We always love hearing from our avid readers, especially when they ask if we could review or analyze a new product. And that’s exactly what happened last week, when @Lendo777 asked us about KOR Lipolytic Ignitor on Twitter.
Kor Lipolytic is formulated by Inspired Nutraceuticals, the same company that brings us the potent DVST8 pre workout that’s been talk of the town.
We’re certainly glad it was brought to our attention because it’s a relatively interesting fat burner from a company we’re going to have to keep our eyes on – this might just be the next fat burner we try after our current run on Olympus Labs IGNIT3 (which is absolutely awesome and definitely bound for our best fat burner list).
You can find out all about KOR Lipolytic below, but first, take a moment to check the best deal and sign up for PricePlow alerts:
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The great thing about Inspired Nutra products is that they’re 100% transparent, which we always love here at PricePlow. KOR Lipolytic is no exception and provides a unique blend of focus and fat burning that’ll have you zoned in like no other thermogenic you’ve most likely encountered.
Note: Doses listed below are based on one full serving (2 capsules)
β2-adrenergic Agonist Matrix
Higenamine HCl (30mg)
Dubbed the “weaker ephedrine”, higenamine is a natural alkaloid found in lotus seeds and a number of other plants and fruits. It activates both the beta-1 and the beta-2 adrenergic receptors. Stimulating these receptors increases the heart rate and releases a bit of adrenaline, which then mobilizes body fat for use as fuel. When used in conjunction with caffeine, as it is here, the whole process is ramped up, which mobilizes even higher amounts of stored fat.[1,2]
Higenamine has a similar weight loss effect as ephedrine, but with none of the dangerous side effects, thus the nickname “weaker ephedrine”. As a matter of fact, it’s very well-researched and has determined to be incredibly safe.[3,4]
This is one of the PricePlow gang’s favorite fat burning ingredients, and you’ll definitely notice the thermogenic kick from it, but not so much that it makes you uncomfortable.
Octopamine HCl (30mg)
A rarely used ingredient, Octopamine is an amine found in the human brain that possesses stimulatory effects similar to its relative, synephrine (which we’ll cover down below). Stim effects aside, octopamine enables fat burning by inhibiting glucose uptake in fat cells (adipocytes) by blocking the beta-3 adrenoceptors.
Additionally, octopamine activates the alpha-1 adrenergic receptors which triggers lipolysis (a.k.a. fat-burning!).
One thing to be aware of though, octopamine is on the WADA banned substances list, so if you’re a drug-tested athlete, you need to avoid this ingredient!
Derived from cocoa extract, Cocoabuterol® is contains several compounds including N-Coumaroyldopamine, N-Caffeoyldopamine, EGCG and Theobromine. The two compounds we’re most interested here are N-coumaroyldopamine and N-caffeoyldopamine, which affect the β2 adrenoceptors in the body inducing both fat loss and muscle growth…just what we want in a fat burner!
EGCG plays a unique role here as well, as it the mechanism that breaks down N-coumaroyldopamine and N-caffeoyldopamine. This allows the two primary compounds to stay active longer and enable more fat burning.
Remember Compound 20’s Original Formula?
The two main constituents here were originally sold in the USPLabs Compound 20 supplement, whose marketing compared them to Clenbuterol, a controlled substance. While we never fully believed that comparison, we did love the repartitioning and leaning effects of the OG Compound 20 formulas. Really not sure why USPLabs moved away from them, as the newer formula simply wasn’t the same…
Anyway, if this is indeed extracted for N-coumaroyldopamine and N-caffeoyldopamine, and you’ve never tried the original Compound 20 or other supplements that have them, you should consider giving this a spin on your next diet. Good things seem to happen with them.
Theobromine is the well-known “feel good” ingredient responsible for the mini-euphoria you feel each time you eat a piece of super-high quality dark chocolate. It’s chemically similar to caffeine, and often referred to as caffeine’s “younger brother.”
Theobromine acts as a stimulant in the body, though not quite as potent as caffeine does. But, the energy kick from theobromine is much smoother and longer-lasting than it’s harsher acting brother.
Renowned for its ability to offset fatigue as well as improve memory and cognition[9,10], Sulbutiamine is a synthetic derivative of the B-vitamin thiamine. It was originally created by a group of Japanese scientists who joined 2 thiamine molecules with a sulphur group. This may seem like a strange inclusion for a fat burner, but there’s reasoning behind its appearance on the ingredient panel.
Thiamine doesn’t cross the blood-brain barrier all that easily, but thanks Sulbutiamine’s increased fat-solubility, it easily crosses the barrier and then increases circulating levels of thiamine in the body.
You will more often see this ingredient discussed in nootropic circles for the focus – but anytime we’re dieting or low-carbing it, we’ll take anything to help with that brain fog.
Thermo Energy Complex
Dicaffeine Malate (300mg)
Forged together with iron and fire (not really), dicaffeine malate is a combination of caffeine and malic acid. These two compounds are joined via an ionic which which yields a hybrid form of caffeine that yields roughly 75% caffeine by volume.
The primary benefit of dicaffeine malate is that it provides a much more sustained energy release, eliminating the harsh caffeine “kick” which is notorious among the fat burner population. Additionally, the addition of malic acid helps offset any potential crash as well as ease caffeine’s sometimes stomach-irritating effects.
TeaCrine™, a.k.a. theacrine, is synthesized from caffeine in certain plant species and actually exhibits a similar structure. Not surprisingly, theacrine exhibits many of the same stimulatory effects as caffeine, however, they are much longer lasting.
Similar to caffeine, theacrine activates the dopamine and adenosine receptors in the brain, which elevates mood and energy levels. The real benefit to using theacrine though is that it doesn’t lead to a tolerance build up like caffeine does.[12,13] This means that you can keep getting the same great energy kick and focus without having to continually up the dose!
Synephrine HCl (30mg)
Our last ingredient also happens to be a beta agonist and it could easily fit in the first grouping of ingredients alongside Higenamine and Octopamine. Also found in Bitter Orange (a.k.a. Citrus Aurantium), synephrine is structurally similar to the now-banned ephedra. But, unlike ephedra, Synephrine has been shown time and again to be safe and effective for use.[14,15]
Synephrine is a potent Beta-2 and Beta-3 adrenergic receptor agonist[16,17] that liberates stored triglycerides and releases them into the bloodstream, a process known as lipolysis. This enables the body to essentially “burn fat for fuel” and save your glycogen stores for intense exercise.
Take 2 capsules once per day. Do not exceed 4 capsules in 24 hours.
We cover a lot of products here at PricePlow, both old and new. Sometimes a gem like this slips under the radar among the mass number of products that hit the wire each week. Thankfully, we were alerted to this by an inquisitive follower. To answer Lendo’s question… we’re VERY interested in KOR Lipolytic.
This fat burner represents everything we’d want in a fat burner, energy, focus, fat burning, and an open label! Now that we’ve been attuned to Inspired Nutraceuticals, we’re going to have to keep an eye on them and see what new products come out of the pipeline.
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- Kang, YJ, et. al.; “Inhibition of activation of nuclear factor kappaB is responsible for inhibition of inducible nitric oxide synthase expression by higenamine, an active component of aconite root“; The Journal of Pharmacology and Experimental Therapeutics; October 1999
- Bai, G, et. al.; “Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist“; Acta Pharmacologica Sinica; October 2008
- Kimura, I, et. al.; “Positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated murine atria“; Japanese Journal of Pharmacology; September 1994
- Feng, S, et. al.; “A phase I study on pharmacokinetics and pharmacodynamics of higenamine in healthy Chinese subjects“; Acta Pharmacologica Sinical; November 2012
- Visentin V1, et al. Dual action of octopamine on glucose transport into adipocytes: inhibition via beta3-adrenoceptor activation and stimulation via oxidation by amine oxidases. J Pharmacol Exp Ther. (2001)
- Flechtner-Mors M1, et al. In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects. J Pharmacol Exp Ther. (2002)
- HONG LU, XIAOFENG MENG, et.al. ENZYMOLOGY OF METHYLATION OF TEA CATECHINS AND INHIBITION OF CATECHOLO- METHYLTRANSFERASE BY ( )-EPIGALLOCATECHIN GALLATE. Drug Metab Dispos. 2003 May;31(5):572-9
- Bizot JC, et al. Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. Prog Neuropsychopharmacol Biol Psychiatry. (2005)
- Tiev KP, Cabane J, Imbert JC. Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo. Rev Med Interne. (1999)
- Cauli, O; Subchronic caffeine exposure induces sensitization to caffeine and cross-sensitization to amphetamine ipsilateral turning behavior independent from dopamine release.; Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari; 2008
- Li, W; Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice.; Institute of Traditional Chinese Medicine and Natural Products, Jinan University; 2013
- Feduccia, A; Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors.; Ernest Gallo Clinic and Research Center, University of California at San Francisco; 2012
- Preuss, HG, et. al; “Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview;” Journal of Medicine; 2002