PEScience TruI3C: The Benefits of Indole-3-Carbinol

PEScience Wellness Stack

This is the “PEScience Wellness Stack” (you only need one of the multivitamins of course). Quite an impressive lineup coming from a brand that started with athletic supplements!

The sports nutrition industry tends to focus more on performance rather than health. It’s much more common to see new pre-workouts, intra-workouts, fat burners, and protein powders enter the market than products that are geared toward health and wellness. However, some brands — such as PEScience — have done a good job releasing a substantial number of products for both categories.

While PEScience is most known for its delicious protein powders, we would argue that its health and wellness line is extremely underrated. PEScience prides itself on using efficacious dosages of high-quality ingredients and it shows in products such as:

  • TruMulti
  • TruZMA
  • Omega-3+
  • Omnizen
  • Renuvia
  • Symbiotic-GI

The last time PEScience added a new supplement to their health and wellness line was in May 2020. The company released a greens powder called Greens & Superfoods. It has a unique ingredient profile and turned out to be one of the tastiest greens powders we’ve tried yet.

The PEScience TruSeries Gets its Third Product

PEScience TruI3C

A simple, yet high-quality indole-3-carbinol supplement!

To close out the year, PEScience expanded its Tru series with a stand-alone indole-3-carbinol (I3C) supplement, called TruI3C. The other supplements included in the Tru series are TruMulti (a comprehensive multivitamin for men and women), and TruZMA (a zinc and magnesium supplement).

Here on the blog, we’ve covered l3C and its primary bioactive metabolite, diindolylmethane (DIM), several times. Mainly, though, it was included in multi-ingredient supplements. PEScience is one of the few companies to offer it as a stand-alone product. It allows users to easily add a high-quality source of I3C to their supplement stack. TruI3C is intended to support healthy hormone levels and cellular health.

One thing that we appreciate most about PEScience is that they third-party test TruI3C to ensure what’s listed on the label is actually in the bottle. PEScience is known for their quality and this just shows that they take their job very seriously.

Keep reading to learn more about TruI3C and the difference between I3C and DIM. But before you do, sign up for PEScience news and deal alerts so you can stay up to date on the company’s future launches and sales!

PEScience TruI3C – Deals and Price Drop Alerts

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PEScience TruI3C Ingredient Breakdown

Each bottle of TruI3C comes with 60 capsules, dosed at 200 milligrams of I3C. For optimal results, PEScience recommends taking two capsules per day, so one bottle will last a full 30 days. Besides the I3C, there are no other active ingredients in TruI3C, so this post will solely focus on the research and benefits behind I3C.

Two capsules of TruI3C contains:

  • Indole-3-Carbinol – 400mg

    PEScience TruI3C Ingredients

    Take two capsules per day and experience the benefits of I3C!

    Indole-3-carbinol is a phytochemical that’s naturally present in a variety of cruciferous vegetables, including broccoli, cauliflower, and cabbage. Research has shown that diets rich in cruciferous vegetables may reduce the risk of developing cancer.[1,2] More research is needed, but the anti-cancer properties of cruciferous vegetables are primarily attributed to their rich glucosinolate content.[1]

    Glucosinolates are classified as a family of secondary metabolites that are unique to cruciferous vegetables. They help plants survive by providing protection against insects.[1] How does this relate to I3C? Well, the breakdown of indole-3-ylmethylglucosinolate (I3M-GS), one of the most widely distributed glucosinolates, leads to the formation of both I3C and indole-3-acetonitrile (I3N). Indole-3-carbinol further breaks down into several metabolites, most notably diindolylmethane (DIM).[1]

    I3C vs. DIM

    If you’ve taken supplements long enough, it’s likely that you’ve come across DIM. It’s one of the key biologically-active metabolites of I3C metabolism and it’s most commonly found in supplements designed to optimize hormone health. You may be wondering why PEScience didn’t just use DIM instead of I3C.

    It turns out that supplementing with DIM on its own isn’t that beneficial because it has poor bioavailability. To put it simply, DIM is rapidly degraded in the stomach before it can be absorbed into the bloodstream and utilized by the body (also known as the first-pass effect). To solve this problem, PEScience decided to use I3C instead because it’s a precursor to DIM. Thus, when I3C is ingested and metabolized, rather than becoming an unusable compound, it turns into DIM, which the body can use.

    Potential Benefits of I3C

    PEScience Greens and Vegan Protein Powder

    PEScience launched Chocolate Peanut Butter Select Vegan Protein Powder along with Greens & Superfoods!

    Several studies have shown that I3C decreases the proliferation of various cancer cell lines, such as breast, colon, prostate, and endometrial.[1,2] The majority of cancers that I3C may help prevent are correlated with high levels of estrogen. Studies show that since I3C is a negative regulator of estrogen, it may decrease the growth of tumor cells induced by estrogen and also promote apoptosis of cancer cells.[2]

    Since I3C serves as a source of DIM, you can also expect a hormone balancing effect from taking TruI3C. DIM is most well-known for supporting healthy estrogen levels. Both males and females can supplement with DIM (or in this case, I3C) to achieve an optimal balance between estrogen and testosterone levels, which is key to overall health.

    Studies show that DIM improves the conversion of estrogen to 2-hydroxyestrone and 2-methoxyestrone — both beneficial metabolites for overall health.[3] Moreover, DIM acts as an aromatase inhibitor and activates aryl hydrogen receptors, which means that it can limit the conversion of testosterone to estrogen and decrease excessive estrogen absorption.[3-5] Overall, by serving as a source of DIM, I3C is effective at preventing high levels of estrogen and supports healthy estrogen metabolism.

Stay Balanced with PEScience TruI3C

PEScience Vegan Protein Collagen

Customize your health-supplement stack with PEScience!

Hormones play a vital role in performance as well as health. There are various factors that can lead to an imbalance in hormone levels, such as:

  • Stress
  • Nutrient deficiencies
  • Body fat levels
  • Nutrition
  • Physical activity
  • Inadequate sleep

Regardless of whether you’re male or female, appropriate amounts of estrogen is necessary for optimal health. It’s well-established that estrogen is important for female reproductive health, but it’s critical for male reproductive health as well. Correcting a hormonal balance can be extremely challenging and may take months, if not years, to fix. Success also depends on an individual’s circumstances.

Beyond modifying lifestyle factors, adding some natural supplements that have been shown to help with hormone imbalances, such as I3C, might be something worth trying. It’s important to note that using a high-quality ingredient that’s third-party tested is crucial to getting the results you’re after. PEScience set out to create a stand-alone I3C supplement that’s not only third-party tested, but also extremely affordable. If you’re concerned about your hormone levels, we highly recommend seeing a qualified healthcare professional before taking any new supplements.

If you want to try TruI3C, use code PricePlow for 15% off and subscribe below for more PEScience deals, news, reviews, and interviews!

PEScience TruI3C – Deals and Price Drop Alerts

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Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public. Mike is currently experimenting with a low Vitamin A diet.

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  1. Katz, E. et al. Jun. 2018. “Indole-3-Carbinol: A Plant Hormone Combatting Cancer.” F1000Research vol. 7.
  2. Auborn, K. et al. July 2003. “Indole-3-Carbinol Is a Negative Regulator of Estrogen.” The Journal of Nutrition vol. 133,7; 2470S-2475S.
  3. Balunas, M. et al. Aug. 2008. “Natural Products as Aromatase Inhibitors.” Anti-cancer Agents in Medicinal Chemistry vol. 8,6; 646-82.
  4. Rajoria, S. Mar. 2011. “3,3′-Diindolylmethane Modulates Estrogen Metabolism in Patients with Thyroid Proliferative Disease: A Pilot Study.” Thyroid: Official Journal of the American Thyroid Association vol. 21,3; 299-304.
  5. Jellinck, P. et al. Mar. 1993. “Ah Receptor Binding Properties of Indole Carbinols and Induction of Hepatic Estradiol Hydroxylation.” Biochemical Pharmacology vol. 45,5; 1129-36.

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