FRESH OUT: Condemned Labz and Fresh Supps Collab Pre-Workout

Condemned Labz x Fresh: Fresh Out Limited Edition Collab

Fresh Supps and Condemned Labz have teamed up for a pre-workout that’s as intense as it gets! Introducing “Fresh Out” – packed with stimulants like caffeine and synephrine, plus HydroPrime for an epic glycerol pump.

Collabs have become a major feature of the supplement industry landscape in the last decade. Originally, they started with collaborative flavors, with a consumer goods brand providing flavoring and branding. But recently, these joint opportunities even involve two supplement brands teaming up, making even more interesting pursuits.

This brings us to a whole new territory, where we can see the styles, tastes, and distribution channels of two growing companies combine forces. We’re excited to announce the industry’s next major collab: Fresh Supps and Condemned Labz have teamed up for a partner release of a brand new pre-workout formula.

Fresh Out: Fresh Supps and Condemned Labz Create a Vivid Masterpiece

Fresh Supps, founded in 2023 by Greg Helton, burst onto the scene with guns blazing with their Fresh Preworkout, a product that lives up to its name. With unique bottle art and on-point formulas, they wasted no time in eating up market share and shelf space. Since then, they’ve mostly stuck to new flavor releases of their flagship products, such as Pink Lemons with Nutrition Faktory.

Condemned Labz x Fresh: Fresh Out

Condemned Labz, meanwhile, is known for their extreme formulations and aggressive branding that pushes the envelope, even in this industry.

Together, the duo are releasing Fresh Out, a brand new pre-workout that is loaded to the gills with stimulants like caffeine and synephrine, as well as some unique additions like HydroPrime for the glycerol-pump action.

We’re going to dive into a little summary on how Fresh Out works, but first, let’s check PricePlow for good deals, and check out our video review of the new formula:

Fresh Supps Condemned Labz Fresh Out Pre-Workout – Deals and Price Drop Alerts

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Condemned Labz x Fresh: Fresh Out Ingredients

Each scoop (19.5g) of Fresh Out contains the following ingredients:

  • Broken Shackles Blood Flow Matrix

    Condemned Labz x Fresh: Fresh Out Ingredients

    • L-Citrulline (6,000mg)

      Citrulline is a conditionally essential amino acid recognized for its ability to enhance nitric oxide (NO) production.[1] In certain conditions like illness, stress, or injury, your body’s natural production of citrulline may be insufficient to meet its increased demands, making supplementation necessary. During these times, ensuring an adequate intake of citrulline is crucial to bridge the gap between your body’s needs and its production capacity.

      Citrulline is converted into arginine, which then produces nitric oxide. While arginine is the direct precursor to NO, its low oral bioavailability makes citrulline a more effective supplement. Citrulline is better absorbed, leading to higher arginine levels in the bloodstream, which in turn promotes NO synthesis.[2,3] Increased NO in the blood induces vasodilation, improving blood flow, tissue oxygenation, nutrient delivery, and metabolic waste removal, ultimately benefiting cardiovascular health and athletic performance.[4-6]

      Citrulline supplementation has been associated with several athletic benefits, including enhanced power output, increased endurance, reduced post-workout muscle soreness, and stimulation of growth hormone secretion.[7-9] It also raises blood levels of ornithine,[10] which helps eliminate ammonia,[11] a toxic byproduct of muscle metabolism that contributes to fatigue.

    • Beta-Alanine (3,200mg)

      Condemned Labz x Fresh: Fresh Out

      Beta-alanine is a well-established sports supplement known for its affordability, safety, and effectiveness as an ergogenic aid, which enhances athletic performance. Its primary mechanism involves binding to L-histidine to form carnosine, a dipeptide highly concentrated in muscle tissue. Carnosine plays a crucial role in reducing lactic acid buildup, a metabolic byproduct that can lead to muscle fatigue during exercise.[12]

      By reducing lactate accumulation, beta-alanine supplementation helps delay the onset of anaerobic fatigue, particularly during moderate to high-intensity exercise, leading to increased endurance. While carnosine itself has poor oral bioavailability, beta-alanine is readily absorbed and effectively boosts carnosine levels in the muscles, making it a more practical supplement for enhancing endurance.

      Research, including two major meta-analyses, has shown that beta-alanine is most effective at increasing endurance during efforts lasting between 30 seconds and 10 minutes.[13,14]

    • HydroPrime (2,000mg)

      HydroPrime is a glycerol-based ingredient from the industry leaders at NNB Nutrition designed to prevent clumping while enhancing muscle pumps. HydroPrime is a 65%+ stabilized glycerol powder that, unlike other forms of glycerol, resists clumping due to its improved stability, making it a reliable choice for supplements. This innovation is particularly valuable as glycerol is known for its hyperhydration properties, promoting water retention and enhancing performance, endurance, and muscle pumps, especially in hot and humid environments.[15,16]

      Condemned Labz x Fresh: Fresh Out

      HydroPrime works by increasing osmotic pressure, drawing water into muscle cells to create a “water-based” pump effect, as well as better hydration, muscular endurance, and cardiovascular efficiency.[17-22] HydroPrime’s introduction offers users the benefits of glycerol without the common issues of clumping, making it an ideal addition to pre-workout formulas and other performance-enhancing supplements.

    • Betaine Anhydrous (2,000mg)

      Betaine, also known as trimethylglycine (TMG), is an ergogenic aid that enhances athletic performance through distinct mechanisms. One of its primary functions is to increase ATP production and improve mitochondrial respiration[23] by acting as a potent methyl donor, which helps regulate cellular processes.[24,25] Additionally, betaine plays a crucial role in reducing homocysteine levels, an amino acid linked to increased cardiovascular risk,[26] making it beneficial for both cardiovascular health and athletic performance.

      Another key mechanism of betaine is its role as an osmolyte, which helps regulate the movement of water into cells, promoting cellular hyperhydration. This increased hydration enhances nutrient access and improves resistance to heat stress, contributing to better performance.[27-29] Research has shown that betaine supplementation can improve strength, endurance, power, and body composition.[30-36]

    • Pink Himalayan Salt (500mg)

      Condemned Labz x Fresh: Fresh Out Tub

      Pink Himalayan salt replenishes sodium, which is lost through sweat during intense workouts. Despite concerns about sodium’s role in hypertension, it is essential for muscle function, performance, and recovery.[37,38]

    • CDP-Choline (250mg)

      Citicoline, a highly bioavailable form of choline, is essential for maintaining healthy cellular membranes and is crucial for cognitive function due to its role as a precursor to acetylcholine, the neurotransmitter responsible for learning and memory.[39] Acetylcholine aids in memory consolidation[40] and also enhances other cognitive skills, including balance and coordination,[41,42] by supporting cerebral blood flow and neuronal mitochondrial function.[43]

      Additionally, citicoline has a significant impact on focus, attention, and mental energy, largely due to its strong dopaminergic activity,[44,45] making it a preferred ingredient in nootropic formulations for enhancing cognitive performance.

  • Shanked Energy and Hyperfocus Matrix

    • Taurine (1000mg)

      Taurine is a versatile supplement increasingly recognized for its wide range of benefits, including boosting athletic endurance, improving cellular hydration, enhancing mitochondrial function, and combating oxidative stress. As an osmolyte, taurine helps maintain cellular hydration, which is crucial for better nutrient access, waste removal, and heat stress resistance during exercise.[46]

      Condemned Labz x Fresh: Fresh Out Transparent

      In addition to its physical benefits, taurine acts as a potent antioxidant[47,48] and plays a role in optimizing calcium signaling within muscle tissue,[49] further supporting exercise performance. It also mimics the neurotransmitter GABA, which has calming effects on the brain by inhibiting excitatory neurons.[50] This GABA-like action, combined with taurine’s ability to stimulate mitochondrial biogenesis in brain cells, makes it valuable for cognitive health.[50,51]

      Moreover, taurine supports brain health by protecting neurons from stress and enhancing dopamine production and signaling, which can help maintain focus and motivation during intense workouts.[52]

    • L-Tyrosine (1000mg)

      L-tyrosine is a valuable pre-workout ingredient primarily because it supports thyroid function, which is essential for athletic performance, fat loss, and muscle building. The thyroid gland relies on tyrosine to produce vital hormones like triiodothyronine (T3) and thyroxine (T4).[53,54] For gym enthusiasts who often engage in intense workouts and calorie restriction, which can elevate cortisol levels and suppress thyroid function, supplementing with tyrosine can help maintain optimal thyroid health.[46,47,55]

      Condemned Labz x Fresh: Fresh Out Tub

      Additionally, tyrosine is a precursor to key neurotransmitters such as dopamine, adrenaline, and noradrenaline,[48-50] which are crucial for focus, motivation, and mental energy during workouts. These neurotransmitters also play a role in stress response and body composition by reducing appetite and boosting fat burning.[51] Tyrosine’s benefits extend beyond the gym, as it has been shown to enhance alertness and cognitive performance, particularly during sleep deprivation, making it a valuable tool for maintaining mental sharpness under challenging conditions.[52,56]

    • Caffeine Anhydrous (400mg)

      Caffeine is a powerful methylxanthine stimulant capable of crossing the blood-brain barrier,[57] influencing the central nervous system to improve mood, focus, and athletic performance.[58] It combats fatigue by inhibiting adenosine, a byproduct of ATP hydrolysis that accumulates in the brain and induces mental and physical tiredness.[59,60] Additionally, caffeine enhances metabolism by inhibiting phosphodiesterase, which raises levels of cAMP, thereby increasing cellular metabolic activity.[58-62]

      Caffeine also aids in fat burning and can significantly improve body composition by increasing the body’s fat-burning rate,[63] with research showing an increase of up to 50%.[64] As a widely used ergogenic aid, caffeine boosts various dimensions of physical performance, including strength, speed, power, and endurance,[58,59,61,63,64] while offering cognitive benefits such as improved attention, vigilance, reaction time, and working memory.[52,56,57]

    • Pine Bark Extract (200mg)

      Condemned Labz x Fresh: Fresh Out

      Pine Bark Extract is rich in proanthocyanidins (PACs),[58] known for their strong antioxidant and anti-inflammatory properties that support cardiovascular health.[59] The extract also contains phenolic acids, which help reduce inflammation, improve lipid profiles, lower blood pressure,[60,61] and enhance vascular function by promoting vessel relaxation and inhibiting LDL oxidation.[62-64]

      Studies have shown that oligomeric proanthocyanidins (OPCs) from pine bark extract offer cardioprotective benefits, including protecting the heart during myocardial infarction[65] and reducing the risk of chronic diseases through their anti-inflammatory effects.[66]

    • CognatiQ Coffee Fruit Extract (100mg)

      CognatiQ, formerly known as NeuroFactor, is a coffee fruit extract that has been widely used in supplements for its ability to boost brain-derived neurotrophic factor (BDNF),[67] a protein essential for neurogenesis—the growth and differentiation of new neurons.[68,69] Increased BDNF levels enhance neuroplasticity, allowing the brain to adapt and improve learning and memory, particularly in the hippocampus.[70]

      Elevated BDNF is also neuroprotective, reducing the risk of neurological diseases,[68,69,71] and combining BDNF-boosting supplements with exercise can further amplify these benefits.[72]

    • VitaShure Caffeine SR (100mg)

      Condemned Labz x Fresh: Fresh Out

      Vitashure caffeine is a slow-release form of caffeine that provides a smoother, more sustained energy boost compared to regular caffeine anhydrous. It results in a slower absorption into the bloodstream, creating a more gradual energy curve with a less intense initial effect and a gentler taper off.

    • p-Synephrine (100mg)

      Synephrine is an alkaloid that boosts metabolic rate and promotes fat burning by acting as a beta-3 adrenoceptor agonist, which increases calorie expenditure and reduces blood glucose levels by stimulating insulin secretion.[73] It can raise daily caloric burn by up to 183 calories[74] and also enhances metabolism indirectly by improving exercise performance. Unlike ephedrine, synephrine is less taxing on the cardiovascular system,[73,75] making it a safer option for those seeking to enhance their metabolism and fat-burning capacity.

    • AstraGin (50mg)

      AstraGin, a patented bioavailability enhancer from NuLiv Science, boosts the absorption of nutrients by increasing the production of adenosine triphosphate in intestinal cells.[76-80] This enhanced absorption makes all other ingredients taken with it more effective, maximizing the benefits of your supplements.

The Condemned Labz / Fresh Out Flavors

Check out our up-to-date list of Fresh Out flavors below:

    Partners in crime

    With this limited-edition marriage, Fresh is bringing Condemned a “fresh” look at powerful ingredients, and Condemned is making introductions to tons of new retailers for Fresh. It’s like an old-school political marriage, though we aren’t convinced there’s no true love there.

    Condemned Labz x Fresh: Fresh Out Limited Edition Collab

    In any case, from this relationship has sprung a beautiful new pre-workout with punky bottle art (hat tip to Greg Helton, it’s a phenomenal looking label), better-dissolving glycerol, and enough caffeine to give a horse a good buzz.

    With vocabulary like “broken shackles” and “shanked” to describe the ingredient matrices, you better keep your head on a swivel.

    Fresh Supps Condemned Labz Fresh Out Pre-Workout – Deals and Price Drop Alerts

    Get Price Alerts

    No spam, no scams.

    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

    About the Author: PricePlow Staff

    PricePlow Staff

    PricePlow is a team of supplement industry veterans that include medical students, competitive strength athletes, and scientific researchers who all became involved with dieting and supplements out of personal need.

    The team's collective experiences and research target athletic performance and body composition goals, relying on low-toxicity meat-based diets.

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    References

    1. Morita, Masahiko, et al; “Oral Supplementation with a Combination of L-Citrulline and L-Arginine Rapidly Increases Plasma L-Arginine Concentration and Enhances NO Bioavailability.”; Biochemical and Biophysical Research Communications; U.S. National Library of Medicine; 7 Nov. 2014; https://www.ncbi.nlm.nih.gov/pubmed/25445598
    2. Ochiai, Masayuki, et al; “Short-Term Effects of L-Citrulline Supplementation on Arterial Stiffness in Middle-Aged Men.”; International Journal of Cardiology; U.S. National Library of Medicine; 8 Mar. 2012; https://www.ncbi.nlm.nih.gov/pubmed/21067832
    3. Agarwal, Umang et al; “Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice.”; The Journal of nutrition; vol. 147,4; 2017; 596-602; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368575/
    4. Orozco-Gutiérrez JJ, Castillo-Martínez L, Orea-Tejeda A, Vázquez-Díaz O, Valdespino-Trejo A, Narváez-David R, Keirns-Davis C, Carrasco-Ortiz O, Navarro-Navarro A, Sánchez-Santillán R. Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction. Cardiol J. 2010;17(6):612-8. PMID: 21154265. https://journals.viamedica.pl/cardiology_journal
    5. Wong A, Alvarez-Alvarado S, Jaime SJ, Kinsey AW, Spicer MT, Madzima TA, Figueroa A. Combined whole-body vibration training and l-citrulline supplementation improves pressure wave reflection in obese postmenopausal women. Appl Physiol Nutr Metab. 2016 Mar;41(3):292-7. doi: 10.1139/apnm-2015-0465; https://cdnsciencepub.com/doi/10.1139/apnm-2015-0465
    6. Alsop P, Hauton D. Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure. Eur J Appl Physiol. 2016 Sep;116(9):1651-61. doi: 10.1007/s00421-016-3418-7; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983290/
    7. Bailey, Stephen J, et al; “l-Citrulline Supplementation Improves O2 Uptake Kinetics and High-Intensity Exercise Performance in Humans.”; Journal of Applied Physiology (Bethesda, Md. : 1985); U.S. National Library of Medicine; 15 Aug. 2015; https://www.ncbi.nlm.nih.gov/pubmed/26023227
    8. Pérez-Guisado, Joaquín, and Philip M Jakeman; “Citrulline Malate Enhances Athletic Anaerobic Performance and Relieves Muscle Soreness.”; Journal of Strength and Conditioning Research; U.S. National Library of Medicine; May 2010; https://www.ncbi.nlm.nih.gov/pubmed/20386132
    9. Sureda A, Córdova A, Ferrer MD, Pérez G, Tur JA, Pons A. L-citrulline-malate influence over branched chain amino acid utilization during exercise. Eur J Appl Physiol. 2010 Sep;110(2):341-51. doi: 10.1007/s00421-010-1509-4; https://link.springer.com/article/10.1007/s00421-010-1509-4
    10. Agarwal, Umang, et al. “Supplemental Citrulline Is More Efficient than Arginine in Increasing Systemic Arginine Availability in Mice123.” The Journal of Nutrition, vol. 147, no. 4, 1 Apr. 2017, pp. 596–602; 10.3945/jn.116.240382; https://academic.oup.com/jn/article/147/4/596/4584706
    11. Miyake, Mika, et al. “Randomised Controlled Trial of the Effects of L-Ornithine on Stress Markers and Sleep Quality in Healthy Workers.” Nutrition Journal, vol. 13, no. 1, 3 June 2014, 10.1186/1475-2891-13-53; https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-53
    12. Trexler, E.T., Smith-Ryan, A.E., Stout, J.R. et al.; “International society of sports nutrition position stand: Beta-Alanine.”; J Int Soc Sports Nutr 12, 30 (2015); https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0090-y
    13. Hobson, R M, et al; “Effects of β-Alanine Supplementation on Exercise Performance: a Meta-Analysis.”; Amino Acids; Springer Vienna; July 2012; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374095/
    14. Saunders, Bryan, et al. “β-Alanine Supplementation to Improve Exercise Capacity and Performance: A Systematic Review and Meta-Analysis.” British Journal of Sports Medicine, vol. 51, no. 8, 18 Oct. 2016, pp. 658–669; https://bjsm.bmj.com/content/51/8/658.long
    15. Patlar, S. et al. Oct. 2012. “The Effect of Glycerol Supplements on Aerobic and Anaerobic Performance of Athletes and Sedentary Subjects.” Journal of Human Kinetics. vol. 34; 69-79. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590833/
    16. Rye, C. et al. May 2019. “22.1. Osmoregulation and Osmotic Balance.” Concepts of Biology 1st Canadian Edition; BCcampus. https://opentextbc.ca/biology/chapter/22-1-osmoregulation-and-osmotic-balance/
    17. Wingo, Jonathan E. et al. Apr.-Jun. 2004. “Influence of a Pre-Exercise Glycerol Hydration Beverage on Performance and Physiologic Function During Mountain-Bike Races in the Heat.” Journal of Athletic Training; vol. 39,2; 169-175. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC419512/
    18. Koenigsberg, P S. et al. July 1995. “Sustained Hyperhydration with Glycerol Ingestion.” Life Sciences vol. 57,7; 645-53. https://pubmed.ncbi.nlm.nih.gov/7637536/
    19. Montner, P., et al. Jan. 1996. “Pre-Exercise Glycerol Hydration Improves Cycling Endurance Time.” International Journal of Sports Medicine vol. 17,1; 27-33. https://pubmed.ncbi.nlm.nih.gov/8775573/
    20. Montner, P., et al. Jan. 1999. “Glycerol Hyperhydration Alters Cardiovascular and Renal Function.” Journal of Exercise Physiology Online 2(1) https://www.asep.org/asep/asep/jan12c.htm
    21. Lyons TP., et al. Aug. 1990. “Effects of Glycerol-Induced Hyperhydration Prior to Exercise.” Medicine & Science in Sports & Exercise. p 447-483 https://journals.lww.com/acsm-msse/Abstract/1990/08000/Effects_of_glycerol_induced_hyperhydration_prior.10.aspx
    22. Anderson, MJ., et al. Sep. 2001. “Effect of Glycerol-Induced Hyperhydration on Thermoregulation and Metabolism During Exercise in The Heat.” Monash University. https://research.monash.edu/en/publications/effect-of-glycerol-induced-hyperhydration-on-thermoregulation-and
    23. Lee I. Betaine is a positive regulator of mitochondrial respiration. Biochem Biophys Res Commun. 2015 Jan 9;456(2):621-5. doi: 10.1016/j.bbrc.2014.12.005; https://pubmed.ncbi.nlm.nih.gov/25498545/
    24. Zhao, Guangfu et al. “Betaine in Inflammation: Mechanistic Aspects and Applications.” Frontiers in immunology vol. 9 1070. 24 May. 2018, doi:10.3389/fimmu.2018.01070 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976740/
    25. Craig, Stuart AS. “Betaine in Human Nutrition.” The American Journal of Clinical Nutrition, vol. 80, no. 3, 1 Sept. 2004, pp. 539–549, 10.1093/ajcn/80.3.539; https://www.sciencedirect.com/science/article/pii/S0002916522035602
    26. Ganguly, Paul, and Sreyoshi Fatima Alam. “Role of homocysteine in the development of cardiovascular disease.” Nutrition journal vol. 14 6. 10 Jan. 2015, doi:10.1186/1475-2891-14-6; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326479/
    27. Boel De Paepe; “Osmolytes as Mediators of the Muscle Tissue’s Responses to Inflammation: Emerging Regulators of Myositis with Therapeutic Potential”; EMJ Rheumatol. 2017;4[1]:83-89; https://www.emjreviews.com/rheumatology/article/osmolytes-as-mediators-of-the-muscle-tissues-responses-to-inflammation-emerging-regulators-of-myositis-with-therapeutic-potential/
    28. Cholewa, Jason M et al. “Effects of betaine on body composition, performance, and homocysteine thiolactone.” Journal of the International Society of Sports Nutrition vol. 10,1 39. 22 Aug. 2013, doi:10.1186/1550-2783-10-39; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844502/
    29. Caldas, Teresa, et al. “Thermoprotection by Glycine Betaine and Choline.” Microbiology, vol. 145, no. 9, 1 Sept. 1999, pp. 2543–2548, 10.1099/00221287-145-9-2543; https://pubmed.ncbi.nlm.nih.gov/10517607/
    30. Roti, M; “Homocysteine, Lipid and Glucose Responses to Betaine Supplementation During Running in the Heat”; Medicine & Science in Sports & Exercise: May 2003 – Volume 35 – Issue 5 – p S271; https://journals.lww.com/acsm-msse/Fulltext/2003/05001/HOMOCYSTEINE,_LIPID_AND_GLUCOSE_RESPONSES_TO.1501.aspx
    31. Armstrong, Lawrence E, et al. “Influence of Betaine Consumption on Strenuous Running and Sprinting in a Hot Environment.” Journal of Strength and Conditioning Research, vol. 22, no. 3, May 2008, pp. 851–860, 10.1519/jsc.0b013e31816a6efb; https://pubmed.ncbi.nlm.nih.gov/18438230
    32. Hoffman, Jay R, et al. “Effect of Betaine Supplementation on Power Performance and Fatigue.” Journal of the International Society of Sports Nutrition, vol. 6, no. 1, 27 Feb. 2009, 10.1186/1550-2783-6-7; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-6-7
    33. Trepanowski, John F, et al. “The Effects of Chronic Betaine Supplementation on Exercise Performance, Skeletal Muscle Oxygen Saturation and Associated Biochemical Parameters in Resistance Trained Men.” Journal of Strength and Conditioning Research, vol. 25, no. 12, Dec. 2011, pp. 3461–3471, 10.1519/jsc.0b013e318217d48d; https://pubmed.ncbi.nlm.nih.gov/22080324/
    34. Pryor, J Luke, et al. “Effect of Betaine Supplementation on Cycling Sprint Performance.” Journal of the International Society of Sports Nutrition, vol. 9, no. 1, 3 Apr. 2012, 10.1186/1550-2783-9-12; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-9-12
    35. Lee, Elaine C, et al. “Ergogenic Effects of Betaine Supplementation on Strength and Power Performance.” Journal of the International Society of Sports Nutrition, vol. 7, no. 1, 2010, p. 27, 10.1186/1550-2783-7-27; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-27
    36. Jason Michael Cholewa, et al; “The Effects of Chronic Betaine Supplementation on Body Composition and Performance in Collegiate Females: a Double-Blind, Randomized, Placebo Controlled Trial”; Journal of the International Society of Sports Nutrition; BioMed Central; 31 July 2018; https://jissn.biomedcentral.com/articles/10.1186/s12970-018-0243-x
    37. Strazzullo P., Leclercq C.; “Sodium.” Advanced Nutrition; March 2014; 5(2) 188-190; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951800/
    38. Valentine, V. 2007. “The Importance of Salt in the Athlete’s Diet.” Current Sports Medicine Reports vol. 6,4 (2007): 237-40. https://pubmed.ncbi.nlm.nih.gov/17617999/
    39. Purves D, Augustine GJ, Fitzpatrick D, et al.; “Neuroscience;” 2nd edition. Sunderland (MA): Sinauer Associates; 2001. Acetylcholine. https://www.ncbi.nlm.nih.gov/books/NBK11143/
    40. Gossell-Williams, M et al. “Choline supplementation facilitates short-term memory consolidation into intermediate long-term memory of young Sprague-Dawley rats.” The West Indian medical journal vol. 55,1 (2006): 4-8. doi:10.1590/s0043-31442006000100002. https://www.mona.uwi.edu/fms/wimj/system/files/article_pdfs/gossell-williams_choline_supplementation.pdf
    41. Hasselmo ME; “The role of acetylcholine in learning and memory;”Curr Opin Neurobiol. 2006;16(6):710–715; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659740/
    42. Jones BE; “From waking to sleeping: neuronal and chemical substrates”. Trends Pharmacol. Sci.; 2005; 26 (11): 578–86; https://www.ncbi.nlm.nih.gov/pubmed/16183137
    43. Silveri, MM et al; “Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy”; NMR Biomed. 2008 Nov;21(10):1066-75. doi: 10.1002/nbm.1281; https://www.ncbi.nlm.nih.gov/pubmed/18816480
    44. Scientific Research Publishing; “Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women.”; Advances in Infectious Diseases; Scientific Research Publishing; 20 June 2012; https://www.scirp.org/journal/PaperInformation.aspx?paperID=19921
    45. Secades, JJ; “Citicoline: pharmacological and clinical review, 2016 update;” Rev Neurol; 2017; https://www.researchgate.net/profile/Julio_Secades/publication/317167480_Citicoline_pharmacological_and_clinical_review_2016_update/links/59280785a6fdcc444353790e/Citicoline-pharmacological-and-clinical-review-2016-update.pdf
    46. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance”; J Int Soc Sports Nutr 7, 5 (2010); https://link.springer.com/article/10.1186/1550-2783-7-5
    47. Nehlig A, Daval JL, Debry G.; “Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects”; Brain Res Rev. 1992;17(2):139-170; https://www.sciencedirect.com/science/article/abs/pii/016501739290012B
    48. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance.”; J Int Soc Sports Nutr 7, 5 (2010); https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777221/
    49. Diepvens, K et al; “Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea;” American Journal of Physiology; 2007; https://journals.physiology.org/doi/full/10.1152/ajpregu.00832.2005
    50. Burke LM. Caffeine and sports performance. Appl Physiol Nutr Metab. 2008 Dec;33(6):1319-34. doi: 10.1139/H08-130; https://cdnsciencepub.com/doi/10.1139/H08-130
    51. Norager, C B, et al; “Metabolic Effects of Caffeine Ingestion and Physical Work in 75-Year Old Citizens. A Randomized, Double-Blind, Placebo-Controlled, Cross-over Study.”; Clinical Endocrinology; U.S. National Library of Medicine; Aug. 2006; https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2006.02579.x
    52. Kahathuduwa CN, Dassanayake TL, Amarakoon AMT, Weerasinghe VS. Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutr Neurosci. 2017 Jul;20(6):369-377. doi: 10.1080/1028415X.2016.1144845; https://www.tandfonline.com/doi/abs/10.1080/1028415X.2016.1144845
    53. Pomeroy, Diane E., et al. “A Systematic Review of the Effect of Dietary Supplements on Cognitive Performance in Healthy Young Adults and Military Personnel.” Nutrients, vol. 12, no. 2, 20 Feb. 2020, p. 545, 10.3390/nu12020545; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071459/
    54. Ikeda-Murakami K, Tani N, Ikeda T, Aoki Y, Ishikawa T. Central Nervous System Stimulants Limit Caffeine Transport at the Blood-Cerebrospinal Fluid Barrier. Int J Mol Sci. 2022 Feb 7;23(3):1862. doi: 10.3390/ijms23031862. PMID: 35163784; PMCID: PMC8836437. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836437/
    55. Cappelletti, Simone et al. “Caffeine: cognitive and physical performance enhancer or psychoactive drug?.” Current neuropharmacology vol. 13,1 (2015): 71-88. doi:10.2174/1570159X13666141210215655; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462044/
    56. McLellan TM, Caldwell JA, Lieberman HR. A review of caffeine’s effects on cognitive, physical and occupational performance. Neurosci Biobehav Rev. 2016 Dec;71:294-312. doi: 10.1016/j.neubiorev.2016.09.001; https://www.sciencedirect.com/science/article/pii/S0149763416300690
    57. Klaassen EB, de Groot RH, Evers EA, Snel J, Veerman EC, Ligtenberg AJ, Jolles J, Veltman DJ. The effect of caffeine on working memory load-related brain activation in middle-aged males. Neuropharmacology. 2013 Jan;64:160-7. doi: 10.1016/j.neuropharm.2012.06.026; https://www.sciencedirect.com/science/article/abs/pii/S0028390812002845
    58. Rauf, Abdur, et al. “Proanthocyanidins: A Comprehensive Review.” Biomedicine & Pharmacotherapy, vol. 116, Aug. 2019, p. 108999. doi:10.1016/j.biopha.2019.108999; https://www.sciencedirect.com/science/article/pii/S0753332219305359
    59. Wang, Tsz Ki et al. “Proanthocyanidins Should Be a Candidate in the Treatment of Cancer, Cardiovascular Diseases and Lipid Metabolic Disorder.” Molecules (Basel, Switzerland) vol. 25,24 5971. 16 Dec. 2020, doi:10.3390/molecules25245971 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766935/
    60. Lutz, Mariane et al. “Roles of Phenolic Compounds in the Reduction of Risk Factors of Cardiovascular Diseases.” Molecules (Basel, Switzerland) vol. 24,2 366. 21 Jan. 2019, doi:10.3390/molecules24020366 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359321/
    61. Kumar, Naresh, and Nidhi Goel. “Phenolic acids: Natural versatile molecules with promising therapeutic applications.” Biotechnology reports (Amsterdam, Netherlands) vol. 24 e00370. 20 Aug. 2019, doi:10.1016/j.btre.2019.e00370 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734135/
    62. de la Iglesia, Rocío, et al. “Healthy Properties of Proanthocyanidins.” BioFactors, vol. 36, no. 3, 2010, pp. 159–68. doi:10.1002/biof.79; https://iubmb.onlinelibrary.wiley.com/doi/10.1002/biof.79
    63. Andriambeloson, E., et al. “Natural Dietary Polyphenolic Compounds Cause Endothelium-Dependent Vasorelaxation in Rat Thoracic Aorta.” The Journal of Nutrition, vol. 128, no. 12, Dec. 1998, pp. 2324–33. doi:10.1093/jn/128.12.2324; https://pubmed.ncbi.nlm.nih.gov/9868177/
    64. Taubert, Dirk, et al. “Nitric Oxide Formation and Corresponding Relaxation of Porcine Coronary Arteries Induced by Plant Phenols: Essential Structural Features.” Journal of Cardiovascular Pharmacology, vol. 40, no. 5, Nov. 2002, pp. 701–13. doi:10.1097/00005344-200211000-00008; https://pubmed.ncbi.nlm.nih.gov/12409979/
    65. Rathinavel, Ashokkumar, et al. “Oligomeric Proanthocyanidins Protect Myocardium by Mitigating Left Ventricular Remodeling in Isoproterenol-Induced Postmyocardial Infarction.” Fundamental & Clinical Pharmacology, vol. 32, no. 1, Feb. 2018, pp. 51–59. doi:10.1111/fcp.12325; https://pubmed.ncbi.nlm.nih.gov/29059499/
    66. Nie, Fanxuan et al. “Oligomeric Proanthocyanidins: An Updated Review of Their Natural Sources, Synthesis, and Potentials.” Antioxidants (Basel, Switzerland) vol. 12,5 1004. 26 Apr. 2023, doi:10.3390/antiox12051004 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215713/
    67. Reyes-Izquierdo, Tania, et al. “Modulatory Effect of Coffee Fruit Extract on Plasma Levels of Brain-Derived Neurotrophic Factor in Healthy Subjects.” The British Journal of Nutrition, vol. 110, no. 3, 28 Aug. 2013, pp. 420–425, 10.1017/S0007114512005338. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/modulatory-effect-of-coffee-fruit-extract-on-plasma-levels-of-brain-derived-neurotrophic-factor-in-healthy-subjects/8B291E8D053143AA5A8D33B65496B034
    68. Phillips, Cristy. “Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection.” Neural Plasticity, vol. 2017, 2017, pp. 1–17, 10.1155/2017/7260130; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591905/
    69. Miranda, Magdalena, et al. “Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain.” Frontiers in Cellular Neuroscience, vol. 13, 7 Aug. 2019, 10.3389/fncel.2019.00363; https://www.frontiersin.org/articles/10.3389/fncel.2019.00363/full
    70. ‌Lu, B et al. “BDNF and synaptic plasticity, cognitive function, and dysfunction.” Handbook of experimental pharmacology vol. 220 (2014): 223-50. doi:10.1007/978-3-642-45106-5_9; https://link.springer.com/chapter/10.1007/978-3-642-45106-5_9
    71. Zuccato, Chiara, and Elena Cattaneo. “Brain-Derived Neurotrophic Factor in Neurodegenerative Diseases.” Nature Reviews Neurology, vol. 5, no. 6, June 2009, pp. 311–322, 10.1038/nrneurol.2009.54; https://www.nature.com/articles/nrneurol.2009.54
    72. Piepmeier, Aaron T., and Jennifer L. Etnier. “Brain-Derived Neurotrophic Factor (BDNF) as a Potential Mechanism of the Effects of Acute Exercise on Cognitive Performance.” Journal of Sport and Health Science, vol. 4, no. 1, 1 Mar. 2015, pp. 14–23; 10.1016/j.jshs.2014.11.001; https://www.sciencedirect.com/science/article/pii/S2095254614001161
    73. Stohs, Sidney J., et al. “A Review of the Receptor-Binding Properties Ofp-Synephrine as Related to Its Pharmacological Effects.” Oxidative Medicine and Cellular Longevity, vol. 2011, 2011, pp. 1–9, doi:10.1155/2011/482973; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166186/
    74. “Effects of P-Synephrine Alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes.”; https://www.medsci.org/v08p0295.htm
    75. Preuss HG, DiFerdinando D, Bagchi M, Bagchi D. Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview. J Med. 2002;33(1-4):247-64. PMID: 12939122; https://pubmed.ncbi.nlm.nih.gov/12939122/
    76. Lin, Hang-Ching, et al. “Method for Regulating Nutrient Absorption with Ginsenosides”; United States Patent and Trademark Office; Patent US20090181904A1; July 16, 2009; https://patents.google.com/patent/US20090181904A1/
    77. Lin, Hang-Ching, et al. “Method for Enhancing Nutrient Absorption with Astragalosides”; United States Patent and Trademark Office; Patent US20120196816A1; August 2, 2012; https://patents.google.com/patent/US20120196816A1/
    78. Lin, Hang-Ching, et al. “Method for Enhancing Nutrient Absorption with Astragalosides”; United States Patent and Trademark Office; Patent US20120196817A1; August 2, 2012; https://patents.google.com/patent/US20120196817A1/
    79. Lin, Hang-Ching, et al. “Method for Enhancing Nutrient Absorption with Astragalosides”; United States Patent and Trademark Office; Patent US8197860B2; June 12, 2012; https://patents.google.com/patent/US8197860B2/en
    80. Lin, Hang-Ching, et al. “Compound for enhancing nutrients uptake”; Taiwan Intellectual Property Office; Patent TWI271195B; 28-Dec 2004; https://patents.google.com/patent/TWI271195B/en

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