American Metabolix Super C: Boost Your Multivitamin’s Immunity

American Metabolix

Today, we’re going to mega-dose with American Metabolix

With everything going on in the world today, it’s understandable that you might want to take something to support your immune system.

The question, though, is what? And isn’t a multivitamin enough?

There are so many nutritional supplements on the market that claim to improve immune function, and many of them have gotten so obscure that most of us have never heard of them. How can we really verify the claim that some herb from halfway around the world with not even a dozen studies supporting its use will help us avoid getting sick?

American Metabolix Super C

Looking to mega-dose Vitamin C? Not enough C, D, or Zinc in your multi? Then we’ve got a simple but powerful supplement here for you in American Metabolix Super C

For the consumer who’s new to this industry, the problem is especially acute. Where should a supplement beginner start?

American Metabolix Super C – Amplify your multivitamin

Enter Super C from the diet experts at American Metabolix.

The Super C stack is formulated from a handful of generic ingredients that almost everyone has heard of. Everything inside has been studied extensively, is relatively inexpensive, and most importantly, has a great safety profile.

And, of course, each ingredient has one big benefit in common: they all boost immunity.

After covering a bunch of “novel” immune supplements, we had a few readers ask for something slightly more mainstream. Super C is just that supplement — something to improve your multivitamin’s gaps — so we cover it below:

American Metabolix Super C Immune Support – Deals and Price Drop Alerts

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Super C Ingredients

In a single two capsule serving of Super C from American Metabolix, you get the following:

  • Vitamin C (as Ascorbic Acid, Calcium Ascorbate) – 1360 mg (1511% DV)

    American Metabolix Super C Ingredients

    Not enough Vitamin C, D, or Zinc in your multi? Then boost your multivitamin with Super C!

    As might be expected from the name, Super C packs a whopping dose of vitamin C, a water-soluble vitamin with a multitude of functions in the body. Vitamin C is so powerful, and so wide-ranging in its effects, that Nobel laureate Linus Pauling, who won the 1954 prize in chemistry, was famously obsessed with its structure and potential uses. Although modern researchers generally agree that Pauling’s optimism about vitamin C was somewhat excessive, it’s a testament to the power of vitamin C that such a brilliant mind could be so captivated by it.

    Vitamin C and Immunity

    A research review from the journal Nutrients concluded that “supplementation with vitamin C appears to be able to prevent and treat respiratory and systemic infections.”[1] So if you feel yourself getting sick, reaching for the vitamin C is not a bad idea, and this is why vitamin C supplements have long dominated the market for over-the-counter cold and flu treatments.

    But even once you get sick, and it’s too late to prevent illness, taking some extra vitamin C is probably not a bad idea. The reason is that many infections and illnesses significantly reduce your body’s levels of vitamin C, due to the increased metabolic requirements demanded by illness. In these cases, it may help to consume more than the daily recommended serving of vitamin C.[1]

    Vitamin C’s Mechanism of Action: Antioxidant Effects

    Vitamin C is probably best known as an antioxidant,[1] which is defined as any substance that can prevent the chemical process of oxidation from taking place.[2] In the human body, oxidative stress caused by the proliferation of “free radicals” reliably causes cellular damage, so antioxidants basically prevent cellular damage.

    Orange Juice Vitamin C

    You can skip the sugar-laden orange juice for your hit of Vitamin C by taking Super C

    Vitamin C is also a cofactor for crucial genes and enzymes,[1] is required for optimal immunity,[1] and also regulates the function of the adrenal glands,[3] which have the highest concentration of vitamin C to be found anywhere in the body.[3]

    Vitamin C and the Adrenal Glands

    Because vitamin C is crucial for catecholamine synthesis,[3] low levels of vitamin C have been implicated in “adrenal insufficiency”[4] as well as a variety of stress-related illnesses, some of which are quite serious.[5] While adrenal-related conditions are often controversial, many believe that these glands tend to “burn out” due to overuse, and we believe the research has at least some merits that vitamin C may assist with.[4]

    Reason being, the research literature shows that vitamin C can directly alleviate the body’s stress response,[6] and it has been shown to reverse the action of an anesthetic that impairs adrenal function.[7]

    Basically, you can think of vitamin C as an adrenal tonic – almost like an adaptogen. It can potentially help restore proper adrenal function, whether the adrenals are underactive or overactive.

    Vitamin C also:

    Vitamin C Collagen Release

    Intracellular and extracellular vitamin C boosts collagen release[8]

    • Increases collagen synthesis[8,9]
    • Supports neurotransmitter production[10]
    • Facilitates inter-neuronal communication[11]
    • Lowers blood pressure[12]
    • Reduces risk of coronary heart disease[13]
    • Fortifies the epithelium (keeping pathogens out of the body)[1]
    • Increases the activity of phagocytes, which directly attack pathogens[1]
    • Is required for apoptosis and autophagy[1]
    • Increases the production of lymphocytes,[1] a type of immune cell

    With such a high dose of vitamin C, we get to cover some other fun topics:

    Vitamin C and Male Fertility

    In mammals, vitamin C deficiencies have been repeatedly linked to compromised testicular function,[14] and in animals who are subjected to severe stress, vitamin C supplementation has been shown to protect testicular tissue from stress-induced damage.[15]

    The effect has been replicated consistently with infertile human males whose sperm quality improved significantly following the administration of vitamin C.[16]

    Although research on the effects of vitamin C in fertile men is scant, from the evidence that exists, it seems clear that vitamin C protects testicular structure and function from many different types of insult, so it could potentially be a good way to preserve your fertility and testosterone production.

    If you have varicocele (a common condition afflicting up to 15% of men), vitamin C supplementation can potentially relieve the increased oxidative burden on your testicular tissue that is caused by this condition.

    Vitamin C’s relevance to contemporary viruses

    When it comes to recent viral outbreaks, vitamin C shows promise in treating symptoms and is generally regarded as safe,[17] so we don’t see a reason to not take it as part of a pro-immunity supplement stack. It should be noted, though, that most of this research examined intravenous administration,[18] so it might not necessarily apply to oral forms of vitamin C, or oral use may have lower efficacy in comparison to those intravenous interventions.

  • Vitamin D3 (as cholecalciferol) – 62.5 mg/2500 IU (312% DV)

    Just like vitamin C, vitamin D is a powerful compound with a wide range of effects in the human body.

    The first thing to note here is that American Metabolix has opted for the cholecalciferol form of vitamin D, which is generally recognized to be the most bioavailable and biologically active – it is the very same form of D that is produced by our skin when exposed to direct sunlight.[19]

    Vitamin D Synthesis

    Supplemental Vitamin D helps your body generate the active hormonal form just like your skin is able to do with sunshine!

    Vitamin D and Testosterone

    Optimal vitamin D blood levels come with a stunning array of hormonal benefits, from aromatase inhibition[20] to increased testosterone production,[21,22] both of which will increase the overall androgenic activity in your body. Generally speaking, there is a clear positive correlation between vitamin D and testosterone – the more D, the more testosterone.[21]

    In a 2011 double-blind, randomized, placebo-controlled study, men who were given 3332 IU of vitamin D daily showed a 25% increase in total testosterone and a 20% increase in free testosterone compared to placebo.[22]

    So if your goals include building muscle and maximizing your athletic performance, vitamin D is a supplement you definitely do not want to sleep on.

    Vitamin D and Immunity

    Vitamin D Immunity

    Vitamin D’s effects on T cells (top) and inhibition of inflammatory cytokine production (bottom)[23]

    In 2011, the Journal of Investigative Medicine published a research review that concluded vitamin D deficiency has a significant negative impact on immune function.[23] This is mainly because most immune cells contain the vitamin D receptor, including T-cells, B-cells, monocytes, and antigen-presenting cells. This means that vitamin D is involved in innate and adaptive immune responses alike.[23,24]

    But interestingly, vitamin D has also been identified as a tolerogen, meaning that it can suppress an unnecessary immune response that really isn’t appropriate, sparing the body of taxing and potentially damaging effort.[23,24] This is important because indiscriminate immune responses are the basis of autoimmune disorders, and have been linked to chronic inflammation,[25] which can cause many devastating and potentially fatal illnesses if left unchecked.[26]

    Vitamin D and Skin Health

    Evidence from animal models and in vitro studies suggests that vitamin D has “photoprotective” effects, meaning that it prevents ultraviolet light exposure from damaging the skin.[27] That’s significant, because all of us get tons of UV exposure from sunlight, and UV exposure is considered to be a risk factor of skin cancer.[28]

    And when you think about why this might be the case, it makes perfect sense – our skin produces vitamin D in response to sunlight. One reason for that is probably to protect our skin from damage during brighter, hotter months.

    Vitamin D also prompts wound healing: in cultured skin cells, it has been shown to increase levels of cathelicidin, a protein that improves “re-epithelialization”, which is the process of restoring the epidermis layer of the skin that is your body’s first line of defense against pathogens and other environmental contaminants.[29]

    Relevance to contemporary viral outbreaks

    Super C

    Get those vitamins!

    It’s generally accepted that low vitamin D levels raise the risk of complications from a wide variety of viral diseases, as this has been consistently shown in research studies and meta-analysis.[30-33]

    If you want to maximize your chances of a speedy recovery from viral infections, don’t let your vitamin D levels drop. If you aren’t getting enough direct sun exposure, consider supplementing with vitamin D3 and avoiding activities and drugs that reduce vitamin D levels.

    A word about vitamin D dosing

    A little more care needs to be taken when we dose vitamin D, because unlike vitamin C, which is water-soluble, vitamin D is fat soluble and can accumulate in the body over long periods of time, eventually producing symptoms of vitamin D toxicity.

    Fortunately, the dose used by American Metabolix is well under the tolerable upper limit (TUL) of 4,000 IU per day,[34] but it’s important to note that the TUL is calculated by adding up all sources of vitamin D intake – so if you want to be on the safe side, you need to ensure that while you’re taking this supplement, you get no more than 1,500 IU of vitamin D from other supplements.

    According to the 2005-2016 National Health and Nutrition Examination Survey (NHANES), 95% of Americans who don’t take vitamin D supplements are below the estimated average requirement (EAR) intake of 400 IU per day,[35] meaning that if you aren’t taking another vitamin D-containing supplement, it’s very unlikely that Super C from American Metabolix will put you at risk of vitamin D overdose. And quite frankly, multivitamins usually don’t have enough of this critical vitamin, so we’re big fans of this dose.

  • Zinc (as Zinc Glycinate Chelate) – 10 mg (92% DV)

    Often called the “master mineral of the male endocrine system”, optimal zinc levels are absolutely essential for optimal health.

    Zinc and Immunity

    Super-C Immune Support

    Multivitamin too weak, or doesn’t have enough ‘room’ for a high-dose of Vitamin C? This one does.

    It’s generally accepted in the research literature that supplementing with zinc at high enough doses can significantly reduce symptoms of the common cold.[36-46] Because of this, most major supplement companies have put out zinc-based immunity products in the past two years, and this was probably a good business strategy since there’s a strong correlation between optimal zinc levels and recovering successfully from novel viruses.[47-49] This is true whether zinc is used in early[50,51] or late treatment.[52,53]

    Zinc and Mood

    Zinc has repeatedly been shown to improve mood in both men and women.[54-58] The studies on this topic are generally long-lasting, use large sample sizes, and have almost universally positive outcomes. One of these studies also showed a reduction in anxiety levels.[58]

    Zinc and Testosterone

    Zinc supplementation has been repeatedly shown to raise testosterone levels. Interestingly, this effect occurs in both sedentary and athletic subjects.[59-62] In some of these studies, increases in free testosterone were also observed,[59,62] something worth noting since free testosterone is the biologically active form of the hormone.

    Zinc and Glucose Metabolism

    People who supplement with zinc generally show lower blood glucose levels[63-65] and better insulin sensitivity[64,65] than controls. This effect is especially pronounced in obese subjects. In the adolescent subpopulation, correcting a zinc deficiency tends to produce fat loss.[66]

    A Note about Satiety
    American Metabolix Immune Stack

    The American Metabolix immune-boosting stack

    Why would correcting a zinc deficiency lead to fat loss? The short answer is that there are multiple inputs to the feeling of satiety. Since hunger is partly your body’s response to micronutrient shortfalls, a single micronutrient deficiency can lead to instinctive overeating as your body tries to correct the deficiency by increasing its food intake.

    For this reason, eating nutrient-dense foods will increase satiety, whereas nutrient-poor foods will more frequently lead to obesity. Supplementation can also help with this.

    Zinc and Acne

    There’s a small body of research that suggests high doses of zinc (~50 mg) may improve acne symptoms.[67-69] Limited success has been observed with lower doses (30 mg) as well.[70]

    Zinc and Cognition

    Zinc supplementation has produced cognitive improvements in subjects of all ages.[71,72]

    Zinc and Other Health Markers

    A lot of other indicators of good health seem to attend zinc supplementation. Some of these include higher IGF-1 levels,[73-75] lower fasting insulin levels,[64,65,76,77] lower C-reactive protein (CRP) levels, which indicates lower levels of inflammation,[64,76,78-80] improved antioxidant activity,[81] and higher levels of thyroid hormones T3 and T4.[59,62]

    What is Zinc Glycinate Chelate?

    The glycinate chelate form of zinc is a zinc molecule bound to the amino acid glycine. The reason to bind zinc like this is because our digestive tract is not very good at absorbing pure minerals. However, it’s excellent at absorbing protein and amino acids. Thus, by binding zinc to glycine, the amount of absorption through the intestinal wall is increased, leading to higher bioavailability.[82] Once it enters the bloodstream, the zinc can be cleaved from the glycine molecule and metabolized according to the body’s needs.

    Vitamin C Supplement

    More than just Vitamin C

  • Other ingredients – Calcium – 40 mg (3% DV)

    There is a small amount of calcium bound to both the vitamin C (calcium ascorbate) and the vitamin D (cholecalciferol) in this product, so it’s labeled in there. This obviously isn’t a calcium supplement, but 40 milligrams is better than 0 milligrams – only 97% more to go to get your daily recommended value!

American Metabolix Keto Meal

Stay tuned… we have some interesting research on the whole egg used in Keto Meal!

Conclusion: Why take C when you can take Super-C?!

Super C from American Metabolix is an awesome stack for somebody who’s just getting started with nutritional supplementation and wants some heavy-hitter ingredients with proven benefits – low-hanging fruit, if you will. The two-capsule serving size makes taking this supplement super convenient, and every ingredient is provided in the most bioavailable and efficacious form available.

One of the big things that all three ingredients in this product have in common is an immunity-boosting effect, so if you’re looking to avoid getting sick, this is a supplement you should consider taking.

We have more interesting research coming with respect to American Metabolix supplements and ingredients, so stay tuned to PricePlow to learn more below:

American Metabolix Super C Immune Support – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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  1. Carr, A., and Maggini, S. Nov. 2017. “Vitamin C and Immune Function.” Nutrients vol. 9,11; 1211;
  2. National Center for Complementary and Integrative Health. “Antioxidants: In Depth.” NCCIH, Nov. 2013;
  3. Patak P, Willenberg HS, Bornstein SR. Vitamin C is an important cofactor for both adrenal cortex and adrenal medulla. Endocr Res. 2004 Nov;30(4):871-5. doi: 10.1081/erc-200044126;
  4. Whitbourne, Kathryn. “Adrenal Fatigue: Is It Real?” WebMD; February 7, 2021;
  5. “The Role of Vitamin C in Stress-Related Disorders.” The Journal of Nutritional Biochemistry, vol. 85, 1 Nov. 2020, p. 108459; 10.1016/j.jnutbio.2020.108459;
  6. “Scientists Say Vitamin c May Alleviate the Body’s Response to Stress.” ScienceDaily,
  7. Das, Deepanwita et al. “Effect of Vitamin C on adrenal suppression by etomidate induction in patients undergoing cardiac surgery: A randomized controlled trial.” Annals of cardiac anaesthesia vol. 19,3 (2016): 410-7. doi:10.4103/0971-9784.185522;
  8. May, James M., and Zhi-chao Qu. “Transport and Intracellular Accumulation of Vitamin c in Endothelial Cells: Relevance to Collagen Synthesis.” Archives of Biochemistry and Biophysics, vol. 434, no. 1, Feb. 2005, pp. 178–186, 10.1016/;
  9. Chambial, Shailja et al. “Vitamin C in disease prevention and cure: an overview.” Indian journal of clinical biochemistry : IJCB vol. 28,4 (2013): 314-28. doi:10.1007/s12291-013-0375-3;
  10. Plevin, D., Galletly, C. The neuropsychiatric effects of vitamin C deficiency: a systematic review. BMC Psychiatry 20, 315 (2020).
  11. May, James M. “Vitamin C transport and its role in the central nervous system.” Sub-cellular biochemistry vol. 56 (2012): 85-103. doi:10.1007/978-94-007-2199-9_6
  12. Juraschek, Stephen P, et al. “Effects of Vitamin c Supplementation on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials.” The American Journal of Clinical Nutrition, vol. 95, no. 5, 4 Apr. 2012, pp. 1079–1088, 10.3945/ajcn.111.027995;
  13. ‌Paul Knekt, et al; “Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts”; The American Journal of Clinical Nutrition, Volume 80, Issue 6, December 2004, Pages 1508–1520,
  14. ‌Chinoy NJ, Mehta RR, Seethalakshmi L, Sharma JD, Chinoy MR. Effects of vitamin C deficiency on physiology of male reproductive organs of guinea pigs. Int J Fertil. 1986 Jul-Aug;31(3):232-9;
  15. Vijayprasad, Sanghishetti et al. “Effect of vitamin C on male fertility in rats subjected to forced swimming stress.” Journal of clinical and diagnostic research : JCDR vol. 8,7 (2014): HC05-8. doi:10.7860/JCDR/2014/8432.4622;
  16. Akmal M, Qadri JQ, Al-Waili NS, Thangal S, Haq A, Saloom KY. Improvement in human semen quality after oral supplementation of vitamin C. J Med Food. 2006 Fall;9(3):440-2. doi: 10.1089/jmf.2006.9.440;
  17. Milani, Gregorio Paolo, et al. “Vitamin c in the Treatment of COVID-19.” Nutrients, vol. 13, no. 4, 1 Apr. 2021, p. 1172, 10.3390/nu13041172;
  18. Hemilä, Harri, and Angelique M. E. de Man. “Vitamin c and COVID-19.” Frontiers in Medicine, vol. 7, 18 Jan. 2021, 10.3389/fmed.2020.559811;
  19. Nair, Rathish, and Arun Maseeh. “Vitamin D: The ‘Sunshine’ Vitamin.” Journal of Pharmacology & Pharmacotherapeutics, vol. 3, no. 2, 2012, pp. 118–26, 10.4103/0976-500X.95506.
  20. ‌Kinuta, Keiko, et al. “Vitamin D Is an Important Factor in Estrogen Biosynthesis of Both Female and Male Gonads*.” Endocrinology, vol. 141, no. 4, 1 Apr. 2000, pp. 1317–1324, 10.1210/endo.141.4.7403;
  21. Wehr, E., et al. “Association of Vitamin D Status with Serum Androgen Levels in Men.” Clinical Endocrinology, Dec. 2009, 10.1111/j.1365-2265.2009.03777.x;
  22. Pilz, S, et al. “Effect of Vitamin D Supplementation on Testosterone Levels in Men.” Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones et Metabolisme, vol. 43, no. 3, 2011, pp. 223–5, 10.1055/s-0030-1269854;
  23. Aranow, C. Aug. 2011. “Vitamin D and the Immune System.” Journal of Investigative Medicine vol. 59,6; 881-6;
  24. Prietl, B. et al. July 2013. “Vitamin D and Immune Function.” Nutrients vol. 5,7; 2502-21;
  25. Duan, Lihua et al. “Regulation of Inflammation in Autoimmune Disease.” Journal of immunology research vol. 2019 7403796. 28 Feb. 2019, doi:10.1155/2019/7403796;
  26. Furman, David et al. “Chronic inflammation in the etiology of disease across the life span.” Nature medicine vol. 25,12 (2019): 1822-1832. doi:10.1038/s41591-019-0675-0;
  27. Lee J, Youn JI. The photoprotective effect of 1,25-dihydroxyvitamin D3 on ultraviolet light B-induced damage in keratinocyte and its mechanism of action. J Dermatol Sci. 1998 Sep;18(1):11-8. doi: 10.1016/s0923-1811(98)00015-2;
  28. D’Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. Int J Mol Sci. 2013;14(6):12222-12248. Published 2013 Jun 7. doi:10.3390/ijms140612222;
  29. Heilborn JD, Nilsson MF, Kratz G, Weber G, Sørensen O, Borregaard N, Ståhle-Bäckdahl M. The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium. J Invest Dermatol. 2003 Mar;120(3):379-89. doi: 10.1046/j.1523-1747.2003.12069.x;
  30. Borsche, Lorenz, et al. “COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate close to Zero Could Theoretically Be Achieved at 50 Ng/ML 25(OH)D3: Results of a Systematic Review and Meta-Analysis.” Nutrients, vol. 13, no. 10, 1 Oct. 2021, p. 3596, 10.3390/nu13103596;
  31. Ben-Eltriki, Mohamed, et al. “Association between Vitamin D Status and Risk of Developing Severe COVID-19 Infection: A Meta-Analysis of Observational Studies.” Journal of the American College of Nutrition, 31 Aug. 2021, pp. 1–11, 10.1080/07315724.2021.1951891;
  32. Varikasuvu, S, et al; “COVID-19 and Vitamin D (Co-VIVID Study): a systematic review and meta-analysis of randomized controlled trials”; medRxiv 2021.08.22.21262216;
  33. Ghasemian, Roya, et al. “The Role of Vitamin D in the Age of COVID-19: A Systematic Review and Meta-Analysis.” International Journal of Clinical Practice, 29 July 2021, p. e14675, 10.1111/ijcp.14675;
  34. Adda Bjarnadottir, MS, LN. “How Much Vitamin D Is Too Much? The Surprising Truth.” Healthline, Healthline Media, 4 June 2017,
  35. Reider, Carroll A et al. “Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES.” Nutrients vol. 12,6 1735. 10 Jun. 2020, doi:10.3390/nu12061735
  36. Hemilä, Harri. “Zinc Lozenges and the Common Cold: A Meta-Analysis Comparing Zinc Acetate and Zinc Gluconate, and the Role of Zinc Dosage.” JRSM Open, vol. 8, no. 5, May 2017;
  37. Eby, G A, et al. “Reduction in Duration of Common Colds by Zinc Gluconate Lozenges in a Double-Blind Study.” Antimicrobial Agents and Chemotherapy, vol. 25, no. 1, 1 Jan. 1984, pp. 20–24;
  38. Godfrey, J. C., et al. “Zinc Gluconate and the Common Cold: A Controlled Clinical Study.” The Journal of International Medical Research, vol. 20, no. 3, 1 June 1992, pp. 234–246, 10.1177/030006059202000305;
  39. Mossad, Sherif B. “Zinc Gluconate Lozenges for Treating the Common Cold.” Annals of Internal Medicine, vol. 125, no. 2, 15 July 1996, p. 81, 10.7326/0003-4819-125-2-199607150-00001;
  40. Petrus, Edward J., et al. “Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Effectiveness of Zinc Acetate Lozenges on Common Cold Symptoms in Allergy-Tested Subjects.” Current Therapeutic Research, vol. 59, no. 9, 1 Sept. 1998, pp. 595–607, 10.1016/S0011-393X(98)85058-3;
  41. Prasad, A. S., et al. “Duration of Symptoms and Plasma Cytokine Levels in Patients with the Common Cold Treated with Zinc Acetate. A Randomized, Double-Blind, Placebo-Controlled Trial.” Annals of Internal Medicine, vol. 133, no. 4, 15 Aug. 2000, pp. 245–252, 10.7326/0003-4819-133-4-200008150-00006;
  42. Prasad, Ananda S., et al. “Duration and Severity of Symptoms and Levels of Plasma Interleukin-1 Receptor Antagonist, Soluble Tumor Necrosis Factor Receptor, and Adhesion Molecules in Patients with Common Cold Treated with Zinc Acetate.” The Journal of Infectious Diseases, vol. 197, no. 6, 15 Mar. 2008, pp. 795–802, 10.1086/528803;
  43. Turner, R. B., and W. E. Cetnarowski. “Effect of Treatment with Zinc Gluconate or Zinc Acetate on Experimental and Natural Colds.” Clinical Infectious Diseases, vol. 31, no. 5, 15 Nov. 2000, pp. 1202–1208, 10.1086/317437;
  44. Weismann, K., et al. “Zinc Gluconate Lozenges for Common Cold. A Double-Blind Clinical Trial.” Danish Medical Bulletin, vol. 37, no. 3, 1 June 1990, pp. 279–281;
  45. Al-Nakib, W., et al. “Prophylaxis and Treatment of Rhinovirus Colds with Zinc Gluconate Lozenges.” Journal of Antimicrobial Chemotherapy, vol. 20, no. 6, 1987, pp. 893–901;
  46. Farr, B M, et al. “Two Randomized Controlled Trials of Zinc Gluconate Lozenge Therapy of Experimentally Induced Rhinovirus Colds.” Antimicrobial Agents and Chemotherapy, vol. 31, no. 8, 1 Aug. 1987, pp. 1183–1187;
  47. Yasui, Yukako, et al. “Analysis of the Predictive Factors for a Critical Illness of COVID-19 during Treatment - Relationship between Serum Zinc Level and Critical Illness of COVID-19” International Journal of Infectious Diseases, vol. 100, Nov. 2020, pp. 230–236, 10.1016/j.ijid.2020.09.008;
  48. “COVID-19: Poor Outcomes in Patients with Zinc Deficiency.” International Journal of Infectious Diseases, vol. 100, 1 Nov. 2020, pp. 343–349, 10.1016/j.ijid.2020.09.014;
  49. Berrocal, Lisa, et al; “Zinc and Vitamin a Deficiency Predisposes to the Need for Intubation and Icu Admission in Patients with COVID-19. An Observational Study”; Research Square; 26 Oct. 2020,
  50. “COVID-19 Outpatients: Early Risk-Stratified Treatment with Zinc plus Low-Dose Hydroxychloroquine and Azithromycin: A Retrospective Case Series Study.” International Journal of Antimicrobial Agents, 26 Oct. 2020, p. 106214, 10.1016/j.ijantimicag.2020.106214;
  51. Thomas, Suma, et al. “Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction among Ambulatory Patients with SARS-CoV-2 Infection.” JAMA Network Open, vol. 4, no. 2, 12 Feb. 2021, p. e210369, 10.1001/jamanetworkopen.2021.0369;
  52. Carlucci, Philip M., et al. “Zinc Sulfate in Combination with a Zinc Ionophore May Improve Outcomes in Hospitalized COVID-19 Patients.” Journal of Medical Microbiology, vol. 69, no. 10, 1 Oct. 2020, pp. 1228–1234; 10.1099/jmm.0.001250;
  53. Frontera, Jennifer, et al; “Treatment with Zinc is Associated with Reduced In-Hospital Mortality Among COVID-19 Patients: A Multi-Center Cohort Study”; Research Square; October 26, 2020;
  54. Sawada, T., and K. Yokoi. “Effect of Zinc Supplementation on Mood States in Young Women: A Pilot Study.” European Journal of Clinical Nutrition, vol. 64, no. 3, 1 Mar. 2010, pp. 331–333; 10.1038/ejcn.2009.158;
  55. Solati, Zahra, et al. “Zinc Monotherapy Increases Serum Brain-Derived Neurotrophic Factor (BDNF) Levels and Decreases Depressive Symptoms in Overweight or Obese Subjects: A Double-Blind, Randomized, Placebo-Controlled Trial.” Nutritional Neuroscience, vol. 18, no. 4, 7 Jan. 2014, pp. 162–168, 10.1179/1476830513y.0000000105;
  56. Siwek, Marcin, et al. “Zinc Supplementation Augments Efficacy of Imipramine in Treatment Resistant Patients: A Double Blind, Placebo-Controlled Study.” Journal of Affective Disorders, vol. 118, no. 1-3, 1 Nov. 2009, pp. 187–195; 10.1016/j.jad.2009.02.014;
  57. E, Ranjbar, et al. “Effects of Zinc Supplementation on Efficacy of Antidepressant Therapy, Inflammatory Cytokines, and Brain-Derived Neurotrophic Factor in Patients with Major Depression.” Nutritional Neuroscience, 1 Feb. 2014;
  58. Siahbazi, Shiva, et al. “Effect of Zinc Sulfate Supplementation on Premenstrual Syndrome and Health-Related Quality of Life: Clinical Randomized Controlled Trial.” Journal of Obstetrics and Gynaecology Research, vol. 43, no. 5, 11 Feb. 2017, pp. 887–894, 10.1111/jog.13299;
  59. Kilic, Mehmet. “Effect of Fatiguing Bicycle Exercise on Thyroid Hormone and Testosterone Levels in Sedentary Males Supplemented with Oral Zinc.” Neuro Endocrinology Letters, vol. 28, no. 5, 1 Oct. 2007, pp. 681–685;
  60. Jalali, Ghanbarali Raeis, et al. “Impact of Oral Zinc Therapy on the Level of Sex Hormones in Male Patients on Hemodialysis.” Renal Failure, vol. 32, no. 4, May 2010, pp. 417–419, 10.3109/08860221003706958;
  61. Netter, A., et al. “Effect of Zinc Administration on Plasma Testosterone, Dihydrotestosterone, and Sperm Count.” Archives of Andrology, vol. 7, no. 1, Jan. 1981, pp. 69–73, 10.3109/01485018109009378;
  62. Kilic, Mehmet, et al. “The Effect of Exhaustion Exercise on Thyroid Hormones and Testosterone Levels of Elite Athletes Receiving Oral Zinc.” Neuro Endocrinology Letters, vol. 27, no. 1-2, 1 Feb. 2006, pp. 247–252;
  63. Seet, Raymond C. S., et al. “Oral Zinc Supplementation Does Not Improve Oxidative Stress or Vascular Function in Patients with Type 2 Diabetes with Normal Zinc Levels.” Atherosclerosis, vol. 219, no. 1, 1 Nov. 2011, pp. 231–239, 0.1016/j.atherosclerosis.2011.07.097;
  64. Kelishadi, Roya, et al. “Effect of Zinc Supplementation on Markers of Insulin Resistance, Oxidative Stress, and Inflammation among Prepubescent Children with Metabolic Syndrome.” Metabolic Syndrome and Related Disorders, vol. 8, no. 6, Dec. 2010, pp. 505–510, 10.1089/met.2010.0020;
  65. Hashemipour, Mahin, et al; “Effect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese children”; Hormones; 8(4):279-285; 2009;
  66. Freire, Simone Cardoso, et al. “Dietary Intervention Causes Redistribution of Zinc in Obese Adolescents.” Biological Trace Element Research, vol. 154, no. 2, 1 Aug. 2013, pp. 168–177, 10.1007/s12011-013-9718-4;
  67. Göransson, K., et al. “Oral Zinc in Acne Vulgaris: A Clinical and Methodological Study.” Acta Dermato-Venereologica, vol. 58, no. 5, 1978, pp. 443–448;
  68. Dreno, B., et al. “Low Doses of Zinc Gluconate for Inflammatory Acne.” Acta Dermato-Venereologica, vol. 69, no. 6, 1989, pp. 541–543;
  69. Verma, K. C., et al. “Oral Zinc Sulphate Therapy in Acne Vulgaris: A Double-Blind Trial.” Acta Dermato-Venereologica, vol. 60, no. 4, 1980, pp. 337–340, 10.2340/0001555560337340;
  70. Dreno, Brigitte, et al. “Multicenter Randomized Comparative Double-Blind Controlled Clinical Trial of the Safety and Efficacy of Zinc Gluconate versus Minocycline Hydrochloride in the Treatment of Inflammatory Acne Vulgaris.” Dermatology, vol. 203, no. 2, 2001, pp. 135–140, 10.1159/000051728;
  71. Tupe, Rama P., and Shashi A. Chiplonkar. “Zinc Supplementation Improved Cognitive Performance and Taste Acuity in Indian Adolescent Girls.” Journal of the American College of Nutrition, vol. 28, no. 4, Aug. 2009, pp. 388–396, 10.1080/07315724.2009.10718101;
  72. Aquilani, Roberto, et al. “Normalization of Zinc Intake Enhances Neurological Retrieval of Patients Suffering from Ischemic Strokes.” Nutritional Neuroscience, vol. 12, no. 5, 1 Oct. 2009, pp. 219–225, 10.1179/147683009X423445;
  73. Rodondi, A., et al. “Zinc Increases the Effects of Essential Amino Acids-Whey Protein Supplements in Frail Elderly.” The Journal of Nutrition, Health & Aging, vol. 13, no. 6, 1 June 2009, pp. 491–497, 10.1007/s12603-009-0099-5;
  74. Blostein-Fujii, A., et al. “Short-Term Zinc Supplementation in Women with Non-Insulin-Dependent Diabetes Mellitus: Effects on Plasma 5′-Nucleotidase Activities, Insulin-like Growth Factor I Concentrations, and Lipoprotein Oxidation Rates in Vitro.” The American Journal of Clinical Nutrition, vol. 66, no. 3, 1 Sept. 1997, pp. 639–642, 10.1093/ajcn/66.3.639;
  75. Blostein-Fujii, A., et al. “Short-Term Zinc Supplementation in Women with Non-Insulin-Dependent Diabetes Mellitus: Effects on Plasma 5′-Nucleotidase Activities, Insulin-like Growth Factor I Concentrations, and Lipoprotein Oxidation Rates in Vitro.” The American Journal of Clinical Nutrition, vol. 66, no. 3, 1 Sept. 1997, pp. 639–642, 10.1093/ajcn/66.3.639;
  76. Seet, Raymond C. S., et al. “Oral Zinc Supplementation Does Not Improve Oxidative Stress or Vascular Function in Patients with Type 2 Diabetes with Normal Zinc Levels.” Atherosclerosis, vol. 219, no. 1, 1 Nov. 2011, pp. 231–239, 10.1016/j.atherosclerosis.2011.07.097;
  77. Mantzoros, Christos S., et al. “Zinc May Regulate Serum Leptin Concentrations in Humans.” Journal of the American College of Nutrition, vol. 17, no. 3, June 1998, pp. 270–275, 10.1080/07315724.1998.10718758;
  78. Bao, Bin, et al. “Zinc Decreases C-Reactive Protein, Lipid Peroxidation, and Inflammatory Cytokines in Elderly Subjects: A Potential Implication of Zinc as an Atheroprotective Agent123.” The American Journal of Clinical Nutrition, vol. 91, no. 6, 1 June 2010, pp. 1634–1641;
  79. Rashidi, Ali A., et al. “Effects of Zinc Supplementation on Serum Zinc and C-Reactive Protein Concentrations in Hemodialysis Patients.” Journal of Renal Nutrition: The Official Journal of the Council on Renal Nutrition of the National Kidney Foundation, vol. 19, no. 6, 1 Nov. 2009, pp. 475–478, 10.1053/j.jrn.2009.04.005;
  80. Jafari, Fatemah, et al. “Effect of Zinc Supplementation on Physical and Psychological Symptoms, Biomarkers of Inflammation, Oxidative Stress, and Brain-Derived Neurotrophic Factor in Young Women with Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.” Biological Trace Element Research, 2 June 2019, 10.1007/s12011-019-01757-9;
  81. Kara, Ersan, et al. “Effect of Zinc Supplementation on Antioxidant Activity in Young Wrestlers.” Biological Trace Element Research, vol. 134, no. 1, 1 Apr. 2010, pp. 55–63, 10.1007/s12011-009-8457-z;
  82. Schlegel P, Windisch W. Bioavailability of zinc glycinate in comparison with zinc sulphate in the presence of dietary phytate in an animal model with Zn labelled rats. J Anim Physiol Anim Nutr (Berl). 2006 Jun;90(5-6):216-22. 10.1111/j.1439-0396.2005.00583.x;

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