Natural or not, everyone loves to make gains. Some are content with reaping all benefits possible with their God-given genetics, while others like to really push their body’s limit beyond its normal capacity and embrace the world of hormonal muscle enhancers, such as prohormones and other anabolics.
If you’re a part of the latter category, then listen up, because today’s product is especially important for you! When stepping out of the natty muscle builder world and into the more aggressive arena, one aspect of supplementation that can’t be stressed heavily enough is liver support.
As the primary filtration unit for the body, the liver bears the brunt of virtually every single thing you put in your body, including anabolics. When running an aggressive cycle, your liver is heavily taxed and exposed to some rather nasty compounds. Due to this, cycle support and PCT are both extremely crucial in order to support, protect, and detoxify your liver and other vital organs.
One of the most trusted brands in this corner of the industry is industry is CEL, or Competitive Edge Labs, who’s provided an extremely effective and affordable option for safeguarding your most vital of organs. TUDCA is a powerful single ingredient supplement that supports your body and allows you to use the more aggressive stuff available with a clear conscience.
We’ve got all the info on TUDCA below, but first, take a moment to check the best deal and sign up for alerts from PricePlow:
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There’s no laundry list of ingredients to get through here with TUDCA. Each capsule contains only one active ingredient — TUDCA! Get ready, we’re going to talk about the importance of bile now.
Note: Doses listed below are based on 1 capsule.
TUDCA (250 mg)
TUDCA, short for, Tauroursodeoxycholic acid, is a taurine conjugated form of ursodeoxycholic acid (UDCA), a pharmaceutical drug commonly prescribed to treat cholestasis — a disease where the production or flow of bile to the liver slows or stops.
Dangers of Cholestasis
Cholestasis can occur as a result of a physical blockage in the bile ducts or as a nasty side effect from compounds such as prohormones or steroids, due to their hepatotoxic effects. Inhibition of bile production / flow can pose serious consequences for an individual as it reduces the digestion of fats, and can lead to jaundice and destruction of liver tissue.
Once initiated, cholestasis stimulates “death” receptors that trigger apoptosis (cell death), and left unchecked this ultimately leads to dying liver tissue and ultimately organ failure. TUDCA can prevent cell death by stimulating receptors that promote cell survival, and counter the actions of the “death” receptors. It also enhances natural bile production and inhibits the formation of toxic steroid metabolites (which adversely impact the liver and other vital organs).
TUDCA vs UDCA
While several studies have previously been conducted on TUDCA, it wasn’t until November 2016, that the first large-scale, randomized, double blind trial was conducted evaluating the efficacy and safety of TUDCA vs. UDCA.
199 primary biliary cholangitis (PBC) patients were randomly assigned to either 250 mg TUDCA plus UDCA placebo or 250 mg UDCA plus TUDCA placebo, 3 times per day for 24 weeks. After the 24 week testing period ended, researchers concluded:
”TUDCA is safe and as efficacious as UDCA for the treatment of PBC, and may be better to relieve symptoms than UDCA.”
This further proved the results of an earlier trial that found 750mg / day of TUDCA (750 mg/d) to be more effective and safe than an equivalent dose of UDCA (750 mg/d). The earlier study investigated TUDCA vs UDCA as a treatment for patients with cirrhosis. FYI, the cirrhosis study also lasted 6 months (i.e. 24 weeks).
Other TUDCA Benefits
TUDCA isn’t just for liver health though, it’s also been shown to:
- Protect against stroke, brain injury and neurological diseases..[5,6,7,8]
- Defend against cell death (not just in the liver!)[9,10]
- Restore glucose homeostasis in muscle, liver, and adipose (fat) tissue)
- Increase insulin sensitivity in liver and muscle
- Reduce liver damage caused by alcohol when taken with or after consumption of alcohol, but increases liver damage when taken before drinking.[13,14]
CEL recommends consuming one capsule two times per day with food. For example, consume your first TUDCA capsule with breakfast and your second capsule with dinner.
Importance for People Using Hormonal / Anabolic Supplements
”In the quest to gain the most impressive physiques or to maximize athletic performance, many people take oral anabolic enhancement products. These product are notoriously harsh on your liver and have been documented to cause liver failure in some people. Many androgens may also raise LDL cholesterol levels. TUDCA may help combat these effects by aiding in the production of bile. TUDCA supports bile flow to remove toxic metabolites from the liver and this can also help protect against cholestasis to ensure cholesterol metabolism. It’s a nice one-two punch – you get the potential for liver protection along with a cholesterol fighter all in one.”
Natty People Stand to Benefit Too!
CEL also mentioned that just because you’re embracing the all natural route on your way to making gains, doesn’t mean TUDCA can’t offer you some benefits as well:
”I think TUDCA is something that many people should consider as part of their general supplement regimen.
We live in a world where there are toxins everywhere – in the fair that we breathe and the food that we eat. And there are many things that people do or have done at some point in their lives that can cause a lot of stress on and damage to their livers. This can include, but is not limited to, consuming alcohol, OTC medications, prescription drugs, recreational drugs, and more. The damage and harm from these things can sometimes be immediate but often times may set the stage for long term negative effects. It amazes me sometimes that you hear people say TUDCA is too expensive to use regularly but the same person saying it often has no problem spending the same $25.00/30.00 that TUDCA would cost them per month on one night out at the bar with their friends.”
In addition to being a great solo ingredient, it also stacks perfectly with CEL’s Cycle Assist — long heralded as the premier choice for both on cycle and PCT needs. Cycle Assist provides a full complement of liver support ingredients that further enhance the effectiveness of TUDCA and offer a number of other benefits TUDCA does not!
When asked about if TUDCA was a good add-on product, CEL said:
”Absolutely. Cycle Assist contains liver support ingredients such as Milk Thistle and N-Acetyl-Cysteine that TUDCA compliments and works very well with. They are great ingredients, TUDCA just goes a step beyond them. However, they are still great additions and plus Cycle Assist contains ingredients to help support other things that TUDCA doesn’t help with such as prostate support, blood pressure support, and more.”
You make joke in the gym about pushing the limits and never taking days off, but one area where there’s no messing around is with your vital organ — especially your liver! Bile doesn’t sound fun, but it’s important.
If you’re willing to dabble in the more aggressive side of muscle-builders, you better be serious about protecting yourself too. No gains are worth risking your health over, and that’s where TUDCA comes to the rescue. Tons of health benefits, liver support, and cost efficient all in one simple capsule!
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- Ishak KG, Zimmerman HJ.; Seminars in Liver Disease; “Hepatotoxic effects of the anabolic/androgenic steroids;” August 1987
- Joana D. Amaral, et. al.; The Journal of Lipid Research; “Bile acids: regulation of apoptosis by ursodeoxycholic acid;” September 2009
- Ma H, Zeng M, Han Y, et al. A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis. Kinoshita. A, ed. Medicine. 2016;95(47):e5391. doi:10.1097/MD.0000000000005391. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134868/
- Pan XL, Zhao L, Li L, et al. Efficacy and safety of tauroursodeoxycholic acid in the treatment of liver cirrhosis: a double-blind randomized controlled trial. J Huazhong Univ Sci Technolog Med Sci2013;33:189–94. https://www.ncbi.nlm.nih.gov/pubmed/23592128
- Rodrigues CM., et. al.; Proceedings of the National Academy of Sciences of the United States of America; “Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats;” May 2003
- Rodrigues CM., et al.; Journal of Cerebral Blood Flow and Metabolism; “Neuroprotection by a bile acid in an acute stroke model in the rat;” April 2002
- Dwan WN., et. al.; Cell Transplantation; “Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson’s disease;” 2002
- Ramalho RM; Journal of Neurochemistry; “Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer’s disease mutant neuroblastoma cells;” September 2006
- Amaral JD., et. al.; The Journal of Lipid Research; “Bile acids: regulation of apoptosis by ursodeoxycholic acid;” September 2009
- Ben Mosbah I., et. al.; Cell Death and Disease; “Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion;” July 2010
- Ozcan U.; Science; “Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes;” August 2006
- Kars M., Diabetes; “Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women;” August 2010
- Henzel K., et. al.; Biochimica et Biophysica Acta; “Toxicity of ethanol and acetaldehyde in hepatocytes treated with ursodeoxycholic or tauroursodeoxycholic acid;” February 2004
- Neuman MG, et. al.; Gastroenterology; “Effect of tauroursodeoxycholic and ursodeoxycholic acid on ethanol-induced cell injuries in the human Hep G2 cell line;” August 1995