Nutrex Lipo-6 Natural: Plant-Based Fat-Burner in One Capsule!

Vegan and plant-based diets often go hand-in-hand with goals of weight loss. While dietary choices (such as what, when, and how frequent to eat) are most important, the key to long-term success in any diet is conquering hunger and appetite over the long-haul. This is done by leveraging protein, avoiding addictive / dopamine-spiking / inflammatory foods, and controlling the blood sugar roller coaster.

Nutrex Lipo-6 Natural

Lipo-6 is an award-winning fat burner, and now it comes in a Natural and Plant-Based version!

But along the way, it’s nice to pick up the metabolism and kick down the appetite with a well-formulated fat burner. And while most fat burners are actually already vegan (depending on the capsule), most are definitely not plant-based, as there are several synthetic ingredients on the market.

Lipo-6 Natural: A plant-based thermogenic

Nutrex Research already has you covered in keeping protein high with Nutrex Plant Protein, but those looking for a plant-based thermogenic stimulant don’t have many great choices. Thankfully, that all changes as they’ve released Lipo-6 Natural, an all-natural version of their famous weight loss supplement. Aligning itself with the modern trends of all-natural and convenient, Lipo-6 Natural is packing a highly effective formula without the synthetics that most of its competition poses.

In our continuation of our coverage of the Natural Series from Nutrex, this post is going to break down all you need to know about Lipo-6 Natural. We’ll get into its ingredients, its benefits, and how it stacks up to the rest of the market! Before we get into all of that, be sure to subscribe to PricePlow for the best supplement deals, news, reviews, and interviews you can get!

Nutrex Lipo-6 Natural – Deals and Price Drop Alerts

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Lipo-6 Natural is an easy one pill serving!

How many times have you bought a pill-based supplement, be it a fat-burner or a multivitamin, and are appalled by the serving size. You look at the label and find out that you need to guzzle down somewhere between 3 and 6 massive capsules in order to reach a full serving. That’s never fun, is it?

Lipo-6 Natural packs all of its ingredients into one capsule! While taking similar products can sometimes be a chore, that’s not the case here. Not only is this a one-stop shop for the fat-burning effects your heart desires, but each capsule is also 100% plant-based. That means it’s safe for use for vegetarians and vegans alike. Nutrex is delivering one of the most convenient, versatile fat-burning supplements we’ve ever seen!

Now that we’ve covered all of that, let’s get into what the ingredients in Lipo-6 Natural can do for a healthy individual looking to enhance their fat-burning efforts!

Advisement: At nearly 250mg caffeine, this is a strong pill, especially for anyone who can’t handle a serious hit of caffeine!


Each bottle of Lipo-6 Natural comes with 60 servings. Here’s exactly what you’ll be getting in each one-capsule serving.

  • Coffea robusta (bean) Extract (std. 98% Caffeine) – 250mg

    Nutrex Lipo-6 Natural Ingredients

    Any vegans who aren’t used to a strong pop of caffeine and grains of paradise are going to FEEL this one!

    Kicking things off, Lipo-6 Natural is packing a solid 245mg of all-natural caffeine. The form used here is derived from the Robusta bean, which is said to contain almost twice the amount of caffeine as its much more available cousin, the Arabica bean.[1] While it’s commonly used for things like instant coffee due to its cheap market price, it’s definitely one of the more potent sources of caffeine you can find.

    The benefits of caffeine in relation to fat-burning are well-documented, as multiple studies conducted over the years have all reached virtually the same conclusion – this stuff works!

    Stimulates fat mass to be used for energy!

    Caffeine is among the most common ingredients used for enhanced energy and alertness levels, and research has shown that it’s quite effective in doing so.[2,3] However, caffeine has also been studied with different focuses in mind, and the results regarding its fat-burning effects solidifies its potency.

    Research from 1990 administered multiple doses (100mg, 200mg, 300mg, and 400mg) of caffeine to healthy subjects, and compared multiple factors to a placebo group. The scientists found that caffeine significantly increased energy expenditure in a dose-dependent manner, with the 400mg specifically elevating blood glycerol levels, a key indicator of fat oxidation.[4] Elevating the metabolism is key in burning extra calories, which in turn can help you burn body fat.

    Caffeine Energy Expenditure

    Caffeine increases energy expenditure by roughly an extra .15 calories per minute. Not huge, but we’ll take it!

    Another study from 2006 tested the effects of caffeine on the elderly. They reached conclusions similar to the previously mentioned study, in addition to an increased level of free fatty acids caused by caffeine.[5] The stimulant is able to help switch on the fat-burning signals within the body, priming it for excess calorie burn!

    Caffeine not only jolts your cognition, but it’s also capable of freeing up fatty acids for energy use. While some formulas go the non-stimulant route, they’re fighting an uphill battle by neglecting the potential of stuff like caffeine. Lipo-6 Natural is sure to utilize stimulants in delivering a comprehensive fat-burning formula.

    The effectiveness of stimulants in helping lose weight cannot be understated, and Nutrex is sure to include an efficacious, all-natural dose here!

    The big thing here is that you’re getting the 245mg pretty much no matter what. We love that dose, but you need to be good with it too, as it’s a one capsule system and you don’t have much choice in the matter once you dive in.

  • Cocoa (Theobroma cacao) (seed) Extract (std. 20% Theobromine) – 200mg

    Coming from the seeds of the plant that has gifted the world chocolate, theobromine shouldn’t just be tossed aside when making candy bars! Instead, it’s best used as an isolated compound, where it can aid weight loss endeavors!

    Blunts hunger

    Theobromine Effects

    Interesting: High-Dose Theobromine can dial up the “feels”

    In an extensive review from 2014, researchers were interested in assessing the true components of multiple weight loss products on the market. While the focus of this study was to find undisclosed synthetic substances, many natural substances, such as theobromine were identified as common inclusions. Interested as to why, these scientists further investigated the effects of these common, natural ingredients.

    In analyzing the chemical structure and biological properties of these compounds, the researchers concluded that theobromine actually reduces feelings of hunger,[6] helping blunt the appetite upon acute administration. When you’re talking about trying to lose weight, feeling less hungry is highly desirable!

    Frees up fatty acids

    Theobromine is a stimulant, although less potent than something like caffeine. Nonetheless, this is important information, and gives credence to the compound’s ability to help burn fatty acids.

    A study from 2006 used mice to assess the biological responses when taking theobromine. They found that the compound induces weight loss due to changes in lipid profile.[7] This means that weight loss occurred due to more fatty acids being burned, proving theobromine’s worth in reducing body fat.

    Nutrex Plant Protein

    Gourmet Taste in a Plant Protein is here! Nutrex Plant Protein launched in three flavors, uses four types of protein, and has no stevia but uses monk fruit instead!!

    Balances cholesterol levels

    While the aforementioned effects are desired, it’s important that integral organs such as the heart are kept healthy, as well. If these things aren’t running properly, then your body won’t be able to run efficiently, and your efforts may not breed the results you want.

    In regards to heart health, having optimal cholesterol levels is incredibly important. Theobromine is able to help in this department. Research has shown that it raises high-density lipoprotein (HDL) levels, while also decreasing low-density lipoprotein (LDL) levels.[8] HDL cholesterol is considered “good” cholesterol, whereas LDL depends on the rest of your lipid profile but is correlated with heart disease if HDL is low and triglycerides are high (which also typically signifies a bad diet and likely hyperinsulinemia). Thus, theobromine gives you more of the protective stuff!

    While a 40mg total yield is a little short of the clinical dose (approximately 150mg), it’s by no means ineffective. Its inclusion here is still welcomed, and works perfectly with everything else on the label!

  • Coleus forskohlii (root) Extract (std. 20% Forskolin) – 50mg

    Forskolin finds its roots in Ayurvedic medicine, where it was anecdotally used to promote overall health and vigor. These days, the root is finding its way into multiple different supplements, most of which relating to weight loss and hormonal production. Research is a bit young compared to other alternatives, however, the potential shown suggests this stuff may be the real deal!

    Primes the body for fat-burning

    Forskolin Weight Loss

    Forskolin causes a chain reaction of events that ultimately lead to fat loss. This is the process of free fatty acid liberation. Then it’s up to you burn it with exercise!

    Cyclic adenosine monophosphate, conveniently abbreviated to cAMP, is a molecule used by the cells for bodily function. Specifically, it helps signal a variety of functions, some of which are tied directly to fat loss.[9]

    Research seems to back up the claims suggested by these elevated cAMP levels. A study published in 2005 examined the effect of forskolin on body composition and metabolic rate in obese men. 30 subjects were tested in a double-blind, placebo-controlled manner, with half of the subjects receiving 50mg of the root daily.

    After 12 weeks, the researchers found that forskolin significantly decreased body fat percentage and fat mass.[10] They also noted a trend towards an increase in lean mass, although statistical outcomes weren’t as conclusive in this case. By activating the cAMP pathway, the root was able to turn on the fat-burning switch many of us struggle to find!

    Ancillary testosterone support

    Because the cAMP pathway also relates to hormonal production, it should be no surprise that forskolin brings something to the table in terms of testosterone levels. Elevated cAMP levels mimic the mechanisms of the luteinizing hormone,[11] a common enemy of testosterone production. With cAMP filling in for the luteinizing hormone, the theory posits that the body would be able to produce more testosterone.


    The diamonds represent the subjects receiving forskolin

    Sure enough, that’s exactly what early research is suggesting. The same study that we mentioned above also tested testosterone levels, and found that forskolin significantly increased free testosterone levels.[10]

    While not directly tied to fat-burning, this can still be of use. Having optimal testosterone levels is key to virtually all bodily functions, and can even help you push harder in your training. A more anabolic state, in turn, can help you burn more body fat. By the transitive property, this effect of forskolin shouldn’t be taken for granted!

    Coming in at 10mg, we must say we would like to have more forskolin here. The clinical dose is around 50mg, which is much higher than what Lipo-6 Natural is packing. However, that dose is often associated with GI distress, something that would surface with the amount of sales Nutrex has in the Lipo-6. Not worth it. Either way, the 10mg here should still bring these effects to some degree, albeit not as much as a more aggressive (and riskier) formulation would have.

  • Ashwagandha (Withania somnifera) (root) – 50mg

    Not a huge dose by any means, but let’s explore anyway:

    Another root with its origins in Ayurvedic medicine, ashwagandha has grown significantly in its popularity in recent years. While typically used within the industry as a stress-combatant, the mechanisms the plant effects suggest potential fat-burning abilities, too!

    Lower cortisol = more fat-burning

    Ashwagandha significantly reduces cortisol

    Ashwagandha is an adaptogenic herb that helps lower cortisol in addition to improving VO2 Max – but typically at far higher doses, which is why we suggest stacking this with Vitadapt below.

    Cortisol is the hormone secreted when we get stressed out. It impacts a number of different areas within the body, none more relevant in this case than its impact on insulin levels. Specifically, cortisol is negatively correlated with insulin sensitivity,[12] which can wreak havoc on your body weight. Having poor insulin sensitivity is highly undesirable, and severely limits your body’s ability to use glucose for energy. What happens when you can’t you these sugars for energy you ask? That’s right, it goes to body fat!

    Ashwagandha helps keep cortisol levels in check. A study from 2012 assessed the effects of ashwagandha on subjects with chronic stress. Subjects given 600mg daily, for 60 days, saw significantly lowered cortisol levels.[13] This can have a huge impact on your weight and body fat levels. When we get stressed out, we tend to crave unhealthy junk food, particularly the kind that fall into the infamous “little protein, high carb, high fat” realm. In keeping cortisol levels low, we’re better to avoid these pitfalls and keep our diet in check.

    Research has also been conducted in regards to fat loss, specifically. One study found that ashwagandha facilitated a 3% decrease in body mass, compared to only a 1.5% decrease in the placebo group.[14] That’s definitely noteworthy, and despite it being the only real study focused on fat loss, cannot be overlooked!

    When talking about the dosing of ashwagandha, we love to see something within the 250 to 600mg range. Here, we only have 50mg, which is honestly the biggest drawback of this one-capsule serving — and we don’t recommend taking a second cap. It’s a mere fraction of what’s proved effective, but despite that, we can’t say that the 50mg won’t have some effect — we’ll take ashwagandha anytime we can get it.

    Want more Ashwagandha? Use the Vitadapt multivitamin

    If you’re interested in more, add in the Vitadapt multivitamin, which will then bring you into the clinical range.

  • Apple Cider Vinegar (4% Acetic Acid) – 50mg

    Lipo-6 Natural

    Follow @nutrexresearch on Social Media! (That’s where we stole this image)

    Apple cider vinegar (ACV) has made its way into the homes of many in recent years, as it has become one of the trendiest “superfood” products on the market. Drawing its powers from the bioactive components within acetic acid, ACV has shown various potential uses.

    Increases satiety, which can reduce weight

    ACV research has focused on a variety of effects, yet none seem to be quite as relevant to this product as its effects on controlling weight. A study from 2009 administered ACV in either a 15mL or 30mL dose, with results compared to a placebo group after 3 months.

    The study found that, regardless of the dosing, ACV significantly reduced body weight, visceral fat, and waist circumference.[15] The researchers believe that these results were a product of the vinegar’s ability to reduce hunger,[16] which other studies have concluded when consuming ACV following a high-carbohydrate meal.

    Control blood glucose levels

    Apple Cider Vinegar Insulin

    Can Apple Cider Vinegar lower insulin and blood sugar spikes? Color us interested… (DOI: 10.2337/diacare.27.1.281)

    In addition to blunting hunger, ACV plays a role in insulin response, as well. Research has shown that ACV can reduce blood glucose and insulin response when consuming carbohydrates.[16]

    One study published in 1995 tested the effects of ACV on blood glucose response. Subjects were given different vinegars, and them consumed 50g of white bread, in order to assess the responses within each group. The study found that the group which received ACV displayed a depressed blood glucose response of 31.4%, compared to the other groups.[17] Lower blood glucose means higher insulin sensitivity, something you’ll definitely want when trying to lose weight!

    Being more insulin sensitive allows you to effectively burn the calories you’re consuming, keeping them from being stored as body fat. In helping regulate insulin levels, ACV proves capable of keeping that fat-burning window open!

  • Grains of Paradise (Aframomum Melegueta) (seed) Extract – 30mg

    Grains of Paradise Energy Expenditure

    Energy expenditure change (ΔEE) after oral ingestion of grains of paradise (GP) extract and placebo. ΔEE before (0 h) and after oral ingestion of 40 mg GP extract (●) or placebo (○). (a), (b) Δ EE, (c), (d) ΔEE adjusted for fat-free mass (FFM), (a), (c) brown adipose tissue (BAT)-positive group (n 12), (b), (d) BAT-negative group (n 7).

    Get ready, Nutrex is looking to spice things up a bit with this one! Grains of paradise, a seed native to the ginger family,[18] is a spice that not only packs some kick, but some real fat-burning potential! It’s one of our favorite fat-burning ingredients, and is something we’re always happy to see on a label!

    The seed contains powerful ketones such as 6-paradol, 6-gingerol, 6-shogaol, each of which play a role in turning up the heat.[18] Research has shown that grains of paradise helps burn brown adipose tissue for energy,[18] activating fatty acid stores within the body. That translates to using stored body fat for energy, which is crucial when you’re talking about body recomposition. It appears to accomplish this via elevated stimulation of the metabolism, increasing your total caloric expenditure![18]

    The dose here is also awesome, as most studies tend to use something around 10mg. Lipo-6 Natural is delivering a full 30mg, more than enough to turn up the temperature and get your metabolism moving!

  • BioPerineⓇ [Black Pepper (Piper nigrum) Extract (fruit)] – 5mg

    As great as all of these ingredients are, sometimes our body can have issues fully absorbing them. In order to make sure nothing slips through the cracks, Nutrex includes black pepper extract via the trademarked BioPerineⓇ.


    Bioperine is the trusted, trademarked form of black pepper extract that promises 95% or greater piperine, the part of black pepper with all the activity!

    Black pepper extract has the ability to enhance the bioavailability in supplemented ingredients,[19] including fat-soluble and water-soluble vitamins and minerals. Moreover, research also suggests that when used within a fat-burning formula, BioPerineⓇ can increase caloric expenditure.[20] Obviously, it wasn’t the sole influencer of this effect, but it nonetheless contributed!

    5mg is the perfect amount to ensure you’re getting everything within one capsule. While it tends to be overlooked, the impact black pepper extract has on bioavailability of a supplement cannot be understated!

Nutrex has been crushing it!

Nutrex is one of the industry’s most well-known, most reputable brands. They’ve been around for quite some time, and have made a major impact within the supplement game. Their products have been around seemingly forever, yet they’ve never failed to innovate and remain a step ahead of the competition.

Although they’ve launched a variety of different product series, they’re truly making noise with their Natural Series. This line of all-natural supplements are made for virtually everyone, fully accessible no matter which dietary or lifestyle restrictions you may have. Whether you’re vegan, gluten-free, or follow some other crazy diet, the Natural Series has something for you!

A quick note on “weight loss” supplements

Cinnamon Cookies Nutrex Plant Protein

Nutrex Plant Protein is also out, and this Cinnamon Cookies flavor is so good!

Before we dive into the Lipo-6 Natural, we’d like to highlight a point that some often neglect. While they can be effective, weight loss supplements are, by no means, a be-all-end-all in your quest to lose some pounds. Yes, the ingredients we cover can aid in proper weight loss, but they don’t necessarily cause weight loss.

If you’re trying to lose weight, it’s absolutely imperative that you make sure your diet is in check. This becomes even more important when you’re looking to cut fat and maintain as much muscle mass as possible. Simply put, your macros need to be in check. In addition to that, your training must be put in check. Mindlessly performing the same lifts, or logging endless hours of low-intensity cardio just won’t cut it. If you’ve got your diet and workouts dialed in, an additional boost from a weight loss product can definitely be useful!

One other important point – these supplements are meant for healthy individuals. If you’re dealing with hormonal issues or other medical problems, then perhaps getting those sorted out before experimenting with a fat-burner is in your best interest. In short, make sure your body is running as smoothly as it should be!

Weight loss and fat-burning supplements are meant to be just that – supplements. They’re not the key to the door of proper weight loss. Rather, think of them as the door-stopper that holds that door open, giving you access to enhanced results assuming everything else is already in check. People these days tend to lose sight of all of this, and it’s something you really just hate to see. We just wanted to take some time to point this out before moving on!

Conclusion – an easy, effective fat-burner for the masses!

As Nutrex’s Plant Protein may just be the best-tasting plant-based protein powder we’ve ever tasted, our expectations for everything else in this line are high. In addition, given the popularity and effectiveness of the multiple iterations of Lipo-6, this all-natural version had a high bar to clear.

Nutrex Naturals

Nutrex has gone Natural! Some of the industry’s most trusted supplements now have a Natural Series counterpart, for those looking to avoid artificial ingredients!

Lipo-6 Natural packs everything you want in a fat-burner. With ingredients that target satiety, others more concerned with metabolic rate, and even hormonal support, Lipo-6 Natural lives up to any precedent set for it. While some of the doses, admittedly, are less than ideal, they’re still adequate enough to deliver a solid weight management experience.

Oh yeah, how could we forget to mention this – it’s all-natural and is only a one-pill serving. You’re not putting any crazy, artificial ingredients into your body, nor are you guzzling down a ridiculous amount of golf-ball sized capsules. Nope, one capsule a day, and you’ll be on your way to body recomposition!

Check back with us soon to see what else Nutrex has coming down the Natural Series pipeline. Hint – it’s legit!

Nutrex Lipo-6 Natural – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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  14. Choudhary, Dnyanraj et al; “Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial”; Journal of evidence-based complementary & alternative medicine; vol. 22,1; (2016); 96-106;
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  16. Ostman, E, et al; “Vinegar Supplementation Lowers Glucose and Insulin Responses and Increases Satiety after a Bread Meal in Healthy Subjects.”; European Journal of Clinical Nutrition; U.S. National Library of Medicine; Sept. 2005;
  17. Brighenti, F, et al; “Effect of Neutralized and Native Vinegar on Blood Glucose and Acetate Responses to a Mixed Meal in Healthy Subjects.”; European Journal of Clinical Nutrition; U.S. National Library of Medicine; Apr. 1995;
  18. Sugita, J, et al; “Grains of Paradise (Aframomum Melegueta) Extract Activates Brown Adipose Tissue and Increases Whole-Body Energy Expenditure in Men.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Aug. 2013;
  19. Research; BioPerine;
  20. Outlaw, Jordan et al; “Effects of ingestion of a commercially available thermogenic dietary supplement on resting energy expenditure, mood state and cardiovascular measures”; Journal of the International Society of Sports Nutrition; vol. 10,1 25; 30 Apr. 2013;

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