Hi-Tech Pro IGF-1: The First Orally Bioavailable IGF-1 Supplement?!

Hi-Tech Pro IGF-1

Hi-Tech Pharmaceuticals has developed the first orally available IGF-1 supplement in Pro IGF-1 using a novel extraction process from whey protein.

Could it finally be real this time — an IGF-1 supplement that doesn’t die in your digestive system?!

Insulin-like Growth Factor-1 (IGF-1) is commonly known to help build muscle. It also promotes healing, combats inflammation, and bolsters the immune system. The problem is that peptides such as IGF-1 have horrendously low bioavailability in the digestive system, and typically need to be injected. This is why you don’t see it included in more oral delivery supplements… until now.

Hi-Tech Pharmaceuticals, one of the true leaders in innovation, has developed what they claim to be the first orally bioavailable IGF-1 product in Pro IGF-1 – and they’re getting it from whey protein!

We’ve got all the details down below on this latest supplement breakthrough, but first, take a moment to check the best deal and sign up for alerts from PricePlow:

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Pro IGF-1 Ingredients

Hi-Tech has manufactured its IGF-1 peptides from whey protein using a molecular biological technique enabling them to extract 175 μg/100g,[10] quite a substantial amount of IGF-1! Following this novel extraction, Hi-Tech then uses its proprietary Liposomal Delivery (LD) system to apply a safe coating around the IGF-1 which ensures the IGF-1 will survive the hazardous path through the digestive process and enable you to reap the true benefits of IGF-1.

Note: Doses listed below are based on 1 full serving (i.e. 5 tablets).

  • IGF-1 (20mcg)

    Hi-Tech Pro IGF-1 Ingredients

    IGF-1 includes 20mcg of pure whey-extracted IGF-1 all wrapped in Hi-Tech’s Liposomal Delivery system for superior bioavailability and absorption.

    As we stated up top, IGF-1 is a protein encoded by the IGF1 gene that’s similar in structure to another well known anabolic hormone — insulin.[1,2] Insulin-Like Growth Factor 1 works in conjunction with Growth Hormone to reproduce and regenerate cells.

    How so?

    Well, the pituitary gland produces Growth Hormone, which then stimulates the liver to produce IGF-1. From here, IGF-1 initiates growth in cells throughout the body, leading to growth and development (from conception through adulthood), construction of tissues (i.e. muscle), improvement of bone density and healing of gut lining, skin, bones, etc.[3]

    IGF-1 exerts its effects in the body by binding to its specific receptor, the insulin-like growth factor 1 receptor (IGF1R), found on several types of cells in various tissues throughout the body. Binding to this receptors signals one of the most important signaling pathways in the body — the AKT signaling pathway,[4] a powerful driver of cell growth and proliferation, as well as an inhibitor of programmed cell death.[5]

    As you can see, if you’re able to increase levels of this protein in your body, you could substantially enhance your ability to build muscle and recover faster from training.[6] The problem always has been the poor bioavailability of these free form peptides though, which is what led Hi-Tech to develop the first orally bioavailable IGF-1 supplement that delivers on the claims.

    How did they accomplish this feat?

    Well, it all has to do with a little bioavailability enhancement from the likes of:

Cyclosome Delivery Technology

Cyclosome

Cyclosome is a new supplement ingredient delivery technology made by Hi-Tech Pharmaceuticals that combines the forces of two other delivery systems. This should make for prohormones that require smaller doses

Those familiar with Hi-Tech’s extensive line of supplements are well acquainted with their use of the patented Cyclosome delivery system, which they’ve used in everything from prohormones to Laxogenin.

Cyclosome is able to increase a compound’s bioavailability since it suspends the target compound (IGF-1 in this case) in a lipid and then places that in a cyclodextrin. Basically, think of Cyclosome as the perfect fusion of liposomal and cyclodextrin delivery technologies where you place your target ingredient in a sugar molecule and wrap that sugar package in a lipid-based delivery system, which protects it from premature breakdown.

Want more info on Cyclosome?

Then check out our in-depth post — Cyclosome: New Age Liposome + Cyclodextrin Delivery System, where we go into all the gory details about this groundbreaking deliver technology.

Will this actually work?

If you’re a bit skeptical of the delivery system, and unsure if it will actually do anything to enhance the bioavailability of IGF-1, there is some research to date showing that delivery technologies enhance uptake by the body of various peptides and proteins:

”Direct delivery of proteins and peptides into living mammalian cells has been accomplished using phospholipid liposomes as carrier particles. Such liposomes are usually taken up via endocytosis where the main part of their cargo is degraded in lysosomes before reaching its destination. Here, fusogenic liposomes, a newly developed molecular carrier system, were used for protein delivery. When such liposomes were loaded with water-soluble proteins and brought into contact with mammalian cells, the liposomal membrane efficiently fused with the cellular plasma membrane delivering the liposomal content to the cytoplasm without degradation.”[7]

”Compartmentalization is one of the key steps in the evolution of cellular structures and, so far, only few attempts have been made to model this kind of “compartmentalized chemistry” using liposomes. The present work shows that even such complex reactions as the ribosomal synthesis of polypeptides can be carried out in liposomes. A method is described for incorporating into 1-palmitoyl-2-oleoyl-sn-3-phosphocholine (POPC) liposomes the ribosomal complex together with the other components necessary for protein expression. Synthesis of poly(Phe) in the liposomes is monitored by trichloroacetic acid of the (14)C-labelled products. Control experiments carried out in the absence of one of the ribosomal subunits show by contrast no significant polypeptide expression. This methodology opens up the possibility of using liposomes as minimal cell bioreactors with growing degree of synthetic complexity, which may be relevant for the field of origin of life as well as for biotechnological applications.”[8]

”Epidermal growth factor receptor (EGFR) is an important anti-cancer therapy target that is applicable to many cancer types. We had previously reported the screening and discovery of a novel peptide ligand against EGFR named GE11. It was shown to bind to EGFR competitively with EGF and mediate gene delivery to cancer cells with high-EGFR expression. In this study, we conjugated GE11 on to liposome surface and examined their binding and distribution to EGFR expressing cancer cells in vitro and in vivo using fluorescence imaging techniques. GE11 liposomes were found to bind specifically and efficiently to EGFR high-expressing cancer cells. In vivo in H1299 xenograft mouse model, GE11 liposomes also extravasated and accumulated into the tumor site preferentially, and demonstrated better targeting and drug delivery capacities..”[9]

The point being, delivery technologies WILL significantly enhance the bioavailability and uptake of proteins and peptides such as IGF-1.

Dosing

Hi-Tech PR Pro IGF-1

Hi-Tech continues to lead the way in breakthroughs in the industry…what could be next?

Take 5 tablets daily. Do not exceed recommended dosing.

Takeaway

The IGF-1 you’ve always wanted may finally be here — non-injected, orally-bioavailable IGF-1!

We’ve seen those dopey sprays and pathetic pills. Could this be different? We’re not sure yet, but if it is, get ready to start making some huge gains without the use of prohormones or other anabolics!

Anyone who’s tinkered with an IGF-1 spray or even deer antler spray or powder will want to check out Pro IGF-1 and compare. It may represent your final last hoorah at making jaw-dropping gains before contemplating the journey into the more “aggressive” side of supplements.

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References

  1. Höppener JWM, de Pagter-Holthuizen P, van Kessel AHMG, et al. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum Genet. 1985;69(2):157-160. doi:10.1007/BF00293288. https://link.springer.com/article/10.1007%2FBF00293288
  2. Laron Z. Insulin-like growth factor 1 (IGF-1): a growth hormone. Molecular Pathology. 2001;54(5):311-316. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187088/
  3. Upadhyay J, Farr OM, Mantzoros CS. The role of leptin in regulating bone metabolism. Metabolism: clinical and experimental. 2015;64(1):105-113. doi:10.1016/j.metabol.2014.10.021.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532332/
  4. Schiaffino S, Mammucari C. Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models. Skeletal Muscle. 2011;1:4. doi:10.1186/2044-5040-1-4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143906/
  5. Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med. 2005;9(1):59-71. https://www.ncbi.nlm.nih.gov/pubmed/15784165
  6. Adams G. Insulin-like growth factor in muscle growth and its potential abuse by athletes. British Journal of Sports Medicine. 2000;34(6):412-413. doi:10.1136/bjsm.34.6.412. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1724245/pdf/v034p00412.pdf
  7. Kube S, Hersch N, Naumovska E, et al. Fusogenic Liposomes as Nanocarriers for the Delivery of Intracellular Proteins. Langmuir. 2017;33(4):1051-1059. doi:10.1021/acs.langmuir.6b04304. https://www.ncbi.nlm.nih.gov/pubmed/28059515
  8. Oberholzer T, Nierhaus KH, Luisi PL. Protein expression in liposomes. Biochem Biophys Res Commun. 1999;261(2):238-241. doi:10.1006/bbrc.1999.0404. https://www.researchgate.net/publication/12874765_Protein_Expression_in_Liposomes
  9. Song S, Liu D, Peng J, et al. Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo. Int J Pharm. 2008;363(1):155-161. http://www.sciencedirect.com/science/article/pii/S0378517308004699
  10. Hi-Tech Pharmaceuticals; “Hi-Tech Pharmaceuticals Announced the First Successful Production of Actual IGF-1 in a Dietary Supplement”; PRNewswire; April 21, 2017; http://www.prnewswire.com/news-releases/hi-tech-pharmaceuticals-announced-the-first-successful-production-of-actual-igf-1-in-a-dietary-supplement-300443302.html
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