Appethyl: Spinach-Powered Weight Loss?


Could this spinach extract be the next key to weight loss?

As kids, we learned that Popeye was strong to the finish ’cause he ate his spinach, and we’ve never forgotten that lesson. Spinach is one of our favorite veggies around here due to its combination of an excellent vitamin and mineral profile and the ease with which it can be incorporated into so many different recipes. Everything from smoothies to sandwiches to quesadillas is fair game!

Aside from just being a natural vitamin supplier, we’ve known for some time that it’s important to get at least five servings of fruits and veggies a day, as research shows it dramatically decreases your chances of getting serious age-related diseases and conditions.[1] Greens are especially important to keep in the regular rotation, and spinach is one of the most accessible and easy to prepare.

But what about weight loss… and even more importantly for some users, appetite suppression?!

Spinach For Weight Loss Too?

So here’s the new and exciting bit. A new dietary supplement called Appethyl, which is created from spinach extract, performed with flying colors in a study of 60 overweight and obese participants.

The participants took Appethyl for 12 weeks between a standardized breakfast and lunch meal along with a pizza dinner, and those that took it lost 43% more weight and reported an 85 to 95% reduction in cravings for unhealthy foods.[2]

Beware the study funding!

Now, here’s the big caveat. The study was funded by Greenleaf Medical, the company that distributes Appethyl.

However, a sponsor-funded survey doesn’t automatically mean the results are totally bogus. This study was controlled and randomized, and Greenleaf has built up a body of eight total clinical trials now that have all come up with similar results. While we’d like to see a neutral third-party study and peer reviews of the existing studies, there’s enough here to make this supplement look extremely interesting.

It’s also worth noting that the study’s lead researcher was Frank Greenway, a leading figure in obesity research. He’s certainly not a paid spokesman for Greenleaf, and here’s what he had to say about the study results:

“I believe that Appethyl is special. It is a safe food made from spinach that decreases hunger and decreases desire for salt, both key attributes that could be beneficial for people trying to maintain a healthy weight and blood pressure.” — Obesity Expert, Dr. Frank Greenway

Appethyl Supplements

Before we get deeper into the science, let’s go over what many of you came here for: how to get it.

There are a few easy ways to try Appethyl – and we provide price comparison widgets for each below. Sign up for price drop alerts if you’d like to wait for a deal:

  1. Appethyl Powder

    The raw powder from the supplier itself comes available in 30 single-serving packets, each with 5g of powder:

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  2. Hydroxycut Appetite Control

    Hydroxycut, MuscleTech’s sister brand (both owned by Iovate in Canada), has a product named Hydroxycut Appetite Control, and it features Kelp fiber and green coffee extract to boot.

    Note that green coffee bean extract is next to useless in terms of weight loss. Its popularity was based on Dr. Oz promoting a research study that was later retracted due to falsified information.[7]

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  3. AppiLess by Purely Inspired

    Purely Inspired is yet another Iovate brand, and AppiLess is a product we’ve discussed before.

    It is a bit simpler than the above version from Hydroxycut, as it only has Kelp Fiber and Appethyl spinach leaf extract.

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  4. MuscleTech Appedex SX-7

    And finally, the most complex product of them all, MuscleTech’s Appedex SX-7. This has a far more advanced label that is discussed in the link above, but what we like is how it’s a 100% open formula, so we know we’re getting 2.5g Appethyl.

    MuscleTech’s SX-7 series is a GNC-exclusive, which often means higher prices, but we also find these products available via Amazon Prime from time to time too.

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  5. How Spinach Works

    So how does spinach manage to have all these miraculous results? The researchers in the Greenleaf studies theorize that thylakoids, cellular membranes that support the process of photosynthesis, naturally slow fat digestion when ingested. This in turn leads to steady and sustained production of satiety hormones (like cholecystokinin) and takes ghrelin (the hormone that gives you the feeling of hunger) out of production.

    Appedex SX-7

    How Appedex SX-7 Works. Image courtesy MuscleTech

    There’s actually a small body of research outside of Greenway that supports the idea that thylakoids can aid in weight loss, but the results are definitely more mixed. For example, one study had overweight women eat a blackcurrant jam mixed with thylakoids prior to eating a high-carb meal. Not surprisingly, the group that ate the jam first ate less, but there are some concerns about the calories and the feelings of satiety caused by the jam itself not being properly controlled for.[3]

    There’s also almost no research on populations that are not obese or overweight … it’s possible that average and fit body types may not have the same response to thylakoids.

    It Almost Certainly Can’t Hurt

    Spinach For Weight Loss

    One of nature’s miracle foods!

    While the claims about spinach and appetite suppression do bear some further research, we can’t actually see any downsides to giving this supplement a try, especially if you have trouble working actual spinach into your diet.

    Want to see a short list of the amazing things spinach will do for you?

    • The nutritional content of spinach varies a bit depending on whether it is cooked or raw, but in general you can expect huge amounts of vitamins A, K, manganese and folate. It also has significant iron, copper and magnesium content. There’s also a good smattering of pretty much every major macronutrient you need and it even has a little omega-3 fat content! Spinach is basically nature’s multivitamin.[4]
    • Glycoclycerolipids in spinach, another molecule involved in the photosynthesis process of leafy plants, have been shown to specifically protect the lining of the digestive tract from inflammation.[5]
    • Spinach has stood alone in studies in offering protection from advanced stages of prostate cancer. The exact mechanism is still unclear, but researchers believe that certain carotenoids (epoxyxanthophylls) that are plentiful in spinach and are known to have anti-cancer properties are responsible.[6]

    In short: Popeye had it right all along – and it’s worth a shot if your appetite is your major diet problem! Just try to find the best deals using PricePlow up above.

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    1. Riboli, E, et. al; “Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk“; The American Journal of Clinical Nutrition; 2003
    2. Rebello, CJ, et. al; “Acute Effects of a Spinach Extract Rich in Thylakoids on Satiety: A Randomized Controlled Crossover Trial“; Journal of the American College of Nutrition; 2005
    3. Stenblom, E, et. al; “Supplementation by thylakoids to a high carbohydrate meal decreases feelings of hunger, elevates CCK levels and prevents postprandial hypoglycaemia in overweight women“; Appetite; June 2012
    4. Rickman, J, et. al; “Nutritional comparison of fresh, frozen and canned fruits and vegetables“; Journal of the Science of Food and Agriculture; March 2007
    5. Asai, A, et. al; “An epoxide-furanoid rearrangement of spinach neoxanthin occurs in the gastrointestinal tract of mice and in vitro: formation and cytostatic activity of neochrome stereoisomers“; Journal of Nutrition; September 2004
    6. Lucarini, M, et. al; “Intake of vitamin A and carotenoids from the Italian population–results of an Italian total diet study“; International Journal of Vitamin and Nutrition Research; May 2006
    7. Husten, L; Paper Behind The Green Coffee Bean Diet Craze Retracted; October 21, 2014; Retrieved from
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