Revive MD Glutamine: Why Add to Your Gut Health Stack

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A few months ago, we wrote an article announcing Revive MD GI+, a gut health supplement formulated by Dr. Domenic Iacovone and Matt Jansen at Revive MD that brought a few unique ingredients to the table. Most notably, it contained N-acetyl-glucosamine, which we explored for its ability to heal intestinal lining — as opposed to other forms of glucosamine that work as joint supplements.

Revive MD Glutamine

Revive MD Glutamine is here to bolster your gut health stack, which includes GI+

Revive MD has done a fantastic job of formulating specific health supplements, introducing us to ingredients that often go forgotten or are simply unknown. Today, they’re adding to their gut health supplement stack with a simple, single-ingredient formula we’ve talked about several times: Revive MD Glutamine.

Glutamine… for Gut Health

We always state that glutamine is not a muscle-building supplement, even though it was originally marketed as one. However, that doesn’t mean the highly-abundant amino acid isn’t without benefits.

In this article, we dive into glutamine’s role as a supporting ingredient to GI+, and look deeper into the mechanisms driving its gut health improvements.

Before we dive in, take a moment to subscribe to PricePlow’s Revive MD news alerts, since the brand is always doing something novel!

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“A key building block for protein and muscle development that helps support immune and gastrointestinal health – aiding in digestion and protecting the stomach lining.”

— Revive MD Newsletter

Revive MD Glutamine Label: Note the 10g scoop size!

Revive MD Glutamine Ingredients

The difference here is that Revive MD is using 10 gram scoops, which is double the norm. Go big for your gut!

This is a 300 gram tub of L-glutamine powder, which is the standard. What’s not standard is that Revive MD has put a scooper that’s twice the size of most other glutamine supplements. Inside, you’re getting 10 grams per serving, which gives us a hint that the brand sees benefits beyond the typical 5 gram dosage. This is especially true for their sponsored athletes, who are generally on the bigger and more athletic end of the spectrum.

Let’s see how this may help with gut health:56

Glutamine and Gut Health

Well known for decades, there is a 1996 review article simply titled “Glutamine” whose abstract states, “There is also considerable evidence that glutamine can enhance the barrier function of the gut.”[1] Digging deeper into that review, we learn of another study demonstrating that the gut consumes large amounts of the amino acid,[1,2] especially during times of critical illness in animals.[2]

Revive MD Glutamine Breakdown

In this article, we focus on the gut health properties of Glutamine

Greater utilization and metabolization during times of stress and trauma

In that 1991 study, seven patients with multisystem trauma were catheterized and analyzed throughout their recovery. While other amino acid levels were unchanged, less glutamine was detected, indicating that more uptake was occurring in the gut. This was also confirmed by elevated levels of citrulline, which occurred due to glutamine’s metabolism.[2]

The body is quite flexible and adaptive at using glutamine — it can be taken either from the small bowel epithelium or straight from the bloodstream.[3] The first pass extraction rate is about 30%, so it’s good to have on a regular basis, especially if sick or “traumatized” from your Matt Jansen powered workout.

The gut atrophies without glutamine

It’s well-known to researchers that the gut atrophies during long-term parenteral nutrition (when nutrition is provided outside of the digestive tract). However, when adding glutamine to parenteral formulas, much of the gut atrophy can be ameliorated.[4]

A barrier for the gut (and immune health)

Revive MD Starter Stack

New to the incredible supplements at Revive MD and not sure where to start? They’ve got it all covered for you in this Revive MD’s Starter Stack, which you can also supplement with glutamine!

Beyond its role as an organ for digestion and absorption, our guts are also barriers against pathogens, acting as a major part of the innate immune system. Several studies have demonstrated that glutamine enhances the mucosal barrier in the gut.[5]

A breakdown in this mucosal barrier’s function is generically referred to as “Leaky Gut Syndrome”, and glutamine is considered the most important nutrient in healing this condition.[6,7] Several studies demonstrate its potency in reducing intestinal permeability from stressors while maintaining normal barrier function.[8-13]

The immune connection

This ties into a lot of the health claims made regarding immunity: if the gut is strengthened and has the amino acids it needs to operate, the immune system stands a stronger chance at defeating invading pathogens. Diets higher in glutamine have been shown to prevent some bacteria from crossing the gut mucosal barrier (known as translocation).[14,15]

This is why it’s not surprising to see lower levels of plasma glutamine contribute to decreased immune system function and greater chances of getting sick.[16]

An “Immunonutrient”: Fuel for your enterocytes

Revive MD Health Stack

Looks like Savannah’s got one more ingredient to add to her Health Stack!

Glutamine provides a major source of energy for the enterocytes and epithelial cells in the intestines.[17] Enterocytes are intestinal absorptive cells, and epithelial cells relate to the epithelium, which line the outer surfaces of blood vessels, organs, and of course the skin’s epidermis. Because of this, researchers call glutamine an immunonutrient, as it enhances immune function, especially in patients with surgical and critical illness.[17]

We close with a 2012 meta-analysis, where researchers concluded that glutamine improves barrier function and morphology, decreases mucosa atrophy, prevents radiation-induced GI injury, reduces oxidative stress, boosts mucosal lymphocyte count, and lowers intestinal permeability and inflammation.[6]

There are other systems that glutamine supports, such as recovery and potential endurance applications, but this article focuses on gut health.

Why did Revive MD launch a glutamine supplement?

From the Revive MD newsletter:

Why did we add Glutamine to the product line?

There are a lot of great benefits from high quality L-Glutamine, especially for individuals and athletes looking for gut and digestive support.

Many products on the market include Glutamine, but if you increase your intake of that multi-ingredient product, then you’re also increasing your glutamine intake, which in reality is likely wasting ingredients.

We wanted to create a single ingredient that could be added to any supplement stack to support your individual needs.

— Revive MD

A supplement too cheap and easy not to try for gut health

Revive MD GI+

Revive MD, a supplement brand that’s no stranger to all-in-one formulas, has put out their comprehensive GI Health supplement, GI+

None of the above is based on new research, but it all seems to have been missed in the decades of false marketing claims regarding glutamine and muscle gains — which it doesn’t really affect.

What it does do is improve gut health, subsequently improving immunity.

Our key takeaway is simple: if your gut health is “jacked up” in any fashion, why not try adding a ten gram dose of glutamine once or twice a day? It’s inexpensive and just may be the amino acid your body is looking for, yet having trouble producing in the quantities it needs.

Those are the situations where supplementation are key, and when it comes to gut health, Revive MD GI+ and Glutamine make a powerful combination worth testing.

Revive MD Glutamine – Deals and Price Drop Alerts

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No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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References

  1. Hall, J C et al.; “Glutamine.”; The British journal of surgery vol. 83,3 (1996): 305-12. doi:10.1002/bjs.1800830306; https://pubmed.ncbi.nlm.nih.gov/8665180/
  2. McAnena, O. J., et al. “Selective Uptake of Glutamine in the Gastrointestinal Tract: Confirmation in a Human Study.” The British Journal of Surgery, vol. 78, no. 4, 1 Apr. 1991, pp. 480–482, pubmed.ncbi.nlm.nih.gov/1903318/, 10.1002/bjs.1800780429; https://pubmed.ncbi.nlm.nih.gov/1903318/
  3. Christensen, H. N. “Interorgan Amino Acid Nutrition.” Physiological Reviews, vol. 62, no. 4, 1 Oct. 1982, pp. 1193–1233, 10.1152/physrev.1982.62.4.1193; https://pubmed.ncbi.nlm.nih.gov/6752985/
  4. O’Dwyer, Sarah T., et al. “Maintenance of Small Bowel Mucosa with Glutamine-Enriched Parenteral Nutrition.” Journal of Parenteral and Enteral Nutrition, vol. 13, no. 6, Nov. 1989, pp. 579–585, 10.1177/0148607189013006579; https://pubmed.ncbi.nlm.nih.gov/2515303/
  5. Alverdy, John C. “Effects of Glutamine-Supplemented Diets on Immunology of the Gut.” Journal of Parenteral and Enteral Nutrition, vol. 14, no. 4_suppl, July 1990, pp. 109S113S, 10.1177/014860719001400415; https://pubmed.ncbi.nlm.nih.gov/2119455/
  6. Rao, RadhaKrishna, and Geetha Samak; “Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions.”; Journal of epithelial biology & pharmacology vol. 5,Suppl 1-M7 (2012): 47-54. doi:10.2174/1875044301205010047; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369670/
  7. DeMarco, Vincent G., et al. “Research Communication: Glutamine and Barrier Function in Cultured Caco-2 Epithelial Cell Monolayers.” The Journal of Nutrition, vol. 133, no. 7, 1 July 2003, pp. 2176–2179, 10.1093/jn/133.7.2176; https://pubmed.ncbi.nlm.nih.gov/12840174/
  8. Yoshida, S., et al. “Effects of Glutamine Supplements and Radiochemotherapy on Systemic Immune and Gut Barrier Function in Patients with Advanced Esophageal Cancer.” Annals of Surgery, vol. 227, no. 4, 1 Apr. 1998, p. 485, 10.1097/00000658-199804000-00006; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC1191301/
  9. Foitzik, T., et al. “Glutamine Stabilizes Intestinal Permeability and Reduces Pancreatic Infection in Acute Experimental Pancreatitis.” Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract, vol. 1, no. 1, 1 Jan. 1997, pp. 40–46; discussion 46-47, 10.1007/s11605-006-0008-8; https://pubmed.ncbi.nlm.nih.gov/9834329/
  10. Panigrahi, P., et al. “Role of Glutamine in Bacterial Transcytosis and Epithelial Cell Injury.” JPEN. Journal of Parenteral and Enteral Nutrition, vol. 21, no. 2, 1 Mar. 1997, pp. 75–80, 10.1177/014860719702100275; https://pubmed.ncbi.nlm.nih.gov/9084009/
  11. Peng, Xi, et al. “Effects of Enteral Supplementation with Glutamine Granules on Intestinal Mucosal Barrier Function in Severe Burned Patients.” Burns, vol. 30, no. 2, Mar. 2004, pp. 135–139, 10.1016/j.burns.2003.09.032; https://pubmed.ncbi.nlm.nih.gov/15019120/
  12. Harward, Timothy R.S., et al. “Glutamine Preserves Gut Glutathione Levels during Intestinal Ischemia/Reperfusion.” Journal of Surgical Research, vol. 56, no. 4, Apr. 1994, pp. 351–355, 10.1006/jsre.1994.1054; https://pubmed.ncbi.nlm.nih.gov/8152229/
  13. Kozar, Rosemary A., et al. “Enteral Glutamine but Not Alanine Maintains Small Bowel Barrier Function after Ischemia/Reperfusion Injury in Rats.” Shock (Augusta, Ga.), vol. 21, no. 5, 1 May 2004, pp. 433–437, 10.1097/00024382-200405000-00006; https://pubmed.ncbi.nlm.nih.gov/15087819/
  14. Gianotti, L., et al. “Oral Glutamine Decreases Bacterial Translocation and Improves Survival in Experimental Gut-Origin Sepsis.” JPEN. Journal of Parenteral and Enteral Nutrition, vol. 19, no. 1, 1 Jan. 1995, pp. 69–74, pubmed.ncbi.nlm.nih.gov/7658604/, 10.1177/014860719501900169; https://pubmed.ncbi.nlm.nih.gov/7658604/
  15. Zhang, W., et al. “Glutamine Reduces Bacterial Translocation after Small Bowel Transplantation in Cyclosporine-Treated Rats.” The Journal of Surgical Research, vol. 58, no. 2, 1 Feb. 1995, pp. 159–164, pubmed.ncbi.nlm.nih.gov/7861767/, 10.1006/jsre.1995.1025; https://pubmed.ncbi.nlm.nih.gov/7861767/
  16. Calder, P C, and P Yaqoob.; “Glutamine and the immune system.”; Amino acids vol. 17,3 (1999): 227-41. doi:10.1007/BF01366922; https://pubmed.ncbi.nlm.nih.gov/10582122/
  17. Kim, Hyeyoung; “Glutamine as an immunonutrient.”; Yonsei medical journal vol. 52,6 (2011): 892-7. doi:10.3349/ymj.2011.52.6.892; https://pubmed.ncbi.nlm.nih.gov/22028151/

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