Rich Piana’s BIGGER BY THE DAY Becomes a Muscle Builder

5% Nutrition Bigger by the Day Muscle Builder

5% Nutrition actualizes Rich Piana’s Bigger by the Day into a muscle building supplement!

Legendary Rich Piana knew at least one thing for sure: only 5% of the people on this planet have the drive and passion to truly pursue and accomplish their dreams. He founded his supplement company, 5% Nutrition, with the aim of supporting those exceptional people’s attempts to achieve whatever they set out to do in life.

Although 5% Nutrition designs and manufactures a wide variety of products that help enable a wide variety of aspirations, there was probably nothing nearer or dearer to Rich Piana’s heart than getting f***ing huge.

Today we’ll be discussing a supplement that’s designed to help any serious athlete or lifter pack on the lean muscle gains.

BIGGER BY THE DAY? That sounds familiar…

It’s called Bigger By The Day, a name that may sound familiar because it was the name of an insanely incredible series of videos in late 2015 and early 2016 from Rich Piana:

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In his series, he documented everything about his growth – with some videos (such as Day 14 embedded below) where he logged over 5 million views:

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Bigger by the Day Muscle Builder

Back to the new supplement, which consists of a handful of carefully-selected and cutting-edge ingredients, Bigger By The Day has some direct anabolic effects, some anti-catabolic activity, and some support for general metabolic and hormonal health. Obviously, it alone won’t get you to Rich Piana size, but it may help you get over a few humps.

Let’s take a closer look at how it works after checking in on the prices and availability with PricePlow:

Rich Piana 5% Nutrition Bigger By The Day – Deals and Price Drop Alerts

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Bigger by the Day Ingredients

In a single three (3) capsule serving of Bigger By The Day from 5% Nutrition, you get the following:

  • Vitamin A (as retinol palmitate) – 1,500 mcg (167% DV)

    5% Nutrition Bigger by the Day Muscle Builder Ingredients

    The 5% Nutrition Bigger by the Day Muscle Builder Ingredients

    The first thing to note about the inclusion of vitamin A is that 5% Nutrition has opted for a retinol form, as opposed to the carotenoids that are often found in plant foods and considered “vitamin A” by nutritional scientists.

    This matters because carotenoids are not actually the form of vitamin A that’s used by the human body – they must be converted into retinol, which is the active form.[1]

    Because the efficiency of this conversion process is different depending on individual genetics[2] and other factors, supplementing with carotenoids is not a reliable way to boost one’s vitamin A levels.

    In order to avoid vitamin A deficiency, it’s much better to eat animal foods like butter, egg yolk, and liver, which all contain naturally occurring retinol[1] that can be directly metabolized by the body without being bottlenecked by a rate-limited conversion.[2]

    Unfortunately, many Americans do not eat enough retinol-containing foods to stave off vitamin A deficiency (VAD). The “2005-2016 National Health and Nutrition Examination (NHANES)” survey found that almost 50% of the American public gets inadequate levels of vitamin A from diet.[3]

    That’s a big problem because it’s pretty much impossible to achieve optimal health without adequate vitamin A.

    Vitamin A

    Animal products — like the ones Rich Piana would eat — bring the active form of Vitamin A. Image courtesy Wikimedia

    One of vitamin A’s chief functions is supporting the thyroid. In fact, vitamin A appears to regulate the function of the whole thyroid-pituitary axis (HPA).[4] When a person is deficient in vitamin A, his or her thyroid will absorb iodine less efficiently.[4] It’s a big issue in itself because low levels of iodine can cause hypothyroidism, which ultimately leads to a lowered basal metabolic rate (BMR).

    Furthermore, the combination of vitamin A and iodine deficiency can produce more severe symptoms of hypothyroidism than just iodine deficiency.[4]

    Anyone seeking to optimize their body composition should take note because the thyroid is the “master switch” of the entire human metabolism and sets a person’s BMR, which is defined as the number of calories a person would burn daily if they remained at rest all day.[5] That’s why thyroid dysfunction is associated with gradual weight gain, eventually resulting in full-blown obesity[5] if not treated.

    Hormones produced by the thyroid gland also regulate your body’s levels of leptin,[6] a hormone that signals satiety, prompting you to stop eating when your metabolic needs have been met. Leptin dysregulation is associated with obesity, so we want to make sure that our leptin levels are optimal at all times.[7]

    So anyone who wants to naturally burn fat while eating less should strongly consider supporting his or her thyroid with solid vitamin A supplementation.

    A research summary of vitamin A

    Here’s a summary of just some of vitamin A’s benefits for human health:

    Rich Piana Motivation

    Rich truly was the king of consistency. This man was all day, every day, until his last day.

    • Obesity and diabetes: animal studies of the nutrient have shown that when vitamin A receptors (also known as retinoic acid receptors or RARs) are stimulated they have anti-diabetic and anti-obesity effects, largely because RAR activity increases insulin sensitivity,[8] which is considered by many to be the “holy grail” of overall metabolic health. In mice whose RARs had been genetically “knocked out,” glucose metabolism was disturbed.[9]
    • Improved sleep: RAR activity has also been associated with a higher quality of REM sleep and the prevention of age-related declines in sleep quality in mice.[10]
    • Better fertility: RAR stimulation plays a central role in the production of new sperm,[11] and RAR knockout mice show impaired testicular function.[12]
    • Immunity boost: stimulating RARs leads to the production of new immune cells[13] and a vitamin A deficiency seems to impair immune response.[14]
    • Gut health: in studies of cell cultures, vitamin A has been found to help maintain the integrity of the stomach’s epithelial barrier,[15] which is responsible for keeping undigested food from leaking out of the gut. If the epithelial barrier is compromised it can lead to “leaky gut,” which can result in inflammatory disorders or even autoimmune disease.[16]
    • Skin and eye health: vitamin A is famous, as most of us have heard, for promoting the health of skin and eyes.[17,18]

    Vitamin A toxicity?

    Unfortunately, you can get too much of a good thing, and this is especially true in the case of vitamin A.

    Vitamin A is fat soluble, meaning that it can build up in our stored body fat if taken in excess. If the overdose is chronic, then our vitamin A stores can reach toxic levels.[19]

    When beginning any retinol supplementation, we strongly recommend calculating your total retinol intake from all sources (not just supplements), and ensuring that it stays under the tolerable upper limit (TUL) of 3,000 micrograms per day.[20]

  • Alpha Hydroxyisocaproic Acid (HICA) – 500 mg

    Also known as leucic acid, HICA is a leucine metabolite that has shown promise as an anabolic agent.

    Leucine itself (also covered below) is known as the amino acid that’s primarily responsible for activating the body’s mammalian target of rapamycin (mTOR) pathway, which drives the synthesis of new skeletal muscle. HICA is actually more effective than leucine at doing this, partly because it’s absorbed faster and used more quickly.

    In the research literature, HICA has been observed to reduce soreness,[21] increase muscle mass,[21] and decrease fat mass.[21]

    HICA Study Graph

    This graph from the ground-breaking HICA study shows the clear differences adding HICA can have on your overall lean mass after only 4 weeks of use![21]

    The reduction in delayed onset muscle soreness (DOMS) in particular is pretty huge for people who train hard, like athletes and bodybuilders. Just note that the studied doses are typically two to three times larger than the 500 milligrams we’re given here. So if you want to maximize the effects of HICA supplementation, consider stacking Bigger By The Day with another source of HICA to achieve the 1.5 grams per day that was used in the study we cited.[21]

  • 5a-hydroxy laxogenin (from Smilax officinalis) – 300 mg

    Laxogenin is a plant compound that occurs naturally in the Smilax genus of plants. It belongs to a chemical class called brassinosteroids – steroid hormones that regulate the growth of plants and were first identified in the Brassica genus, which they’re named after.

    If you’re worried about running afoul of anti-doping regulations or messing up your hormonal system, you can rest assured that brassinosteroids are both non-hormonal and legal. Also, they do not cause any of the side effects associated with anabolic steroid use.

    5% Nutrition Crea-TEN

    TEN forms of creatine? YES. This is what you stack with Bigger by the Day — Crea-Ten.

    Early research has shown that laxogenin promotes muscle protein synthesis and inhibits muscle protein breakdown,[22,23] making it a powerful one-two punch for anyone who’s trying to get strong and lean.

    One study on laxogenin found that it also promotes athletic performance compared to a placebo control.[22] Additionally, laxogenin has been shown to improve recovery, lower cortisol, and decrease inflammation.[24]

    However, it should be noted that although these results are promising, they come from animal models and should be considered preliminary. But that’s pretty much par for the course if you’re trying to stay on the cutting edge of supplement science.

    In general, we see anecdotally some strength gains from laxogenin as well. Be smart and talk to a physician if you have any concerns about the safety of laxogenin.

  • L-Leucine (200 mg)

    Leucine is one of the branched-chain amino acids (BCAAs), which have been studied extensively as a group for their anti-catabolic[25-27] and endurance-promoting[28-30] properties. The latest research suggests that leucine is the main driver behind the effects of BCAAs since it initiates muscle protein synthesis through mTOR activation,[31-33] which is why 5% cuts to the chase here by including just leucine.

    A smaller dose than usual at just 200 milligrams, but remember that this leucine is being stacked with HICA, which is a leucine metabolite. So the combination of this leucine and its own metabolite is probably having a biological effect equivalent to a much larger dose of leucine.

  • Green Tea Extract (90% epicatechin) – 200 mg

    Epicatechin is a flavanol that occurs naturally in dark chocolate and green tea. In recent years, it’s become a popular supplement ingredient because of its documented ability to increase muscle mass gains and athletic performance. The research literature shows the following benefits associated with epicatechin consumption:

    Epicatechin Myostatin Follistatin

    This recent study was performed on elderly, but alongside resistance training, epicatechin had the best results on myostatin and follistatin levels![34]

    • Increased strength and muscle growth[35,36]
    • Increased glucose tolerance[37]
    • Higher physical endurance [38]
    • Reduced fatigue[38]
    • Increased nitric oxide (NO) production[39]

    A big part of the reason that epicatechin is able to do all this is that it inhibits myostatin, a protein compound that inhibits muscle growth.[36]

  • Black Pepper Extract (BioPerine) – 10 mg

    A common criticism of nutritional supplements is that, owing to the uneven bioavailability of supplement ingredients, the consumer is liable to pass most of them unabsorbed and end up paying for “expensive pee”.

    That’s where BioPerine comes in: by inhibiting the stomach enzymes that break these ingredients down,[40] it massively increases their bioavailability, pretty much across the board. Because of this, you’ll see BioPerine used in a wide variety of nutritional supplements, from multivitamins to pre-workouts.[40]

    Beyond merely enhancing the effectiveness of other ingredients, BioPerine has some benefits of its own, too. It’s been shown to upregulate a transporter called GLUT4,[41] which moves glucose out of the bloodstream and into muscle tissue where it belongs. It also helps improve insulin sensitivity and fatty liver,[42] and has antioxidant activity.[43]

The obvious stack choice here is Rich Piana’s classic creatine supplement, Crea-Ten. If you’re big on carbs, drive them in with Freak Show and don’t forget to sip on ALL DAY YOU MAY!

Get Bigger by the Day

Rich Piana Freak Show

Love carbs and need to drive them home? Then join the FREAK SHOW

Overall, Bigger By The Day is a good supplement and worth the money, but understand that this alone will obviously not make you Rich Piana (and for most people, nothing will – Rich was nearly untouchable in that department). But for some natty size and strength increases, it may be able to push you past a plateau.

We would like to see a bigger dose of leucine since doses in the 200-milligram range are not typically studied in research settings. But since the main value of leucine is in its signaling activity, even a dose this small is probably of significant value. It’s also better than filling the rest of the capsule with rice flour!

One thing to keep in mind about leucine here is that it’s being stacked with one of its own metabolites — HICA. So the overall “leucine-driven effect” of the leucine and HICA is almost certainly much larger than 200 milligrams of leucine would suggest.

Rich Piana 5% Nutrition Bigger By The Day – Deals and Price Drop Alerts

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No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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  1. Gilbert, Clare. “What is vitamin A and why do we need it?.” Community eye health vol. 26,84 (2013): 65;
  2. Tang, Guangwen. “Bioconversion of dietary provitamin A carotenoids to vitamin A in humans.” The American journal of clinical nutrition vol. 91,5 (2010): 1468S-1473S. doi:10.3945/ajcn.2010.28674G;
  3. Reider CA, Chung RY, Devarshi PP, Grant RW, Hazels Mitmesser S. Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES. Nutrients. 2020;12(6):1735. Published 2020 Jun 10. doi:10.3390/nu12061735;
  4. Zimmermann MB. Interactions of vitamin A and iodine deficiencies: effects on the pituitary-thyroid axis. Int J Vitam Nutr Res. 2007 May;77(3):236-40. doi: 10.1024/0300-9831.77.3.236. PMID: 18214025;, Rashmi et al. “Thyroid hormone regulation of metabolism.” Physiological reviews vol. 94,2 (2014): 355-82. doi:10.1152/physrev.00030.2013;
  5. Mullur, Rashmi et al. “Thyroid hormone regulation of metabolism.” Physiological reviews vol. 94,2 (2014): 355-82. doi:10.1152/physrev.00030.2013;
  6. Blum WF, Englaro P, Attanasio AM, Kiess W, Rascher W. Human and clinical perspectives on leptin. Proc Nutr Soc. 1998 Aug;57(3):477-85. doi: 10.1079/pns19980068;
  7. de Luis DA, Perez Castrillón JL, Dueñas A. Leptin and obesity. Minerva Med. 2009 Jun;100(3):229-36. Epub 2008 Apr 4. PMID: 19182739.
  8. Berry, Daniel C., and Noa Noy. “All- Trans -Retinoic Acid Represses Obesity and Insulin Resistance by Activating Both Peroxisome Proliferation-Activated Receptor β/δ and Retinoic Acid Receptor.” Molecular and Cellular Biology, vol. 29, no. 12, 15 June 2009, pp. 3286–3296, 10.1128/mcb.01742-08;
  9. Brun, Pierre-Jacques et al. “Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass.” FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 29,2 (2015): 671-83. doi:10.1096/fj.14-256743;
  10. Kitaoka, K., et al. “Disturbance of Rapid Eye Movement Sleep in Senescence-Accelerated Mouse Prone/8 Mice Is Improved by Retinoic Acid Receptor Agonist Am80 (Tamibarotene).” Neuroscience, vol. 167, no. 3, May 2010, pp. 573–582, 10.1016/j.neuroscience.2010.01.059;
  11. Wolgemuth, D J, and S S W Chung. “Retinoid signaling during spermatogenesis as revealed by genetic and metabolic manipulations of retinoic acid receptor alpha.” Society of Reproduction and Fertility supplement vol. 63 (2007): 11-23;
  12. Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub MP, LeMeur M, Chambon P. High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7225-9. doi: 10.1073/pnas.90.15.7225. PMID: 8394014;
  13. Larange, Alexandre, and Hilde Cheroutre. “Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System.” Annual Review of Immunology, vol. 34, no. 1, 20 May 2016, pp. 369–394, 10.1146/annurev-immunol-041015-055427. Accessed 12 Dec. 2019;
  14. Pino-Lagos, Karina et al. “Retinoic acid in the immune system.” Annals of the New York Academy of Sciences vol. 1143 (2008): 170-87. doi:10.1196/annals.1443.017;
  15. Osanai, M., et al. “Cellular Retinoic Acid Bioavailability Determines Epithelial Integrity: Role of Retinoic Acid Receptor Agonists in Colitis.” Molecular Pharmacology, vol. 71, no. 1, 11 Oct. 2006, pp. 250–258, 10.1124/mol.106.029579;
  16. Arrieta, M C et al. “Alterations in intestinal permeability.” Gut vol. 55,10 (2006): 1512-20. doi:10.1136/gut.2005.085373;
  17. Zasada, Malwina, and Elżbieta Budzisz. “Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments.” Postepy dermatologii i alergologii vol. 36,4 (2019): 392-397. doi:10.5114/ada.2019.87443;
  18. Basavaraj, K H et al. “Diet in dermatology: present perspectives.” Indian journal of dermatology vol. 55,3 (2010): 205-10. doi:10.4103/0019-5154.70662;
  19. Penniston KL, Tanumihardjo SA. The acute and chronic toxic effects of vitamin A. Am J Clin Nutr. 2006 Feb;83(2):191-201. doi: 10.1093/ajcn/83.2.191. PMID: 16469975.
  20. Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US); 2001. 4, Vitamin A;
  21. Mero, Antti A., et al. “Effects of Alfa-hydroxy-isocaproic Acid on Body Composition, DOMS and Performance in Athletes”; Journal of the International Society of Sports Nutrition; 7.1; 2010;
  22. Esposito D, Komarnytsky S, Shapses S, Raskin I; “Anabolic effect of plant brassinosteroid”; The FASEB Journal; 2011; 25(10):3708-3719;
  23. Syrov, V. N., & Kurmukov, A. G; “Experimental study of the anabolic activity of 6-ketoderivatives of certain natural sapogenins”; Farmakologiia i toksikologiia; 39(5), 631-635; 1975;
  24. Fasciola, Andre Armel; “Phytosterol spirostane and spirostene derivatives having a wide variety of utilities in humans and other animals”; US Patent & Trademark Office; September 18, 2014;
  25. Freund, H et al. “Infusion of the branched chain amino acids in postoperative patients. Anticatabolic properties.” Annals of surgery vol. 190,1 (1979): 18-23. doi:10.1097/00000658-197907000-00004;
  26. Wolfe, RR; “Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?”; J Int Soc Sports Nutr; 14(1):30; 2017;
  27. Kobayashi H, Kato H, Hirabayashi Y, Murakami H, Suzuki H; “Modulations of muscle protein metabolism by branched-chain amino acids in normal and muscle-atrophying rats”; J Nutr. 2006;136;
  28. Ea, Newsholme, and Blomstrand E. “Branched-Chain Amino Acids and Central Fatigue.” The Journal of Nutrition, 1 Jan. 2006;
  29. E, Blomstrand, et al. “Administration of Branched-Chain Amino Acids during Sustained Exercise–Effects on Performance and on Plasma Concentration of Some Amino Acids.” European Journal of Applied Physiology and Occupational Physiology, 1991;
  30. Ab, Gualano, et al. “Branched-Chain Amino Acids Supplementation Enhances Exercise Capacity and Lipid Oxidation during Endurance Exercise after Muscle Glycogen Depletion.” The Journal of Sports Medicine and Physical Fitness, 1 Mar. 2011;
  31. Lynch, Christopher J., et al. “Leucine Is a Direct-Acting Nutrient Signal That Regulates Protein Synthesis in Adipose Tissue.” American Journal of Physiology-Endocrinology and Metabolism, vol. 283, no. 3, Sept. 2002, pp. E503–E513, 10.1152/ajpendo.00084.2002;
  32. Lynch, Christopher J., et al. “Tissue-Specific Effects of Chronic Dietary Leucine and Norleucine Supplementation on Protein Synthesis in Rats.” American Journal of Physiology-Endocrinology and Metabolism, vol. 283, no. 4, 1 Oct. 2002, pp. E824–E835, 10.1152/ajpendo.00085.2002;
  33. Lynch, C. J., et al. “Regulation of Amino Acid-Sensitive TOR Signaling by Leucine Analogues in Adipocytes.” Journal of Cellular Biochemistry, vol. 77, no. 2, 1 Mar. 2000, pp. 234–251;
  34. Mafi, Farnoosh, et al. “Improvement in Skeletal Muscle Strength and Plasma Levels of Follistatin and Myostatin Induced by an 8-Week Resistance Training and Epicatechin Supplementation in Sarcopenic Older Adults.” Journal of Aging and Physical Activity, vol. 27, no. 3, June 2019, pp. 384–391, 10.1123/japa.2017-0389;
  35. Gutierrez-Salmean G, Ciaraldi TP, Nogueira L, Barboza J, Taub PR, Hogan MC, Henry RR, Meaney E, Villarreal F, Ceballos G, Ramirez-Sanchez I. Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. J Nutr Biochem. 2014 Jan;25(1):91-4. doi: 10.1016/j.jnutbio.2013.09.007. Epub 2013 Oct 18. PMID: 24314870; PMCID: PMC3857584.
  36. Gutierrez-Salmean G, Ciaraldi TP, Nogueira L, et al. Effects of (−)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. The Journal of nutritional biochemistry. 2014;25(1):10.1016/j.jnutbio.2013.09.007. doi:10.1016/j.jnutbio.2013.09.007.
  37. Grassi, D; Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons.; Department of Internal Medicine and Public Health, University of L’Aquila; 2005
  38. Nogueira, L., Ramirez-Sanchez, I., Perkins, G. A., Murphy, A., Taub, P. R., Ceballos, G., Villarreal, F. J., Hogan, M. C. and Malek, M. H. (2011), (–)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. The Journal of Physiology, 589: 4615–4631. doi:10.1113/jphysiol.2011.209924.
  39. Fraga CG, Litterio MC, Prince PD, Calabró V, Piotrkowski B, Galleano M. Cocoa flavanols: effects on vascular nitric oxide and blood pressure. Journal of Clinical Biochemistry and Nutrition. 2011;48(1):63-67. doi:10.3164/jcbn.11-010FR.
  40. Bhardwaj, R. et al. Aug. 2002. “Piperine, A Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4.” The Journal of Pharmacology and Experimental Therapeutics vol. 302, 2. 645-50.
  41. ‌Maeda A, Shirao T, Shirasaya D, Yoshioka Y, Yamashita Y, Akagawa M, Ashida H. Piperine Promotes Glucose Uptake through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle. Mol Nutr Food Res. 2018 Jun;62(11):e1800086. doi: 10.1002/mnfr.201800086. Epub 2018 May 17. PMID: 29683271.
  42. Choi S, Choi Y, Choi Y, Kim S, Jang J, Park T. Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice. Food Chem. 2013 Dec 15;141(4):3627-35. doi: 10.1016/j.foodchem.2013.06.028. Epub 2013 Jun 17. PMID: 23993530.
  43. Mittal R, Gupta RL. In vitro antioxidant activity of piperine. Methods Find Exp Clin Pharmacol. 2000 Jun;22(5):271-4. doi: 10.1358/mf.2000.22.5.796644. PMID: 11031726.

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