PES ERGONINE – The Once-Per-Day Muscle Supplement

DISCONTINUATION NOTICE: This supplement was discontinued and is now out of stock. We’re leaving this article up because we loved the product so much.

PES Ergonine

Can one supplement handle all of your muscle-building needs at just $1/day? See what we think about Ergonine below

PES Ergonine is the workout enthusiast’s “one-a-day” supplement promised to take care of all of your basic needs in regards to enhancing performance and building muscle.

Rather than opening 9 different tubs or combining multiple pills, powders, and other potions to cover all your bases, PEScience has taken the complication and hassle out of the equation; bringing everything you need in 1 all-encompassing tasty scoop.

Originally launched under the brand Athletix (which was acquired by PEScience), a no-fuss, direct-to-user supplement vendor with no-middleman to markup the price, Ergonine has been moved back to the PES product line.

Ergonine’s proposed benefits include:

  • Increases in lean body mass
  • Reduced fatigue
  • Enhanced recovery

The key word here is “ergogenic” — this is a product geared towards muscle building.

PES Ergonine – Deals and Price Drop Alerts

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What’s in it and are these ingredients really proven to work?Is it truly a $1/day catch-all supplement worth investing in? Let’s find out below as we delve into the ingredient list!

PES Ergonine Ingredients

  • Creatine Anhydrous (3g)

    Ergonine Ingredients

    The ingredients / supplement facts

    We all know what creatine is by now, it’s one of the foundational bodybuilding supplements with countless studies to prove it’s benefits in regards to:

    • Increased Power and Strength[1,2]
    • Lean Mass / Body Composition[3-5]
    • Cell Hydration[6]
    • Reduced Fatigue[7]

    PEScience breaks away from the tried and true creatine monohydrate or Creatine HCl and uses a novel form that is 100% pure, unadulterated creatine. Creatine anhydrous contains 12% more creatine by weight than creatine mono does.[8]

    What about the dosage?

    Research has shown that the efficacious dosage of creatine is 3-5g per day and we get 3g of 100% pure creatine. Looks like Ergonine is 1 for 1 – Good start!

  • Betaine Anhydrous (2.5g)

    Betaine Anhydrous

    Image Egregiously Stolen from PES

    Betaine, aka trimethylglycine, is an the amino acid glycine with 3 methyl groups bonded (tri-methyl) to it. Betaine is a great partner to creatine and provides many of the same benefits when the two are paired together:

    • Increased Power Output[9]
    • Reduced Soreness[10]
    • Cell Hydration[11]
    • Cortisol Level Reduction[12]

    What about the dosage?

    The dosage administered in all of the studies on betaine indicated 2.5g was needed to reap the research-backed benefits of its supplementation.As you can see, PEScience has used that exact amount in Ergonine.2 ingredients down, 7 more to go!

  • SynerGlut Blend (2.5g)

    Ergonine’s SynerGlut Blend is a combination of 2 amino acids, L-Alanine and L-Glutamine.Now, you may be wondering why are these two paired together?

    Glutamine is well-known to have muscle recovery benefits[13], but the problem is when taken alone, it is completely absorbed in the stomach and never makes its way to the muscle tissue. Enter Alanine!!!

    Research has shown that when Glutamine is consumed in tandem with Alanine, Glutamine makes its way to your muscle cells supplying the much needed recovery benefits your body needs after each and every training session.[14,15]

    What about the dosage?

    The studies used a dosage varying between 1g – 2g of the Glutamine/Alanine combo. There was no significant difference in the outcomes between the 1g dose and the 2g dose. PES appears to be going the safer route here and going on the higher end for dosing, thus ensuring maximum absorption is achieved.

  • L-Carnitine-L-Tartrate (LCLT) (2g)

    L-Carnitine L-Tartrate

    LCLT is the form of L-Carnitine that you want if you’re into building muscle

    Similar to L-Glutamine, the mythos of the bodybuilding world have long touted the benefits of L-Carnitine supplementation.However, studies on pure L-carnitine supplementation continually showed no results unless you’re carnitine deficient (which is primarily reserved for vegetarians and the elderly).

    But enter the L-Carnitine-L-Tartrate (LCLT) form and things change.

    When administered is a 2g dose, LCLT supplementation demonstrated:

    • Increased Fat Oxidation[16,17]
    • Improved Recovery[18]
    • Reduced Soreness[19]

    What about the dosage?

    Ergonine comes fully loaded with the clinically backed 2g dosage of LCLT, so no need to go buying a tub to top off your needs for carnitine supplementation.

  • Hydroxy-Isocaproic Acid (HICA) (1.5g)

    PES Alphamine also contains HICA

    PES’ Alphamine, which we currently rank as the best fat burner, is one of the few weight loss products to include HICA

    HICA, also known as Leucic Acid, is a metabolite of the BCAA Leucine. Leucine is the most studied of the BCAAs and provides the catalyst for the mTOR pathway in the body. This is crucial because the mTOR pathway stimulates muscle protein systhesis, so…no leucine, no muscle-building.

    HICA supplementation has been noted to provide numerous benefits including:

    • Increased Lean Mass[20]
    • Improved Performance[20]
    • Reduced Soreness[20]
    • Decreased Fat Mass[20]

    What about the dosage?

    The dosage required to extoll the numerous benefits of HICA was 1.5g. PES doesn’t cut any corners again and includes a full 1.5g clinically-backed dose in Ergonine.

  • PerformaLean Blend (1.1g)

    Ergonine’s PerformaLean Blend is comprised of a proprietary blend of Choline Bitartrate, Glycerol 65% (HydroMAX), and Ferula Asafoetida (Root) Extract (95% Ferulic Acid).

    This is primarily a support blend for the other ingredients (for instance, the choline boosts the carnitine).

    Let’s look at the primary and secondary benefits of each one:

    • Choline Bitartrate

      Choline has long been touted for its benefits in improving mood and focus during workouts, but it also offers so much more! Choline has been shown to aid in fat loss and exercise endurance.[21,22]

      But the real reason it’s here is because it’s been shown to increase the muscle’s absorption of carnitine![23]

      Furthermore, strenuous and repeated bouts of exercise deplete the body of its choline stores and reducing the amount of neurotransmitters circulating in the body. This leads to a decline in mood, energy, and focus. So, to keep bringing it everyday in the gym, you’re going to want to be topping of your choline reserves daily!

    • Glycerol 65% (HydroMAX)

      We LOVE this ingredient

      Glycerol has long been known as a key ingredient in many of the “pump” products on the market. The main reason it’s here, however, is to provide for fluid balance in your system.

      The problem is, most other products use glycerol monostearate (GMS), which is glycerol attached to a bunch of saturated fatty acid chains. You’ll notice these as those pesky clumps that never seem to dissolve in your shaker bottle…

      Ergonine instead uses HydroMAX which is 65% glycerol by weight, while GMS is roughly ¼ glycerol by weight. This also solves the problem of those clumps in your pre-workout and makes for easy dissolving.

    • Ferula Asafoetida (Root) Extract (95% Ferulic Acid)

      Ferulic Acid is a relative newcomer to the supplement world and more than likely hasn’t been included in any supplement you’ve tried before.PEScience opted to include this novel ingredient in Ergonine because research has shown that in as little as 30mg/day, there were noticeable improvements in recovery, strength, endurance, and muscle mass![24,25]

    What about the dosage?

    Seeing that this is a proprietary blend, we have no way of knowing if Ergonine contains the efficacious doses of these 3 ingredients. Based on all of the other ingredients being dosed at clinically proven levels, leads us to believe that PES won’t short change us here, but as always buyer beware of proprietary blends.

    We’ll just say this: with choline on top of of a three-ingredient blend at 1.1g, that means you’re getting a minimum of 367mg choline. That’s more than a lot of “focus” supplements use, and this isn’t even marketed towards that!

PES Ergonine – Deals and Price Drop Alerts

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Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

Available Flavors

So far in early 2015… (see the PricePlow widgets above and below to have an updated list)

  • Blue Ice
  • Nanaberry (an amalgamation of banana and strawberry!)

Recommended Dosage:

On training days, mix 1 scoop in 10-12 oz of water and consume 30-60 minutes prior to exercise.This is within the timeframe you’ll be guzzling your pre-workout anyway, so what’s one more powder to throw in the old shaker bottle?!

On non-training days, take your serving in the morning with or without food

The General Consensus / Pre-Review

In one word: Finally!

PES promised a $1/day supplement to take care of all of your basic needs as an exercise enthusiast. It’s retailing for $29.99 for a 30 serving tub and should you choose to buy more than one, there are some volume discounts.

On the surface, it appears Ergonine will be a worthwhile addition to your supplement stack as it uses scientifically proven ingredients dosed in research-backed amounts.Seeing as it’s just released, there aren’t any substantial reviews to validate its effectiveness, but it goes without saying that this is going to work well for nearly everyone.

Cover the gap that your other supplements don’t

With tons and tons of underdosed pre workouts out there (we rant about this in our recent “Creatine is Broken” article), this is the product that will cover your gaps – on workout days and off days – once and for all!

Time will tell, but the arrow is pointing up and you can be sure once we’ve had the chance to test it out, we’ll have our thoughts posted up ASAP!

Where to buy Ergonine

Ergonine was originally not going to be at major retailers – this is a direct-to-consumer product with free shipping that will keep the costs low for you:

PES Ergonine – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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  2. Bemben, M; The effects of supplementation with creatine and protein on muscle strength following a traditional resistance training program in middle-aged and older men.; Neuromuscular Lab, Dept. Health & Exercise Science, U. Oklahoma; 2010
  3. Chilibeck, P; Effect of creatine ingestion after exercise on muscle thickness in males and females.; College of Kinesiology, University of Saskatchewan; 2004
  4. Branch, J; Effect of creatine supplementation on body composition and performance: a meta-analysis.; Department of Exercise Science, Physical Education, and Recreation at Old Dominion University; 2003
  5. Eckerson, J; Effect of thirty days of creatine supplementation with phosphate salts on anaerobic working capacity and body weight in men.; Department of Exercise Science, Creighton University; 2008
  6. Häussinger D, et al. Cellular hydration state: an important determinant of protein catabolism in health and disease. Lancet. (1993)
  7. Anomasiri, W; Low dose creatine supplementation enhances sprint phase of 400 meters swimming performance.; Department of Biochemistry, Faculty of Medicine, Chulalongkorn University; 2004
  8. Jäger, Ralf; Analysis of the Efficacy, Safety, and Regulatory Status of Novel Forms of Creatine. Amino Acids 40.5 (2011): 1369-383.
  9. Lee EC, et al. Ergogenic effects of betaine supplementation on strength and power performance. J Int Soc Sports Nutr. (2010)
  10. Cholewa, J; Effects of betaine on body composition, performance, and homocysteine thiolactone.; Department of Kinesiology, Recreation, and Sport Studies, Coastal Carolina University; 2013
  11. Courtenay ES, et al. Vapor pressure osmometry studies of osmolyte-protein interactions: implications for the action of osmoprotectants in vivo and for the interpretation of “osmotic stress” experiments in vitro. Biochemistry. (2000)
  12. Apicella JM, et al. Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise. Eur J Appl Physiol. (2013)
  13. Bowtell JL, et al. Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise. J Appl Physiol. (1999)
  14. Harris, R; L-glutamine Absorption Is Enhanced after Ingestion of L-alanylglutamine Compared with the Free Amino Acid or Wheat Protein. Nutrition Research 32.4 (2012).
  15. Hoffman, J; L-alanyl-L-glutamine Ingestion Maintains Performance during a Competitive Basketball Game. Journal of the International Society of Sports Nutrition 9.1 (2012)
  16. Hungo, N; Carnitine and Choline Supplementation with Exercise Alter Carnitine Profiles, Biochemical Markers of Fat Metabolism and Serum Leptin Concentration in Healthy Women. The Journal of Nutrition 133.1 (2003)
  17. Villani, R.; L-Carnitine Supplementation Combined with Aerobic Training Does Not Promote Weight Loss in Moderately Obese Women. Int J Sport Nutr Exerc Metab 10.2 (2000)
  18. Volek J; L-Carnitine L-Tartrate Supplementation Favorably Affects Markers of Recovery from Exercise Stress. American Journal of Physiology, Endocrinology and Metabolism 282.2 (2002)
  19. Spiering, Barry A., et al. Effects of L-Carnitine L-Tartrate Supplementation on Muscle Oxygenation Responses to Resistance Exercise. Journal of Strength and Conditioning Research 22.4 (2008)
  20. Mero, Antti A., et al. Effects of Alfa-hydroxy-isocaproic Acid on Body Composition, DOMS and Performance in Athletes. Journal of the International Society of Sports Nutrition 7.1 (2010)
  21. Elsawy, G; Effect of Choline Supplementation on Rapid Weight Loss and Biochemical Variables Among Female Taekwondo and Judo Athletes. J Hum Kinet 40 (2014)
  22. Penry, J; Choline: An Important Micronutrient for Maximal Endurance-exercise Performance? Int J Sport Nutr Exerc Metab 18.2 (2008)
  23. Hongu, N; Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women.; Department of Nutrition and Agricultural Experiment Station, The University of Tennessee; 2003
  24. You, Yanghee, et al. Stimulatory Effects of Ferulic Acid on Endurance Exercise Capacity in Mice. Bioscience, Biotechnology, and Biochemistry 73.6 (2009)
  25. Bucci; Effect of ferulate on strength and body composition of weightlifters. J Appl Sport Sci Res. 1990;4:104–9

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