-62. doi:10.4489/MYCO.2005.33.3.158 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774877/
  3. Sun, Jun-En et al. “Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice.” Journal of ethnopharmacology vol. 118,1 (2008): 7-13. doi:10.1016/j.jep.2008.02.030 https://www.sciencedirect.com/science/article/abs/pii/S0378874108001086
  4. Xu, Yan-Feng. “Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming.” International journal of medicinal mushrooms vol. 18,12 (2016): 1083-1092. doi:10.1615/IntJMedMushrooms.v18.i12.30; https://www.dl.begellhouse.com/journals/708ae68d64b17c52,57162b26264a3b98,4ad6a16757705f93.html
  5. Li, Xing-Tai et al. “Protective effects on mitochondria and anti-aging activity of polysaccharides from cultivated fruiting bodies of Cordyceps militaris.” The American journal of Chinese medicine vol. 38,6 (2010): 1093-106. doi:10.1142/S0192415X10008494; https://www.worldscientific.com/doi/10.1142/S0192415X10008494
  6. Kuo, Y C et al. “Cordyceps sinensis as an immunomodulatory agent.” The American journal of Chinese medicine vol. 24,2 (1996): 111-25. doi:10.1142/S0192415X96000165; https://www.worldscientific.com/doi/10.1142/S0192415X96000165
  7. Weng, Shu-Cheng et al. “Immunomodulatory functions of extracts from the Chinese medicinal fungus Cordyceps cicadae.” Journal of ethnopharmacology vol. 83,1-2 (2002): 79-85. doi:10.1016/s0378-8741(02)00212-x; https://pubmed.ncbi.nlm.nih.gov/12413710/
  8. Park, Seong-Yeol et al. “Anti-inflammatory effects of Cordyceps mycelium (Paecilomyces hepiali, CBG-CS-2) in Raw264.7 murine macrophages.” Oriental pharmacy and experimental medicine vol. 15,1 (2015): 7-12. doi:10.1007/s13596-014-0173-3; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371127/
  9. Zhang, Guoqing et al. “Hypoglycemic activity of the fungi Cordyceps militaris, Cordyceps sinensis, Tricholoma mongolicum, and Omphalia lapidescens in streptozotocin-induced diabetic rats.” Applied microbiology and biotechnology vol. 72,6 (2006): 1152-6. doi:10.1007/s00253-006-0411-9; https://link.springer.com/article/10.1007/s00253-006-0411-9
  10. Mori, Koichiro et al. “Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells.” Biological & pharmaceutical bulletin vol. 31,9 (2008): 1727-32. doi:10.1248/bpb.31.1727 http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/31.1727?from=PubMed
  11. Hefti, F. “Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections.” The Journal of neuroscience : the official journal of the Society for Neuroscience vol. 6,8 (1986): 2155-62. doi:10.1523/JNEUROSCI.06-08-02155.1986 https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/3746405/
  12. Hefti, F et al. “Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases.” Neurobiology of aging vol. 10,5 (1989): 515-33. doi:10.1016/0197-4580(89)90118-8 https://linkinghub.elsevier.com/retrieve/pii/0197-4580(89)90118-8
  13. Vetvicka V, Vetvickova J; “Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts;” Ann Transl Med. 2014;2(2); https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202470/
  14. Fujita, Rumi et al. “Anti-androgenic activities of Ganoderma lucidum.” Journal of ethnopharmacology vol. 102,1 (2005): 107-12. doi:10.1016/j.jep.2005.05.041 https://www.sciencedirect.com/science/article/abs/pii/S0378874105003673
  15. Jiang, Jiahua et al. “Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling.” International journal of oncology vol. 29,3 (2006): 695-703. https://www.spandidos-publications.com/ijo/29/3/695
  16. Vetvicka V, Vetvickova J; “Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts;” Ann Transl Med. 2014;2(2); https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202470/
  17. Dai, Xiaoshuang et al. “Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults.” Journal of the American College of Nutrition vol. 34,6 (2015): 478-87. doi:10.1080/07315724.2014.950391; https://www.tandfonline.com/doi/abs/10.1080/07315724.2014.950391?journalCode=uacn20
  18. Jeong S-C, et al. ‘Macrophage-Stimulating Activity of Polysaccharides Extracted from Fruiting Bodies of Coriolus versicolor (Turkey Tail Mushroom)’;’ Journal of Medicinal Food. 2006;9(2):175-181; https://www.ncbi.nlm.nih.gov/pubmed/16822202
  19. Jayachandran M, et al; “A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota;” International Journal of Molecular Sciences. 2017;18(9):1934; https://www.mdpi.com/1422-0067/18/9/1934
  20. Sousa VMC de, et al; “The Importance of Prebiotics in Functional Foods and Clinical Practice;” FNS. 2011;02(02):133-144; https://www.scirp.org/html/13-2700053_4536.htm
  21. Inano, Akihiro et al. “Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2.” Biopharmaceutics & drug disposition vol. 24,8 (2003): 357-65. doi:10.1002/bdd.371; https://onlinelibrary.wiley.com/doi/10.1002/bdd.371
  22. Mohd Yusof, Yasmin Anum. “Gingerol and Its Role in Chronic Diseases.” Advances in experimental medicine and biology vol. 929 (2016): 177-207. doi:10.1007/978-3-319-41342-6_8; https://link.springer.com/chapter/10.1007/978-3-319-41342-6_8
  23. Parnetti, L, et al; “Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type”; Eur J Clin Pharmacol. 1992; 42(1):89-93; https://www.ncbi.nlm.nih.gov/pubmed/1541322
  24. Semwal, Ruchi Badoni et al. “Gingerols and shogaols: Important nutraceutical principles from ginger.” Phytochemistry vol. 117 (2015): 554-568. doi:10.1016/j.phytochem.2015.07.012; https://www.sciencedirect.com/science/article/abs/pii/S0031942215300509
  25. Kleinkauf-Rocha, J., Bobermin, L. D., Machado, P. de M., Gonçalves, C.-A., Gottfried, C., & Quincozes-Santos, A. (2013). Lipoic acid increases glutamate uptake, glutamine synthetase activity and glutathione content in C6 astrocyte cell line. International Journal of Developmental Neuroscience, 31(3), 165–170. https://www.ncbi.nlm.nih.gov/pubmed/23286972
  26. Wang, S.-J., & Chen, H.-H. (2007). Presynaptic mechanisms underlying the α-lipoic acid facilitation of glutamate exocytosis in rat cerebral cortex nerve terminals. Neurochemistry International, 50(1), 51–60. https://www.sciencedirect.com/science/article/pii/S0197018606002385
  27. Sferrazza, Gianluca et al. “Hovenia dulcis Thumberg: Phytochemistry, Pharmacology, Toxicology and Regulatory Framework for Its Use in the European Union.” Molecules (Basel, Switzerland) vol. 26,4 903. 9 Feb. 2021, doi:10.3390/molecules26040903 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914479/
  28. Vaidya, AB, et al. “Picrorhiza Kurroa (Kutaki) Royle Ex Benth as a Hepatoprotective Agent–Experimental & Clinical Studies.” Journal of Postgraduate Medicine, 1996, www.jpgmonline.com/article.asp?issn=0022-3859;year=1996;volume=42;issue=4;spage=105;epage=8;aulast=Vaidya. Accessed 18 Nov. 2021.
  29. Shetty, Sapna N et al. “A study of standardized extracts of Picrorhiza kurroa Royle ex Benth in experimental nonalcoholic fatty liver disease.” Journal of Ayurveda and integrative medicine vol. 1,3 (2010): 203-10. doi:10.4103/0975-9476.72622 https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3087357/
  30. Kasperczyk, Sławomir, et al. “The Administration of N-Acetylcysteine Reduces Oxidative Stress and Regulates Glutathione Metabolism in the Blood Cells of Workers Exposed to Lead.” Clinical Toxicology, vol. 51, no. 6, 4 June 2013, pp. 480–486, 10.3109/15563650.2013.802797; https://pubmed.ncbi.nlm.nih.gov/23731375/
  31. Green, Jody, et al. “Oral and Intravenous Acetylcysteine for Treatment of Acetaminophen Toxicity: A Systematic Review and Meta-Analysis.” Western Journal of Emergency Medicine, vol. 14, no. 3, 1 May 2013, pp. 218–226, 10.5811/westjem.2012.4.6885; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3656701/
  32. Al-Okbi, Sahar Y et al. “Protective effect of clove oil and eugenol microemulsions on fatty liver and dyslipidemia as components of metabolic syndrome.” Journal of medicinal food vol. 17,7 (2014): 764-71. doi:10.1089/jmf.2013.0033 https://www.liebertpub.com/doi/10.1089/jmf.2013.0033
  33. Witschi, A., et al. “The Systemic Availability of Oral Glutathione.” European Journal of Clinical Pharmacology, vol. 43, no. 6, 1992, pp. 667–669, 10.1007/BF02284971; https://pubmed.ncbi.nlm.nih.gov/1362956/
  34. Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2015 Mar;54(2):251-63. doi: 10.1007/s00394-014-0706-z. Epub 2014 May 5. PMID: 24791752. https://pubmed.ncbi.nlm.nih.gov/24791752/
  35. Garrido-Maraver J., et al; “Clinical applications of coenzyme Q10;” Frontiers in Bioscience; 2014; https://www.ncbi.nlm.nih.gov/pubmed/24389208
  36. Konstantopoulos, Panagiotis et al. “Metabolic effects of Crocus sativus and protective action against non-alcoholic fatty liver disease in diabetic rats.” Biomedical reports vol. 6,5 (2017): 513-518. doi:10.3892/br.2017.884 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431529/
  37. Azizi, Monireh et al. “Investigating the effect of Crocus sativus L. petal hydroalcoholic extract on inflammatory and enzymatic indices resulting from alcohol use in kidney and liver of male rats.” Journal of inflammation research vol. 12 269-283. 8 Oct. 2019, doi:10.2147/JIR.S216125 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790211/
  38. Portari, Guilherme Vannucchi et al. “Protective effect of treatment with thiamine or benfotiamine on liver oxidative damage in rat model of acute ethanol intoxication.” Life sciences vol. 162 (2016): 21-4. doi:10.1016/j.lfs.2016.08.017 https://www.sciencedirect.com/science/article/abs/pii/S0024320516304799
  39. Sauve, Anthony A. “NAD+ and vitamin B3: from metabolism to therapies.” The Journal of pharmacology and experimental therapeutics vol. 324,3 (2008): 883-93. doi:10.1124/jpet.107.120758 https://jpet.aspetjournals.org/content/324/3/883.long
  40. Chen, Tu-Wen et al. “Vitamin B3 Provides Neuroprotection via Antioxidative Stress in a Rat Model of Anterior Ischemic Optic Neuropathy.” Antioxidants (Basel, Switzerland) vol. 11,12 2422. 8 Dec. 2022, doi:10.3390/antiox11122422 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774344/
  41. Ryan-Harshman, M, and Aldoori, W. “Vitamin B12 and health.” Canadian family physician Medecin de famille canadien vol. 54,4 (2008): 536-41. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2294088/
  42. Patak P, Willenberg HS, Bornstein SR. Vitamin C is an important cofactor for both adrenal cortex and adrenal medulla. Endocr Res. 2004 Nov;30(4):871-5. doi: 10.1081/erc-200044126. PMID: 15666839. https://pubmed.ncbi.nlm.nih.gov/15666839/
  43. Sebastian J Padayatty, John L Doppman, Richard Chang, Yaohui Wang, John Gill, Dimitris A Papanicolaou, Mark Levine, Human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone, The American Journal of Clinical Nutrition, Volume 86, Issue 1, July 2007, Pages 145–149, https://doi.org/10.1093/ajcn/86.1.145
  44. Mazloom Z, Ekramzadeh M, Hejazi N. Efficacy of supplementary vitamins C and E on anxiety, depression and stress in type 2 diabetic patients: a randomized, single-blind, placebo-controlled trial. Pak J Biol Sci. 2013 Nov 15;16(22):1597-600. doi: 10.3923/pjbs.2013.1597.1600. PMID: 24511708. https://pubmed.ncbi.nlm.nih.gov/24511708/
  45. Pickering, Gisèle et al. “Magnesium Status and Stress: The Vicious Circle Concept Revisited.” Nutrients vol. 12,12 3672. 28 Nov. 2020, doi:10.3390/nu12123672 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761127/
  46. Sosa Henríquez, Manuel, and M Jesús Gómez de Tejada Romero. “Cholecalciferol or Calcifediol in the Management of Vitamin D Deficiency.” Nutrients vol. 12,6 1617. 31 May. 2020, doi:10.3390/nu12061617 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352679/
  47. Danik, J. et al. Aug. 2012. “Vitamin D and Cardiovascular Disease.” Current Treatment Options in Cardiovascular Medicine vol. 14,4; 414-24. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449318/
  48. Naeem, Z. Jan. 2010. “Vitamin D Deficiency – An Ignored Epidemic.” International Journal of Health Sciences vol. 4,1. ttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068797/
  49. Akpınar, Şerife, and Makbule Gezmen Karadağ. “Is Vitamin D Important in Anxiety or Depression? What Is the Truth?.” Current nutrition reports vol. 11,4 (2022): 675-681. doi:10.1007/s13668-022-00441-0 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468237/
  50. Srivastava, Janmejai K et al. “Chamomile: A herbal medicine of the past with bright future.”; Molecular medicine reports vol. 3,6 (2010): 895-901; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/
  51. Zick, Suzanna M et al.; “Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study.”; BMC complementary and alternative medicine vol. 11 78. 22 Sep. 2011; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198755/
  52. Hieu, TH et al; “Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: A systematic review and meta-analysis of randomized trials and quasi-randomized trials.”; Phytother Res. 2019 Jun;33(6):1604-1615; https://www.ncbi.nlm.nih.gov/pubmed/31006899
  53. Adib-Hajbaghery, Mohsen, and Seyedeh Nesa Mousavi. “The effects of chamomile extract on sleep quality among elderly people: A clinical trial.” Complementary therapies in medicine vol. 35 (2017): 109-114. doi:10.1016/j.ctim.2017.09.010 https://linkinghub.elsevier.com/retrieve/pii/S0965-2299(17)30260-1
  54. Amsterdam, Jay D et al. “Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study.” Alternative therapies in health and medicine vol. 18,5 (2012): 44-9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600408/
  55. Amsterdam, Jay D et al. “Putative Antidepressant Effect of Chamomile (Matricaria chamomilla L.) Oral Extract in Subjects with Comorbid Generalized Anxiety Disorder and Depression.” Journal of alternative and complementary medicine (New York, N.Y.) vol. 26,9 (2020): 813-819. doi:10.1089/acm.2019.0252 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488203/
  56. Chang, Shao-Min, and Chung-Hey Chen. “Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women: a randomized controlled trial.” Journal of advanced nursing vol. 72,2 (2016): 306-15. doi:10.1111/jan.12836 https://pubmed.ncbi.nlm.nih.gov/26483209/
  57. Keller, J et al. “HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition.” Molecular psychiatry vol. 22,4 (2017): 527-536. doi:10.1038/mp.2016.120 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313380/
  58. Duval, Fabrice et al. “Interaction between the serotonergic system and HPA and HPT axes in patients with major depression: implications for pathogenesis of suicidal behavior.” Dialogues in clinical neuroscience vol. 4,4 (2002): 417. doi:10.31887/DCNS.2002.4.4/fduval https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181696/
  59. Buckley, Theresa M., and Alan F. Schatzberg. “On the Interactions of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Sleep: Normal HPA Axis Activity and Circadian Rhythm, Exemplary Sleep Disorders.” The Journal of Clinical Endocrinology & Metabolism, vol. 90, no. 5, May 2005, pp. 3106–3114, www.academic.oup.com/jcem/article/90/5/3106/2837129, 10.1210/jc.2004-1056
  60. Dressle, Raphael J., et al. “HPA Axis Activity in Patients with Chronic Insomnia: A Systematic Review and Meta-Analysis of Case-Control Studies.” Sleep Medicine Reviews, Jan. 2022, p. 101588, 10.1016/j.smrv.2022.101588. Accessed 21 Jan. 2022. https://www.sciencedirect.com/science/article/abs/pii/S1087079222000016
  61. Klein, Marianne O., et al. “Dopamine: Functions, Signaling, and Association with Neurological Diseases.” Cellular and Molecular Neurobiology, vol. 39, no. 1, 16 Nov. 2018, pp. 31–59, 10.1007/s10571-018-0632-3. https://pubmed.ncbi.nlm.nih.gov/30446950/
  62. Smith, Matthew D, and Christopher V Maani. “Norepinephrine.” Nih.gov, StatPearls Publishing, 23 July 2019. https://www.ncbi.nlm.nih.gov/books/NBK537259/
  63. Ngo, Dai-Hung, and Thanh Sang Vo. “An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid.” Molecules, vol. 24, no. 15, 24 July 2019, p. 2678, 10.3390/molecules24152678. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696076/
  64. Zhou, Y., and N. C. Danbolt. “Glutamate as a Neurotransmitter in the Healthy Brain.” Journal of Neural Transmission, vol. 121, no. 8, 1 Mar. 2014, pp. 799–817, 10.1007/s00702-014-1180-8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133642/
  65. Linde, Klaus, et al. “St John’s Wort for Major Depression.” Cochrane Database of Systematic Reviews, 8 Oct. 2008, 10.1002/14651858.cd000448.pub3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032678/
  66. Misra, Laxminarain, and Hildebert Wagner. “Extraction of Bioactive Principles from Mucuna Pruriens Seeds.” Indian Journal of Biochemistry & Biophysics, vol. 44, no. 1, 1 Feb. 2007, pp. 56–60. https://pubmed.ncbi.nlm.nih.gov/17385342/
  67. Katzenschlager, R, et al. “Mucuna Pruriens in Parkinson’s Disease: A Double Blind Clinical and Pharmacological Study.” Journal of Neurology, Neurosurgery, and Psychiatry, vol. 75, no. 12, 1 Dec. 2004, pp. 1672–1677, 10.1136/jnnp.2003.028761. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1738871/
  68. Portavella, Manuel et al. “Oleoylethanolamide and Palmitoylethanolamide Protect Cultured Cortical Neurons Against Hypoxia.” Cannabis and cannabinoid research vol. 3,1 171-178. 19 Sep. 2018, doi:10.1089/can.2018.0013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148719/
  69. Vendemiale, G et al. “Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease.” Scandinavian journal of gastroenterology vol. 24,4 (1989): 407-15. doi:10.3109/00365528909093067; https://pubmed.ncbi.nlm.nih.gov/2781235/
  70. Tchantchou, Flaubert et al. “S-adenosylmethionine mediates glutathione efficacy by increasing glutathione S-transferase activity: implications for S-adenosyl methionine as a neuroprotective dietary supplement.” Journal of Alzheimer’s disease : JAD vol. 14,3 (2008): 323-8. doi:10.3233/jad-2008-14306; https://pubmed.ncbi.nlm.nih.gov/18599958/
  71. De La Cruz, J P et al. “Effects of chronic administration of S-adenosyl-L-methionine on brain oxidative stress in rats.” Naunyn-Schmiedeberg’s archives of pharmacology vol. 361,1 (2000): 47-52. doi:10.1007/s002109900153; https://pubmed.ncbi.nlm.nih.gov/10651146/
  72. Wan, Xinkun et al. “S-Adenosylmethionine Alleviates Amyloid-β-Induced Neural Injury by Enhancing Trans-Sulfuration Pathway Activity in Astrocytes.” Journal of Alzheimer’s disease : JAD vol. 76,3 (2020): 981-995. doi:10.3233/JAD-200103; https://pubmed.ncbi.nlm.nih.gov/32597804/
  73. Sharma, Anup et al. “S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research.” The Journal of clinical psychiatry vol. 78,6 (2017): e656-e667. doi:10.4088/JCP.16r11113 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501081/
  74. Fava, M et al. “Neuroendocrine effects of S-adenosyl-L-methionine, a novel putative antidepressant.” Journal of psychiatric research vol. 24,2 (1990): 177-84. doi:10.1016/0022-3956(90)90057-w https://linkinghub.elsevier.com/retrieve/pii/0022-3956(90)90057-W
  75. Cuomo, Alessandro et al. “S-Adenosylmethionine (SAMe) in major depressive disorder (MDD): a clinician-oriented systematic review.” Annals of general psychiatry vol. 19 50. 5 Sep. 2020, doi:10.1186/s12991-020-00298-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487540/
  76. Bressa, G. M. “S-Adenosyl-l-Methionine (SAMe) as Antidepressant: Meta-Analysis of Clinical Studies.” Acta Neurologica Scandinavica, vol. 89, no. S154, May 1994, pp. 7–14, 10.1111/j.1600-0404.1994.tb05403.x; https://pubmed.ncbi.nlm.nih.gov/7941964/
  77. Papakostas, George I. “Evidence for S-Adenosyl-L-Methionine (SAM-e) for the Treatment of Major Depressive Disorder.” The Journal of Clinical Psychiatry, vol. 70, no. suppl 5, Nov. 2009, pp. 18–22, 10.4088/jcp.8157su1c.04; https://pubmed.ncbi.nlm.nih.gov/19909689/
  78. Chua, Han Chow et al. “Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism.” PloS one vol. 11,6 e0157700. 22 Jun. 2016, doi:10.1371/journal.pone.0157700 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917254/
  79. Sarris, J et al. “The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum.” Psychopharmacology vol. 205,3 (2009): 399-407. doi:10.1007/s00213-009-1549-9 https://link.springer.com/article/10.1007/s00213-009-1549-9
  80. Gericke, Nigel & Viljoen, Alvaro. (2008). Sceletium-A review update. Journal of ethnopharmacology. 119. 653-63. 10.1016/j.jep.2008.07.043. https://www.researchgate.net/publication/23227379_Sceletium-A_review_update
  81. Chiu, S., et al.; “Proof-of-concept randomized controlled study of cognition effects of the proprietary extract sceletium tortuosum(zembrin) targeting phosphodiesterase-4 in cognitively healthy Subjects: implications for alzheimer’s dementia”; Evidence-Based Complementary and Alternative Medicine, 2014; https://www.ncbi.nlm.nih.gov/pubmed/25389443
  82. Fujita, M et al. “cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor.” Molecular psychiatry vol. 22,5 (2017): 754-759. doi:10.1038/mp.2016.171 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388600/
  83. Sutanto, Clarinda et al. “The Impact of 5-Hydroxytryptophan Supplementation on Sleep Quality of Older Adults in Singapore: A Randomized Controlled Trial.” Current Developments in Nutrition vol. 5,Suppl 2 372. 7 Jun. 2021, doi:10.1093/cdn/nzab037_082; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193546/
  84. Bruni, Oliviero et al. “L -5-Hydroxytryptophan treatment of sleep terrors in children.” European journal of pediatrics vol. 163,7 (2004): 402-7. doi:10.1007/s00431-004-1444-7 https://link.springer.com/article/10.1007/s00431-004-1444-7
  85. Meloni, M et al. “Efficacy and safety of 5-hydroxytryptophan on depression and apathy in Parkinson’s disease: a preliminary finding.” European journal of neurology vol. 27,5 (2020): 779-786. doi:10.1111/ene.14179 https://academic.oup.com/nutritionreviews/article/78/1/77/5555860?login=false
  86. Javelle, Florian et al. “Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.” Nutrition reviews vol. 78,1 (2020): 77-88. doi:10.1093/nutrit/nuz039 https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1093/nutrit/nuz039?login=false

Comments and Discussion (Powered by the PricePlow Forum)