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5% Nutrition Turkesterone 1200: Extra Ecdysterone for Extra Gains!

5-Percenters asked for it, and they got more than what they asked for — a 5% Nutrition Turkesterone supplement with added ecdysterone!

Legendary bodybuilder Rich Piana believed that only 5% of the people on the planet had the grit, talent, and motivation to realize their potential and become the best possible version of themselves.

5% Nutrition Turkesterone 1200

5% Nutrition Turkesterone 1200 goes above and beyond, with a huge 1200 milligram dose of turkesterone and added ecdysterone with absorption enhancers!

Wanting to help those high-achievers — the extraordinary 5% — push themselves to the next level, Piana set out to create supplements of uncompromising quality and efficacy.

Ever since, the culture of 5% Nutrition, the company Piana launched, has emphasized perfection in all things. It’s no wonder, then, that 5% Nutrition is the company moving the state of turkesterone supplementation forward after their hit 5% Nutrition Test release.

Turkesterone 1200 is the first product we’ve seen to address some long-standing problems associated with phytoecdysteroid use. The approach 5% Nutrition takes distinguishes this product from the pack and raises the standard for turkesterone supplements.

Reason being, they’ve added more to it — with extra ecdysterone — another anabolic phytoecdysteroid that will stack incredibly with the main ajuga extract’s turkesterone.

Rich Piana 5% Nutrition Turkesterone 1200 – Deals and Price Drop Alerts

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Ingredients

In a single 4-capsule serving of Turkesterone 1200 from 5% Nutrition, you get the following:

  • Ajuga Extract (Ajuga turkestanica) (whole herb) – 1200 mg

    5% Nutrition Turkesterone 1200 Ingredients

    More than just a big dose of ajuga turkestanica extract, Turkesterone 1200 has added beta-ecdysterone and absorption enhancers!

    Turkesterone is one of the hottest anabolic supplements on the market right now. It belongs to a class of botanical compounds called phytoecdysteroids, which are responsible for coordinating plant growth, development, and reproduction. In humans, it’s used to…

    The term “turkesterone” is applied somewhat confusingly, though. Sometimes it refers to the whole-plant extract of the Ajuga turkestanica plant, which happens to contain a number of other phytoecdysteroids besides turkesterone.

    Other times, turkesterone refers to the specific phytoecdysteroid turkesterone.

    This kind of makes sense when you know that whole-plant extracts of A. turkestanica are usually standardized for turkesterone, which is marketed as the most important bioactive constituent of the plant.

    The many phytoecdysteroids of A. turkestanica

    Like the human anabolic hormone testosterone, phytoecdysteroids are also derived from cholesterol[1] and are similar to testosterone in their chemical structure.

    Turkesterone vs. Testosterone

    The molecular structures of Turkesterone and Testosterone… they look like relatives!

    As we discussed above, there are several phytoecdysteroids in the A. turkestanica plant, and some of them have been shown in the research literature to interfere with the action of estrogen by displacing the hormone from its receptors. This can have downstream anabolic effects[2,3] by improving the testosterone-to-estrogen ratio in your body.

    5% Nutrition Turkesterone 1200

    For example, one study from 2014 found that giving phytoecdysteroids to rats caused a drop in their estrogen blood levels.[3]

    Many phytoecdysteroids have a low affinity for androgen receptors[2,4] and don’t really interact with them at all, meaning that they probably won’t cause the downregulation of endogenous testosterone production associated with anabolic steroid use.

    The best example of a phytoecdysteroid that acts on the estrogen receptor is ecdysterone, which is currently the best researched of all the phytoecdysteroids.

    Turkesterone 1200 contains some pure ecdysterone and it also occurs naturally in A. turkestanica. So let’s get into how ecdysterone works, but remember this section for the next ingredient, because we’re going to get even more of it added below!

    Ecdysterone / 20HE

    Animal models on ecdysterone have shown that it can reduce blood estrogen levels while elevating blood insulin-like growth factor 1 (IGF-1) levels, which leads to greater muscle fiber size.[2,3] A research review published the late ’90s found that ecdysterone was significantly anabolic in rats,[5] as was turkesterone. The crazy thing about this article was that it showed ecdysterone and turkesterone outperforming mainstay anabolic steroids.[5]

    Ecdysterone is distinguished among the phytoecdysteroids by the large volume of human research that’s been done on it. One illustrative example of this research was a 2019 study involving German university students showing that ecdysterone was dose-dependently anabolic:

    Ecdysterone Strength

    Ecdysterone increased strength gains in collegiate male weightlifters[6]

    Ecdysterone Body Weight Muscle Mass

    Ecdysterone increased muscle mass gains in collegiate male weightlifters[6]

    So impressive were the findings of this study that in the conclusion, the authors suggest that ecdysterone should be banned from use in athletic competition by the World Anti-Doping Agency.[6] Notably, it’s an opinion held by other researchers too.[2]

    Turkesterone: not as well researched, but insane potential

    Rich Piana Limitless

    Be Limitless

    Impressive as ecdysterone is – and remember, it occurs naturally in the whole-plant extract of A. turkestanica – it’s possible that turkesterone may be even more powerfully anabolic.

    The only problem is that research on the phytoecdysteroid turkesterone remains limited. For a hint at its potential, we need to go back to 1998, which is when researchers at the Academy of Sciences of Uzbekistan administered a variety of anabolic agents to exercising rats in order to measure the effect of each one.

    The results of this study were mind-blowing: turkesterone caused greater muscle gain than methandrostenolone, also known as dbol.[7] Since dbol is one of the most powerful anabolic steroids in existence, this finding really puts turkesterone’s potential in perspective.

    Turkesterone vs. dbol

    The anabolic effects of turkesterone were greater than those of dbol in rats![7]

    Unfortunately, when it comes to turkesterone, that’s pretty much all the research we have to discuss. But given how incredibly well substantiated the effectiveness of ecdysterone has been, you can rest assured that your A. turkestanica extract is going to do work.

    The composition of A. turkestanica

    There are eight known phytoecdysteroids in A. turkestanica.[8] Ecdysterone and turkesterone are only two.

    It’s possible there may even be more than eight. Researchers believe that additional studies may allow for the isolation of additional bioactive compounds in A. turkestanica.[8]

  • Beta Ecdysterone – 200 mg

    Here, 5% Nutrition includes a little extra ecdysterone, presumably because of its impressive research record including ample human trials. The research is discussed above, and this is why we’re so excited about this supplement compared to much of the competition that has just standard ajuga turkestanica itself. With 5% Nutrition, we know we’re getting a sold dosage of ecdysterone – not just hoping for it!

    5% Nutirtion Turkesterone 1200 Bottles

    We think this is a great move, and it’s something we haven’t seen in any other turkesterone supplements. Looks like someone’s been reading our blog and taking our advice…

  • Hyper Transport & Absorption Matrix

    One of the problems with oral phytoecdysteroid supplements is that their bioavailability is quite low. It makes perfect sense, then, for 5% Nutrition to add some powerful bioavailability-enhancing ingredients to Turkesterone 1200.

    These ingredients, including Astragin, cyclodextrin, and naringin, can increase your body’s ability to digest, absorb, and utilize the primary ingredients of Turkesterone 1200, ensuring that you get the best value for your money.

    • AstraGin (Astragalus membranaceus & Panax notoginseng)(root) – 50 mg

      NuLiv Science AstraGin Ingredient Info

      Increase the absorption and effectiveness of your supplements with AstraGin from NuLiv Science!

      AstraGin increases bioavailability because it contains astragalosides and ginsenosides that increase adenosine triphosphate (ATP) production. In turn, that means there’s more energy available for your intestinal cells to use for doing the hard work of absorbing nutrients from the digestive tract.[9,10]

      AstraGin has been studied pretty extensively, and there over 20 published papers showing that it’s capable of increasing the absorption of amino acids, vitamins, and other nutrients.[11-16]

      One thing to note here is that 5% Nutrition uses a big dose of AstraGin. We typically see 12.5 or 25 milligrams in comparable supplements. Needless to say, a 50-milligram dose is pretty impressive.

    • Cyclodextrin – 30 mg

      Using cyclodextrin to increase bioavailability is something we haven’t seen before.

      5% Nutrition TEST

      5% Nutrition TEST is here on 5% Nutrition Day, and it brings booming doses of Longjack and Shilajit

      Turkesterone (the phytoecdysteroid) is fat soluble — not water soluble meaning it doesn’t easily dissolve in water.[17] In other words, it’s hydrophobic (“hates water”), as opposed to hydrophilic (“loves water”).

      Cyclodextrin can help increase the bioavailability of hydrophobic compounds by enclosing them inside a cyclodextrin ring, and since cyclodextrin itself is very hydrophilic, it can act as a kind of water-soluble envelope for hydrophobic compounds, increasing total bioavailability.

      There is research showing that cyclodextrin can massively increase the water solubility of ecdysterone, the other phytoecdysteroid we’ve discussed in this article. In fact, cyclodextrin-ecdysterone complexes are 100-times more water soluble than ecdysterone alone.[18] Well played, Team Piana!

    • Naringin (Citrus grandis)(fruit) – 20 mg

      Naringin is a flavonoid that occurs naturally in citrus fruits, most notably oranges. It has been identified as an herbal bioavailability enhancer,[19] and has been shown to increase the absorption of various drugs in rats, possibly because it antagonizes certain cytochrome P450 enzymes that are responsible for eliminating foreign compounds from the body.[20,21]

Dosage

5% Nutrition is actually pretty specific about this — Take 2 capsules daily with a high-protein meal! Take it at the same time each day.

If you do AM/PM dosing, you can split it up into 1 capsule each, but keep it with a solid protein source each time.

Conclusion: Turkesterone Turned UpThe

Turkesterone 1200 is probably the best entry into the turkesterone market that we’ve seen yet. It’s formulated to solve specific problems with phytoecdysteroid supplementation, like low oral bioavailability, and includes an extra dose of ecdysterone, the most studied and proven phytoecdysteroid.
5% Nutrition Turkesterone 1200 Benefits

It’s clear that 5% Nutrition went a bit above and beyond with this formula – there have been a few “me-too” turkesterone supplements to compete with, so they decided to step it up. While the competition’s formulas are doing well and giving great results, we love that 5% added extra ecdysterone and a few more absorption mechanisms above and beyond a large dose of AstraGin.

Our final comment is that this may feel extra good if you stack it with 5% Nutrition’s Test, which is a natural testosterone booster with some pretty legit dosages of well-researched ingredients. These two stacked together may not put you at Rich Piana’s “supraphysiological” levels, but their combination is quite powerful for being a full-on legal natty stack.

Rich Piana 5% Nutrition Turkesterone 1200 – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

References

  1. Das, Niranjan, et al. “The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review.” Acta Pharmaceutica Sinica B, vol. 11, no. 7, 1 July 2021, pp. 1740–1766; 10.1016/j.apsb.2020.10.012; https://www.sciencedirect.com/science/article/pii/S2211383520307644
  2. ‌Parr MK, Botrè F, Naß A, Hengevoss J, Diel P, Wolber G; “Ecdysteroids: A novel class of anabolic agents?” Biol Sport. 2015 Jun;32(2):169-73. doi: 10.5604/20831862.1144420; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4447764/
  3. Parr MK, Zhao P, Haupt O, Ngueu ST, Hengevoss J, Fritzemeier KH, Piechotta M, Schlörer N, Muhn P, Zheng WY, Xie MY, Diel P. “Estrogen receptor beta is involved in skeletal muscle hypertrophy induced by the phytoecdysteroid ecdysterone”; Mol Nutr Food Res. 2014 Sep;58(9):1861-72. doi: 10.1002/mnfr.201300806; https://pubmed.ncbi.nlm.nih.gov/24974955/
  4. Gorelick-Feldman, Jonathan, et al. “Phytoecdysteroids Increase Protein Synthesis in Skeletal Muscle Cells.” Journal of Agricultural and Food Chemistry, vol. 56, no. 10, May 2008, pp. 3532–3537, 10.1021/jf073059z; https://pubmed.ncbi.nlm.nih.gov/18444661/
  5. Syrov, V. N. “Comparative Experimental Investigation of the Anabolic Activity of Phytoecdysteroids and Steranabols.” Pharmaceutical Chemistry Journal, vol. 34, no. 4, Apr. 2000, pp. 193–197, 10.1007/bf02524596; https://link.springer.com/article/10.1007/BF02524596
  6. Isenmann, Eduard, et al. “Ecdysteroids as Non-Conventional Anabolic Agent: Performance Enhancement by Ecdysterone Supplementation in Humans.” Archives of Toxicology, vol. 93, no. 7, 23 May 2019, pp. 1807–1816, 10.1007/s00204-019-02490-x; https://link.springer.com/article/10.1007/s00204-019-02490-x
  7. Mamatkhanov, A. U., et al. “Isolation of Turkesterone from the Epigeal Part OfAjuga Turkestanica and Its Anabolic Activity.” Chemistry of Natural Compounds, vol. 34, no. 2, 1 Mar. 1998, pp. 150–154, 10.1007/BF02249133; https://link.springer.com/article/10.1007/BF02249133
  8. Guibout L, Mamadalieva N, Balducci C, Girault JP, Lafont R. The minor ecdysteroids from Ajuga turkestanica. Phytochem Anal. 2015 Sep-Oct;26(5):293-300. doi: 10.1002/pca.2563. Epub 2015 May 8; https://pubmed.ncbi.nlm.nih.gov/25953625/
  9. Kiela, Pawel R., and Fayez K. Ghishan. “Physiology of Intestinal Absorption and Secretion.” Best Practice & Research Clinical Gastroenterology, vol. 30, no. 2, Apr. 2016, pp. 145–159, 10.1016/j.bpg.2016.02.007. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956471
  10. Cooper, Geoffrey M. “Endocytosis.” Nih.gov, Sinauer Associates, 2014. https://www.ncbi.nlm.nih.gov/books/NBK9831/
  11. Lee, Shih-Yu, et al. “Astragaloside II Promotes Intestinal Epithelial Repair by Enhancing L-Arginine Uptake and Activating the MTOR Pathway.” Scientific Reports, vol. 7, no. 1, 26 Sept. 2017, p. 12302, 10.1038/s41598-017-12435-y. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614914/
  12. AstraGin product dossier, sections 6.4 – 6.17; https://docdro.id/rA01t9O
  13. AstraGin product dossier, section 6.9; https://docdro.id/rA01t9O
  14. AstraGin product dossier, sections 6.10; https://docdro.id/rA01t9O
  15. AstraGin product dossier, section 6.11 – 6.12; https://docdro.id/rA01t9O
  16. AstraGin product dossier, sections 6.13; https://docdro.id/rA01t9O
  17. “CAS 41451-87-0 Turkesterone – BOC Sciences.” Www.bocsci.com, www.bocsci.com/product/turkesterone-cas-41451-87-0-92080.html. Accessed 28 June 2022.
  18. Temirgaziyev BS, Kučáková K, Baizhigit YA, Jurášek M, Džubák P, Hajdúch M, Dolenský B, Drašar PB, Tuleuov BI, Adekenov SM. Bioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins. Steroids. 2019 Jul;147:37-41. doi: 10.1016/j.steroids.2018.11.007; https://www.sciencedirect.com/science/article/abs/pii/S0039128X18302113?via%3Dihub
  19. Kesarwani, Kritika et al. “Bioavailability enhancers of herbal origin: an overview.” Asian Pacific journal of tropical biomedicine vol. 3,4 (2013): 253-66. doi:10.1016/S2221-1691(13)60060-X; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634921/
  20. ‌Zhang H, Wong CW, Coville PF, Wanwimolruk S. Effect of the grapefruit flavonoid naringin on pharmacokinetics of quinine in rats. Drug Metabol Drug Interact. 2000;17(1-4):351-63. doi: 10.1515/dmdi.2000.17.1-4.351; https://pubmed.ncbi.nlm.nih.gov/11201303/
  21. Lim SC, Choi JS. Effects of naringin on the pharmacokinetics of intravenous paclitaxel in rats. Biopharm Drug Dispos. 2006 Dec;27(9):443-7. doi: 10.1002/bdd.523; https://onlinelibrary.wiley.com/doi/10.1002/bdd.523