PEScience Mag-GP: Meet Magnesium Glycerophosphate

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Over the past two years, we’ve had the opportunity to highlight numerous forms of immunity-boosting ingredients such as zinc, copper, vitamin D, and even mushrooms, all of which are part of PEScience’s Immune-ST formula. Today, it’s time to get back to another mineral that sadly hasn’t received as much attention as it deserves: magnesium.

PEScience Mag-GP

PEScience Mag-GP introduces to a new, high-bioavailability / high-absorption form of chelated magnesium: Magnesium glycerophosphate, which they claim mixes clear, is tasteless, and non-laxative

As the second-most abundant electrolyte in our bodies, magnesium plays a critical role in bone and cell structure, metabolism, antioxidant synthesis, nerve impulses, muscle contractions, and far more.[1] Supplementing it has several benefits, as we’ll cover below. However, as we’ve seen with various other minerals, not all forms of magnesium work the same!

PEScience Mag-GP: Magnesium Glycerophosphate Chelate

This winter, PEScience is happy to have a new magnesium alternative for you to add to your daily regimen: PEScience Mag-GP, which utilizes magnesium glycerophosphate chelate. Like the minerals used in Immune-ST, this is a chelated form of magnesium that’s bound to highly absorbed molecules that provide benefits themselves.

We get into some background on Mag-GP below, and then discuss why it’s so important to keep magnesium levels high on a daily basis. But first, check our coupon-powered prices on PricePlow:

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Why Magnesium Glycerophosphate Chelate?

Dietary magnesium is never sold or packaged alone in dietary supplements – it’s always going to be bound to something. We often see magnesium oxide as a low-cost form of the mineral, but just like zinc oxide, it has awfully low bioavailability – as low as 4%.[2]

Meanwhile, magnesium found in food generally has a 20-30% absorption rate,[3-5] although some leafy vegetables can range as high as 40-60%.[6,7] In general, absorption is roughly one-third, in line with what we see from magnesium citrate,[8,9] a more common form.

Using mineral glycerophosphates (combining glycerol, phosphate, and magnesium)

PEScience Mag-GP Label

The PEScience Mag-GP Label

In an attempt to do even better, PEScience has opted for magnesium glycerophosphate, which is made using glycerophosphoric acid (also known as glycerol-1-phosphate), which takes glycerol (found in PEScience’s High Volume pre workout) bound to a phosphate group.[10]

These are both beneficial in their own right, and the idea is to attach magnesium[11] (something that isn’t absorbed well) to glycerol (something that is absorbed well). The kicker is that the phosphate plays a parallel role with magnesium, as it’s needed for the production of our cellular “energy currency” adenosine triphosphate, also known as ATP.[12]

There isn’t much peer-reviewed research on magnesium glycerophosphate itself, but it’s interesting to note that when researchers need a very high-quality form of the mineral (such as in situations with cardiac disease), this is one that they go to.[13]

As a sugar alcohol, glycerol has a positive taste and solubility, and this leads to PEScience’s advertised benefits:

PEScience Mag-GP Ingredients

PEScience Mag-GP Ingredients

  • “Taste-free”
  • “Dissolves easily”
  • “Digests perfectly”
  • “Non-laxative”

Mag-GP Dosage

As commonly seen with other chelated minerals, it takes a good amount of powder to get an efficacious dose — Mag-GP’s content is around 12% magnesium by weight, so you’ll need roughly 3.5 grams total if you want to get 420 milligrams of magnesium, or ~100% daily recommended intake.

Generally, you’ll get some magnesium from your diet so it’s important to understand what you eat and how much you need to save on money.

Why supplement magnesium?

With so many biochemical reactions that require magnesium, it’s incredibly important to sustain high enough levels. Deficiency can lead to numerous conditions, including anxiety, muscle weakness, hypertension, and mood disorders.[14] However, magnesium deficiency is very difficult to diagnose, since serum magnesium levels may seem fine because the body is pulling magnesium from bone tissue and cells where it’s needed.[14-16] Making matters worse, symptoms can range widely amongst individuals.[17,18]

Mineral Vegetable Content

The average amount of calcium, magnesium, and iron in vegetables like spinach, lettuce, cabbage, and tomatoes has plummeted as much as 80–90% since 1914.[21] Sadly we have to supplement it back in.

The average American is not getting anywhere near the recommended amount of magnesium,[19,20] and given the drastically reduced amount of magnesium content in our food thanks to poor farming practices and high time preference soil management,[21-27] we’re led to believe that Westerners are generally running a “low-level” magnesium deficiency at best, and moderate deficiencies is more likely.

Nearly everyone should supplement at least some

The solution — until we fix our soil and food production through regenerative grazing and agriculture — is to universally supplement it, finding a dose that feels good but doesn’t provide side effects. This will generally be between 50-100% DV, or somewhere between one and two scoops of Mag-GP.

Magnesium Benefits in human research

The following benefits have been demonstrated in humans, but note that they were done using alternative forms of magnesium. So long as we have a bioavailable form, we believe it’s OK to cite them in this article:

  • Better sleep[28,29]
  • Improved mood / reduced anxiety[30,31]
  • Lower blood pressure[32-35]
  • Reduced HbA1c and blood glucose levels[32,36,37]
  • Decreased fasting insulin levels[32,36,38]
  • Improved insulin sensitivity[32,36,37]
  • Better bone mineral density[39]
  • Lower PMS symptoms[30,40-42]

The benefits go on, and given the metabolic and cardiac improvements, we feel that it’s a great idea to supplement magnesium, and with the taste and solubility benefits of PEScience Mag-GP, this is one that you can easily add to any drink for some incredible benefits.

If you can add it in a small amount of water, it could be worth considering before bed, as many have noted sleep improvements when using it in this fashion.

A new magnesium worth trying

PEScience has brought us many innovative supplements over the years, but it’s always great to get back to the foundational basics of improved mineral status. Just like Immune-ST brought us chelated minerals we now have a new form of magnesium to test. Whether it’s for bone strength, better sleep or improved metabolism, the magnesium glycerophosphate in Mag-GP is one absolutely worth trying for anyone on their health and wellness journey.

PEScience Mag-GP – Deals and Price Drop Alerts

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Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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References

  1. Altura, B. M. “Basic Biochemistry and Physiology of Magnesium: A Brief Review.” Magnesium and Trace Elements, vol. 10, no. 2-4, 1991, pp. 167–171; https://pubmed.ncbi.nlm.nih.gov/1844549/
  2. Firoz, M., and M. Graber. “Bioavailability of US Commercial Magnesium Preparations.” Magnesium Research, vol. 14, no. 4, 1 Dec. 2001, pp. 257–262; https://pubmed.ncbi.nlm.nih.gov/11794633/
  3. Siener, Roswitha, and Albrecht Hesse. “Influence of a Mixed and a Vegetarian Diet on Urinary Magnesium Excretion and Concentration.” British Journal of Nutrition, vol. 73, no. 5, May 1995, pp. 783–790, 10.1079/bjn19950081; https://pubmed.ncbi.nlm.nih.gov/7626596/
  4. Siener, R, et al. “Influence of a Mineral Water Rich in Calcium, Magnesium and Bicarbonate on Urine Composition and the Risk of Calcium Oxalate Crystallization.” European Journal of Clinical Nutrition, vol. 58, no. 2, 29 Jan. 2004, pp. 270–276, 10.1038/sj.ejcn.1601778; https://www.nature.com/articles/1601778
  5. Graham, L. A., et al. “Gastrointestinal Absorption and Excretion of Mg 28 in Man.” Metabolism: Clinical and Experimental, vol. 9, 1 July 1960, pp. 646–659; https://pubmed.ncbi.nlm.nih.gov/13848379/
  6. Schwartz, R., et al. “Magnesium Absorption from Leafy Vegetables Intrinsically Labeled with the Stable Isotope 26Mg.” The Journal of Nutrition, vol. 110, no. 7, 1 July 1980, pp. 1365–1371, 10.1093/jn/110.7.1365; https://pubmed.ncbi.nlm.nih.gov/7381600/
  7. Schwartz, R., et al. “Magnesium Absorption in Human Subjects from Leafy Vegetables, Intrinsically Labeled with Stable 26Mg.” The American Journal of Clinical Nutrition, vol. 39, no. 4, 1 Apr. 1984, pp. 571–576, pubmed.ncbi.nlm.nih.gov/6711467/, 10.1093/ajcn/39.4.571; https://pubmed.ncbi.nlm.nih.gov/6711467/
  8. Lindberg, J S, et al. “Magnesium Bioavailability from Magnesium Citrate and Magnesium Oxide.” Journal of the American College of Nutrition, vol. 9, no. 1, Feb. 1990, pp. 48–55; 10.1080/07315724.1990.10720349; https://pubmed.ncbi.nlm.nih.gov/2407766/
  9. Walker, Ann F., et al. “Mg Citrate Found More Bioavailable than Other Mg Preparations in a Randomised, Double-Blind Study.” Magnesium Research, vol. 16, no. 3, 1 Sept. 2003, pp. 183–191; https://pubmed.ncbi.nlm.nih.gov/14596323/
  10. PubChem. “Glycerophosphoric Acid.”; https://pubchem.ncbi.nlm.nih.gov/compound/glycerophosphate
  11. PubChem. “Magnesium Glycerophosphate.”; https://pubchem.ncbi.nlm.nih.gov/compound/Magnesium-glycerophosphate
  12. Shrimanker I, Bhattarai S; “Electrolytes”; [Updated 2021 Jul 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan; https://www.ncbi.nlm.nih.gov/books/NBK541123/
  13. Lewis, R. V., et al. “Oral Magnesium Reduces Ventricular Ectopy in Digitalised Patients with Chronic Atrial Fibrillation.” European Journal of Clinical Pharmacology, vol. 38, no. 2, 1990, pp. 107–110, 10.1007/BF00265966; https://pubmed.ncbi.nlm.nih.gov/1692533/
  14. DiNicolantonio, James J, et al. “Subclinical Magnesium Deficiency: A Principal Driver of Cardiovascular Disease and a Public Health Crisis.” Open Heart, vol. 5, no. 1, Jan. 2018, p. e000668, 10.1136/openhrt-2017-000668; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5786912/
  15. Rude, Robert K., and Helen E. Gruber. “Magnesium Deficiency and Osteoporosis: Animal and Human Observations.” The Journal of Nutritional Biochemistry, vol. 15, no. 12, Dec. 2004, pp. 710–716, 10.1016/j.jnutbio.2004.08.001; https://pubmed.ncbi.nlm.nih.gov/15607643/
  16. Smith, R. H. “Calcium and Magnesium Metabolism in Calves. 4. Bone Composition in Magnesium Deficiency and the Control of Plasma Magnesium.” Biochemical Journal, vol. 71, no. 4, Apr. 1959, pp. 609–614, 10.1042/bj0710609; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC1196844/
  17. Costello, Rebecca B, et al. “Perspective: The Case for an Evidence-Based Reference Interval for Serum Magnesium: The Time Has Come12345.” Advances in Nutrition, vol. 7, no. 6, 10 Nov. 2016, pp. 977–993, 10.3945/an.116.012765; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5105038/
  18. “Magnesium Deficiency.” British Medical Journal, vol. 2, no. 5546, 22 Apr. 1967, p. 195; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC1841168/
  19. Jacka, Felice N., et al. “Association between Magnesium Intake and Depression and Anxiety in Community-Dwelling Adults: The Hordaland Health Study.” Australian & New Zealand Journal of Psychiatry, vol. 43, no. 1, Jan. 2009, pp. 45–52, 10.1080/00048670802534408; https://pubmed.ncbi.nlm.nih.gov/19085527/
  20. Beltsville Human Nutrition Research Center; “What We Eat In America, NHANES 2005-2006, Usual Nutrient Intakes from Food and Water Compared to 1997 Dietary Reference Intakes for Vitamin D, Calcium, Phosphorous, and Magnesium”; US Department of Agriculture; https://web.archive.org/web/20211126033239/https://www.ars.usda.gov/ARSUserFiles/80400530/pdf/0506/usual_nutrient_intake_vitD_ca_phos_mg_2005-06.pdf
  21. Workinger, Jayme, et al. “Challenges in the Diagnosis of Magnesium Status.” Nutrients, vol. 10, no. 9, 1 Sept. 2018, p. 1202, 10.3390/nu10091202; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163803/
  22. USDA, Agricultural Research Service USDA National Nutrient Database for Standard Reference, Release 28; https://www.ars.usda.gov/northeast-area/beltsville-md-bhnrc/beltsville-human-nutrition-research-center/nutrient-data-laboratory/docs/usda-national-nutrient-database-for-standard-reference/
  23. Beeson K.C. The Mineral Composition of Crops with Particular Reference to the Soils in Which They Were Grown: A Review and Compilation. U.S. Department of Agriculture; Washington, DC, USA: 1941; https://www.google.com/books/edition/The_Mineral_Composition_of_Crops_with_Pa/7asoAAAAYAAJ
  24. Firman B. Ash and Mineral Cation Content of Vegetables. Soil Sci. Soc. Am. Proc. 1948;13:380–384; https://web.archive.org/web/20180818163118/https://njaes.rutgers.edu/pubs/bear-report/ash.php
  25. Lindlahr H. Nature Cure. Volume I The Nature Cure Publishing Co.; Chicago, IL, USA: 1914. (Philosophy and Practice Based on the Unity of Disease and Cure; The Nature Cure Series); https://www.google.com/books/edition/Nature_Cure/OMsvAQAAMAAJ
  26. USDA, Agricultural Research Service USDA National Nutrient Database for Standard Reference, Release 13; https://www.ars.usda.gov/northeast-area/beltsville-md-bhnrc/beltsville-human-nutrition-research-center/nutrient-data-laboratory/docs/usda-national-nutrient-database-for-standard-reference/
  27. Marier, J. R. “Magnesium Content of the Food Supply in the Modern-Day World.” Magnesium, vol. 5, no. 1, 1986, pp. 1–8; https://pubmed.ncbi.nlm.nih.gov/3515057/
  28. Nielsen, Forrest H., et al. “Magnesium Supplementation Improves Indicators of Low Magnesium Status and Inflammatory Stress in Adults Older than 51 Years with Poor Quality Sleep.” Magnesium Research, vol. 23, no. 4, 1 Dec. 2010, pp. 158–168, 10.1684/mrh.2010.0220; https://pubmed.ncbi.nlm.nih.gov/21199787/
  29. Held, Katja, et al. “Oral Mg(2+) Supplementation Reverses Age-Related Neuroendocrine and Sleep EEG Changes in Humans.” Pharmacopsychiatry, vol. 35, no. 4, 1 July 2002, pp. 135–143, 10.1055/s-2002-33195; https://pubmed.ncbi.nlm.nih.gov/12163983/
  30. Ebrahimi, Elham, et al. “Effects of Magnesium and Vitamin B6 on the Severity of Premenstrual Syndrome Symptoms.” Journal of Caring Sciences, vol. 2012, no. 4, pp. 183–189, 10.5681/jcs.2012.026; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4161081/
  31. L, Barragán-Rodríguez, et al. “Efficacy and Safety of Oral Magnesium Supplementation in the Treatment of Depression in the Elderly with Type 2 Diabetes: A Randomized, Equivalent Trial.” Magnesium Research, 1 Dec. 2008; https://pubmed.ncbi.nlm.nih.gov/19271419/
  32. Guerrero-Romero, Fernando, and Martha Rodríguez-Morán. “Magnesium Improves the Beta-Cell Function to Compensate Variation of Insulin Sensitivity: Double-Blind, Randomized Clinical Trial.” European Journal of Clinical Investigation, vol. 41, no. 4, 17 Jan. 2011, pp. 405–410, 10.1111/j.1365-2362.2010.02422.x; https://pubmed.ncbi.nlm.nih.gov/21241290/
  33. Hatzistavri, L. S., et al. “Oral Magnesium Supplementation Reduces Ambulatory Blood Pressure in Patients with Mild Hypertension.” American Journal of Hypertension, vol. 22, no. 10, 1 Oct. 2009, pp. 1070–1075, 10.1038/ajh.2009.126; https://pubmed.ncbi.nlm.nih.gov/19617879/
  34. Kawano, Yuhei, et al. “Effects of Magnesium Supplementation in Hypertensive Patients.” Hypertension, vol. 32, no. 2, Aug. 1998, pp. 260–265, 10.1161/01.hyp.32.2.260; https://pubmed.ncbi.nlm.nih.gov/9719052/
  35. Guerrero-Romero, F, and M Rodríguez-Morán. “The Effect of Lowering Blood Pressure by Magnesium Supplementation in Diabetic Hypertensive Adults with Low Serum Magnesium Levels: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.” Journal of Human Hypertension, vol. 23, no. 4, 20 Nov. 2008, pp. 245–251, 10.1038/jhh.2008.129; https://pubmed.ncbi.nlm.nih.gov/19020533/
  36. Rodriguez-Moran, M., and F. Guerrero-Romero. “Oral Magnesium Supplementation Improves Insulin Sensitivity and Metabolic Control in Type 2 Diabetic Subjects: A Randomized Double-Blind Controlled Trial.” Diabetes Care, vol. 26, no. 4, 1 Apr. 2003, pp. 1147–1152, 10.2337/diacare.26.4.1147; https://pubmed.ncbi.nlm.nih.gov/12663588/
  37. Mooren, F. C., et al. “Oral Magnesium Supplementation Reduces Insulin Resistance in Non-Diabetic Subjects – a Double-Blind, Placebo-Controlled, Randomized Trial.” Diabetes, Obesity and Metabolism, vol. 13, no. 3, 24 Jan. 2011, pp. 281–284, 10.1111/j.1463-1326.2010.01332.x; https://pubmed.ncbi.nlm.nih.gov/21205110/
  38. Golf, S.W., et al. Cardiovascular Drugs and Therapy, vol. 12, no. 2suppl, 1998, pp. 197–202, 10.1023/a:1007708918683; https://pubmed.ncbi.nlm.nih.gov/9794094/
  39. Carpenter, Thomas O., et al. “A Randomized Controlled Study of Effects of Dietary Magnesium Oxide Supplementation on Bone Mineral Content in Healthy Girls.” The Journal of Clinical Endocrinology & Metabolism, vol. 91, no. 12, Dec. 2006, pp. 4866–4872, 10.1210/jc.2006-1391; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2995550/
  40. Quaranta, S., et al. “Pilot Study of the Efficacy and Safety of a Modified-Release Magnesium 250 Mg Tablet (Sincromag) for the Treatment of Premenstrual Syndrome.” Clinical Drug Investigation, vol. 27, no. 1, 2007, pp. 51–58, 10.2165/00044011-200727010-00004; https://pubmed.ncbi.nlm.nih.gov/17177579/
  41. Walker, Ann F., et al. “Magnesium Supplementation Alleviates Premenstrual Symptoms of Fluid Retention.” Journal of Women’s Health, vol. 7, no. 9, Nov. 1998, pp. 1157–1165, 10.1089/jwh.1998.7.1157; https://pubmed.ncbi.nlm.nih.gov/9861593/
  42. Facchinetti, F., et al. “Oral Magnesium Successfully Relieves Premenstrual Mood Changes.” Obstetrics and Gynecology, vol. 78, no. 2, 1991, pp. 177–181; https://pubmed.ncbi.nlm.nih.gov/2067759/

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