NutraBio MultiSport Men’s Formula Revitalized with Better B Vitamins!

When debating the top brands in the supplement industry, one would be remiss to neglect NutraBio. First launching in 1996 behind their forward-thinking leader, Mark Glazier, NutraBio can be consistently found at the forefront of the industry. If you’ve been following along with PricePlow over the past few years, you’ve no doubt seen content focused on them – with a massive product profile, high-quality formulas, third party testing, and incredibly transparent manufacturing practices (check out our exclusive tour of their facilities for more information on this one!), NutraBio truly embodies the best qualities that shape sports nutrition.

NutraBio MultiSport

The best just got better! NutraBio has switched their Vitamin B6 and B2 to more Bioavailable Forms!

We’ve talked about the brand a ton in 2019, as evidenced on our NutraBio News page. But this small but incredibly important update shouldn’t go unnoticed:

NutraBio tweaks their multivitamin formulas

NutraBio has recently reconfigured their loaded multivitamins, MultiSport Men’s and Women’s Formulas, in the light of relatively new research grabbing their attention. The MultiSport series is a comprehensive, high-quality multivitamin built for maintaining good health, packed full of all the vitamins and minerals that keep the active body going.

The formula has been revitalized, as it now utilizes more bioavailable forms of vitamins B2 and B6, replacing the forms previously used. We all know how important a good multivitamin is, and with this upgrade, NutraBio is ensuring that MultiSport remains one of the top options available!

In this post, we will provide a brief overview of the ingredients in MultiSport, though we’ll spend most of our time discussing MultiSport’s upgrade and what it could possibly mean for the multivitamin market as a whole.

Before we jump into that, make sure you’re all caught up with PricePlow. We scour the web for awesome supplement deals, while also covering what’s what in terms of supplement news, reviews, and interviews!

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MultiSport – using base coenzymes for optimal uptake

NutraBio Multi Sport Benefits

NutraBio Multi Sport Benefits and Features. Wait until you see the changes below!

The formula of any good multivitamin is lead by the four fat-soluble vitamins – vitamin A, vitamin D, vitamin E, and vitamin K – and the two water-soluble vitamins – vitamin C and the B complex. These essential vitamins help facilitate countless bodily processes, all of which help keep things running smoothly. While one can get most of them from various foods, we often look to multivitamins to help supplement our daily intake – some doses get us our daily values immediately, while others simply make up a portion of it.

  • Potential toxicity of supplemental B6 as Pyridoxine

    Vitamin B6, in particular, is one of the eight vitamins that make up the B complex. It operates in ways similar to that of the other B vitamins – it helps fuel the metabolism, converting glucose to glycogen for energy. It works as a coenzyme, working with enzymes within the body in order to carry out their functions.

    Due to its importance, it’s virtually always included in multivitamins (as well as numerous energy drinks) in one of two main supplemental formspyridoxine and pyridoxal. Pyridoxine is the form of B6 most commonly found in fruits and vegetables,[1] while pyridoxal is found mainly in animal-based foods.

    Vitamin B6 Pyridoxine Cell Death

    What’s the deal with Pyridoxine causing all of that cell death?! It’s probably best not to supplement it. In this chart, higher is WORSE![4]

    That being said, it seems that the body has issues properly processing the plant form that is so often used. The preferred form of vitamin B6 within the body is pyridoxal-5’-phosphate (PLP or P5P), which is readily dephosphorylated and absorbed.[2] When dealing with pyridoxine or pyridoxal, the body can absorb it, though it’s not nearly as bioavailable as P5P.

    There’s potential hazard with supplemental pyridoxine. While no adverse effects have been caused by food-derived and animal-derived B6, the same cannot be said for its most popular supplemental form. Research has found that oversaturation of supplemented B6 from pyridoxine can cause severe sensory neuropathy.[3] Why? Well, according to research from 2017, supplemental B6 from pyridoxine actually inhibits B6-dependent enzymes within the body, while also competitively limiting PLP absorption![4]

    You read that right – taking this form of B6 actually reduces your body’s ability to utilize B6!!

    Taking the cheaper, supplemented forms not only causes issues when taken in excess, but it practically fights against any other B6 ingestion whatsoever. That’s both counterproductive and dangerous, which raises the question – how does one go about fixing this, aside from throwing all of those energy drinks in the trash?!

    Pyridoxal-5’-phosphate for the win!

    The answer is simple – use the natural stuff! Research has not yet found any dangers in P5P ingestion, and it has shown that it’s simply the body’s preferred form of B6. In fact, P5P is what the body uses to yield the effects of vitamin B6 – energy conversion,[5], metabolic functioning,[5] and neurotransmitter signaling.[5] By ingesting P5P, either naturally or in a multivitamin, you’re providing the body the most readily-available form of B6 there is, which its puts to work very quickly!

    Vitamin B6 Metabolism

    Vitamin B6 Metabolism[4]

    Sounds obvious, right? Try telling that to a portion of manufacturers and formulators in the supplement industry.

    Most multivitamins don’t use P5P!

    Whether its due to simply not knowing or purposeful neglect, most brands don’t use P5P in their multivitamins! Instead, most formulas contain some form of pyridoxine, which, as research has shown, is not only ineffective, but counterproductive! It’s essentially a net-negative dose – it doesn’t provide any benefit and fights actual B6 for attention. Not only that, but in cases where an individual is loading up on B6, it can become dangerous, too.

  • The same goes for B2, too!

    NutraBio MultiSport Women's

    NutraBio MultiSport Women’s Formula also got the same changes!

    Most of what’s been said in regards to P5P goes for vitamin B2, which is more commonly referred to as riboflavin. The most bioavailable form of riboflavin is riboflavin-5’-phosphate, which makes up about 90% of most supplemented riboflavin listings.[6] While its important to note that research has not found adverse effects due to excess B2 intake, riboflavin is still subject to the same issue central to supplemental B6.

    Most multivitamins simply list “riboflavin” as its B2 source, and though that’s not necessarily a major issue, it’s not optimal. Simple riboflavin is not the most bioavailable form of B2 – riboflavin-5’-phosphate is.[7] Though most dosages are such that you’re still getting enough B2, the truth is that riboflavin is a suboptimal ingredient, and a multivitamin would be better served using riboflavin-5’-phosphate instead!

MultiSport Ingredients

In addition to more bioavailable B2 and B6, MultiSport throws 33 other ingredients your way, delivering an encompassing supply of vitamins and minerals the body needs. Here’s a brief overview of what MultiSport has to offer:

NutraBio MultiSport Men's Formula

The New MultiSport Men’s Formula

NutraBio MultiSport Women's Formula

The New MultiSport Women’s Formula

  • Fat-soluble vitamins – vitamin A, vitamin D, vitamin E, vitamin K, each dosed well above its respective daily value. These vitamins support the immune system, fight free radicals, regulate blood health, and maintain skin and eye health.
  • Water-soluble vitamins – vitamin C and vitamin B complex (thiamine, riboflavin-5’-phosphate, niacin, pantothenic acid, pyridoxal-5’-phosphate, biotin, folate, and B12). While used for various purposes, these vitamins are generally associated with immune health and metabolic functioning, respectively.
  • Calcium, potassium, and phosphorus, supplied through the powerful patented ingredient Calci-KⓇ.
  • Iron – helps maintain proper blood health, specifically by helping the body produce hemoglobin.
  • Iodine – incredibly important for thyroid health and metabolic functioning, but often an afterthought these days!
  • Magnesium, zinc, copper, manganese, chromium, molybdenum, boron, vanadium – MultiSport uses TRAACSⓇ patented ingredients to deliver these necessary, multi-faceted trace minerals.
  • Selenium – helps support hormonal function, while also fighting off free radicals.
NutraBio MultiSport Men's

NutraBio MultiSport Men’s: Ready for 2020

While the dosing of these ingredients varies, each one has been methodically evaluated by the brains over at NutraBio. Some of the ingredients that are below their DVs, such as iron and phosphorus, can be easily consumed with a proper diet (and are best not to overconsume). Others, like magnesium, simply require more space than is reasonable with a serving size that is already four capsules.

Either way, the MultiSport products give you the things you need, whether that means supplying the entire daily value to prevent deficiency or simply giving you a mineral head start!

Some extra ingredients, too!

That’s not all MultiSport brings to the table, however! NutraBio is, at its core, a sports supplement brand, having expanded their product profile into general health in recent years. This gives them a bifurcated knowledge of supplementation – they know what works in terms of fitness, but they also know what works for overall health, as well.

They’ve used that knowledge to inject a bit of uniqueness into MultiSport – in addition to essential vitamins and minerals, they’ve included a couple of ingredients that the inner-fitness enthusiast in all of us appreciates:

  • Alpha lipoic acid – research has shown this ingredient can reduce AMP-activated protein kinase (AMPK) function, which can help both blunt hunger and boost metabolism.[8]
  • N-acetylcysteine – helps fight free radicals, control levels of stress,[9] and regulate neurotransmitter signaling.[10]
  • NutraBio UpSorb

    What good are your nutrients if you don’t absorb them?! Utilize them fully with NutraBio UpSorb

    Choline bitartrate – used to make acetylcholine,[11] the all-important “learning neurotransmitter” that improves brain functioning.
  • Citrus bioflavonoids – works similarly to vitamin C (which also typically comes from citrus fruits) in that it supports immune health, among other things.
  • Inositol – mimics insulin activity in regards to metabolic activity, which means it supports insulin sensitivity.[12]
  • BioPerineⓇ – this patented blend of black pepper extract has been shown to enhance the bioavailability of supplemented ingredients,[13] especially vitamins and minerals – hey, that just so happens to make up the majority of what we’re dealing with here!

Never stop innovating

One of their traits that we admire most about NutraBio their ability to innovate, especially since they run their own manufacturing and can update things quickly. Failure to innovate breeds stagnation, which, in turn, yields complacency. NutraBio strives to avoid such doldrums, with Glazier and his team constantly searching for new markets to enter, new products to formulate, and sometimes, potential improvements to make on existing product lines.

The ability to reassess and evaluate existing formulas when new information presents itself is honorable, though when NutraBio revamps any of their products, there’s surely some strong, novel research supporting their decision!

NutraBio – re-adjusting with new knowledge

This isn’t the first time the general consensus within the supplement industry looks misguided. We understand things as a certain way until new information convinces us otherwise. Things change in our industry constantly.

What a great way to close out a monster year, although there’s one more announcement to go before the clock rings 2020!

Conclusion: MultiSport improves an already impressive formula

The importance of multivitamins in the wake of a poor diet (or even a low-calorie one) is extremely hard to understate – they provide essential nutrients the body practically craves, each of which play specific roles in various bodily functions. That’s true for any quality multivitamin, though. Not all formulas are created equally, as some differ in terms of ingredients, dosing, and perhaps most importantly, effectiveness.

NutraBio Alpha-GPC

One of the best ways to get more choline in, NutraBio Alpha-GPC boosts both focus and strength. 300mg active per capsule!

We’ve seen instances of the use of subpar ingredients before, but the widespread use of ineffective vitamins B2 and B6 is especially concerning. These two vitamins are crucial, especially in terms of metabolic functioning. While many people are still getting enough of these two vitamins through foods, the inclusion of non-phosphate-bonded B2 and B6 is troublesome in two ways – it actively competes against true B2 and B6 for absorption, and people who depend on supplementation to get adequate amounts of these two vitamins aren’t getting the right stuff.

NutraBio doesn’t stand for anything suboptimal. Mark Glazier built his brand on effectiveness and transparency, two traits that still persist today. When customers speak out, or when new research sheds light on something once unknown, NutraBio listens. They respond by releasing new products, utilizing new ingredients, and sometimes, re-configuring existing products.

MultiSport has long been the brand’s multivitamin, but that doesn’t necessarily mean its immune to improvement. Finding room for potential enhancement, NutraBio swapped out its existing vitamin B2 and vitamin B6 sources for more bioavailable options. The upgrade is a testament both to the product’s overall quality and NutraBio’s business ethics, both of which are highly respectable.

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NutraBio MultiSport Men's Label

The NutraBio MultiSport Men’s Label

NutraBio MultiSport Women's Label

The NutraBio MultiSport Women’s Label

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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References

  1. Bender, D.A; “VITAMIN B6: Physiology.”; Encyclopedia of Food Sciences and Nutrition (Second Edition); Academic Press; 6 Dec. 2003; https://www.sciencedirect.com/science/article/pii/B012227055X013171
  2. McCormick D. Vitamin B6. In: Bowman B, Russell R, eds. Present Knowledge in Nutrition. 9th ed. Washington, DC: International Life Sciences Institute; 2006; https://www.scirp.org/(S(i43dyn45teexjx455qlt3d2q))/reference/ReferencesPapers.aspx?ReferenceID=559786
  3. Schaumburg, H, et al; “Sensory Neuropathy from Pyridoxine Abuse. A New Megavitamin Syndrome.”; The New England Journal of Medicine; U.S. National Library of Medicine; 25 Aug. 1983; https://pubmed.ncbi.nlm.nih.gov/6308447
  4. Vrolijk, Misha F, et al; “The Vitamin B6 Paradox: Supplementation with High Concentrations of Pyridoxine Leads to Decreased Vitamin B6 Function.”; Toxicology in Vitro : an International Journal Published in Association with BIBRA; U.S. National Library of Medicine; Oct. 2017; https://pubmed.ncbi.nlm.nih.gov/28716455
  5. Ebadi, M, et al; “Hippocampal Zinc Thionein and Pyridoxal Phosphate Modulate Synaptic Functions.”; Departments of Pharmacology and Neurology, Univeristy of Nebraska College of Medicine; 1990; https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1990.tb28053.x
  6. Said HM, Ross AC. Riboflavin. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. Modern Nutrition in Health and Disease. 11th ed. Baltimore, MD: Lippincott Williams & Wilkins; 2014:325-30; https://jhu.pure.elsevier.com/en/publications/modern-nutrition-in-health-and-disease-eleventh-edition
  7. Rivlin RS. Riboflavin. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010:691-9; https://www.crcpress.com/Encyclopedia-of-Dietary-Supplements/Coates-Betz-Blackman-Cragg-Levine-Moss-White/p/book/9781439819289
  8. Kim, Min-Seon, et al; “Anti-Obesity Effects of Alpha-Lipoic Acid Mediated by Suppression of Hypothalamic AMP-Activated Protein Kinase.”; Nature Medicine; U.S. National Library of Medicine; July 2004; https://pubmed.ncbi.nlm.nih.gov/15195087
  9. Cascella, Roberta, et al; “S-Linolenoyl Glutathione Intake Extends Life-Span and Stress Resistance via Sir-2.1 Upregulation in Caenorhabditis Elegans.”; Free Radical Biology & Medicine; U.S. National Library of Medicine; Aug. 2014; https://pubmed.ncbi.nlm.nih.gov/24835770
  10. Purves, Dale; “Glutamate.”; Neuroscience. 2nd Edition.; U.S. National Library of Medicine; 1 Jan. 1970; https://www.ncbi.nlm.nih.gov/books/NBK10807/
  11. Poly, Coreyann et al; “The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort.”; The American journal of clinical nutrition; vol. 94,6; 2011; 1584-91; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252552/
  12. Saltiel, A R; “Second Messengers of Insulin Action.”; Diabetes Care; U.S. National Library of Medicine; Mar. 1990; https://pubmed.ncbi.nlm.nih.gov/2137771
  13. Research; BioPerine; https://www.bioperine.com/index.php/researchhighlight

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