Prime Intra-MD – Is it Worth the Hype?

Prime Intra-MD

It’s the Mountain Dog’s first formula with Prime, and whoa is it a doozy. But are the Highly Branched Cyclic Dextrins worth the extra cost?

Prime Nutrition and world-renowned coach John Meadows have joined forces to unleash the ultimate intra-workout formula, Prime Intra-MD.

Specifically formulated for those that train to the max, Intra-MD is the answer for faster recovery and less soreness. Combining fast-acting carbs and a blend of BCAAs & EAAs ensures you can train to the absolute MAX everyday!

Intra-MD’s Benefits

Like most intra workout supplements that you take during your training, Intra-MD should help with the following:

  • Increased Recovery[6,10,17,19]
  • Reduced Soreness[1,2,3,10,19]
  • Cell Volumization[23,24,25]
  • Improved Stamina [1,2,3,10]
  • Support Muscle Protein Synthesis[4,5,13]

The biggest question, though, is whether or not this is really worth the hype.

To answer that, it’s really going to come down to the biggest difference-maker in this formula – the carbohydrate. Sure, we love the open formula and the massive amount of amino acids, but that’s in a lot of intra workout formulas.

The carb, though, is the question. It’s indeed extremely fast-digesting and fast-absorbing, which is exactly what users want. So that’s the first one we get into.

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Prime Intra-MD Ingredients

Keeping with Prime’s commitment to completely open and non-proprietary labels, it’s easy to get into the nitty-gritty with each ingredient, but again will come down to the first one and the most important one:

  • Highly Branched Cyclic Dextrin (HBCD)

    John Meadows

    The man behind Mountain Dog Training and Intra-MD, John Meadows

    We all know that carbs fuel performance and creating an insulin spike is a great way to shuttle nutrients into muscle cell. The tried and true answer was simple carbs, i.e. dextrose. The problem with dextrose is that it has a high osmolality which delays gastric emptying (and subsequently absorption) by the small intestines.

    Enter the answer to your prayers in the form of HBCD, short for highly branched cyclic dextrin.

    Formed by the breakdown of amylopectin, a low osmolality, high molecular weight molecule is formed. Once this branched dextrin cluster hits the stomach it passes through the stomach[1] — not at “warp speed” but “ludicrous speed!”

    This is exactly what you want in an intra-workout supplement. In and out of the stomach quickly to be absorbed by the small intestine, in conjunction with the amino acids in Intra-MD, will allow you to push through the extra sets and not have to worry about the dreaded DOMS.[2,3]

  • BCAAs & EAAs

    No intra-workout formula is any good without a serious dose of these.

    Quick intro for beginners

    The three Branched-Chain Amino Acids

    Leucine, Valine, and Isoleucine are the three BCAAs, and they’re an extremely important part of your diet

    If you’re new to all of this, note that BCAA stands for Branched Chain Amino Acid and EAA stands for Essential Amino Acid.

    There are nine essential amino acids, and they’re “essential” because the body does not produce them itself – you need to get them in through diet or supplementation or some physical processes in your body will significantly suffer.

    The three BCAAs (listed first below) are part of the nine essential aminos.

    • Prime Intra-MD Ingredients

      The Prime Intra-MD Ingredients

      L-Leucine (2.5g)

      Leucine, the most studied of the 3 BCAAs, acts as the mTOR pathway in the body which stimulates muscle protein synthesis and can also stimulate insulin secretion.[13]

      This itself is a better dose than most intra workouts contain… and there’s a lot more coming:

    • L-Valine (1.5g)

      Although not studied to the level of leucine, Valine (also a BCAA) does provide a similar effect to its better known counterpart in its ability to promote glycogen synthesis within muscle cells and has been found to cause insulin secretion by the pancreas. [14,16]

    • L-Isoleucine (1g)

      Leucine’s weaker relative, Isoleucine’s main benefit lies in its ability to generate glucose uptake in the body and its utilization during intense bouts of exercise.[14,15] It is the last of the three BCAAs

    • L-Glycine (2g)

      Abundantly available in most high-protein foods, glycine is the simplest of the 20 amino acids, but provides a host of benefits for the body in terms of creating muscle tissue, converting glucose into energy, and boosting creatine levels in the body.[22]

    • Taurine (2g)

      Another of the conditionally essential amino acids, taurine acts synergistically with glycine and BCAAs to reduce muscle soreness.[18]

    • L-Glutamine (1g)

      When consumed in the presence of carbohydrates, as is the case with Intra-MD, glutamine increases the rate of glycogen replenishment allowing you to continue to train longer than you previously did.[17]

    • L-Methionine (1g)

      Prime Intra-MD Review

      Prime Nutrition Athlete Darron Glenn (@ifbbdarronglenn) shows his beast mode

      A precursor to L-Taurine and L-Cysteine, Methionine acts as an antioxidant in the body and helps prevent the proliferation of free radicals and oxidative damage onset by bouts of intensive training.

    • DL-Phenylalanine (500mg)

      DL-Phenylalanine is first converted to Tyrosine and then later converted into epinephrine, norepinephrine, and L-Dopa (3 big neurotransmitters in the body) which will lead to an increase in mood and energy.[18]

    • L-Threonine (500mg)

      Threonine is required for the production of glycine and serine to stimulate muscle protein synthesis in the body

    • L-Tryptophan (100mg)

      Tryptophan has been shown to increase pain tolerance levels as well as improve overall mood when added to the diet

  • Citrulline Malate (2g)

    L-citrulline is converted to L-Arginine in the body and acts as a nitric oxide booster (think PUMPS!!). It has been show to reduce soreness and fatigue while increasing training capacity. [10,11]

    Effective dosages of citrulline malate need to be at least 6g; however, being that this is an intra-workout supplement, stacking with a pre-workout that contains at least some other form of citrulline should have you covered pretty well.

  • Electrolytes

    • Magnesium (20 mg)
    • Sodium (350 mg)

    We’ve long known the benefits electrolytes play since we saw our first Gatorade commercial when we were kids. Electrolytes are critical to maintaining proper hydration levels in the body and making sure the muscles continue to fire on all cylinders during prolonged exercise. Combined with the enhanced gastric emptying brought about by HBCD, the electrolytes in Intra-MD will be absorbed faster into the body to allow you to keep pushing the weights around.

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Available Flavors

So far in early 2015… (see the PricePlow widgets above and below to have an updated list)

  • Orange Carnage
  • Grape Titan

Recommended Dosage:

As prescribed by the Mountain Dog himself, start with 1 scoop mixed in 32 oz. of water (or beverage of your choosing) 10 minutes before training, and sip throughout your workout.

Depending on your recovery, the next day you may need to increase to 1.5 – 2 scoops if you have any residual soreness from the prior day’s thrashing of the weight room.

For those “extreme” training days (think LEGS!!!), you will need to 2 scoops and 16 oz. more of water. To ensure optimal recovery, finish consuming Intra-MD 5 minutes before completing your workout.

The general consensus

Prime Nutrition Intra-MD

Not gonna lie… Prime’s got some seriously good looking athletes on their Facebook feed

Overall, Intra-MD appears to be an extremely solid intra-workout supplement to add to your workouts if you are the type of person who likes to grind out 1.5 – 2 hour gyms sessions.

Seeing as it’s relatively new to the market, the jury is still out on whether this is the be-all, end-all intra-workout supplement it’s touted to be but initial reviews have been quite positive.

Recent reviews?

The reviews from trusted sources have backed up the claims – something does feel different here, and it’s nearly immediate. This makes us think that for once, the carb is doing what it’s claimed to do.

We won’t BS you – if you’re on a crazy strict budget, this isn’t the first thing you want to buy. Eat some dextrose and go easy on your wallet.

But if you’re really getting after it or want to get past a plateau… and you have the extra cash to try, it looks worth a shot. We’ve seen far far worse formulas that aren’t open like this one, and cost a whole lot more.

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Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer on your own.

Posts are sponsored in part by the retailers and/or brands listed on this page.

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References

  1. Takli H, et al. Fluids containing a highly branched cyclic dextrin influence the gastric emptying rate. Int J Sport Med. (2005)
  2. Hiroshi T, et al. Enhancement of Swimming Endurance in Mice by Highly Branched Cyclic Dextrin. Bioscience, Biotechnology, and Biochemistry, Vol. 63, Issue 12 (1999)
  3. Takashi F, et al. Effects of ingesting highly branched cyclic dextrin during endurance exercise on rating of perceived exertion and blood components associated with energy metabolism. Bioscience, Biotechnology, and Biochemistry, Vol. 78, Issue 12 (2014)
  4. Drummond MJ, et al. Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis. J Physiol. (2009)
  5. Consuming a supplement containing branched-chain amino acids during a resistance-training program increases lean mass, muscle strength and fat loss
  6. Shimomura Y, et al. Branched-chain amino acid supplementation before squat exercise and delayed-onset muscle soreness. Int J Sport Nutr Exerc Metab. (2010)
  7. Ispoglou T, et al. Daily L-leucine supplementation in novice trainees during a 12-week weight training program. Int J Sports Physiol Perform. (2011)
  8. Portier H, et al. Effects of branched-chain amino acids supplementation on physiological and psychological performance during an offshore sailing race. Eur J Appl Physiol. (2008)
  9. Bigard AX, et al. Branched-chain amino acid supplementation during repeated prolonged skiing exercises at altitude. Int J Sport Nutr. (1996)
  10. Perez-Guisado; Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.; Department of Medicine, University of Córdoba; 2010
  11. Hickner, R; L-citrulline reduces time to exhaustion and insulin response to a graded exercise test.; Human Performance Laboratory, East Carolina University; 2006
  12. Hankard RG, et al. Effect of glutamine on leucine metabolism in humans. American Journal of Physiology (Oct 1996)
  13. Newsholme P, et al. New insights into amino acid metabolism, beta-cell function and diabetes. Clin Sci (Lond). (2005)
  14. Doi M, et al. Isoleucine, a potent plasma glucose-lowering amino acid, stimulates glucose uptake in C2C12 myotubes. Biochem Biophys Res Commun. (2003)
  15. Kleinert M, et al. An amino acid mixture enhances insulin-stimulated glucose uptake in isolated rat epitrochlearis muscle. J Appl Physiol. (2011)
  16. Fasching P, et al. Insulin production following intravenous glucose, arginine, and valine: different pattern in patients with impaired glucose tolerance and non-insulin-dependent diabetes mellitus. Metabolism. (1994)
  17. Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise
  18. http://www.med.nyu.edu/content?ChunkIID=21664#P4
  19. Ra SG, et al. Additional effects of taurine on the benefits of BCAA intake for the delayed-onset muscle soreness and muscle damage induced by high-intensity eccentric exercise. Adv Exp Med Biol. (2013)
  20. Seltzer S, et al. Alteration of human pain thresholds by nutrional manipulation and l-tryptophan supplementation. Pain (1982)
  21. http://www.vitaminstuff.com/amino-acid-threonine.html
  22. http://www.vitaminstuff.com/amino-acid-glycine.html
  23. Maughan RJ, et al. Recovery from prolonged exercise: restoration of water and electrolyte imbalance. J Sport Sci (1997)
  24. Rehrer NJ, et al. Fluid and electrolyte imbalance in ultra-endurance sport. Sport Med (2001)
  25. Silva AC, et al. Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. J Pediatr Gastroenterol Nutr. (1998)
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