Primeval Labs Sanctuary: Your PCT Safe Haven

Primeval Labs Sanctuary

Sanctuary from Primeval Labs provides comprehensive and effective post cycle therapy (PCT) in one daily serving.

Prohormone and exogenous testosterone cycles offer a variety of benefits for those that choose to embrace them during their journey for endless gains. Unfortunately, like all good things in life, you need to take some time away from the hormones to give your body a break and let it recharge, so to speak.

One the problem when coming off cycle is choosing the proper natural Post Cycle Therapy support supplement. There are tons of products out there, but the problem is, you usually need to purchase multiple products to address all of your needs. Primeval Labs has other ideas for your stack.

The brand that’s been making it rain greatness lately with the likes of EAA Max and the nootropic Gray Matter are back at it again with your PCT safe haven in Sanctuary.

Before we get to the breakdown, take a moment to sign up for PricePlow alerts and receive the very best deals from around the web, but you can also see PrimevalLabs.com to compare against our coupons:

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Sanctuary PCT Ingredients

Primeval Labs has pulled out all the stops for Sanctuary to deliver a post cycle therapy supplement that provides comprehensive coverage all in one daily dose of 7 capsules. As you can imagine, at that serving size, this stuff is no joke.

Note: Doses listed below are based on one serving (i.e. 7 capsules).

  • Bulbine Natelensis 100:1 (750mg)

    Primeval Labs Sanctuary Ingredients

    Sanctuary contains everything you need for complete protection when coming off cycle. Note that this is a preliminary label, an updated one with the details / standardizations covered in this post is coming soon!

    Bulbine natalensis has been used for thousands of years as an aphrodisiac and natural testosterone booster. Clinical studies back this up too, as Bulbine Natalensis has been shown to increase serum testosterone levels, Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH),and testicle size![1,2]

    Bulbine is also effective for lowering estrogen levels in the body[3], something every prohormone user should be aware of. To further drive home Bulbine’s usefulness, it also increase ejaculation frequency and latency, and mounting and intromission frequency.[4]

  • Tribulus Terrestris (750mg)

    Frequently seen in testosterone boosters, Tribulus Terrestris is an Ayurvedic herb well known to increase male virility and vitality. Tribulus’ power is primarily attributed to its high saponin content[5,6,7], which Sanctuary’s extract is standardized to 45% steroidal saponins.

    Tribulus has been noted to increase IGF-1 and Testosterone, enhance lean body mass, AND reduce body fat![8] This is exactly the kind of ingredient you want when coming off cycle.

    This will also help keep the libido high, which is hugely important as your body needs to transition back from exogenous hormone production to its own. Oftentimes, libido gets lost in that shuffle, but none of us are interested in feeling like lesser men in the downstairs department! So tribulus should help keep you going there too.

    Sanctuary PCT

    Clinical Post Cycle Therapy Support – Get it Now through PricePlow or PrimevalLabs.com

  • Atractylodes Macrocephala (500mg)

    When you’re coming off cycle and testosterone and estrogen are bouncing around, you gotta keep that estrogen at bay.

    Atractylodes macrocephala is a medicinal herb used throughout China and many other Asian countries to treat digestive disorders. Sanctuary includes it in a 10:1 root powder extract.

    Current studies on Atractylodes find its successful at promoting mitochondrial function and energy metabolism as well as defending against several forms of cancer cells.[9,10]

    Atractylodes is loaded with potent bioactives called atractylenolides. Studies conducted In vitro show this bioactive is a particularly strong aromatase inhibitor — it possesses a 94.5% inhibition ratio,[11] and that’s the real reason it’s in here./li>

  • Magnesium (450mg)

    Primeval Labs Sanctuary Close Up

    Don’t play games with your most vital organs coming off cycle. ensure protection and hormonal balance with Sanctuary

    Magnesium is required for a number of processes in the body including DNA construction, protein synthesis, muscle function, and blood sugar regulation, among others.[12,13,14] Sanctuary includes 450mg of Magnesium Aspartate, one of the more bioavailable forms of magnesium, which supplies 81mg Magnesium (as Magnesium glycinate) approximately  20% DV. This is the same form that’s in ZMA supplements.

    Magnesium is one of the most common mineral deficiencies in adults, particularly athletes. Men especially need to be concerned about this as low levels of magnesium are associated with decreased testosterone production in the body.[15]

  • Mucuna Pruriens (300mg)

    Mucuna Pruriens is a medicinal plant prized for its high L-Dopa content. In case you weren’t aware, L-Dopa is the precursor to the neurotransmitter dopamine, and Primeval includes the really good stuff here is they use an extract standardized for 99% L-Dopa.

    L-Dopa can cross the blood-brain barrier (BBB), where it can affect hormones, especially prolactin. Specifically, L-Dopa inhibits prolactin production from the anterior pituitary, which offsets any nasty side effects brought on high prolactin levels (liver or kidney disease or even gyno).[16]

    Additionally, L-Dopa increases dopamine, which further inhibits prolactin and elevates mood![17] But there’s more — L-Dopa raises libido, testosterone and luteinizing hormone (LH), while also lowering cortisol levels.[18,19] This culminates in a perfect hormonal “muscle-building” environment when coming off cycle.

  • Maca Root (250mg)

    Primeval Labs Tri-Andro Beast

    Primeval supplies one of the most powerful prohormone stacks in the industry in Tri-Andro. Now they’ve got the ultimate PCT supplement to match!

    Maca (Peruvian Ginseng) is a member of the cruciferous family of vegetables, but more importantly, it’s also an adaptogen that helps the body deal with all sorts of stressors. boost vitality and fertility.

    Throughout history,  Peruvian tribes used it to boost fertility and vitality, and research has verified those tribes were right, Maca does indeed heighten libido, fertility, and sexual desire.[20,21] So this is a great pair to go along with the tribulus, and may even improve testicular size, which is sometimes a concern for exogenous hormone users.

  • DIM (200mg)

    Diindolylmethane (DIM) is the main active component of indole-3-carbinol (I3C) — a powerful cancer-fighting compound present in a variety of cruciferous vegetables. DIM and I3C research document they’re incredibly effective as estrogen blockers and aromatase inhibitors.

    This happens in a few different ways, but the end result is dramatically less estrogen in the body — something critical when coming off cycle! More to the point, DIM stimulates Phase I enzymes[22], which yields more “good estrogen” and less “bad estrogen”[23], and it also increases 2-hydroxyestrone (a “good” estrogen).[24]

  • N-Acetyl L-Cysteine (150mg)

    N-Acetyl L-Cysteine (NAC) is a prove and powerful antioxidant and liver-protecting agent.[25,26,27] It’s the rate-limiting substrate for the production of glutathione, a non-essential amino acid that’s a fairly potent antioxidant in its own right.[28,29]

    Basically, if you’re lacking NAC, your body can’t produce sufficient glutathione to protect against reactive oxygen species (ROS) and oxidative stress. By the way, oxidative stress is a side effect of prohormone use!

    The addition of NAC to Sanctuary ensures your body has the raw materials needed for glutathione synthesis and subsequent antioxidant fighting power!

  • 5a-hydroxy-laxogenin (50mg)

    Laxogenin

    Laxogenin is a strength-boosting plant “steroid” that’s the answer to declining strength levels coming off cycle.

    Laxogenin is a steroidal sapogenin found in Smilax Sieboldii, a relative of asparagus. Sapogenins are a class of plant steroids known as brassinosteroids found in the seeds, leaves, and pollen of several kinds of plants.

    Clinical trials using laxogenin note it’s incredibly effective for stimulating muscle protein synthesis and lowering cortisol levels.[30] On top of that, laxogenin also improves strength and recovery — two aspects of athleticism that take a serious dive when coming off cycle.

  • Zinc (30mg)

    Zinc is essential mineral vital to immune system function and assorted enzymatic processes[31], but it’s also crucial to testosterone production too.

    High intensity training drains vitamin and mineral stores making athletes and lifters more vulnerable to deficiencies of this highly important mineral. Low zinc is associated with decreased testosterone production and libido, not exactly the hallmarks of a man’s man.

    If you haven’t figured out how crucial zinc is, then consider this, it also increases IGF-1 release, which is vital to proper growth and recovery from exercise.[32]

  • BioPerine® (5mg)

    There’s a bunch of bioactive goodies in Sanctuary, and you’re going to want some insurance to make sure you’re absorbing every last milligram of product. For this, Primeval Labs includes the industry-leading black pepper extract BioPerine®.

  • Vitamin D3 (1,000IU)

    Primeval Labs Sanctuary Stack

    The search is over, you’ve found your PCT Sanctuary!

    Vitamin D, a.k.a. the “sunlight vitamin”, is a fat-soluble vitamin most individuals are lacking, based on the fact they spend too much time inside cooped up behind computers or TVs.

    Low Vitamin D levels are associated with low free testosterone, as well as higher estrogen levels.[33] Additionally, individuals with low D have been documented to have lower fertility, increased risk of CVD, higher body fat, and less lean muscle mass — not really an ideal scenario for anyone!

    However, when patients with low Vitamin D levels supplemented with the vitamin, studies have shown testosterone increased by as much as 20 percent![34] Add to this that some other research indicates Vitamin D helps inhibit aromatase, which provides another venue for increased testosterone production.[35]

Dosing

Primeval Labs recommends to consume all 7 capsules (1 serving) one time per day. Use for 8 weeks at most, and to take an 8 week break in between cycles.

Sanctuary Summary

Primeval Labs

Primeval Labs continues to deliver stellar new releases, what’s up next for the brand?!

Talk about loaded! This would likely be an extremely feel-good supplement even to a natural athlete who’s not coming off cycle!

Proper PCT can be an engrossing and often confusing subject for many prohormone users out there. Primeval Labs has taken out the guesswork by compiling a comprehensive and effective PCT supplement in Sanctuary.

We can’t stress it enough, if you’re messing around with prohormones, you NEED to run post cycle therapy, oftentimes prescription-grade stuff, but Sanctuary just makes it that much easier to get the natural side covered, protecting your liver, libido, and estrogen levels from further damage.

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References

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  2. Yakubu MT, Afolayan AJ; Reproductive toxicologic evaluations of Bulbine natalensis Baker stem extract in albino rats . Theriogenology. (2009) http://www.ncbi.nlm.nih.gov/pubmed/19410284
  3. Shindel AW, et al; Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo . J Sex Med. (2010) http://www.ncbi.nlm.nih.gov/pubmed/20141584
  4. Yakubu, M. T. and Afolayan, A. J. (2009), Effect of aqueous extract of Bulbine natalensis (Baker) stem on the sexual behaviour of male rats. International Journal of Andrology, 32: 629–636. doi:10.1111/j.1365-2605.2008.00910.x. https://www.ncbi.nlm.nih.gov/pubmed/18710410
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  7. Do J, et al; Effects and Mechanism of Action of a Tribulus terrestris Extract on Penile Erection . Korean J Urol. (2013) http://www.ncbi.nlm.nih.gov/pubmed/23526694
  8. Wilk, Michal, et al; “Endocrine Responses to Physical Training and Tribulus Terrestris Supplementation in Middle-Age Men”; Central European Journal of Sport Sciences and Medicine; Vol. 13, No. 1, 2016: 65–71; http://psjd.icm.edu.pl/psjd/element/bwmeta1.element.psjd-649c060c-d07d-466b-85af-0357a4a5cd5e/c/CEJSSM_13_1-2016_06_Wilk_etAl.pdf
  9. Song MY, Kang SY, Oh TW, Kumar RV, Jung HW, Park Y-K. The Roots of Atractylodes macrocephala Koidzumi Enhanced Glucose and Lipid Metabolism in C2C12 Myotubes via Mitochondrial Regulation. Evidence-based Complementary and Alternative Medicine : eCAM. 2015;2015:643654. doi:10.1155/2015/643654.
  10. Zhou J, Qu F, Yu Y. Chemical and Ecological Evaluation of a Genuine Chinese Medicine: Atractylodes Macrocephala Koidz. African Journal of Traditional, Complementary, and Alternative Medicines. 2011;8(4):405-411.
  11. Jiang H, Shi J, Li Y. Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala koidz. Molecules. 2011;16(4):3146-3151. doi:10.3390/molecules16043146.
  12. Institute of Medicine (IOM). Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Washington, DC: National Academy Press, 1997.
  13. Rude RK. Magnesium. In: Coates PM, Betz JM, Blackman MR, Cragg GM, Levine M, Moss J, White JD, eds. Encyclopedia of Dietary Supplements. 2nd ed. New York, NY: Informa Healthcare; 2010:527-37.
  14. Stephenson EW, Podolsky RJ; Regulation by magnesium of intracellular calcium movement in skinned muscle fibers . J Gen Physiol. (1977)
  15. Marcello Maggio, Francesca De Vita, Fulvio Lauretani, et al., “The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men,” International Journal of Endocrinology, vol. 2014, Article ID 525249, 9 pages, 2014. doi:10.1155/2014/525249
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  17. Müller, T; “Acute levodopa administration reduces cortisol release in patients with Parkinson’s disease”; J Neural Transm. 2007 Mar;114(3):347-50; http://www.ncbi.nlm.nih.gov/pubmed/16932991
  18. Shukla, Kamla Kant et al.; “Mucuna pruriens improves male fertility by its action on the hypothalamus–pituitary–gonadal axis”; Fertility and Sterility, Volume 92, Issue 6, 1934-1940; http://www.fertstert.org/article/S0015-0282%2808%2903935-6/fulltext
  19. Yamada T, et al. Effect of chronic L-dopa administration on serum luteinizing hormone levels in male rats . Toxicology. (1995)
  20. Shin B-C, Lee MS, Yang EJ, Lim H-S, Ernst E. Maca (L. meyenii) for improving sexual function: a systematic review. BMC Complementary and Alternative Medicine. 2010;10:44. doi:10.1186/1472-6882-10-44.
  21. Gonzales, G. F., Córdova, A., Vega, K., Chung, A., Villena, A., Góñez, C. and Castillo, S. (2002), Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia, 34: 367–372. doi:10.1046/j.1439-0272.2002.00519.x
  22. Sanderson JT, Slobbe L, Lansbergen GW, Safe S, van den Berg M. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Toxicol Sci. 2001;61(1):40-48.
  23. Jellinck PH, Forkert PG, Riddick DS, Okey AB, Michnovicz JJ, Bradlow HL. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem Pharmacol. 1993;45(5):1129-1136.
  24. Bradlow HL, Telang NT, Sepkovic DW, Osborne MP. 2-hydroxyestrone: the “good” estrogen. J Endocrinol. 1996;150 Suppl:S259-65.
  25. Ozaras R1, et al; N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat. World J Gastroenterol. (2003)
  26. Caro AA1, et al; N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically . Alcohol Clin Exp Res. (2014)
  27. Aydin S1, et al; N-acetylcysteine reduced the effect of ethanol on antioxidant system in rat plasma and brain tissue . Tohoku J Exp Med. (2002)
  28. Winterbourn CC1, Metodiewa D; The reaction of superoxide with reduced glutathione . Arch Biochem Biophys. (1994)
  29. Cardey B1, Foley S, Enescu M; Mechanism of thiol oxidation by the superoxide radical . J Phys Chem A. (2007)
  30. Esposito D, Komarnytsky S, Shapses S, Raskin I. Anabolic effect of plant brassinosteroid. The FASEB Journal. 2011;25(10):3708-3719. doi:10.1096/fj.11-181271.
  31. Kylie, M., et. al. (2006). The effect of exhaustion exercise on thyroid hormones and testosterone of elite athletes receiving oral zinc. Neuro Endocrinology Letters. 27(1-2): 247-252
  32. Rocha ED de M, de Brito NJN, Dantas MMG, Silva A de A, Almeida M das G, Brandao-Neto J. Effect of Zinc Supplementation on GH, IGF1, IGFBP3, OCN, and ALP in Non-Zinc-Deficient Children. J Am Coll Nutr. 2015;34(4):290-299. doi:10.1080/07315724.2014.929511.
  33. Lee DM, Tajar A, Pye SR, et al. Association of hypogonadism with vitamin D status: the European Male Ageing Study. Eur J Endocrinol. 2012;166(1):77-85. doi:10.1530/EJE-11-0743.
  34. Pilz S, Frisch S, Koertke H, et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res = Horm und Stoffwechselforsch = Horm  Metab. 2011;43(3):223-225. doi:10.1055/s-0030-1269854.
  35. Dahlquist DT, Dieter BP, Koehle MS. Plausible ergogenic effects of vitamin D on athletic performance and recovery. J Int Soc Sports Nutr. 2015;12(1):33. doi:10.1186/s12970-015-0093-8.
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