5% Nutrition Core L-Citrulline 3000: Citrulline with a Hit of Glycerol

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Most bodybuilding enthusiasts have heard of legendary bodybuilder Rich Piana. And most readers here know that he founded his own nutritional supplement company. He named it 5% Nutrition, as an allusion to his belief that only 5% of people on the planet have the grit, determination, and talent to achieve their highest potential and become the best possible version of themselves.

Rich founded his company to serve this 5% by creating premium supplements that support their mental and physical performance while in pursuit of their goals.

5% Nutrition Core L-Citrulline 3000

5% Nutrition’s Core L-Citrulline 3000 has more than just citrulline – in true Rich Piana fashion, they’ve added some extra glycerol for water pumps too!

And Rich always knew that a little extra nitric oxide pump was a great thing to have – even in non-workout situations!

The 5% Take on Citrulline: No Nonsense

5% Core L-Citrulline 3000 is a no nonsense, back-to-basics approach to achieving added pumps – or slightly lowered blood pressure, which can be useful in many situations.

Citrulline is one of the most trusted and effective pump-inducing ingredients on the supplement market today, and is also incredibly safe, even in large doses. This means we can add more to your current stack, anytime, anywhere.

But 5% went further – as with most of the rest of the 5% Core Line, they don’t just go with single ingredients! Here, they’ve added a hit of glycerol to increase cellular hydration while at it.

The strength of a product like 5% Core L-Citrulline 3000 is not just that you can easily double or triple scoop it if you desire a bigger effect: you can also easily combine it with other products just to up the citrulline and glycerol as needed.

Rich Piana 5% Nutrition Core L-Citrulline 3000 – Deals and Price Drop Alerts

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5% Nutrition Core L-Citrulline 3000 Ingredients

In a single 1-scoop (3.9 g) serving of Core L-Citrulline 3000 from 5% Nutrition, you get the following:

  • L-Citrulline – 3,000 mg

    5% Nutrition Core L-Citrulline 3000 Ingredients

    The amino acid L-citrulline is popular as a nitric-oxide (NO) boosting ingredient[1] — as popular as they come, in fact.

    Citrulline is considered conditionally essential, meaning that although your body is capable of synthesizing its own citrulline endogenously, it can’t produce it fast enough to cover your nutritional citrulline requirements during periods of elevated consumption, such as illness or injury.

    Between citrulline and NO, there’s actually an intermediate step: citrulline is converted into arginine, which is then converted to NO.**

    We like NO boosters because increasing NO production causes vasodilation, a phenomenon where blood vessels grow in diameter and facilitates better circulation. Not only does blood perfuse your tissues more deeply, but your heart and arteries don’t have to work as hard – heart rate and blood pressure drop in response to NO-mediated vasodilation.[2-4]

    One upshot of all this is that oxygen and nutrients are delivered to your tissues – including muscles – more efficiently. And metabolic waste products are also cleared out more efficiently. This helps you perform better athletically. Endurance, particularly, seems to benefit from increased NO production.

    And when your workout ends, you can recover from it faster.

    Rich Piana Pumps

    There’s pumps, and there’s Rich Piana pumps

    The evidence shows that citrulline can:

    • Increase power by increasing oxygen uptake[5]
    • Prolong athletic endurance by as much as 50%[6]
    • Reduce delayed onset muscle soreness (DOMS) after exercise by about 50%[6]
    • Increase growth hormone (GH) production after exercise[7]
    • Reduce amino acid catabolism[8]
    • Activate muscle protein synthesis[9,10]

    Finally, supplementing with citrulline increases your body’s levels of ornithine,[11] an amino acid that detoxifies ammonia.[12] Since ammonia levels are a major factor in both mental and physical fatigue, this is one explanation for citrulline’s endurance-boosting effects.

    Ornithine’s impact on metabolic function can even improve sleep quality and reduce perceived stress in those who take it, partly by decreasing cortisol-to-DHEA ratio.[12]

    Rich Piana Positivity

    Stay positive, Rich Piana and 5% Nutrition are here to get you to the moon!

    The minimum effective dose of citrulline has been measured at 3,000 milligrams, so that’s why 5% Nutrition has selected that dose as the baseline for Core L-Citrulline 3000.

    However, note that this product has 60 servings per container – you could double your intake daily and still have a month’s supply from one container.

    In fact, the point of diminishing returns on citrulline supplementation is as high as 10,000 milligrams per day![13] So if you want an even better pump than what the standard 3-gram dose provides, try double, or even triple-scooping.

    One of the reasons we love the simplicity of this formula is that it allows consumers to choose their own citrulline dose. When you stack citrulline with stimulants like caffeine, rauwolscine, or yohimbine, it limits how much you can take in a day. Core L-Citrulline 3000 doesn’t have that problem.

    **The reason you supplement with citrulline instead of arginine is that citrulline is orally bioavailable, whereas arginine is not.[14,15]

  • Glycerol Powder (65% Glycerol)(GlycerSize) – 500 mg

    Glycerol is a sugar-alcohol byproduct produced when the body burns burns glucose and fatty acids for energy.[16,17]

    It’s important for hepatic gluconeogenesis,[18] the process the liver uses to convert non-glucose substrates like protein into glucose.

    Glycerol

    No doubt, the simple glycerol molecule has “mission critical” status with the body. But when we supplement far more, incredible benefits related to hydration occur!

    Oral glycerol supplements are metabolized by the liver and kidneys before they’re distributed to every part of the body. However, your brain and eyes are exempt from this process and unaffected by glycerol supplementation.[19]

    Glycerol works by increasing the osmotic pressure in your tissues, which naturally forces water into cells.[19]

    Recall that osmosis is the mechanism that moves water from an area of higher solute concentration to one of lower solute concentration, typically across a membrane (in this case, the cellular membrane).[20]

    The benefits of hyperhydration: Increased endurance

    This higher-than-usual cellular water content creates a state called cellular hyperhydration,[21] which comes with a number of benefits.

    Chief among them is increased endurance for your cells, including muscle cells. During exercise, this effect is significant enough to actually delay the onset of whole-body fatigue.[19]

An unflavored supplement

Normally, we’re huge fans of 5% Nutrition’s flavoring – and that’s why we’re not flavored here. Core L-Citrulline 3000 is meant to be added to your existing supplement to get an even more powerful boost. If you’re already taking a Rich Piana pre-workout supplement (Kill It Reloaded is our general go-to), you already have great flavoring, so just add this in.

Not just for pre-workout!

5% Nutrition Kill It Reloaded Cosmic Candy

Need even more citrulline in Kill It Reloaded? You’re at the right place

But as we said in the intro, there are other reasons you’d want to improve nitric oxide levels. For instance, adding Core L-Citrulline 3000 to your Sleep Drink Grow sleep aid could theoretically help lower blood pressure and improve sleep.[22,23] Reason being, nitric oxide plays a key role in sleep governance.[23]

Additionally, the glycerol may help you retain more urine! You can read more about this in our article titled Urination at Night?! Add GLYCEROL to Your Sleep Aid!, which cites a few studies where athletes taking glycerol urinated less.

Getting back to athletics, another idea is to simply add it to your ALL DAY YOU MAY intra workout supplement to keep those pumps coming long into your Rich Piana style all day arm workout. There’s really never a time when some citrulline’s a bad idea!

Conclusion: Citrulline and a bit more

Supplement manufacturers try to outdo each other, a kind of pump arms race (no pun intended) has escalated. It’s gotten to the point where, most of the time, you see ingredients like citrulline and glycerol stacked with so many other ingredients that something in the formula limits how much of the product you can take.

For example, you might see these two in a pre-workout containing 300 milligrams of caffeine, which is most people’s upper limit. Very few people can comfortably take more than 300 milligrams of caffeine at once.

So in this hypothetical product, you’re really limited to consuming a single serving, or less.

There’s not much more to say about this one – citrulline and glycerol are both awesome ingredients, ones that we would recommend to almost anybody because they just work.

Stacking them in a no-frills, two-ingredient formula creates a great, no-BS product that most supplement consumers will reach for again and again.

5% Nutrition Core L-Citrulline 3000

A full look 5% Nutrition Core L-Citrulline 3000

Rich Piana 5% Nutrition Core L-Citrulline 3000 – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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References

  1. Morita, Masahiko, et al; “Oral Supplementation with a Combination of L-Citrulline and L-Arginine Rapidly Increases Plasma L-Arginine Concentration and Enhances NO Bioavailability.”; Biochemical and Biophysical Research Communications; U.S. National Library of Medicine; 7 Nov. 2014; https://www.ncbi.nlm.nih.gov/pubmed/25445598
  2. Orozco-Gutiérrez JJ, Castillo-Martínez L, Orea-Tejeda A, Vázquez-Díaz O, Valdespino-Trejo A, Narváez-David R, Keirns-Davis C, Carrasco-Ortiz O, Navarro-Navarro A, Sánchez-Santillán R. Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction. Cardiol J. 2010;17(6):612-8. PMID: 21154265. https://journals.viamedica.pl/cardiology_journal
  3. Wong A, Alvarez-Alvarado S, Jaime SJ, Kinsey AW, Spicer MT, Madzima TA, Figueroa A. Combined whole-body vibration training and l-citrulline supplementation improves pressure wave reflection in obese postmenopausal women. Appl Physiol Nutr Metab. 2016 Mar;41(3):292-7. doi: 10.1139/apnm-2015-0465; https://cdnsciencepub.com/doi/10.1139/apnm-2015-0465
  4. Alsop P, Hauton D. Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure. Eur J Appl Physiol. 2016 Sep;116(9):1651-61. doi: 10.1007/s00421-016-3418-7; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983290/
  5. Bailey, Stephen J, et al; “l-Citrulline Supplementation Improves O2 Uptake Kinetics and High-Intensity Exercise Performance in Humans.”; Journal of Applied Physiology (Bethesda, Md. : 1985); U.S. National Library of Medicine; 15 Aug. 2015; https://www.ncbi.nlm.nih.gov/pubmed/26023227
  6. Pérez-Guisado, Joaquín, and Philip M Jakeman; “Citrulline Malate Enhances Athletic Anaerobic Performance and Relieves Muscle Soreness.”; Journal of Strength and Conditioning Research; U.S. National Library of Medicine; May 2010; https://www.ncbi.nlm.nih.gov/pubmed/20386132
  7. Sureda A, Córdova A, Ferrer MD, Pérez G, Tur JA, Pons A. L-citrulline-malate influence over branched chain amino acid utilization during exercise. Eur J Appl Physiol. 2010 Sep;110(2):341-51. doi: 10.1007/s00421-010-1509-4; https://link.springer.com/article/10.1007/s00421-010-1509-4
  8. Breuillard C, Cynober L, Moinard C. Citrulline and nitrogen homeostasis: an overview. Amino Acids. 2015 Apr;47(4):685-91. doi: 10.1007/s00726-015-1932-2; https://link.springer.com/article/10.1007/s00726-015-1932-2
  9. Jourdan M, Nair KS, Carter RE, Schimke J, Ford GC, Marc J, Aussel C, Cynober L. Citrulline stimulates muscle protein synthesis in the post-absorptive state in healthy people fed a low-protein diet – A pilot study. Clin Nutr. 2015 Jun;34(3):449-56. doi: 10.1016/j.clnu.2014.04.019; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309748/
  10. Bahri S, Zerrouk N, Aussel C, Moinard C, Crenn P, Curis E, Chaumeil JC, Cynober L, Sfar S. Citrulline: from metabolism to therapeutic use. Nutrition. 2013 Mar;29(3):479-84. doi: 10.1016/j.nut.2012.07.002; https://www.sciencedirect.com/science/article/abs/pii/S0899900712002584?via%3Dihub
  11. Agarwal, Umang, et al. “Supplemental Citrulline Is More Efficient than Arginine in Increasing Systemic Arginine Availability in Mice123.” The Journal of Nutrition, vol. 147, no. 4, 1 Apr. 2017, pp. 596–602; 10.3945/jn.116.240382; https://academic.oup.com/jn/article/147/4/596/4584706
  12. Miyake, Mika, et al. “Randomised Controlled Trial of the Effects of L-Ornithine on Stress Markers and Sleep Quality in Healthy Workers.” Nutrition Journal, vol. 13, no. 1, 3 June 2014, 10.1186/1475-2891-13-53; https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-53
  13. Allerton, Timothy D et al. “l-Citrulline Supplementation: Impact on Cardiometabolic Health.” Nutrients vol. 10,7 921. 19 Jul. 2018, doi:10.3390/nu10070921; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073798/
  14. Ochiai, Masayuki, et al; “Short-Term Effects of L-Citrulline Supplementation on Arterial Stiffness in Middle-Aged Men.”; International Journal of Cardiology; U.S. National Library of Medicine; 8 Mar. 2012; https://www.ncbi.nlm.nih.gov/pubmed/21067832
  15. Agarwal, Umang et al; “Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice.”; The Journal of nutrition; vol. 147,4; 2017; 596-602; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368575/
  16. Simon P Van Rosendal, Mark A Osborne, Robert G Fassett, Jeff S Coombes; “Physiological and performance effects of glycerol hyperhydration and rehydration”; Nutrition Reviews, Volume 67, Issue 12, 1 December 2009, Pages 690–705, https://doi.org/10.1111/j.1753-4887.2009.00254.x; https://academic.oup.com/nutritionreviews/article/67/12/690/1938382
  17. Baba, H et al; “Glycerol gluconeogenesis in fasting humans.”; Nutrition (Burbank, Los Angeles County, Calif.); vol. 11,2; 1995; 149-53; https://pubmed.ncbi.nlm.nih.gov/7647479/
  18. Ross, B D et al; “The rate of gluconeogenesis from various precursors in the perfused rat liver.”; The Biochemical journal; vol. 102,3; 1967; 942-51; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1270348/
  19. Patlar, Suleyman et al; “The effect of glycerol supplements on aerobic and anaerobic performance of athletes and sedentary subjects.”; Journal of human kinetics; vol. 34; 2012; 69-79; doi:10.2478/v10078-012-0065-x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590833/
  20. Rye, Connie, et al; “22.1. Osmoregulation and Osmotic Balance.”; Concepts of Biology 1st Canadian Edition; BCcampus; 1 May 2019; https://opentextbc.ca/biology/chapter/22-1-osmoregulation-and-osmotic-balance/
  21. Robergs, R A, and S E Griffin; “Glycerol. Biochemistry, pharmacokinetics and clinical and practical applications.”; Sports medicine (Auckland, N.Z.); vol. 26,3; 1998; 145-67; doi:10.2165/00007256-199826030-00002; https://www.ncbi.nlm.nih.gov/pubmed/9802172/
  22. Gautier-Sauvigné, Sabine, et al. “Nitric Oxide and Sleep.” Sleep Medicine Reviews, vol. 9, no. 2, 1 Apr. 2005, pp. 101–113, 10.1016/j.smrv.2004.07.004; https://pubmed.ncbi.nlm.nih.gov/15737789/
  23. Cespuglio, Raymond, et al. “Nitric Oxide in the Regulation of the Sleep-Wake States.” Sleep Medicine Reviews, vol. 16, no. 3, June 2012, pp. 265–279, 10.1016/j.smrv.2012.01.006; https://pubmed.ncbi.nlm.nih.gov/22406306/

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