With all the hoopla surrounding picamilon lately, several companies have gone back to the drawing board and decided to reformulate several of their products. Myokem’s original focus-centric fat burner Pyroxamine was one of those.
With the “controversial” state of the ingredient leaving its fate rather undetermined, Myokem opted to reformulate their popular thermogenic and the details have just been released.
Picamilon out, L-Theanine and Theacrine in
The major changes include using l-theanine in lieu of the maligned picamilon as well as adding the new long-lasting theacrine stimulant.
With Pyroxamine, it’s all about focus and thermogenic heat – nearly every ingredient contributes to these two things one way or another, and it makes for quite the unique dieting experience.
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Fans of the original Pyroxamine won’t notice too many changes to the formula, aside from the removal of picamilon, a.k.a. Pikatropin™. Perhaps the biggest change Myokem’s made is that the label is entirely open, fully-disclosing the amounts of each of the ingredients used. No more proprietary blends!
This is extremely rare in fat burners and stim blends in general as companies like to keep those mixes a trade secret. However, that’s not how Myokem rolls anymore (and that’s also why we consider it the best fat burner pill). Now you know exactly how much of each fat shredding compound you’re getting.
Let’s see what they’ve got in store for the new Thermo-Focal Matrix!
Caralluma fimbriata (125mg)
Caralluma fimbriata is an herbal powder that is the main appetite suppressant in Pyroxamine. Several studies conducted using the herb have noted significant reductions in waist circumference, BMI, weight and saturated fat intake.[1,2]
Just in case the media gets nosy for another ingredient to attack, fear not with this one. Caralluma fimbriata was introduced to the FDA in 2004 for use in supplements and has been considered GRAS (generally regarded as safe).[3,4]
Olive Leaf Extract (100mg)
Olive leaf extract is used is a wide variety of fat burners and thermogenics on the market, and for good reason. It helps to regulate blood pressure, cholesterol, and blood glucose levels.[5,6,7]
The magic to olive leaf’s effectiveness is in its oleuropein content. Pyroxamine is standardized to 10% minimum, and extracted from the richest source in the plant, olive leaves.
No fat burner is complete without caffeine and Myokem ensures there’s just enough included to reap the benefits of this well known CNS stimulant without sending you through the roof.
Caffeine is great not only for waking you up, but also improves performance, concentration, and metabolism. Too many fat burners hop you up on caffeine and give you little else. Pyroxamine includes enough to get all the positives and none of the negatives.
Oftentimes, 100mg fat burners don’t bring enough energy to the table, sometimes not even at two capsules – but with the massive blend to follow, you can rest assured you’ll have plenty of that.
Here’s the main change from the OG version of Pyroxamine. We’ve already mentioned that Picamilon was removed from the formula, and many wondered what, if anything would replace it.
Theanine is the amino acid replacing Picamilon. It’s included in the same amount as picamilon was in the original formula as well.
Theanine helps enhances the cognitive focus effects of caffeine, according to several studies. Additionally, theanine helps alleviate stress, anxiety, and fatigue.[9,10]
Cognizin® Citicoline (50mg)
Another potent focus booster in Pyroxamine is citicoline. Lots of pre workouts and fat burners use lower quality forms of choline supplements to improve focus, but citicoline is the most bioavailable supplement form of choline.
Choline also helps to memory and improve your “mind-muscle” connection when working out, or doing any other task really. Basically, when using citicoline, you’ll just be more “with it” and cognizant of what’s going on.
The honest truth is that we thought there was a larger dose of citicoline when using this product – the focus-drive works so well. This has to be part of it, but there’s got to be more from the other nootropics below.
TeaCrine® Theacrine (50mg)
Another new ingredient in the new formula for Pyroxamine is theacrine. It’s a molecule that’s chemically similar to caffeine and also acts as a mild CNS stimulant.
What separates theacrine from caffeine though is that it’s energy is smoother and longer lasting than the immediate jolt users often feel from caffeine. Plus, studies show that there is no tolerance build up with theacrine, as opposed to caffeine. Therefore, you won’t need to continually up the dosage to feel its effects.
Bacopa Monniera Extract (50mg)
Bacopa is an herb that confers lots of anti-anxiety benefits to the body, but it also does so much more. This potent herb also helps improve cognitive functioning as well – something nearly all Pyroxamine users feel and review it highly for.
Bacopa has been used as a neuroprotective agent, primarily for its ability to possibly reverse memory loss and prevent cognitive decline.[15,16,17]
So, not only will you have better brain function all around, you’ll also feel more relaxed and less edgy when using Bacopa.
Paradoxine™ Grains of Paradise Extract (40mg)
Grains of Paradise is most often seen as a seasoning in the culinary arts, but it’s also a potent thermogenic agent. If you’ve ever used a fat burner that has cayenne pepper extract, you’ll be really familiar with that heated sensation you get in your stomach and all over.
Grains of Paradise has been shown to increase overall energy expenditure and mobilize brown adipose (fat) tissue for use. This will help engage the “fat-burning” mode in your body so you can be burning fat just by sitting around!
If you’re feeling any heat, much of it will come from the grains of paradise – this heat component makes Pyroxamine a winter-time favorite.
You can read more about Paradoxine in our in-depth article titled Grains of Paradise: Fat Fighting Spice of the Goddesses.
Evodiamine works similar capsaicin in that it stimulates the vanilloids in your body, which helps reduce fat uptake by the cells. Additionally, evodiamine also suppresses circulating levels of caffeine in the body.[20,21]
This helps to smooth out the stim effects from caffeine, and all the other stims included in Pyroxamine. If that’s not enough, this extract also improves cognition, furthering Pyroxamine’s role as a mental-boosting supplement.
Think of theobromine as caffeine’s little brother. It comes from the cocoa plant yields a “feel-good” sensation taken or eaten, as is the case with dark chocolate. Similar to caffeine, theobromine possesses a mild stimulatory effect on the body, but it’s smoother and longer lasting.
Much like our previous ingredient, theobromine also helps to smooth out any potential jitters you’ll experience when taken in high amounts of stimulants.
Hordenine is a beta-adrenergic agonist and found in the Citrus Aurantium plant. As a beta receptor agonist, hordenine increases the production of adrenaline and noradrenaline, which raises both heart rate and breathing rate.
Hordenine also works as a noradrenaline reuptake modulator in the body.[25,26] This helps noradrenaline stay active longer in your body which leads to better and longer lasting energy, alertness, and focus – and helps your body keep free fatty acids available to burn for energy now (you have to work out to use them up, otherwise they can re-attach).
Higenamine is another beta adrenergic included in Pyroxamine. It’s sometimes referred to as a “weaker ephedrine” (which has long since been banned for use in supplements).
Like Hordenine, it has its own mild stim kick, but really shines when used alongside caffeine and other stims. As a beta agonist, hordenine boosts production of noradrenaline, which causes a chain reaction stimulating the “fight or flight” response in the body. This increases focus, boosts concentration, and mobilizes stored fat for use as energy.
Huperzine A (50mcg)
Our last focus boosting compound, and carryover from the original Pyroxamine, is the nootropic compound, Huperzine A, a.k.a. Toothed Clubmoss. While citicoline increased the amount of choline production in the body, Huperzine actually prevents its breakdown in the body.
Furthermore, huperzine has also been shown to be improve overall brain health. Not only does it slow brain cell death, but it’s also help in the creation of new brain cells, making it potentially neurogenerative.[29,30]
To help your body make the most of all the ingredients included in Pyroxamine, Myokem includes the popular patented black pepper extract, BioPerine®. Black pepper extracts inhibits the body’s metabolization of the other ingredients included, which has the bonus effect of making them more bioavailable.
Each bottle of Pyroxamine contains 60 capsules, enough for a 30-day supply if dosing 2 caps per day, or 60-day supply if only using 1 cap per day.
At the time of writing, the new Pyroxamine specified here isn’t out yet, but it should hit stores sometime within the next two months (just in time to shed those holiday pounds, you’ll likely get).
Although unnecessary drama and investigations into picamilon forced Myokem’s hand into reformulating a truly great fat burner, it looks like all the trouble was well worth it. The new formula for Pyroxamine looks great and the fact that the label is 100% open is only another point in Myokem’s favor.
Sadly the product doesn’t launch for quite a while, but we have high hopes for it when it does and expect it to continue to maintain a spot on our Top 10 Fat Burners list.
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- Giesbrecht, Timo, et al; “The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness”; Nutritional Neuroscience; 2010
- Kimura K, et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. (2007)
- Owen GN, et al. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci. (2008)
- Ball KT, Poplawsky A. Low-dose oral caffeine induces a specific form of behavioral sensitization in rats. Pharmacol Rep. 2011 Nov;63(6):1560-3. PubMed PMID: 22358105.
- Pearce LV, et al; Evodiamine functions as an agonist for the vanilloid receptor TRPV1 . Org Biomol Chem. (2004)
- Noh K, et al; Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats . Arch Pharm Res. (2011)
- Tsai TH, Chang CH, Lin LC; Effects of Evodia rutaecarpa and rutaecarpine on the pharmacokinetics of caffeine in rats . Planta Med. (2005)
- Frank M, et al; Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse; Equine Vet J. (1990)
- Barwell C.; School of Pharmacy; “Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat;” 1989
- Nedergaard O.; British Journal of Pharmacology; “Action of various sympathomimetic amines on the isolated stripped vas deferens of the guinea-pig;” November 1968
- Zhao, Q; Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; 2002