Blackstone Labs Metha-Quad Extreme – Makin’ All Kinds of Gains!

Blackstone Labs Metha-Quad

Blackstone Labs is back again with another aggressive formula, this time they’re bringing back the prohormone power stack Metha-Quad Extreme.

Blackstone Labs has been continuously populating the supplement industry newswire ever since their partial acquisition by Jared Wheat of Hi-Tech Pharmaceuticals. The biggest benefit to come out of the joining is that DMAA is back at Blackstone, which we’ve previously covered in both Dust Extreme pre workout and the wildly interesting fat burner, King Cobra.

But the edgy BSL isn’t content to sit back and chill on their DMAA-refueled success.. they’re getting ready to up their prohormone game with the re-release of one of the industry’s most comprehensive and aggressive prohormone stack.

Metha-Quad Extreme is quite possibly the most potent prohormone stack recently released on the open market, given the new rules in the post-DASCA world.

We’ve got all the info ahead on this prohormone behemoth, but before we get there, take a moment to check the best deal and sign up for alerts from PricePlow:

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Metha-Quad Extreme Ingredients

As the name implies, Metha-Quad Etxreme stacks 4 muscle-building ingredients all into 1 Liposomal Tablet, giving you bigger, better gains with the promise of enhanced absorption due to the Cyclosome delivery technology.

  • Androsterone (150mg)

    Blackstone Labs Metha-Quad Extreme Ingredients

    Metha-Quad Extreme uses 4 incredibly potent compounds to boost muscle mass and testosterone while limiting estrogen.

    Androsterone, a.k.a 3α-hydroxy-5α-androstan-17-one, is frequently confused with 1-Androsterone, but the two are very different compounds. While they are both relatives of DHEA, Androsterone is a naturally-occurring metabolite of DHEA via androstenedione/testosterone/DHT/etc.

    The best way to understand what Androsterone does exactly is to read Thomas Scott’s book, Concise Encyclopedia Biology, where he details how the compound works in the body:

    ”Androsterone, 3α-hydroxy-5ß-androstan-17-one: an Androgen which is formed in the interstitial cells of the testes. Its androgenic potency is 7 times less than that of testosterone, but it is used as the international reference standard for androgenic activity: 1.0 international unit (IU) corresponds to 0.1mg A.A. is excreted in urine as a metabolic product of testosterone.”[1]

    Notice how he references 3α-hydroxy--androstan-17-one as opposed to 3α-hydroxy--androstan-17-one, which is the one used here in Metha-Quad Extreme. So, the effects might vary slightly, but the anabolic potential is definitely present. It’s also worth mentioning that Androsterone can get converted to dihydrotestosterone (DHT) via 3α-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase, for even more muscle-building potential.[2]

  • 1-Andro (50mg)

    1-Andro Results

    These are some serious lean mass gains — as in TRUE steroid-like gains. But note that this is a ‘harsher’ dose than what’s in Metanabol, so you may need to set more realistic expectations.

    If there’s one prohormone on the market today that’s grabbing everyone’s attention, it’s 1-Andro, a.k.a. 1-DHEA. We’ve gone in-depth into this particular prohormone before in our mega guide titled: 1-Andro / 1-Androsterone / 1-DHEA: 2016’s Prohormone, so rather than rehash that entire piece, we’ll just hit the highlights and you can head over there for all the gory details.

    1-Andro undergoes a 2-step conversion in the body where it converts to 1-Androstenediol and then converts to 1-Testosterone, the “target anabolic.” Essentially, you can think of 1-Andro as a “pre-prohormone” given its multi-step process.

    In terms of effects, 1-Andro is about as good as it gets, as reserach conducted at Texas A&M University were able to gain ,10 pounds of muscle after only 4 weeks of use.[3] However, those subjects were consuming 330mg / day of the prohormone, which is far more than the dose here, however it does serve to highlight to potency of this prohormone.

  • 4-Andro (50mg)

    Need testosterone? Well here it is!

    Much like 1-Andro, 4-Andro also undergoes a 2-step conversion process in the body on its way to becoming actual testosterone! 4-Andro converts to both 4-androstenedione (Andro Dione) and 4-androstenediol (Andro Diol — a.k.a. 4-AD) by way of 3-hydroxysteroid dehydrogenase and 17-hydroxysteroid dehydrogenase enzymes.

    The one we’re really interested in is 4-AD because, as we’ve stated before, 4-AD converts to testosterone! This is done via the 3 beta hydroxysteroid dehydrogenase enzyme.

    In other words, 4-Andro provides the “testosterone base” to Metha-Quad, ultimately boosting your Testosterone production, yielding more gains and masculinity!

    But, when using 4-Andro, you MUST be aware that some of it does easily convert to estrogen! For this reason, it’s absolutely essential to use an aromatase inhibitor alongside any prohormone stack that involves 4-AD and get blood tests too!

    Fortunately, the fourth ingredient in Metha-Quad Extreme provides all of your aromatase inhibiting needs!

  • Arimistane (50mg)

    Blackstone Labs Metha-Quad Extreme Here

    The ultimate mass stack is here in Metha-Quad Extreme.

    BSL knows what’s up with 4-Andro and its potential estrogenic sides, and for that exact reason, they’ve included a stout 50mg dose of Arimistane in each tablet of Metha-Quad. Arimistane is one of the most potent suicidal aromatase inhibitors (A.I.) on the market. AIs prevents the aromatase enzyme from converting testosterone into estrogen.[4,5]

    Plus, arimistane also helps regulate estrogen and cortisol levels in the body, both of which are counterproductive for your prohormone cycle. Including Arimistane in Metha-Quad Extreme ensures maximum Testosterone product for serious mass gains during your cycle.

Cyclosome Delivery Technology

To ensure your body puts as much anabolic goodness to use as possible, Blackstone Labs has included Cyclosome delivery technology to enhance bioavailability of all the ingredients in Metha-Quad Extreme.

The reason Cyclosome works so well as opposed to other delivery methods on the market is that Cyclosome suspends the active ingredients in both a sugar molecule (cyclodextrin) and wraps it in a lipid-based delivery system (liposome), thereby protecting it from premature breakdown. This gives a “best of both worlds” approach that ensure maximum potency and effectiveness for your prohormones..

For a much more detailed explanation on Cyclosome, check out our mega post titled: Cyclosome: New Age Liposome + Cyclodextrin Delivery System.


Consume 1 tablet 1 hour before training. Do not consume more than 2 tablets per day.

Post cycle therapy required!

Blackstone Labs Metha-Quad Home

The revamped Metha-Quad Extreme has finally returned home after its long voyage away.

Once your cycle is over, it’s crucial to begin a comprehensive, prescription-grade post cycle therapy (PCT) run. 1-Andro and 4-Andro lower natural testosterone production, and it must be brought back slowly. For this reason, we strongly encourage consulting your endocrinologist alongside blood tests.

Check out our in-depth guide on post cycle therapy (PCT) for all the details, but, again, go see your doctor and have blood tests ready to go!


For the time being, prohormones are the where it’s at for edgy, legal supplements. Until the FDA decides to chase them down like they are DMAA, prohormones will continue to reign supreme as the next step in muscle building once you surpass your “natural” means using the likes of creatine, betaine, laxogenin, etc.

Metha-Quad Extreme uses a four-headed beast to give you a prohormone / A.I. stack unlike anything you’ve used before. You get 4-Andro as your testosterone base, and 1-andro / Androsterone for bigger, better gains. So gone are the 1-AD / 4-AD days, but here are the 1-Andro / 4-Andro days, with supporting ingredients like arimistane.

Just remember, consult with your doctor, get blood tests done, use on cycle AND post cycle therapy, and, of course, follow the proper dosing instructions — NO exceptions! Now go hit it hard!

Blackstone Labs Metha-Quad Extreme - Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is a biohacker with extensive experience in supplementation and dietary modification, whose personal expertise stems from several "n=1" experiments done on himself.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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  1. Scott, T; Concise Encyclopedia Biology. Walter de Gruyter. p. 49. ISBN 978-3-11-010661-9; 1996
  2. Henderson, B; Hormones, Genes, and Cancer; Oxford University Press. p. 23. ISBN 978-0-19-513576-3; 2003
  3. Granados, J. et al; “Prohormone Supplement 3 -Hydroxy-5 -Androst-1-En-17-One Enhances Resistance Training Gains But Impairs User Health”; Journal of Applied Physiology; 116.5 (2013): 560-569; Retrieved from (via
  4. National Center for Biotechnology Information; PubChem Open Chemistry Database; “In Vitro Competitive Inhibitory Activity Was Measured On Cytochrome P450 19A1 Of Human Placental Microsomes”; Retrieved from
  5. Numazawa, M; “Synthesis of androst-5-en-7-ones and androsta-3,5-dien-7-ones and their related 7-deoxy analogs as conformational and catalytic probes for the active site of aromatase.”; J Med Chem. 1994 Jul 8;37(14):2198-205; Retrieved from

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