Jack’d Up: Hi-Tech’s Jack3d Replacement w/ DMHA!

Update April 27, 2018: This has been re-released with DMHA, not DMAA! Updates coming soon!

Update December 7, 2015: Hi-Tech has finally allowed us disclose the DMAA dose!!! Read on to see the numbers!

Hi-Tech Pharmaceuticals

If you thought your favorite supp company had balls, then take a look at what Hi-Tech is up to…

If you’ve been in the world of fitness supplements for a few years now, you surely remember Jack3d and DMAA. A lot of people remember it with extreme fondness, as proven by continued interest in the last remaining stock of discontinued fat burner OxyELITE Pro, which is selling for well over $100 a bottle!

Unfortunately, after a long and hard battle with the FDA, DMAA-based pre workout supplements have been hard to come by… until now.

Ready to get Jack’d Up?

It’s important to note that DMAA is not illegal and was never actually formally banned — most companies are just afraid to sell it due to FDA “pressure”.

Yet there’s clearly a huge demand for it given the results consumers were getting with products like the original Jack3d. So, given that it’s not actually 100% illegal, it was only a matter of time before it popped back up somewhere.

Enter Hi-Tech Pharmaceuticals and Jack’d Up

Jack'd Up

Miss Jack3d? Hi-Tech is simultaneously bringing it back to consumers and suing the FDA in the process. Hold on to your hats…

Hi-Tech is no stranger to a good fight, and boy are they bringing it hard with this one.

They were actually manufacturing knockoffs of USP Labs’ products years ago, before the FDA stepped in with their “ban” of DMAA, which scared nearly everyone away with aggressive warning letters.

But one company doesn’t scare so easily. Hi-Tech is the first to move back into the fray with Jack’d Up, a product that is quite up-front about being a clone of Jack3d – yet with even better supporting ingredients than the original.

The interesting news? It came out in 2014, it has DMAA, and it’s out now!

Hi-Tech Pharma Jack'd Up - Deals and Price Drop Alerts

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How is this legal? The quick backstory…

Now wait, isn’t this being marketed and sold as a supplement? How can that be legal?

Hi-Tech claims that they are not flaunting the law, because no law was ever passed fully banning DMAA! So they are taking the fight right back to the FDA! They’ve been in a running legal battle over the product since late 2013, suing and being countersued by the FDA in both their home state of Georgia and in federal court.[1]

We are keeping all of that up to date on our Hi-Tech vs. FDA DMAA Lawsuit article, but the basic gist is that Hi-Tech is suing for the right to sell DMAA, stating that the FDA didn’t follow established legal guidelines in their DMAA ban, so it should be considered null and void.[2]

The FDA initially responded by seizing their product, but doesn’t seem to be doing so any longer, and Hi-Tech’s HydroxyElite and Jack’d Up are now currently available in a number of stores, such as those shown in the price comparisons above.

This basically picks up where USPLabs left off, which ultimately gave in after a long and drawn out battle regarding whether or not DMAA could be found in nature via a species of geranium flower (hint: the answer is maybe, but the FDA disagreed / didn’t care, forcing USP to dump $8 million in product down the drain[10]).

While these new set of court cases wind its way through the courts, the product is in a state of flux, but it’s definitely available – and DMAA fans are loving it!

So let’s get into what’s inside Jack’d Up and why it’s become so popular so fast.

The Jack’d Up Ingredients: Now more fully disclosed!

This part has been updated on December 7, 2015. We bugged Hi-Tech to publish the formula, and they’re allowing us to be the first to announce — The image says it all:

Jack'd Up Formula Disclosed!

Hi-Tech has finally allowed us to disclose the Jack’d Up formula – at least the most important stuff we care about!

Per Scoop:

  • DMAA: 25mg

  • Caffeine: 100mg

  • Beta Alanine: 1.3g

  • Creatine: 2g

This makes Jack’d Up nearly perfect anywhere in the 1.5-2.5 scoop range, depending on your tolerance!

Now for the full label image, and the rest of our write-up:

Jack'd Up Ingredients

The Jack’d Up Ingredients / Supplement Facts. Note that most other labels out there have a few of the ingredients in the wrong order!

We think this product might actually be better than the original Jack3d formulation, but unfortunately, like the original, it’s in a proprietary formula. This makes it difficult to analyze and even more difficult to make dosage recommendations.

The upgrades are mainly due to the creatine nitrate content but also from a small dash of agmatine, both of which will add slightly improved pumps over Jack3d’s basic creatine monohydrate + AAKG combination.

Let’s take a more in-depth look at each of the ingredients to see what makes the formula work so well, starting with the key to the formula, 1,3.

  • 1,3 Dimethylamylamine HCl (DMAA)

    DMAA’s primary known function is actually as a neural stimulant that boosts mood and focus. It’s an aliphatic amine, a class of compounds commonly known for these stimulating effects, and works quite well alongside caffeine.

    The compound, also known as methylhexanamine (but sometimes just called 1,3 for short), was originally created in 1944 by Eli Lilly and Company and was sold as a nasal decongestant until 1983.

    DMAA Structure

    DMAA’s Structure is similar, but still very much different to amphetamines. It is not an amphetamine. That said, low-quality drug tests have been tripped up by it.

    The less well-researched function is as an appetite suppressant. Anecdotal (but very consistent and numerous) user reports of unparalleled appetite suppression when using these products is widely thought to be attributable to the DMAA — the same products that came back out minus DMAA were widely reported to no longer suppress appetite.

    The problem is, DMAA was already under its “quasi-ban” once this effect was noticed, which put the kibosh on patient studies investigating it further.

    Further, DMAA’s behavior as a nasal decongestant can anecdotally be “felt” as an endurance-booster, due to what is perceived to be an increase in VO2max and a lower rate of perceived exertion. Again, this is anecdotal (but commonly agreed-upon).

    That’s the good end of DMAA. The bad end is that it actually has been shown to increase blood pressure, at least when dosed at 75mg.[3] This study was one of the key pieces of evidence that the FDA used to justify their warning letters.

    The USPLabs-based Research

    However, in an attempt to defend their product, USP Labs conducted their own series of seven studies on patients.[4]

    Now, of course there’s the possibility of bias here, and USP did use healthy trained athletes rather than people with more average levels of fitness.

    But their studies came up with no serious events, while also noting that DMAA did tend to raise blood pressure (but not resting heart rate). The difference was that the dosing was much lower, and more in line with that used in most supplements — 75mg is about three times what most of these products were using per dose.

    We think it’s also worth noting that literally tens of millions of servings of products containing DMAA were sold before the ban, and the end result was only 84 reports of possible adverse health effects. And again, no definitive link could be drawn to DMAA causing any of those — it was simply found present in people’s systems at the time.

    Meanwhile, a blow to the FDA’s arguments came in the form of a 2013 Department of Defense report which stated that serious adverse events that occurred could not be causally linked to DMAA use. The review interviewed 1,700 military service members and is 109 pages long.[9]

    DMAA Research

    Seven studies performed by USPLabs have been archived here on PricePlow. Are they biased? Perhaps. But they were done on trained athletes, used reasonable doses, and never hid the fact that blood pressure does indeed go up.

    Our stance

    We’ve therefore taken the stance that the FDA ban was likely a bit hasty and the dangers of DMAA may be overstated, especially compared to other drugs that they willingly approve.

    Now that we know the DMAA dose, and personally love it between 1 and 2 scoops, we can be even more confident!

    This doesn’t mean it shouldn’t be treated with caution, however —

    • it shouldn’t be mixed with other stimulants outside of the caffeine provided in Jack’d Up,
    • you need to see your doctor and get a clean bill of health, and
    • you should keep your doses light (we personally recommend staying under two servings per any 24 hour period, unlike what the label says).
    Your body, your choice?

    In summation, we feel that you have the right to choose what you put in your body, but when it comes to stimulants, we also feel that you should know the exact dose you’re getting per serving. Now we know this. This makes it clear from both sides – you know what you’re getting and the modus moves slightly towards you to do the research.

    Professional athletes who are drug tested also need to avoid it, as it’s banned by nearly every drug-testing organization on the planet.

    But make no mistake, if you’re buying Jack’d Up, you’re buying it for this ingredient, and it provides most healthy users with absolutely phenomenal benefits when used appropriately. Yet this is still not a product for beginners, nor is it a product for the stimulant-sensitive, so buyer beware.

    .. but you should know the dose too, in order to make a proper choice

    Update: This part is no longer necessary

    Honestly, the biggest issue we have here is that the DMAA dosage is unknown, and that’s why you need to start light.

    If you understand what you’re getting yourself into here (and we feel we’ve been open in explaining the situation), can use it properly and wisely, and Hi-Tech would disclose the formula, we’re on board.

  • L-Arginine Alpha-Ketoglutarate

    Agmatine and Arginine

    Both agmatine and arginine are in this formula, but likely not in enough dose to give huge pumps. But let’s be honest – we’re here for the DMAA focus and energy, not the pumps.

    Also known as AAKG, Hi-Tech included as a nitric oxide booster, the results thus far on alpha-ketoglutarate are mixed, but it may help as a pump enhancer.[6]

    Fact is, though, compared to the nitric oxide boosters that have come out since the original Jack3d, AAKG is pretty weak and not fully reliable. There are some benefits to having L-arginine around, but when it comes to nitric oxide pumps, we’re happy it has been supplemented by the nitrate in creatine nitrate above.

    That said, Jack’d Up isn’t necessarily a “pump up” supplement — it’s an energy supplement where pumps come second, and that’s how it’s always been. If you want more pumps, you can stack in your favorite stimulant-free pre workout supplement.

  • Creatine Nitrate, Creatine HCL, Disodium Creatine Phosphate, and Creatine Monohydrate

    Creatine monohydrate was in the original Jack3d are retained, but creatine nitrate, Creatine HCL, and Disodium creatine phosphate have been added here as well.

    While creatine monohydrate is honestly usually good enough all by itself, HCL and nitrate have shown some promise for increased solubility and uptake.[5]

    What we like here is the fact that the nitrate (from the creatine nitrate) is going to provide for far better pumps and endurance than you would have gotten with just the AAKG in Jack3d original.

    2g per scoop now disclosed

    Jose Canseco Mark McGwire - More than just Creatine Users

    Long gone are the days when we thought these guys were only using creatine and it could be dangerous. Creatine won’t give you McGwire like gains, but it WILL give you some serious performance, strength, and muscle gains if you use enough of it each and every day. Too bad we don’t know how much is in this pre workout.

    Now that we know how much creatine is in here, and it’s a great dose, we know that you’re going to get to the minimum clinical dose (of 3g/day) at only 1.5 scoops of Jack’d Up! That’s incredible – because many users will be right around there or even higher!

    Creatine is the second ingredient in the formula (after AAKG above), but after that comes beta alanine. Don’t forget, we also have creatine nitrate and disodium creatine phosphate, so it might even be a touch higher.

    So if you’re using 1.5 scoops or more, you really don’t need any more creatine in a day, unless you decide to load (which is fine since bulk creatine is cheap).

  • CarnoSyn Beta-Alanine: 1.3g per scoop

    We’re fans of beta alanine in supplements – this is a muscular endurance boosting ingredient that helps your body produce more carnosine. In tandem with that carnosine, it balances muscle tissue pH, which makes you feel less tired and allows you to increase workout intensity.[7]

    It’s one of the more well-studied ingredients in the supplement world – nearly every sport has success with it, but it seems to work best in activities lasting 1-4 minutes long.

    The tingles are back

    If you’ve taken Jack3d or any other supplement with beta alanine, you’ve possibly noticed the tingling sensation, also known as paresthesia. For some, it’s annoying, for others, it’s a “wake-up” call that the product is kicking in and it’s time to start working out, and for still others, they don’t feel it at all.

    Regardless of the tingles, beta alanine has been shown to be safe and nontoxic, so it’s not to be worried about. But it is here in Jack’d Up, just like in the original Jack3d.

    The clinically studied dose is 3.2g per day. You might get that here if you use quite a high dose. Otherwise, you can add some bulk beta alanine during the opposite end of your day.

    Hi-Tech Pharmaceuticals Jack'd Up

    Hi-Tech makes no attempt to hide what they’re cloning here

  • Caffeine: 100mg per scoop

    DMAA really doesn’t feel like it gets going without a bit of caffeine to start the engine.

    Now that we can see Jack’d Up using a 100mg caffeine / 25mg DMAA ratio, we’re extremely happy. Thank you Hi-Tech for disclosing this blend.

    You don’t need a ton of caffeine when combined with DMAA, and this ratio is just about exactly what we would have produced..

  • Agmatine Sulphate

    Pixie Dusting

    Pixie Dusting alert! We’ll take the agmatine, but there can’t be enough to make much of a difference here. Still more than OG Jack3d though..

    Since this is nearly at the end of the formula (after the DMAA, which means there’s not going to be much of it), the dose here is going to be too small to care about. We love the ingredient, but this has got to be a clear case of pixie-dusting. So be it, but most people won’t care.

    That said, even 20mg is better than 0mg, which is what was in the original Jack3d, so we’ll take it… but not rely on it.

  • Schisandra Chinensis (Berry) Extract

    Schisandra has shown a lot of promise as a cognitive-enhancing nootropic.[8] Reportedly it acts similarly to ginseng boosting concentration, alertness and mood. We’d like to know how much is actually present, however, as it’s in a proprietary blend here.

    Despite the massive success of Jack3d (it was named schizandrol A on the label), schisandra never took off as well as DMAA, but there seems to be some kind of feel-good synergy going on here.

Hi-Tech Pharma Jack'd Up - Deals and Price Drop Alerts

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Posts are sponsored in part by the retailers and/or brands listed on this page.

Request to Hi-Tech to Open this Formula Granted!!!

This section is now obsolete!

Hi-Tech is the only company with the guts to produce this stuff right now, so we don’t see a reason for them to hide their formula. If anything, it’s more dangerous this way. We haven’t yet heard of any adverse health reports linked to Jack’d Up, but there’s no reason to risk it at this stage of the game.

We’d love to see this as an open formula, or at least disclose how much caffeine, 1,3, creatine, and beta alanine are in here so that we can dose appropriately and can add a bit extra creatine and beta alanine elsewhere, if necessary.

Our final thoughts

While we never mind seeing a good dose of creatine and beta alanine, the real draw with any DMAA product is the focus and tunnel-vision mindset. Reports are that it works nearly as well as Jack3d did, but with better pumps! The reviews so far confirm this, but we’ll update with a review when we get our hands on it.

We’re excitedly watching to see what happens with this product, because Hi-Tech is seriously bringing the fight to the FDA and these guys are a force to be reckoned with.

If you like reading about the law and supplement industry news, keep your popcorn handy for this one.

Until then… DMAA appears to be back … at least until the court cases settle!

Dose it smart!

Hi-Tech Jack'd Up

The dosing instructions… we recommend going even lighter, especially in the beginning!

Note that this page isn’t meant to be full-throated cheerleading for DMAA. There’s enough medical evidence that it’s an ingredient that needs to be treated with caution and dosed properly – which it is in this formula.

So once again, if you’re going to try this, do so wisely and don’t ruin it for everyone else. Don’t mix it with any other stimulant-based products (not even a cup of tea!) and start light, such as 1 to 1.25 scoops. We urge you to get a doctor’s consent before taking any new supplement, and to stick with a maximum of two scoops in a 24 hour period.

Stay smart and you just might love this stuff as much as the original Jack3d.

Hi-Tech Pharma Jack'd Up - Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

Jack'd Up Warning

The official Jack’d Up Warning – Read it carefully!

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is a biohacker with extensive experience in supplementation and dietary modification, whose personal expertise stems from several "n=1" experiments done on himself.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

4 Comments | Posted in , | Tagged , , , , , , , , , .


  1. http://www.naturalproductsinsider.com/News/2013/11/Hi-Tech-Pharmaceuticals-Prepares-for-Extended-DMA.aspx
  2. http://www.nutraingredients-usa.com/Regulation/Hi-Tech-sues-FDA-over-bullying-campaign
  3. Bloomer, RJ, et. al; “Effects of 1,3-dimethylamylamine and caffeine alone or in combination on heart rate and blood pressure in healthy men and women“; The Physician and Sportsmedicine; September 2011
  4. [USPLabs DMAAResearch PDFs Available Upon Request]
  5. Pandit, A, et. al; “Equilibrium solubility studies of creatine nitrate, creatine monohydrate and buffered creatine”; FIP Pharmaceutical Sciences World Congress 2010
  6. Willoughsby, DS, et. al; “Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise“; International Journal of Sports Nutrition and Exercise Metabolism; August 2011
  7. Baguet, A, et. al; “Important role of muscle carnosine in rowing performance“; Journal of Applied Physiology; July 2010
  8. http://www.webmd.com/vitamins-supplements/ingredientmono-376-schisandra.aspx?activeingredientid=376&activeingredientname=schisandra
  9. Col John Lammie; Report of the Department of Defense 1,3 Dimethylamylamine (DMAA) Safety Review Panel; Department of Defense; June 2013
  10. $8 Million Worth of Jack3d and OxyELITE Pro… Down the Drain; PricePlow Blog; July 2013

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